Ege Tip Dergisi最新文献

{"title":"Kısa gözyaşı kırılma zamanı olan hastalarda etafilcon A ve nesofilcon A’nın oküler konfor seviyeleri açısından kıyaslanması: prospektif karşılaştırmalı çalışma","authors":"A. Penbe, Raziye DÖNMEZ GÜN","doi":"10.19161/etd.1125785","DOIUrl":"https://doi.org/10.19161/etd.1125785","url":null,"abstract":"Aim: The aim of the study was to compare the two different hydrogel daily disposable contact lenses (HyDDCLs) satisfaction levels in patients with meibomian gland disfunction (MGD) and allergic conjunctivitis accompanied with short noninvasive tear break-up time (NIBUT). \u0000Material and Methods: Fifty patients who had no history of contact lens and had short NIBUT were included to the study into two groups: allergic conjunctivitis findings (group 1) and MGD findings (group 2). All patients used both etafilcon A and nesofilcon A, respectively. The OSDI (Ocular Surface Disease Index) and CLDEQ-8 (Contact Lens Dry Eye Questionnaire- 8) tests were performed by the patients for each lens and the mean scores were compared. In addition, the decisions of all patients regarding the continued use of each lens were questioned. \u0000Results: The mean of total scores of OSDI and CLDEQ-8 were statistically lower in nesofilcon A, significantly. The mean scores of the all OSDI subscales and the CLDEQ-8 subscales of dryness, discomfort, blurred vision and closing eyes were lower in nesofilcon A. Four patients (8%) were not satisfied by any of the lenses. 36 (72%) patients preferred nesofilcon A and remaining 10 (20%) patients preferred etafilcon A to continue. \u0000Conclusion: Due to the hydrophilic structure and low modulus of the HyDDCLs, the satisfaction rate was found to be higher in the study group (92%). HyDDCLs could be a suitable option in cases where ocular surface diseases are accompanied. Hydrogel material with higher water content offers better comfort levels at the end of the day.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67798478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid diagnosis of bacteria and determination of sensitivity in blood culture","authors":"Münevver KAYIN DİNÇ, V. Özenci, S. Aydemir","doi":"10.19161/etd.1125186","DOIUrl":"https://doi.org/10.19161/etd.1125186","url":null,"abstract":"Aim: In patients with bloodstream infection; identifying the causative agent in a short time and applying appropriate antimicrobial therapy is very important in terms of reducing morbidity and mortality. In this study, it was aimed to evaluate a new method developed for direct identification and antibiotic susceptibility testing from blood culture. \u0000Materials and Methods: Bacterial pellet was obtained from blood culture samples that showed positive signals in the BacT/Alert 3D system by washing and centrifugation. Identification was made from this pellet using Vitek MS, followed by direct antibiotic susceptibility testing in the VITEK 2 automated system. The results were compared with the standard method. \u0000Results: Identification was performed on 80 blood culture samples. In the direct identification process, 73 samples were identified, of which 72 (90%) resulted in agreement with the standard method. Direct antibiotic susceptibility tests were found to be compatible with a rate of 97.9%. Among the evaluated 635 antibiotic susceptibility results; it was observed that 10 of them had major errors and 3 of them had minor errors. \u0000Conclusions: Using the procedures applied in the study from blood culture samples, without the need for costly reagents or long processing time, it has been observed that identification and antibiotic susceptibility results can be obtained within 24 hours, similar to standard results.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67798481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of p53 gene polymorphisms in myelodysplastic syndrome disease","authors":"Bahar Vatansever, Duygu Aygüneş Jafari, Hale Güler Kara, Ege Sevinc, B. Kaymaz, G. Alp, F. Şahin, G. Saydam, B. Kosova","doi":"10.19161/etd.1127363","DOIUrl":"https://doi.org/10.19161/etd.1127363","url":null,"abstract":"Aim: Myelodysplastic syndrome (MDS) is a clonal disease with a high risk of conversion to acute myeloid leukemia, characterized by increased apoptosis and decreased hematopoiesis. The pathogenesis of MDS has not been fully explained. ~50% of cases have abnormal karyotype and this rate is around 80% in secondary MDS. \u0000The p53 protein is an important regulator of stem cell homeostasis and is involved in a range of cellular events such as cell cycle regulation, apoptotic and inflammatory response. The TP53 gene, which has important roles in maintaining genomic integrity, is frequently mutated in cancers; however, some gene polymorphisms are known to be associated with cancer, as well as mutations. Our aim in the study is to determine the prevalence of four common p53 single nucleotide polymorphisms in MDS and their effects on disease development. For this reason, 100 cases followed up with the diagnosis of MDS or newly diagnosed in Ege University Faculty of Medicine, Department of Internal Medicine, Department of Hematology were included in the study. \u0000Materials and Methods: DNAs isolated from peripheral blood leukocytes of MDS cases were studied by real-time PCR method, p53 polymorphisms (rs35163653, rs35993958, rs1800371, rs1042522) were determined by using appropriate probes and melting curve analysis. \u0000Results: Among the four common p53 polymorphisms examined, especially the non-ancestral G allele in the rs1042522 polymorphism was observed to be increased in MDS cases (C: 30.3%; G: 69.7%). In this polymorphism, which is known to be functional, that is, affecting the function of the synthesized protein, the transition of the C nucleotide at position 417 to G (C>G) causes the coding of the amino acid proline at position 72 of the protein to arginine (P72R). \u0000Conclusion: Our study is the first to investigate the p53 polymorphisms of rs35163653, rs35993958, rs1800371 and rs1042522 in the MDS disease group. Of these, rs1042522 polymorphism has been shown to be associated with cancer susceptibility and susceptibility, and it is thought that it may pose a high risk for MDS disease as well. In conclusion, rs1042522 polymorphism may be used as a marker in the diagnosis of MDS in the future by repeating this study for MDS disease with a larger case group.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67799588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors in patients with recurrent squamous cell carcinoma of the vulva and the ınfluence of recurrence to the overall survival","authors":"F. Di̇nçer, G. Demirtas, M. Gökçü, M. Şancı","doi":"10.19161/etd.1125271","DOIUrl":"https://doi.org/10.19161/etd.1125271","url":null,"abstract":"Aim: The effects of many factors have been investigated in vulvar cancer patients with recurrence. In our study, we aimed to compare clinical and pathological factors and investigate the effect of recurrence on overall survival in patients with recurrent and non-recurrent squamous cell vulvar cancer. Materials and Methods: The files of vulvar cancer patients who were operated in İzmir Tepecik Education and Research Hospital Gynecological Oncology Clinic between 1995 and 2018 and were followed up in our hospital were retrospectively reviewed. Patients were divided into two groups, with and without recurrence. The groups were compared in terms of age, stage, tumor size, midline status of the tumor, localization of the tumor, operation, surgical margin, depth of tumor invasion, presence of metastatic lymph node, adjuvant therapy variables and the effect of recurrence on survival was investigated. Results: Variables such as age, stage, tumor size, midline status of the tumor, localization of the tumor, operation, surgical margin, tumor invasion depth, presence of metastatic lymph node, adjuvant therapy were not found to be statistically significant in terms of recurrent patients with vulvar cancer. There was also no correlation between recurrence and overall survival. \u0000Conclusion: Many prognostic factors mentioned in the literature were not found to be significant in terms of recurrence in our study, and no difference was found between the groups with and without recurrence in terms of overall survival.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48769408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of arrhythmia frequency by holter electrocardiography in patients with acute ischemic cerebrovascular events","authors":"M. Kış, Tuncay Güzel","doi":"10.19161/etd.1127448","DOIUrl":"https://doi.org/10.19161/etd.1127448","url":null,"abstract":"Aim: After acute ischemic cerebrovascular accident (CVA), identification of high-risk patients, appropriate cardiac follow-up and detection of arrhythmias are important to prevent cardiac morbidity and mortality. The aim of our study is to determine the underlying etiology and the frequency of arrhythmia by holter electrocardiography (ECG) in patients referred to the cardiology clinic due to acute ischemic CVA. \u0000Materials and Methods: A total of 135 consecutive patients who had acute ischemic CVA between January 2019 and June 2021 and whose basal ECG was sinus rhythm were included in the study. This study was a retrospective cross-sectional study. \u0000Results: The mean age of the patients was 72.02±11.02 years, the mean systolic arterial blood pressure was 138.84±20.45 mmHg, and the mean heart rate was 81.63±16.18 beats/min. The most common comorbid diseases were HT (n=67, %49.6) and CAD (n=55, %40.7). 5.9% of patients had prosthetic heart valve and 5.2% had permanent pacemaker. Intracardiac thrombus was detected in 5 (3.7%) patients. The mean left ventricular ejection fraction was 54.4±9.1%. In carotid doppler ultrasonography (USG), 27 (20%) patients had unilateral and 17 (12.6%) bilateral severe carotid arterial stenosis. The most common arrhythmias detected on holter ECG were ventricular extrasystole (n=34, 25.2%) and paroxysmal atrial fibrillation (n=31, 23%). In addition, non-sustained ventricular tachycardia was detected in 6 (4.4%) patients. \u0000Conclusion: Determining the underlying etiology in patients with acute ischemic CVA is important for the treatment of the disease. The incidence of arrhythmia that should be treated in this patient group is too high to be ignored.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48818110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro ve in silico analizi ile metforminin meme tümörü hücrelerinde protein profili üzerindeki etkinliği","authors":"Güven Yenmi̇ş, Nail Beşli̇","doi":"10.19161/etd.1126777","DOIUrl":"https://doi.org/10.19161/etd.1126777","url":null,"abstract":"Aim: This study aimed to uncover the varieties in protein profiles of Met in breast tumor (BT) cells by assessment of in vitro and in silico analysis. \u0000Materials and Methods: Here, the cells obtained from mastectomy patients were cultured, the effective Met-dose was determined as 25 mM through cell viability and BrdU tests. Protein identification in the breast tumor cells was implemented by employing LC-MS/MS technology. \u0000Results: The expression of SSR3, THAP3, FTH1, NEFM, ANP32A, ANP32B, KRT7 proteins was significantly decreased whereas the GARS protein increased in the 25 mM Met group compared to the Non-Met (0 mM) control group. In silico analysis, we analyzed the probable interactions of all these proteins with each other and other proteins, to evaluate the analysis of the larger protein network, and which metabolic pathway proteins are involved in. \u0000Conclusion: The stated proteomics analysis in our study proposes a better understanding of the prognosis of breast cancer and future studies to investigate the effect of metformin in this field on proteomic pathways in other sorts of cancer.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67798676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of systemic inflammatory markers in prediction of medical treatment failure in patients with tubo-ovarian abscess","authors":"Sezin Ertürk Aksakal, Huriye Güvenç Sacinti, Ş. Kıykaç Altınbaş, Ö. Tapısız, Y. Engin-Üstün","doi":"10.19161/etd.1125743","DOIUrl":"https://doi.org/10.19161/etd.1125743","url":null,"abstract":"Aim: Aimed to evaluate the role of systemic inflammatory markers and Aspartate aminotransferase to Platelet Ratio Index (APRI) sore in predicting medical treatment failure in patients with Tubo-ovarian abscess (TOA). \u0000Materials and Methods: Patients (n=240) hospitalized with a diagnosis of TOA between August 2016 - October 2020 were included in the study. Patients' demographic and clinical characteristics and mean C-Reactive protein (CRP) level, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and APRI score measured on admission were also recorded. The role of these parameters was investigated in predicting medical treatment failure in patients who only received medical treatment or who needed surgical treatment. \u0000Results: The mean age (40.95 ± 6.96 vs. 38.09 ± 7.69), abscess size (67.57 ± 19.86 mm vs. 52.78 ± 16.63 mm), CRP level, (140.61 ± 110.88 vs. 75.24 ± 36.64 mg/L), white blood cell count (13818.86 ± 5445.80 and 11845.31 ± 4424.39 μL), neutrophil count (11146.81 ± 5284.83 and 9242.03 ± 4278.60 μL) and NLR (9.52 ± 6.88 and 6.64 ± 6.30) of patients who received surgical treatment were significantly higher than those who received only medical treatment. In receiver operating characteristics (ROC) analysis area under the curve (AUC) 0.607 was statistically significant for CRP with a cut-off value of 11.57 to predict medical treatment failure (95% 0.531-0.682, sensitivity 63.3%, specificity 55.4%). \u0000Conclusion: NLR, PLR and APRI score are ineffective in predicting the need for surgical treatment. CRP could be used as a marker in predicting the need for surgical treatment in patients with TOA.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67798464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mide kanserli hastaların demografik özelliklerinin sağ kalıma etkisi","authors":"Andaç Karadeniz, Mehmet Bilici, Meliha R. Şimşek","doi":"10.19161/etd.1125583","DOIUrl":"https://doi.org/10.19161/etd.1125583","url":null,"abstract":"Aim: This study aimed to investigate the relationship between some demographic and clinical factors and survival in patients with gastric cancer. \u0000Materials and Methods: We retrospectively evaluated the records of 252 gastric cancer patients followed up in the medical oncology department between 01.01.2016 and 10.01.2020. Gastric lymphoma, gastrointestinal stromal tumor, and neuroendocrine tumor were excluded. Factors evaluated in the study included age, sex, urban/non-urban residence, admitting complaints, smoking history, Eastern Cooperative Oncology Group (ECOG) score, stage at diagnosis, histological subtype, surgical history, tumor location, grade, diameter and macroscopic view of tumor, metastatic lymph node ratio, chemotherapy regimens, febrile neutropenia, post-chemotherapy radiological reports, chemoradiotherapy (CRT) history and survival after diagnosis. \u0000Results: Mean overall survival (OS) time was significantly shorter in patients with weight loss (p","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67798928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kolorektal lateral yayılımlı tümörlerde başarısız endoskopik mukozal rezeksiyon sonrası endoskopik submukozal diseksiyonun uygulanabilirliği: tek merkez deneyimi","authors":"Abdullah Murat Buyruk, Ayten Livaoğlu, Aydın Aktaş","doi":"10.19161/etd.1125260","DOIUrl":"https://doi.org/10.19161/etd.1125260","url":null,"abstract":"Aim: Endoscopic mucosal resection might technically be unsuccessful (interrupted endoscopic mucosal resection) in some cases when treating large colorectal laterally spreading tumors. In the literature, data on the outcomes of the endoscopic submucosal dissection method in endoscopic mucosal resection interrupted tumors are lacking. In this study, we evaluated the results of patients who underwent endoscopic submucosal dissection for endoscopic mucosal resection interrupted laterally spreading tumors. \u0000Materials and Methods: Between February 2019 and April 2021, 8 patients with endoscopic mucosal resection interrupted colorectal laterally spreading tumors underwent endoscopic submucosal dissection. The primary endpoint was en bloc, R0, and curative resection rates of endoscopic submucosal dissection. \u0000Results: In all cases, endoscopic submucosal dissection was successfully completed. The mean tumor size was 61.5 mm (35–100 mm). The rate of en bloc resection, R0 resection and curative resection was 100%, 87.5% and 87.5% respectively. Intra-procedural perforation occurred in 1 patient (12.5%) and was successfully treated with clip application. Delayed bleeding occurred in 1 patient (12.5%), and was successfully treated with endoluminal hemostasis. Furthermore, histopathological examination revealed that laterally spreading tumors in 4 patients (50.0%) had submucosal invasion. Surgical resection was performed after endoscopic submucosal dissection in 1 patient owing to the presence of deep submucosal invasion. \u0000Conclusion: Endoscopic submucosal dissection is an effective and relatively safe method in endoscopic mucosal resection interrupted colorectal laterally spreading tumors.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67798824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urological laparoscopic procedures and results performed by a single urologist in a secondary state hospital","authors":"T. Bahçeci","doi":"10.19161/etd.1127748","DOIUrl":"https://doi.org/10.19161/etd.1127748","url":null,"abstract":"Aim: To evaluate the results of urological laparoscopic operations performed by a single surgeon in secondary public hospital \u0000Materials and Methods: The data of 30 patients who underwent urological laparoscopic surgery in Şanlıurfa Training and Research Hospital between January 2018 and January 2021 were retrospectively analyzed. The operation type, duration of operation, side, removal time of drain, length of stay in the hospital and complications were noted. \u0000Results: All patients underwent laparoscopy via transperitoneal route. Laparoscopic nephrectomy was performed in 15 patients, dismembred pyeloplasty in 4 patients, ureterolithotomy in 8 patients, and cyst excision in 3 patients. The mean patient age was 40.43 + 16.72 (14-76). A male/female ratio of 13/17 was found to be 43.3% male and 56.7% female. Considering the operation times, nephrectomy was 173.26 (120-240) minutes, pyeloplasty 240 ± (210-270) minutes, ureterolithotomy 110.75 (75-180) minutes, and cyst excision 112.66 (100-138) minutes. All patients had a trace amount of drains (","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67799637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}