Ege Tip Dergisi最新文献_第8页

Identification of the phenomenon of anastasis in breast cancer cells 乳腺癌细胞转移现象的鉴定

Ege Tip Dergisi Pub Date : 2022-09-12 DOI: 10.19161/etd.1168087

Bakiye Göker Bağca

{"title":"Identification of the phenomenon of anastasis in breast cancer cells","authors":"Bakiye Göker Bağca","doi":"10.19161/etd.1168087","DOIUrl":"https://doi.org/10.19161/etd.1168087","url":null,"abstract":"Aim: This study aimed to define the expression changes and potential roles of the apoptosis-related genes in the anastasis process in breast cancer, which is one of the most common cancer types. \u0000Materials and Methods: Different types of breast cancer cell lines (MCF7 and MDA-MB-231), breast cancer stem cells, and healthy breast cell line (MCF10A) were used. Apoptotic and anastatic cell percentages were determined by the Annexin V test and flow cytometry. Gene expression changes in anastatic cells compared to apoptotic cells were determined by the qRT-PCR and 2-ΔΔCt method. The pathways and biological processes of genes that show significant changes were determined using the STRING v11.5 database. \u0000Results: In all cell groups, it was determined that the percentage of apoptosis increased as a result of ethanol application, and the percentage of apoptotic cells decreased with the removal of the apoptosis-inducing factor. The change in the percentage of apoptotic cells between the control, apoptosis, and anastasis groups was determined the most in MCF7 cells. Consistently, expression changes were determined in the largest number of genes in this cell line. CASP7 and APAF1 genes downregulated in all cell lines. In all cell groups, it was determined that anastasis affects Cysteine-type endopeptidase activity involved in execution phase of apoptosis (GO_ID: 0043027), and drug resistance-related pathways (KEGG_ID: hsa01524). \u0000Conclusion: The definition of the interaction of the anastasis phenomenon in cells with apoptosis regulatory mechanisms is important in terms of elucidating both the oncogenic transformation of healthy cells and the mechanisms of drug resistance in cancer.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67800772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors affecting success in endovascular treatment of acute aortic transections 影响急性主动脉切断术血管内治疗成功的因素

Ege Tip Dergisi Pub Date : 2022-09-12 DOI: 10.19161/etd.1166899

Özlem Balcıoğlu, S. Karaca, M. Parildar, Ümit Kahraman, H. Posacioglu

{"title":"Factors affecting success in endovascular treatment of acute aortic transections","authors":"Özlem Balcıoğlu, S. Karaca, M. Parildar, Ümit Kahraman, H. Posacioglu","doi":"10.19161/etd.1166899","DOIUrl":"https://doi.org/10.19161/etd.1166899","url":null,"abstract":"Aim: In this study, it was aimed to present the results of patients treated with endovascular treatment between 2002 and 2018 with the diagnosis of Acute Aortic Transection and the factors that may affect the success. \u0000Materials and Methods: A total of 17 patients were included in the study and it was planned as retrospectively. All data of the patients were collected by file searching method and demographic features of the patients were recorded. \u0000Written informed consent was obtained from all patients prior to study. Trauma types and gender ratios of the patients were calculated as percentages.. Contrast-enhanced thoraco-abdominal computed tomography was performed for definitive diagnosis, and endovascular treatment was evaluated. All patients deemed suitable for endovascular treatment were intervened within the first 24 hours. \u0000Results: The most majority of our patient group was in stage 4 and the most common etiology was recorded as in - vehicle traffic accidents. Of the 17 patients included in the study, 2 died in the early period and 1 died in the follow-up period. Complications such as graft migration, pseudo aneurysm and graft kinking, which are known as complications of endovascular treatment, were not encountered. Although the left subclavian artery was closed in 12 of 17 patients, only two of them required carotid-subclavian bypass. \u0000Conclusion: The fact that endovascular treatment can be applied with low mortality compared to conventional surgery reduces mortality in acute aortic transections. The most important factors affecting the success of the treatment are that the intervention is performed in the 24 hours, in experienced centers, and that 10% of the aortic diameter is not exceeded in the graft selection, and balloon dilatation is avoided.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67799762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orta seviye torakal vertebra fraktürlerinde perkütan balon kifoplasti deneyimi 应用冲击球囊卵母细胞成形术治疗高级别阴唇椎骨骨折的实验研究

Ege Tip Dergisi Pub Date : 2022-09-12 DOI: 10.19161/etd.1168170

Gokhan Gurkan, İ. Kaya, M. Atar, İnan Uzunoğlu, İlker Deniz Ci̇ngoz, Baran Taskala, Nurullah Yuceer

{"title":"Orta seviye torakal vertebra fraktürlerinde perkütan balon kifoplasti deneyimi","authors":"Gokhan Gurkan, İ. Kaya, M. Atar, İnan Uzunoğlu, İlker Deniz Ci̇ngoz, Baran Taskala, Nurullah Yuceer","doi":"10.19161/etd.1168170","DOIUrl":"https://doi.org/10.19161/etd.1168170","url":null,"abstract":"Aim: Balloon kyphoplasty is a popular minimally invasive technique for vertebral fractures. Although vertebral fractures occur mostly in the thoracolumbar region, compression fractures can be seen in the entire vertebral column. The mid-thoracic levels are difficult areas in terms of complications in minimally invasive procedures. Our study aimed to examine the effect of balloon kyphoplasty on vertebral height, kyphosis angle, and cement leaks as a complication in mid-thoracic vertebral fractures. \u0000Materials and Methods: Radiological images, patient files, and pathology results of patients who underwent kyphoplasty due to a single or multiple mid-thoracic vertebral fractures between 2017 and 2020 were retrospectively analyzed. \u0000Results: A total of 19 patients (9 males and 10 females) and 28 operated vertebrae were included in the study. The mean age of the patients was 58.42±18.79 (23-86) years, and the mean operation time was 40.18±15.01 minutes (17-99). The amount of cement used during the procedures was 3.68±1.13 mL (1.5-7), and postoperative cement leakage was observed in 12 levels (42.9%). Anterior and median vertebral heights and kyphosis angle improved significantly compared to preoperative values (p","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67800695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Makuler hol cerrahisinin anatomik ve fonksiyonel başarısını etkileyen parametreler 影响黄斑裂孔手术解剖和功能成功的参数

Ege Tip Dergisi Pub Date : 2022-09-12 DOI: 10.19161/etd.1168207

E. Kırıkkaya, S. Kaynak

引用次数: 0

Dispepsili hastalarda gastrointestinal parazitoz sıklığı ve proton pompa inhibitörü kullanımının gastrointestinal parazitoz ve histopatolojik bulgular üzerinde etkisi 消化不良患者对胃肠道甲状旁腺功能频率有影响，质子泵抑制剂的使用对胃肠道甲状腺功能和组织病理学结果有影响

Ege Tip Dergisi Pub Date : 2022-09-12 DOI: 10.19161/etd.1168097

Elvina Almuradova, E. Erdoğan, Rashad Ismayilov, Sebnem OKTEM USTUN, Rukiye Vardar

{"title":"Dispepsili hastalarda gastrointestinal parazitoz sıklığı ve proton pompa inhibitörü kullanımının gastrointestinal parazitoz ve histopatolojik bulgular üzerinde etkisi","authors":"Elvina Almuradova, E. Erdoğan, Rashad Ismayilov, Sebnem OKTEM USTUN, Rukiye Vardar","doi":"10.19161/etd.1168097","DOIUrl":"https://doi.org/10.19161/etd.1168097","url":null,"abstract":"Aim: The main purpose of this study was to investigate the frequency of gastrointestinal parasites in patients with upper gastrointestinal system (GIS) complaints. The secondary aim was to evaluate the effect of proton pump inhibitors (PPI) on gastrointestinal parasite frequency and histopathological findings. \u0000Materials and Methods: Adult patients who underwent endoscopy for upper GIS symptoms were included in the study. Biopsy specimen for histopathological evaluation, gastric and duodenal aspiration fluid, and stool specimen for parasitological evaluation were also obtained from the patients. \u0000Results: A total of 40 patients (29 female and 11 male) were included in the study. The mean age of women was 54 ± 14.6 and men was 38.4 ± 18.7 years (p = 0.008). The patients were divided into two groups as not using PPI [14 patients (35%)] and using PPI [26 patients (65%)]. Parasites were detected in 3 patients (7.5%). Two of them were from the group using PPI, and one from the group not using PPI (p = 0.95). It was also observed that the effect of PPI on histopathological findings was not statistically significant. Helicobacter pylori positivity was associated with inflammation (p = 0.002) and intestinal metaplasia (p < 0.001). \u0000Conclusion: It was determined that dyspeptic complaints were more common in women. The effect of PPI on histopathological findings or the frequency of parasites were not statistically significant. Inflammation and intestinal metaplasia were found to be statistically higher in Helicobacter pylori positive cases than negatives.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48486408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elit genç futbol akademisi sporcularında yaralanma insidansı: 3 yıllık geriye dönük takip 埃利特年轻的足球学院因运动员受伤：三年后，

Ege Tip Dergisi Pub Date : 2022-09-12 DOI: 10.19161/etd.1168192

Serdar Arslan, Engin Di̇nç

引用次数: 0

Brachial neuritis with isolated long thoracic nerve involvement 臂神经炎伴孤立性胸长神经受累

Ege Tip Dergisi Pub Date : 2022-09-12 DOI: 10.19161/etd.1168151

Yağmur Çağla Rei̇s, Tugba Alisik, B. Nacır

引用次数: 0

Investigation of nasopharyngeal microbiota in children with asthma and allergic rhinitis comorbidity 哮喘合并变应性鼻炎患儿鼻咽菌群调查

Ege Tip Dergisi Pub Date : 2022-09-12 DOI: 10.19161/etd.1167440

C. Çavuşoğlu, H. Yüksel, A. Yaşar, Tarik Inci, Furkan Polat, Ayça AYDIN UYSAL, A. Aykut

{"title":"Investigation of nasopharyngeal microbiota in children with asthma and allergic rhinitis comorbidity","authors":"C. Çavuşoğlu, H. Yüksel, A. Yaşar, Tarik Inci, Furkan Polat, Ayça AYDIN UYSAL, A. Aykut","doi":"10.19161/etd.1167440","DOIUrl":"https://doi.org/10.19161/etd.1167440","url":null,"abstract":"Aim: The goal of this study was to compare the nasopharyngeal bacterial microbiota of healthy children with asthma and allergic rhinitis, identify potential microbial dysbiosis in patients. \u0000Materials and Methods: The study included a total of 15 patients. There were five patients with asthma, five with allergic rhinitis, and five healthy controls. The upper respiratory tract microbiota were identified using 16S metagenomics analysis of nasal lavage samples. \u0000Results: Firmucutes was the most prevalent phylum in the upper respiratory tract microbiota of asthma patients, while Proteobacteria were found in the healthy control and allergic rhinitis groups. Dolosigranulum was identified as the most dominant genus in the upper respiratory tract microbiota of asthma patients. Moraxella was the most prevalent genera in the upper respiratory tract microbiota of the healthy control group. When asthma patients were compared to the control group, the ratio of the Moraxella genus decreased while the ratios of Staphylococcus, Streptococcus, and Corynebacterium species increased. \u0000Conclusion: In conclusion, it has not been determined that upper respiratory tract microbiota has a role in determining the pathogenesis of allergic rhinitis and asthma in childhood. The fact that there is a proportional difference between groups’ supports that there may be a possible difference if the entire airway microbiome is studied.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67800542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naringin CCl4 İndüklü Hepatosit Hasarını Endoplazmik Retikulum Stresini Engelleyerek Hafifletir Naringin的CCl4红外肝病损失斑块内网状流工程照明

Ege Tip Dergisi Pub Date : 2022-07-18 DOI: 10.19161/etd.1133788

Umut Kerem Kolaç

{"title":"Naringin CCl4 İndüklü Hepatosit Hasarını Endoplazmik Retikulum Stresini Engelleyerek Hafifletir","authors":"Umut Kerem Kolaç","doi":"10.19161/etd.1133788","DOIUrl":"https://doi.org/10.19161/etd.1133788","url":null,"abstract":"Amaç: Karaciğerin çeşitli kimyasallara maruz kalması hepatik hasar oluşmasına neden olur. Karbon tetraklorür (CCl4), kimyasal toksin kaynaklı hepatik hasarı araştırmak için yaygın şekilde kullanılmaktadır. Çalışmamızda turunçgillerde bol bulunan bir flavanon olan naringinin (NRG), CCl4 ile indüklenen karaciğer hasarında endoplazmik retikulum (ER) stresi ve stres aracılı apoptoz üzerine etkileri incelenmiştir. \u0000Gereç ve Yöntem: THLE-3 hücreleri 24 saat boyunca değişen konsantrasyonlarda CCl4’ e maruz bırakıldıktan sonra farklı dozlarda NRG ile 4 saat tedavi edildi. Konsantrasyonların hücre canlılığı üzerindeki etkileri belirlendi. Ardından hepatositlerde ER stres belirteçlerinin protein ifadeleri tespit edildi. Son olarak akış sitometri ile Bcl2 aktif / inaktif hücre oranları belirlendi. \u0000Bulgular: NRG tedavisi (5 ve 10 µM), CCl4 uygulaması ile azalan hücre canlılıklarında anlamlı bir artış sağladı. Benzer biçimde ER stres belirteçlerinde CCl4 uygulaması sonucu artan seviyeler NRG tedavisiyle anlamlı biçimde azaldı. Son olarak NRG, Bcl2 inaktif hücre oranını anlamlı seviyede düşürerek apoptozun önüne geçilmesinde faydalı oldu. \u0000Sonuç: NRG tedavisi CCl4 ile indüklenen hepatosit hasarında ER stresinin bastırılmasında ve ER stresi kaynaklı apoptozun önlenmesinde etkilidir.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67799690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endometrium kanserli obez hastalarda laparoskopik ve açık cerrahinin karşılaştırılması 在肥胖癌症中，子宫内膜比较腹腔镜和开放手术

Ege Tip Dergisi Pub Date : 2022-06-13 DOI: 10.19161/etd.1125610

Ceren Sancar, Nuriye Yıldırım, Ahmet Bi̇lgi̇, Sevki Gokulu, L. Akman, Mustafa COŞAN TEREK, Ahmet AYDIN ÖZSARAN

{"title":"Endometrium kanserli obez hastalarda laparoskopik ve açık cerrahinin karşılaştırılması","authors":"Ceren Sancar, Nuriye Yıldırım, Ahmet Bi̇lgi̇, Sevki Gokulu, L. Akman, Mustafa COŞAN TEREK, Ahmet AYDIN ÖZSARAN","doi":"10.19161/etd.1125610","DOIUrl":"https://doi.org/10.19161/etd.1125610","url":null,"abstract":"Aim: The aim of the study is to compare the results of total laparoscopic hysterectomy and total abdominal hysterectomy in obese women with endometrial cancer (EC). Materials and Methods: Patients with endometrial cancer whose BMI ≥30 kg/m2 and who were undergone total laparoscopic hysterectomy (n=68) or total abdominal hysterectomy (n=161) were included in the study. Demographic and histopathological features, disease-free survival and overall survival of the patients were recorded. All these data of laparoscopy and laparotomy patients were compared with each other. \u0000Results: No significant difference was observed between two groups in terms of stage, tumor grade, histology, lymph node dissection rate and number of removed lymph nodes. Cardiovascular diseases were more common in laparotomy group (p=0.002). ASA (American Society of Anesthesiologists) score was higher in laparotomy group (p=0.001). Perioperative and postoperative complications were similar in both groups. The operation time was significantly longer and postoperative hospital stay was significantly shorter in the laparoscopy group (p","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47248872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0