Folia Medica Indonesiana最新文献

{"title":"Identification of Pathogenic Bacteria in Food Samples from Cafeterias of A University in Denpasar, Indonesia","authors":"Anak Agung Ayu Lila Paramasatiari, Putu Indah Budiapsari, P. Suryanditha, N. Widhidewi","doi":"10.20473/fmi.v58i4.34968","DOIUrl":"https://doi.org/10.20473/fmi.v58i4.34968","url":null,"abstract":"Highlights:\u0000\u0000Eschericia colli was the most contaminant bacteria among food samples from Warmadewa Cafeterias\u0000Further suggestions to increase the hygiene in food processing must be offered.\u0000\u0000 \u0000Abstract :\u0000Foodborne diseases still remain a problem especially in public areas. This study aimed to identify pathogenic bacteria in foods sold at  the  cafeterias  of  Universitas Warmadewa,  Denpasar,  Indonesia.  The  presence  of  pathogenic bacteria  in  the  food  samples  was identified using the brain heart infusion (BHI) agar for the growth of Escherichia coli and Streptococcus aureus, selenite for Shigella and Salmonella, and alkaline peptone for Vibrio cholerae, then bacterial culture was conducted to identify the species. The results showed  that  Escherichia  coli  were  found  in  two  food  samples,  kangkong  and  jinggo  rice,  with  the  colony  counts  of  50-118. Escherichia coli was the most commonly found contaminant in food samples from the Warmadewa Cafeterias. Further suggestions must be offered to increase hygiene in the food processing by advising the stalls’ owners to serve good foods and conducting regular inspections to assess the food quality.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48571869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healing in Nurses After Assignment in Natural Disasters","authors":"Fitriana Kurniasari Solikhah, Ronal Surya Aditya","doi":"10.20473/fmi.v58i4.37410","DOIUrl":"https://doi.org/10.20473/fmi.v58i4.37410","url":null,"abstract":"Highlight : \u0000\u0000Disasters impact a large number of people, including nurses who are deployed in the disaster relief.\u0000Culturally sensitive psychological first aid sessions, post-assignment in crisis situations monitoring, and grit have implications in pushing the nurses to overcome their trauma and obstacles.\u0000Government policies are also important in helping nurses to heal after deployment in disaster relief.\u0000\u0000 \u0000Abstract :\u0000Disasters are defined as catastrophic occurrences that impact a large number of people quickly and with an abrupt onset. On average, one natural disaster is reported globally each day. However, the impact of a traumatic occurrence on an individual may be compared to a rock colliding with the surface of a water body. Systematic searches were conducted in Cochrane, Google Scholar, PubMed, Scopus, Embase, and Web of Science databases. The following keywords were used to perform a literature search: \"nurse,\" \"healing,\" and \"natural catastrophes\". As a result of reviewing 362 abstracts and titles, ten were determined to meet the study goals. The research methods in four of the ten literatures were qualitative, five quantitative, and one was a blend of both. Generally, culturally appropriate psychological first aid sessions, post-natural disaster assignment monitoring, and grit push people to overcome obstacles and accomplish achievements over time. Nurses who have been deployed to natural catastrophes must heal and need time to rest physically and mentally. This study aimed to find out the implications of culturally sensitive psychological first aid sessions, post-assignment in crisis situations monitoring, and grit in pushing individuals to overcome obstacles and achieve success over time; and how the government policies relate to trauma recovery.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43868610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifungal Activity of Kinar (Kleinhovia hospita L.) Leaf Ethanol Extract Against Malassezia furfur","authors":"Muhammad Zaid Wakano, E. Astuty, Amanda Gracia Manuputty","doi":"10.20473/fmi.v58i4.38387","DOIUrl":"https://doi.org/10.20473/fmi.v58i4.38387","url":null,"abstract":"Highlights :\u0000\u0000Alternative medicine is needed for pityriasis versicolor because there are recurrence cases and resistance to antifungal agents.\u0000Kinar leaf ethanol extract cannot inhibit the growth of Malassezia furfur.\u0000Further studies are suggested on the type of solvent and appropriate concentration to attract more bioactive compounds.\u0000\u0000Abstract :\u0000Pityriasis versicolor is a superficial dermatomycosis that can decrease human self-confidence. This infection is caused by the fungus Malassezia furfur. Eighty percent of recurrence cases after treatment and resistance to antifungal agents were found. Therefore, alternative medicine is needed. Kinar (Kleinhovia hospita Linn.) is a tropical plant that have bioactive compounds, such as alkaloids, flavonoids, tannins, and saponins. The purpose of this study was to determine the effectiveness of kinar leaf extract against the growth of Malassezia furfur. This research was a laboratory experimental study using paper disc diffusion method. Kinar leaves (green and yellow leaves) were macerated using 96% ethanol and made into concentrations of 10%, 20%, 40%, 60%, 80%, and 100%. As much as 200 mg of ketoconazole was used as a positive control and distilled water as a negative control then tested on Malassezia furfur using Sabouraud dextrose agar (SDA). The parameter observed was the clear zone formed around the paper disc. The tests and observations showed that there was a clear zone formed around the paper disc. It means that the kinar leaf extract cannot inhibit the growth of Malassezia furfur.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46382214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Phytochemical Analysis and Invitro Antiplasmodial Activity of Terminalia mantaly Against Plasmodium falciparum","authors":"B. Usman, D. Attah, D. Y. Kanya","doi":"10.20473/fmi.v58i4.34180","DOIUrl":"https://doi.org/10.20473/fmi.v58i4.34180","url":null,"abstract":"Highlights:\u0000\u0000Malaria is prevalent in many populations of communities despite preventive measures.\u0000The experimental was screened for bioactive components which could be the reason for the antimalarial effect and the plant shows dose dependent antimalarial activity.\u0000\u0000 \u0000Abstract :\u0000Malaria has been one of the world’s worst killer diseases throughout recorded human history. Despite attempts to eradicate the disease, it remains a global burden. This could be a result of parasite resistance to current therapy. However, this research aimed at evaluating the in vitro antimalarial activity of ethanolic extracts of Terminalia mantaly on Plasmodium falciparum. The plant extracts were prepared by cold maceration in 70% ethanol and air-dried by a rotary evaporator. The phytochemical analysis was carried out using standard procedures outlined in the Analytical methods of the Association of Official Analytical Chemists (AOAC, 1990) which indicates the presence of tannins, alkaloids, saponins, flavonoids, glycosides, phenol, steroids, and balsam. The in vitro antimalarial assay was carried out according to the method described by WHO (2001). All data were represented as Mean ± Standard deviation. Ethanolic extracts of the three parts of the plant were subjected to in vitro antimalarial activity at three concentrations (300 mg, 150 mg, and 75 mg) in four replicates with artemether (standard drug) as a positive control. Stem bark at 300 mg/kg completely cleared the parasites with a 0.00% parasitaemia rate and there was no significant difference when compared with positive control at p<0.005 value of 1.00. This study affirms the use of the plant for the treatment of malaria.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48194648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Importance of Sarcopenia And How It Impacts Orthopaedic-Trauma Patients and The Surgical Outcomes","authors":"Ahmad Fauzi, David Idrial, A. Asdi","doi":"10.20473/fmi.v58i4.35971","DOIUrl":"https://doi.org/10.20473/fmi.v58i4.35971","url":null,"abstract":"Highlights:\u0000\u0000Sarcopenia can cause deleterious effects on patients.\u0000The Asian Working Group for Sarcopenia (AWGS) and the European Working Group on Sarcopenia in Older People (EWGSOP) provide the most widely used criteria to diagnose sarcopenia.\u0000Knowledge of sarcopenia should be a trigger for clinicians and surgeons to evaluate the treatment plan and anticipate the implications experienced by the patients.\u0000\u0000 \u0000Abstract:\u0000Sarcopenia is a condition of low muscle strength, mass, and low physical performance that is affected by age (primary sarcopenia) and one or combination of systemic diseases, physical inactivity, and insufficient intake of energy (secondary sarcopenia). This condition affects one in ten healthy adults aged ≥60 years. There are two widely used criteria to diagnose sarcopenia, the Asian Working Group for Sarcopenia (AWGS) and the European Working Group on Sarcopenia in Older People (EWGSOP). These working groups created algorithms to facilitate the diagnosis. Establishing the diagnosis is crucial because it has deleterious impacts on patients, such as increasing risks of mortality, morbidity, falls, complications during and after surgery, disability, prolonged hospitalization, and fractures. Sarcopenia is considered an independent mortality risk. It is paramount for physicians to assess this condition before treating the patients because it can predict the risk and plan better treatment options to achieve better outcomes. Early assessment is crucial, even for surgeons. Sarcopenia also negatively impacts patients who had surgery. Up to 44% patients who underwent orthopedic trauma surgery had sarcopenia. The high percentage was affected by the increased risk of falls and fractures. On that account, this condition needs to be treated. The main treatments for this condition are exercise dan adequate nutrition intake. The recommended exercise as a first-line treatment is resistance or strength training. Overall, knowledge on sarcopenia can prepare clinicians and surgeons in anticipating the implications of sarcopenia.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41807020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium Hyaluronate Eye Drops for College Students with Computer Vision Syndrome in Indonesia","authors":"B. S. Zulkarnain, R. Loebis, T. Aryani","doi":"10.20473/fmi.v58i4.6704","DOIUrl":"https://doi.org/10.20473/fmi.v58i4.6704","url":null,"abstract":"Highlight:\u0000\u0000Computer vision syndrome (CVS) that causes dry eyes becomes a health problem for college students.\u0000Sodium hyaluronate eyedrops can be used as one of the CVS therapy strategies for students suffering from CVS.\u0000\u0000 \u0000Abstract:\u0000The use of computers and mobile devices is increasing. Computers and mobile devices help our daily work or study. However, prolonged use of them may cause computer vision syndrome (CVS). Nowadays, CVS becomes a health problem for everyone working with computers or mobile devices including college students because it causes dry eyes. It may disrupt reading, doing professional work, or using a computer which is important for college students to complete academic tasks. Sodium hyaluronate can be used to overcome the dry eye problem due to CVS. To assess the effectiveness of sodium hyaluronate eyedrops on students suffering from CVS, pre- and post-administration of sodium hyaluronate was measured for two weeks. Inclusion criteria for this study were college students aged 20-35 years, using a computer for >2 hours a day, not using nonsteroidal anti-inflammatory drugs (NSAIDs), not consuming drugs, or having a disease that affects tear production and bearing no pregnancy. Parameters assessed include tear break-up time using the Tear Break-Up Time (TBUT) test, tear production using the Schirmer I test, the number of clinically subjective symptoms, and Ocular Surface Disease Index (OSDI) scores. Data were analyzed using student paired t-tests or Wilcoxon Rank Test. There were statistically significant differences before and after the TBUT (4.4 vs 6.7 seconds; p<0.0001); the Schirmer I Test (4 vs 6 mm; p<0.05), and the number of clinically subjective symptoms (3 vs 0 clinically subjective symptoms; p<0.0001). The OSDI scores did not show statistical differences before and after administration of sodium hyaluronate (27 vs 21; p>0.05), but there was a positive impact from moderate to mild dry eye. Sodium hyaluronate eyedrops can be used as one of the CVS therapy strategies for students suffering from CVS.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41873006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Model of Performance Evaluation for Healthcare Workers Based on Satisfaction and Remuneration (Financial and Non-Financial)","authors":"Joni Wahyuhadi, Nur Hidayah, Qurratul Aini","doi":"10.20473/fmi.v58i4.38126","DOIUrl":"https://doi.org/10.20473/fmi.v58i4.38126","url":null,"abstract":"Highlights:\u0000\u0000\u0000This study aimed to formulate an evaluation model of the performance of health workers.\u0000\u0000\u0000Employee performance targets and employee satisfaction were assessed by considering the financial and non-financial remuneration, Job Description Index (JDI), competencies, and motivation.\u0000\u0000\u0000The performance evaluation model for health workers shows the importance of remuneration for government agencies, employees, and employee performance.\u0000\u0000\u0000 \u0000Abstract:\u0000This study aimed to formulate an evaluation model of the performance of health workers from the perspective of financial and non-financial satisfaction and remuneration. The research method used was a literature study with a literature review approach. The research findings were the healthcare workers' performance evaluation model based on satisfaction and remuneration. The evaluation was conducted by assessing the employee performance targets (sasaran kerja pegawai/SKP) and employee satisfaction related to the financial and non-financial remuneration, Job Description Index (JDI), competencies, and motivation. In addition, this model has been also used for the evaluation of performance appraisal based on remuneration among employees (i.e. health workers) in government agencies, especially hospitals.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43704778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Safety Communications and Safety Promotion Policies on Safety Performance among Nurses in The Emergency Department at a Tertiary Hospital in Surabaya, Indonesia","authors":"Ratih Berliana, Noeroel Widajati, Nurhayati Saridewi, Endang Dwiyanti","doi":"10.20473/fmi.v58i4.35246","DOIUrl":"https://doi.org/10.20473/fmi.v58i4.35246","url":null,"abstract":"Highlights:\u0000\u0000To reduce the occurrence of work-related accidents, the application of occupational safety and health principles in work activities is necessary.\u0000This research analyzed the safety communications and safety promotion policies on the safety performance among nurses.\u0000Safety communications have influence on safety performance, while safety promotion policies have no influence on safety performance.\u0000\u0000 \u0000Abstract:\u0000The application of the occupational safety and health principles in work activities is expected to reduce the occurrence of work-related accidents. This research was conducted in the Emergency Department of a tertiary hospital of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, in 2019 and aimed to determine the influence of safety communications and safety promotion policies on the safety performance among nurses. This research was a quantitative research with a cross-sectional design study. The population in this study were 208 emergency room nurses at Dr. Soetomo General Academic Hospital with a total sample of 68 people using a simple random sampling technique. The results showed that the correlation between safety communications variable with safety performance had a p-value of 0.035 (<0.05) and the correlation between safety promotion policies variable with safety performance had a p-value of 0.319 (>0.05), indicating that there was    an influence of safety communications on safety performance, while there was no influence of safety promotion policies on safety performance among nurses in the Emergency Department of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44768852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality Assesment of Pediatric Septic Patients Through Pediatric Sofa+Anion Gap and Pelod-2 Scores","authors":"Johaan Pawe Siampa, Arie Utariani, Elizeus Hanindito","doi":"10.20473/fmi.v58i4.14726","DOIUrl":"https://doi.org/10.20473/fmi.v58i4.14726","url":null,"abstract":"Highlight:\u0000\u0000Sepsis and septic shock cause morbidity and mortality in pediatric patients.\u0000The accuracy of pediatric sequential organ failure assessment and anion gap (pSOFA+AG) was compared with AG and pediatric logistic organ dysfunction-2 (AG+PELOD-2).\u0000The mortality assessment of pediatric septic patients showed that pSOFA was more sensitive than PELOD-2, while pSOFA+AG was not more sensitive than PELOD-2.\u0000\u0000 \u0000Abstract:\u0000Sepsis and septic shock are some of the causes of morbidity and mortality (50-60%) in pediatric patients treated in intensive care rooms. This study aimed to compare the accuracy of pediatric Sequential Organ Failure Assessment (pSOFA) score combined with anion gap (AG) score to Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score in the assessment of mortality in pediatric septic patients at the Resuscitation Room of Dr. Soetomo Geeneral Academic Hospital, Surabaya, Indonesia. This was a retrospective observational cohort study using pediatric sepsis diagnosis guidelines based on the 2016 Pediatric Sepsis Consensus and medical records between January-December 2018. All data of patients aged 1 month to 16 years with suspected infection at the Resuscitation Room were collected based on predisposing infections, signs of infection, and warning signs. Organ dysfunction was assessed by calculating the pSOFA+AG scores, PELOD-2 scores, and corrected anion gap (cAG) in the first 24 hours. Sepsis mortality was assessed by comparing the results of the pSOFA, pSOFA+AG, and PELOD-2. The results showed 94.9% sensitivity and 70.0% specificity (p<0.0001) in the pSOFA, 89.9% sensitivity and 71.3% specificity (p<0.0001) in the PELOD-2, 79.7% sensitivity and 65% specificity (p<0.0001) in the AG, 79.7% sensitivity and 73.8% specificity (p<0.0001) in the cAG, and 79.3% sensitivity (p<0.0001) in the pSOFA+AG. In conclusion, pSOFA was more sensitive than PELOD-2, while the use of pSOFA+AG was not more sensitive than PELOD-2 in assessing the mortality of pediatric septic patients.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47462976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healing of Radiation Dermatitis with Ozonated Aloe Vera Oil by Increasing PDGF and Epidermal Thickness in Sprague-Dawley Rats","authors":"Widoasti Putri Utami, Yan Wisnu Prajoko, Christina H.N. Prihharsanti, U. Sadhana, N. Susilaningsih, M. Restiwijaya, M. Nur","doi":"10.20473/fmi.v58i4.38234","DOIUrl":"https://doi.org/10.20473/fmi.v58i4.38234","url":null,"abstract":"Highlights:\u0000\u0000This study demonstrated the effect of ozonated Aloe vera oil in the healing of radiation dermatitis wound.\u0000Groups that received no treatment was compared with groups that received treatment using 2.5% hydrocortisone ointment and ozonated Aloe vera.\u0000Ozonated Aloe vera oil improves the healing of radiation dermatitis wound by increasing PDGF expression and epidermal thickness.\u0000\u0000 \u0000Abstract :\u0000The long-term use of corticosteroids as a standard treatment for skin disorders, such as radiation dermatitis, can cause many side effects. Alternatively, ozonated Aloe vera oil may replace corticosteroids due to its fewer side effects and benefits in wound healing process. Re-epithelialization and the formation of growth factors, such as platelet-derived growth factor (PDGF), play an important role in the healing of dermatitis wound. This study intended to demonstrate the effect of ozonated Aloe vera oil to improve the healing of radiation dermatitis wound by increasing PDGF expression and epidermal thickness. This study used a post-test only control group design. A sample of 36 Sprague-Dawley rats was divided into 6 groups (C1=without treatment, C2=2.5% hydrocortisone ointment, P1=pure Aloe vera (AV), P2=300 mg/mL ozonated Aloe vera (OAV), P3=600 mg/mL OAV, P4=1200 mg/mL OAV. The expression of PDGF was assessed using Allred scoring with immunohistochemical staining, whereas the epidermal thickness was assessed using hematoxylin and eosin (H&E) staining at 400x microscopic magnification. The PDGF expression and epidermal thickness between the control and the treatment groups showed significant differences using a Kruskal-Wallis test (P=0.001) and one-way ANOVA test (P<0.001). The groups that was given ozonated Aloe vera oil had higher average of PDGF expression and thicker epidermis than the other groups. The Spearman's correlation test showed a strong positive relationship (p<0.001 and r=0.709) between the two variables. In conclusion, ozonated Aloe vera oil improves healing of radiation dermatitis wound by increasing PDGF expression and epidermal thickness.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42345373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}