Folia Medica Indonesiana最新文献

{"title":"Chondroregenerative Potential of Platelet-Rich Fibrin (PRF)-Impregnated Decelulrized Bovine Cartilage Scaffold Implanted Subcutaneously","authors":"P. Widyatmika, Muhammad Sjaifuddin Noer, M. Hutagalung","doi":"10.20473/fmi.v58i4.16499","DOIUrl":"https://doi.org/10.20473/fmi.v58i4.16499","url":null,"abstract":"Highlights:\u0000\u0000This research compared the hondroregenerative potential between bovine cartilage scaffold with platelet-rich fibrin (BCPRF) and autologous cartilage.\u0000The formation of newly-regenerated chondrocyte, the thickness of type II collagen, and the rate of cartilage resorption following the subcutaneous implantation were assessed.\u0000BCPRF is highly biocompatible and can be developed as an alternative to alloplastic porous polyethylene (Medpor) implant material.\u0000\u0000 \u0000Abstract:\u0000The invention of alternative implants with regenerative potential comparable to autologous cartilage continues to be encouraged due to high morbidity of the donor site related to autologous harvesting process. This research attempted an invention of alternative implant using tissue engineering techniques in the form of endogenous regeneration by combining decellularized bovine cartilage scaffold with platelet-rich fibrin (BCPRF) that was implanted subcutaneously. The study aimed to compare the chondroregenerative potential between BCPRF and autologous cartilage in terms of the formation of newly-regenerated chondrocyte, the thickness of type II collagen produced, and the rate of cartilage resorption following the subcutaneous implantation. This study was conducted in a pretest-posttest control group design using New Zealand white rabbits. Forty-eight experimental samples were divided into two groups, then treated with subcutaneous implantation of BCPRF and autologous cartilage respectively. The results were evaluated after six weeks of implantation. Thirty-nine samples were evaluated. There was a significant difference found from both groups in terms of the formation of newly-regenerated chondrocyte, the thickness of type II collagen (p=0.000), and the implant resorption rate (p=0.000). The microscopic images demonstrated a superior chondroregenerative potential in the group receiving implantation of autologous cartilage compared to the group receiving BCPRF. The chondroregenerative potential for autologous cartilage and BCPRF differed significantly in terms of the formation of newly-regenerated chondrocyte, the deposition of type II collagen matrix, as well as the resorption rate.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43594385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Castor Plant (Ricinus communis L.) Leaf Extract as Potential Antibacterial Against The Growth of Mycobacterium Tuberculosis","authors":"Fikriaddin Syafiq Istaufa, Yoyok Subagio, Irma Suswati, Isbandiyah","doi":"10.20473/fmi.v58i4.29307","DOIUrl":"https://doi.org/10.20473/fmi.v58i4.29307","url":null,"abstract":"Highlight :\u0000\u0000Patients experiencing failure of first-line drug and developing multidrug resistant tuberculosis (MDR-TB) has increased throughout 2011-2015.\u0000Castor plant leaf extract (Ricinus communis L.) has an antibacterial potential against the growth of Mycobacterium tuberculosis bacteria.\u0000\u0000 \u0000Abstract:\u0000Mycobacterium tuberculosis is the cause of pulmonary tuberculosis that can reduce human health. In the therapy of the disease, patients can develop resistance to tuberculosis drugs. Based on the 2015 health profiles of Indonesia, 15,380 people were suspected to have multidrug-resistant tuberculosis (MDR-TB), while 1,860 people were confirmed patients with MDR-TB. There is a need for innovation to develop the latest treatments using natural ingredients, one of which is castor plant (Ricinus communis L.) that contains antibacterial compounds against Mycobacterium tuberculosis. This study aimed to understand the antimicrobial potential of castor plant (Ricinus communis L.) leaf extract against the growth of Mycobacterium tuberculosis. This scientific paper was a quantitative systematic review study. Literature in the form of journal articles and books were obtained through search engines, i.e. ebook database, Google Scholar, Cochrane, Wiley, and PubMed. The results of the literature source search were 19 journal articles and 4 ebooks, as well as 4 journal articles that were in accordance with the title of this literature review and discussed the effects of castor plants on the growth of Mycobacterium tuberculosis. The results of the analysis showed that castor plant (Ricinus communis L.) leaf extract has the potential in the antibacterial activity against the growth of Mycobacterium tuberculosis because it contains phytochemicals in the form of flavonoids, saponins, alkaloids, tannins, and fatty acid amides derived from ricinoleic acid as the main constituent of castor plants (Ricinus communis L.). There is antimicrobial potential for castor plant (Ricinus communis L.) leaf extract against the growth of Mycobacterium tuberculosis.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42695691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Workload and Work Fatigue among Tank Car Drivers at Surabaya Integrated Terminal","authors":"Tasya Endah Milinia, Dani Nasirul Haq, Siti Arum Alia","doi":"10.20473/fmi.v58i4.36305","DOIUrl":"https://doi.org/10.20473/fmi.v58i4.36305","url":null,"abstract":"Highlights:\u0000\u0000Physical workload had no correlation with work fatigue among tank car drivers.\u0000Companies and tank car drivers are advised to carry out work fatigue management by exercising lightly and fulfilling nutritional and water intake.\u0000\u0000 \u0000Abstract :\u0000Every year, there are nearly a thousand times more of non-fatal accidents than fatal accidents. In Indonesia, Java Island has the highest number of traffic accidents. Work accidents have three main factors, i.e. worker factors, labor factors, and environmental factors. Fatigue is one of the conditions called silent killer. The aim of this research was to analyze the correlation of physical workload with work fatigue in tank car drivers at Surabaya Integrated Terminal. This research was an observational cross-sectional study. The sample were 205 tank car drivers fufilling the inclusion criteria as fuel tank car drivers and willing to participate in this research. The independent variable in the study was physical workload, while the dependent variable was subjective work fatigue. Data were collected using the IFRC questionnaire. The Spearman’s correlation test  revealed the value of Sig. (2-tailed)=0.437, indicating no significant correlation between physical workload and subjective work fatigue. The results showed that the physical workload had no correlation with work fatigue. Fatigue found among the drivers are probably induced by other factors not analyzed in this study. Companies and tank car drivers are advised to carry out work fatigue management by, for example, drinking water regularly, carrying out light exercise, and fulfilling nutritional intake.\u0000 ","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41459360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spike-Receptor Binding Domain (SRBD) Antibodies Secretion in COVID-19 Survivors and Non-Survivors Post-Pre-Endemic Vaccination","authors":"Museyaroh, Evy Dyah Woelansari, Dwi Kriharyani","doi":"10.20473/fmi.v58i3.37209","DOIUrl":"https://doi.org/10.20473/fmi.v58i3.37209","url":null,"abstract":"Highlights\u0000\u0000The research this for determine the presence of immune response post-vaccine\u0000The results of this study indicate that there are differences in immune responses, in survivors patients have higher SRBD antibody levels than non-survivors\u0000\u0000 \u0000Abstract :\u0000The development of a vaccine for SARS-COV-2 began in mid-2020 with the aim of stimulating an individual's immune response against SARS-CoV-2 infection. The purpose of this study was to determine the levels of post-vaccine SRBD antibody secreted in COVID-19 survivors and non-survivors. Antibodies are considered to play a more important role in evaluating immunity because antibody tests may provide information about a person's immune status against SARS-CoV-2. The study was conducted at Husada Utama Hospital, Surabaya, Indonesia, in April – May 2021. The samples were taken prospectively with a total sample of 60 patients, consisting of 40 non-survivors and 20 survivors of COVID-19 who had received Sinovac vaccine doses 1 and 2. Examination of Sars-CoV-2 SRBD antibody was conducted by using CL series of Mindray device by means of CLIA method. The average level of antibody was assessed in each sample group and the results were subjected to the Mann Whitney test. The mean SRBD antibody level in female patients was 428.24 ± 271.25, while in male patients it was 310.40 ± 113.71 U/mL. The results of the Mann Whitney test revealed a P-Value of 0.09 > 0.05, indicating no difference in post-vaccine SRBD antibody levels between females and males, but there were differences in SRBD antibody levels in COVID-19 survivors and non-survivors with a P-Value of <, i.e. 0.00 < 0.05 There was no difference in post-vaccine SRBD antibody levels between females and males in COVID-19 survivors and non-survivors, but there were differences in post-vaccine antibody levels between COVID-19 survivors and non-survivors.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48441880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penetrating Ocular Injury Management in Intraocular Foreign Body (IOFB) and Traumatic Cataract","authors":"Nerissa Tamara Putri, Muhammad Firmansjah, Reni Prastyani","doi":"10.20473/fmi.v58i3.12513","DOIUrl":"https://doi.org/10.20473/fmi.v58i3.12513","url":null,"abstract":"Highlight:\u0000\u0000The management of penetrating ocular injury with IOFB and traumatic cataracts needs a thorough examination of the mechanism of injury, location, size, and composition of IOFB.\u0000Endophthalmitis, retinal detachment, and development of PVR are potentially vision-threatment.\u0000\u0000 \u0000Abstract:\u0000Most IOFB are metallic and found in males of productive age as a consequence of work-related accidents. A 45-year-old man complained of sudden blurred vision in the left eye (3/60 pinhole 5/12) after getting hit by a foreign body when cutting grass with a lawn mower. Anterior segment examination revealed a 10 mm long, one-plane, straight, full thickness, already sutured inferonasal corneal laceration, inferonasal traumatic iridectomy size 3x7 mm, and opaque lens. Head CT-scan revealed opacity with metallic density intraocularly. Ultrasonography revealed an echogenic lesion, particle-shaped with 100% RCS complex density, located at the inferonasal of the vitreous cavity. Focal laser photocoagulation was performed preoperatively because there was a tear at the superonasal of the retina. The patient underwent cataract extraction, intraocular lens implantation, vitrectomy, and IOFB extraction in a one-step procedure. IOFB was found at the inferonasal side of a vitreous cavity with size 3 x 1 mm, metallic, and not attached to the retina. Silicon oil tamponade was used as a precaution because there were retinal tears. Postoperatively, the left eye's visualacuity was 5/20. After 6 months, the silicon oil was evacuated and the visual acuity became 5/8.5.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45681238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovering Patterns of Cardiovascular Disease and Diabetes in Myocardial Infarction Patients Using Association Rule Mining","authors":"Anju Singh, Divakar Singh, Shikha Sharma, K. Upreti, Manish Maheshwari, V. Mehta, J. Sharma, Pratishtha Mehra, P. Dabla","doi":"10.20473/fmi.v58i3.34975","DOIUrl":"https://doi.org/10.20473/fmi.v58i3.34975","url":null,"abstract":"Highlights:\u0000\u0000Association Rule Mining tools predict the association of early-onset Myocardial Infarction with Hypertension and Diabetes Mellitus.\u0000Association Rule Mining tools using clinical and biochemical attributes can predict the development of Hypertension and Diabetes Mellitus in Myocardial Infarction patients.\u0000\u0000Abstract: \u0000Cardiovascular diseases (CVDs) are a major cause of mortality in diabetic patients. Hypertensive patients are more likely to develop diabetes and hypertension contributes to the high prevalence of CVDs, in addition to dyslipidemia and smoking. This study was to find the different patterns and overall rules among CVD patients, including rules broken down by age, sex, cholesterol and triglyceride levels, smoking habits, myocardial infarction (MI) type on ECG, diabetes, and hypertension. The cross-sectional study was performed on 240 subjects (135 patients of ST-elevation MI below 45 years and 105 age matched controls). Association rule mining was used to detect new patterns for early-onset myocardial infarction. A hotspot algorithm was used to extract frequent patterns and various promising rules within real medical data. The experiment was carried out using \"Weka'', a tool for extracting rules to find out the association between different stored real parameters. In this study, we found out various rules of hypertension like “Rule 6” says that if levels of BP Systolic > 131 mmHg, LpA2 > 43.2 ng/ml, hsCRP > 3.71 mg/L, initial creatinine > 0.5 mg/dl, and initial Hb ≤15 g/dl (antecedent), then the patient will have 88% chance of developing hypertension (consequent). Similarly for diabetes mellitus with finding their lift and confidence for different support like “Rule 6”, if MI type on ECG = ’Inferior Wall MI’ with STATIN=No, and levels of Triglycerides ≤325 (antecedent), then the patient had a 67% chance of developing diabetes mellitus. We concluded that early-onset myocardial infarction is significantly associated with hypertension and diabetes mellitus.Using association rule mining, we can predict the development of hypertension and diabetes mellitus in MI patients.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47729436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge on The Risk of The Ischemic Heart Disease Estimation by WHO Charts in Cempaka Baru, Indonesia","authors":"Hasna Luthfiah Fitriani, Karina Ajeng DA Ridwan","doi":"10.20473/fmi.v58i3.33683","DOIUrl":"https://doi.org/10.20473/fmi.v58i3.33683","url":null,"abstract":"Highlights:\u0000\u0000The risk estimation of ischemic heart disease.\u0000High blood pressure and cholesterol levels affect Ischemic heart disease.\u0000\u0000 \u0000Abstract:\u0000In 2018, Indonesia became the country with the second-highest number of deaths and disabilities (DALYs) due to ischemic heart disease. Based on Riskesdas data in 2018, Jakarta is one of the provinces with a high percentage (1.9%) of ischemic heart disease. Risk factors for ischemic heart disease that are not treated quickly will increase the severity of ischemic heart disease in the future. Therefore, this study was to provide education regarding the assessment of risk estimation for ischemic heart disease with WHO/ISH charts among participants in Cempaka Baru sub-district. This study used pre-test and post-test questionnaires. After the seminars, the interview and examination results were carried out as well as calculating the estimated risk of ischemic heart disease using the WHO chart. These charts were divided into low risk (<10%), moderate (10-20%), and severe (>20%). The evaluation was conducted by comparing the pre-test and post-test results, which indicated that the knowledge level increased significantly from the Paired T-Test with a p-value = 0.000 (p<0.05). The significant estimation of high risk of ischemic heart disease for high blood pressure was 72.7% (p=0.023) and total cholesterol level was 66.7% (p=0.049). The increasing knowledge of the stratification risk of ischemic heart disease with the WHO chart was expected to reduce the risk of ischemic heart disease in the future.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44523888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory Effect of Garlic and Vitamin C on Candida Albicans","authors":"Muhammad Fauzi Lufthansyahrizal, Kusuma Andriana, Sri Adila Nurainiwati","doi":"10.20473/fmi.v58i3.28605","DOIUrl":"https://doi.org/10.20473/fmi.v58i3.28605","url":null,"abstract":"Highlight:\u00001. Garlic and Vitamin C effect on Candida Albicans.\u00002.  Vitamin C has the ability to inhibit C. albicans in PBS media but it did not have significant MIC due to the presence of glucose in the media if combined with garlic petroleum extract.\u0000 \u0000Abstract:\u0000Garlic can downregulate ECE1, a gene that regulates the production of candidalysin as a virulence factor for C. albicans. Allicin in garlic has antifungal properties because allicin can penetrate cell membranes and damage cell organelles such as vacuoles and mitochondria, causing irreversible structural and functional damage that leads to cell death. Garlic that is processed into extracts also has antifungal abilities. Purely squeezed garlic extract had a MIC of 50%, while the ethanol extract of garlic had a MIC of 40%. This difference is thought to be due to differences in the use of concentrations used and the use of extract solvents. Vitamin C can inhibit C. albicans in PBS media, there is an active metabolism and oxygen, low free iron concentration, there is mitochondrial inhibition ongoing, and in the early stationary growth phase. However, the combination of garlic petroleum ether extract and vitamin C did not show significant MIC due to the presence of glucose in the media, which could increase the growth of C.albicans.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41747420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferning and Schirmer Test 1 for the Detection of Grading Severity of Dry Eye Syndrome in Post Phacoemulsification Patients","authors":"T. S. H. Zubaidah, R. R. Lubis, L. Feriyawati","doi":"10.20473/fmi.v58i3.34804","DOIUrl":"https://doi.org/10.20473/fmi.v58i3.34804","url":null,"abstract":"Highlights:\u00001. Females were the most gender who suffer from dry eye syndrome than males.2. Undergone phacoemulsification patients had frequent dry eye syndrome.3. Post-phacoemulsification patients were not statistically significant between the Ferning and the Schirmer test.\u0000 \u0000Abstract:\u0000Dry eye syndrome is a multifactorial disease on the surface of the eyeball characterized by loss of tear film homeostasis, which is associated with eye symptoms, where there is tear instability and hyperosmolarity, inflammation, and damage to the surface of the eye, as well as neurosensory disorders that act as the cause of this syndrome. The aim of this study was to identify relationship between the Ferning pattern and the Schirmer test 1 in post-phacoemulsification patients. The design of this study was an analytical observational study with a cross-sectional data collection method where the Ferning and Schirmer test 1 were examined to determine the severity of dry eye syndrome in post-phacoemulsification patients. The Ferning test was assessed according to Rolando’s classification. In this study, it was found that the gender who suffer from dry eye syndrome are women. The most considerable age is age ≥ 60 years (56,7%). The results showed that the majority of patients experienced dry eyes measured with the Ferning test, and these results were following the previous Schirmer Test 1 examination. The Ferning and Schirmer tests were found to be abnormal in most of the subjects. It was found that there was a significant relationship between the Ferning pattern and the Schirmer test with the calculation of the t-value of 7.345 with a p-value of 0.001. There was a statistically significant difference between the results of Ferning and the Schirmer test in post-phacoemulsification patients.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46741537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Durability of S-RBD IgG Antibody Levels after Sinovac Vaccination in Healthcare Workers","authors":"J. Nugraha, Cynthia Ayu Permatasari, Munawaroh Fitriah","doi":"10.20473/fmi.v58i3.35873","DOIUrl":"https://doi.org/10.20473/fmi.v58i3.35873","url":null,"abstract":"Highlights:\u0000\u0000The effectiveness of vaccination through the kinetics of the antibody response to the SARS-COV-2 vaccine administration by examining IgG S-RBD levels was aimed.\u0000Two doses of the Sinovac vaccine formed antibodies in healthy individuals in the first 3rd month after vaccination.\u0000An S-RBD IgG antibody in the 6th-month post-vaccination was significantly different between groups without a history and groups with a history of infection with COVID-19.\u0000\u0000 \u0000Abstract:\u0000Since it was declared a pandemic in early 2020, Coronavirus Disease 2019 (Covid-19) has caused high morbidity and mortality in the world. In view of the urgency of the situation, vaccination efforts are needed to break the chain of disease transmission. Various types of vaccines have been successfully developed and obtained approval for emergency use. However, the effectiveness of these vaccines, both in the short and long term, has not been fully known. This study aimed to examine the effectiveness of vaccination through the kinetics of the antibody response to the administration of the SARS-COV-2 vaccine by examining IgG S-RBD levels. This study was an observational analytic study with a prospective cohort approach carried out between January and November 2021 at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Fifty health workers who received Sinovac vaccination in as many as 2 doses underwent venous blood taking and measurement of quantitative S-RBD antibody level. Then, quantitative S-RBD IgG antibody levels were measured and recorded in each subject. The mean S-RBD IgG antibody was found to have fluctuation. The titer was found to significantly increase on day 14 and dropped significantly in month 3 (p <0.001). There was a significant difference in S-RBD IgG levels 6 months after vaccination between Covid-19 uninfected groups and Covid-19 infected groups (p <0.001). In a conclusion, two doses of the Sinovac vaccine formed antibodies, although humoral immunity obtained tended to decrease in 3rd month after vaccination to healthy individuals. The average level of S-RBD IgG antibody in the sixth month post-vaccination was found to be significantly different between groups without history and groups with a history of with infection COVID-19.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46367434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}