Ege Tip Dergisi最新文献

{"title":"Comparing the efficacy of imaging techniques in detecting myometrial invasion, cervicalinvolvement and pelvic lymph-nodal metastasis in endometrial cancer","authors":"Alpay Yilmaz, Fatih Yilmaz, H. Şahin, Fatma Öz Atalay, D. Uysal, H. Ozan","doi":"10.19161/etd.1209113","DOIUrl":"https://doi.org/10.19161/etd.1209113","url":null,"abstract":"Aim: To compare sensitivity, specificity, positive predictive and negative predictive value of\u0000preoperative imaging techniques for detecting myometrial invasion, cervix involvement, and alsopelvic\u0000lymph nodal metastasis in endometrial cancer\u0000Materials and Methods: The medical records of patients who underwent an operation for endometrial\u0000cancer in the years between 2005 and 2017 were collected from the database at our institution.\u0000Preoperative imaging reports of 252 ultrasonography (USG), 89 computerized tomographies (CT),147 \u0000magnetic resonance imaging (MRI) of patients with endometrial cancer, and postoperative pathologic\u0000reports were collected and compared.\u0000Results: In our study 252 ultrasonography (USG), 89 computerized tomography (CT), 147 magnetic\u0000resonance imaging (MRI) examinations were evaluated. Among deep myometrial invasion; all imaging \u0000modalities have low specificities (respectively 26.7%, 37.9%, and 32.4%) but higher sensitivities\u0000(respectively 68.5%, 79.1%, and 89.4%). To rule out cervical invasion all modalities have high and\u0000comparable sensitivities (respectively 98.3%, 95.0%, and 87.0%). On the other hand, USG has\u0000superiority to detect cervical invasion over CT and MRI (respectively 71.4%, 15.4%, and 22.7%). CT \u0000has much highersensitivity than MRI for detection of pelvic lymph node metastasis (87.5% vs 53.1%).\u0000Conclusion: Preoperative imaging modalities have high sensitivities for deep myometrial invasion, but \u0000low detection rates for cervical involvement and pelvic lymph node metastasis. MRI should be the\u0000preferred modality for myometrial invasion, on the other hand, The USG is much better to detect\u0000cervical involvement. CT has superiority on other imaging modalities among lymph node metastasis.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49328818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maluliyet hesaplamasında göz önünde bulundurulan cetvellerde yer almayan arızaların değerlendirilmesi","authors":"Hayrettin Altindağ, Ender Şenol","doi":"10.19161/etd.1209123","DOIUrl":"https://doi.org/10.19161/etd.1209123","url":null,"abstract":"Amaç: Maluliyet raporları, Adli Tıp’ın önemli çalışma alanlarından birisidir. Bu raporlar düzenlenirken kullanılan yönetmeliklerde eksiklikler olduğu bilinmektedir. Bu eksiklikler nedeniyle hak kayıpları yaşandığı, düzenleyen kurumun veya doktorun yönetmeliği yorumlarken kullandığı takdir farklılığından aynı olgu hakkında alınan raporlarda çelişkiler olduğu görülmektedir. Çalışmamızda yönetmeliklerin eksikliklerine dikkat çekmek, çelişkili raporlar düzenlenme nedenlerini araştırmak amaçlanmıştır.\u0000Gereç ve Yöntem: Bu çalışmada; 01.01.2015-01.01.2020 tarihleri arasında Ege Üniversitesi Tıp Fakültesi (EÜTF) Adli Tıp Anabilim Dalında düzenlenen Maluliyet Raporları incelenerek raporlar içerisindeki ilgili yönetmelikte arıza karşılığı bulunmayan arıza çeşidi; ilgili yönetmelikte arıza çeşidine en yakın olarak takdir kullanılarak belirlenen toplam 542 adet rapor dahil edildi. Araştırmaya dahil edilen raporlar incelenerek, arızanın Meslekte Kazanma Gücü Kayıp Oranı Tespit Cetvellerine (MKGKOTC) ve Engel Oranları Alan Kılavuzuna (EOAK) göre hangi maddeye karşılık geldiği, kullanılan takdirin niteliği (oranlama, yakın takdir, eşik altı değer, karşılığı yok, karşılığı var) olgu rapor formlarına kaydedildi. \u0000Bulgular: Çalışmaya dahil edilen MKGKOTC’ye göre en çok takdir kullanılan bölgelerin omuz eklemi (%15,5), diz eklemi (%13), ayak bileği (%12,5), el bileği (%8,5), kalça eklemi (%7,4), Ruh Sağlığı ve Hastalıkları (%6,5) olduğu görüldü. EOAK’ya göre en çok takdir kullanılan bölümlerin Kas İskelet Sistemi Arızaları (%77,7) olduğu görüldü. MKGKOTC’ye göre düzenlenen raporlarda yer alan arızalarda yakın takdir ve oranlama kullanımı anlamlı olarak yüksek bulundu (p<0.05). \u0000Sonuç: Meslekte Kazanma Gücü Kayıp Oranı Tespit Cetvellerinin çağımızın gereklerini karşılayamadığı, eksiklikler nedeniyle bilirkişilerin takdir kullanmak zorunda kaldıkları görülmüştür. Yönetmeliğin; onu kullanan hekimin tecrübesi ya da uzmanlık alanı nedeniyle oluşan yorum farkına neden olması sonucunda, aynı arızaya sahip bir kişi için düzenlenen raporlarda dramatik farklılıklar oluşabilmektedir. Bu nedenle, yönetmelikte uzmanlık alanı ne olursa olsun aynı şekilde kullanılmasını sağlayabilecek bir düzenleme yapılması gerekmektedir.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67802695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glukagon benzeri peptit-1'in yağ doku kaynaklı mezenkimal kök hücrelerinin kardiyomiyositlere dönüşmesi üzerindeki etkisi","authors":"Ö. Tekin, Y. Uyanikgi̇l, Dilek Taşkıran","doi":"10.19161/etd.1180666","DOIUrl":"https://doi.org/10.19161/etd.1180666","url":null,"abstract":"Amaç: Mezenkimal kök hücreler, çeşitli protokoller kullanılarak in vitro koşullarda kolaylıkla\u0000kardiyomiyositlere farklılaşabilir. Ancak bu protokollerde kullanılan ajanların hücre canlılığı üzerinde bazı\u0000olumsuz etkileri olduğu bildirilmiştir. Azasitidin mezenkimal kök hücreleri kalp kası hücrelerine\u0000farklandırmak için kullanılmaktadır. Bu çalışmanın amacı, bir GLP-1 reseptör agonisti olan Eksenatid'in\u0000insan yağ dokusu kaynaklı kök hücrelerinin kardiyomiyositlere farklılaşması ve canlılığı üzerindeki\u0000etkilerini araştırmaktır.\u0000Gereç ve Yöntem: Azasitidin ve Eksenatid'in insan yağ doku kaynaklı mezenkimal kök hücreler\u0000üzerinde hücre canlılığı ve proliferasyonu üzerindeki etkileri ile sitotoksisite testleri yapıldı. Farklılanma\u0000protokolü için, hücreler dört hafta boyunca Azasitidin ve Eksenatid ile inkübe edildi. Hücrelerin morfolojik\u0000değişiklikleri izlendi ve kardiyomiyojenik farklılaşma belirteçlerinin (cTnI, GATA4 ve MYH7)\u0000ekspresyonları immünohistokimyasal olarak değerlendirildi. Ayrıca kültürlerdeki kardiyak troponin I\u0000(cTnI) seviyeleri enzime bağlı immünosorbent testi kullanılarak ölçüldü. Veriler, tek yönlü varyans analizi\u0000(ANOVA) ve post-hoc testi ile değerlendirildi.\u0000Bulgular: İnsan yağ doku kaynaklı mezenkimal kök hücreler üzerine Azasitidin uygulaması, kontrole\u0000grubuna kıyasla hücre canlılığını önemli ölçüde azaltırken (%54.4) hücrelerin Azasitidin+Eksenatid ile\u0000uygulaması doza bağlı bir şekilde hücre ölümünü önledi. Azasitidin ve Eksenatid uygulanan hücreler,\u0000kardiyomiyojenik farklılaşma ile uyumlu önemli morfolojik değişiklikler ve kardiyomiyojenik belirteçlerde\u0000artış gösterdi. Ayrı ayrı ve birlikte uygulama yapılan gruplarda cTnI seviyeleri kontrole göre anlamlı\u0000derecede yüksek bulundu.\u0000Sonuç: Bu bulgular GLP-1 reseptör agonisti Eksenatid'in, Azasitidin uygulamasının neden olduğu hücre\u0000hasarını azaltarak İnsan yağ doku kaynaklı mezenkimal kök hücrelerin kardiyomiyojenik farklılaşması\u0000üzerinde faydalı etkileri olabileceğini düşündürmektedir.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48843487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative anxiety on postoperative pain in craniotomy patients","authors":"B. Yilmaz, M. Uyar, A. Derbent, C. Eyigör, S. Karaman","doi":"10.19161/etd.1209456","DOIUrl":"https://doi.org/10.19161/etd.1209456","url":null,"abstract":"Aim: This study aimed to determine preoperative anxiety and pain levels in patients who underwent craniotomy and investigate the effects on the development of postoperative acute-chronic pain. \u0000Materials and Methods: In this prospective, observational study, STAI-I (State-Trait Anxiety Inventory) and STAI-II were used to measure preoperative anxiety levels in a total of 104 patients who underwent craniotomy, and a visual analog score (VAS) was used to determine pain. Demographic data of the patients, ASA (American Society of Anesthesiologists) scores, comorbidities, preoperative and postoperative VAS scores, cause of preoperative anxiety, type, and duration of operation were recorded.\u0000Results: The mean values of STAI tests showed that 31.3% of our patients had mild preoperative anxiety, 58.7% had moderate and 10% had severe preoperative anxiety. In the STAI tests we performed before the operation, the mean values were 44 ± 11.2 for STAI-I and 44.5 ± 9.4 for STAI-II. The causes of preoperative anxiety in patients were determined as surgical operation (35.6%), anesthesia applications (17.3%), insufficient information (11.5%), and the possibility of postoperative pain (3.8%). It was observed that 60.6% of our patients had pain in the preoperative period, 51.9% of patients had acute pain in postoperative the 0th minute, 69.2% in 30th minute, 54.8% in 1st hour, 44.2% in 2nd hour, 34.6% in 24th hour, 22.1% in 48th hour, and 51% of patients had chronic pain in postoperative 6th month. We found a significant relationship between STAI-I and VAS scores at the 48th hour and, between STAI-II and VAS scores at the 2nd, 24th hour, and 6th month (p<0.05). \u0000Conclusion: It was observed that craniotomy patients mostly had moderate anxiety and moderate to severe pain before the operation, and moderate-severe acute and chronic pain developed after the operation. A significant correlation was found between preoperative anxiety and postoperative pain.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67802498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostatın benign, prekürsör ve malign epitelyal proliferasyonlarında ERG ile PTEN ekspresyonlarının araştırılması ve bulguların klinikopatolojik korelasyonu","authors":"Banu Sarsık Kumbaracı, Emre Kanat, Umut Aykutlu, Fuat Kizilay, S. Şen","doi":"10.19161/etd.1209075","DOIUrl":"https://doi.org/10.19161/etd.1209075","url":null,"abstract":"Amaç: Prostat kanseri farklı klinik gidişata ve geniş bir tedavi yelpazesine sahip, klinik ve moleküler olarak oldukça heterojen bir kanser türüdür. Özellikle “prostatik intraepitelyal neoplazi” (PİN), “atipik intraduktal proliferasyon” (AİP) ve “intraduktal karsinom” (İDK) benzer morfolojik özelliklere sahip olması açısından ayırıcı tanı zorluğu yaratan tanılar olup, hasta tedavi ve takibi de farklı olan antitelerdir. Çalışmamızda bu lezyonlarda ERG ve PTEN ekspresyon düzeylerini belirlemeyi ve bu biyobelirteçlerin prognostik ve diagnostik değerini araştırmayı amaçladık. Gereç ve Yöntem: EÜTF Tıbbi Patoloji Anabilim Dalında 2011-2012 yılında radikal prostatektomi veya iğne biyopsi materyallerinde “Adenokarsinom” tanısı almış 87 olgu çalışmaya alındı. Histopatolojik olarak AİP, İDK ve PİN içeren alanlar belirlendi. immunohistokimyasal olarak bu alanlarda ERG ve PTEN ekspresyonları değerlendirildi.Bulgular: Olguların 6’sında İDK, 29’unda AİP ve 52’sinde PİN belirlendi. İDK AİP, DG 3 ve üstünde olan tümörlerde daha fazla görüldü. İDK ve AİP in eşlik ettiği prostat karsinomlarının sağ kalım süresi daha kısaydı (p=0.043). İDK ve AİP içeren tümörlerde ERG ve PTEN durumu invaziv komponentle uyum içindeydi. Ayrıca tüm İDK alanlarında ERG pozitifti. PTEN ile heterojen boyanma görülmüş olup, PTEN’in invaziv karsinom ve İDK alanlarında negatifliği daha fazlaydı (p=0,63). ERG pozitifliği ve PTEN negatifliği istatistiksel olarak anlamlı olmamakla birlikte AİP tanısını desteklediği dikkati çekti.Sonuç: Özellikle ayırıcı tanı sorunu yaratan intraduktal lezyonlarda ERG pozitifliği ve PTEN negatifliği klinik öneme sahip prostat karsinomuna eşlik edebileceği için özellikle biyopsilerde gözardı edilmemeli ve hasta tedavi ile takibi buna göre yapılmalıdır.  ","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67802563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Santral venöz kateterin neden olduğu venöz tromboz zemininde gelişen şilotoraks olgusu","authors":"Dilara Gürsoy, Tevfik İlker Akçam, Ahmet Kayahan Tekneci̇, Alpaslan Çakan","doi":"10.19161/etd.1208976","DOIUrl":"https://doi.org/10.19161/etd.1208976","url":null,"abstract":"Venöz tromboz (VT) santral venöz kateterizasyon (SVK) sonucu ortaya çıkabilmektedir. VT duktus torasikus’un drene olduğu angulus venosus’a uzanıp lenfatik akımı engellediğinde şilotoraks gelişebilmektedir. Uzun süreli SVK’ya bağlı VT sonucu şilotoraks ortaya çıkan ve yaşamını yitiren 76 yaşındaki bir olgu sunularak; hem VT’nin şilotoraks nedeni olabileceği hem de SVK’lı olguların tromboz gelişimi açısından düzenli kontrollerinin yapılması gerektiği vurgulanmak istenmiştir.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47620238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of lipoprotein lipase mutation in patients with severe hypertriglyceridemia and the characteristic features of hypertriglyceridemic pancreatitis","authors":"U. Soyaltin, Ayşe Bengu KANDEMIR BOZKURT, A. Solmaz, Gülden Hakverdi, Ilgın Yıldırım Şımşır","doi":"10.19161/etd.1209062","DOIUrl":"https://doi.org/10.19161/etd.1209062","url":null,"abstract":"Aim: We conducted a retrospective study with the aim of determining the prevalence of lipoprotein \u0000lipase (LPL) mutation in patients with severe hypertriglyceridemia (HTG) and to study differences in \u0000characteristic features of HTG induced acute pancreatitis (AP). \u0000Materials and Methods: Seventy adults with a serum triglyceride (TG) level ≥500 mg/dL were \u0000included in the study. Baseline characteristics, LPL mutation and risk factors between those with and \u0000without HTG-AP were compared. \u0000Results: The mean age was 43 ± 12 years, and males accounted for 55.7%. Of the patients 35 had \u0000TG level","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67802414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and functional analysis of closed reduction-plastering and volar locking plate methods in distal radius fractures in patients over 60 years of age","authors":"Ceyhun Çağlar, Ali Said Nazlıgül, Batuhan Akbulut, M. Akkaya","doi":"10.19161/etd.1208986","DOIUrl":"https://doi.org/10.19161/etd.1208986","url":null,"abstract":"Aim: Many different methods have been described in the treatment of distal radius fractures (DRF) in the elderly population, and which one is the better method is a matter of debate among orthopedic surgeons. The aim of this study was to compare the results of closed reduction and plastering (CRP) and volar locking plate (VLP), which are used in the treatment of DRF in the elderly population. \u0000Materials and Methods: Between January 2019 and December 2020, 36 patients with DRF aged > 60 years were evaluated retrospectively. There were 19 patients in the CRP group and 17 patients in the VLP group. Wrist flexion, extension, pronation, supination, ulnar deviation, and radial deviation degrees and grip strength were measured in the first year of their treatment. The patients were evaluated functionally by patient-rated wrist evaluation (PRWE), modified Green and O'Brien score (MGOS), and resting and stress visual analogue scale (VAS). \u0000Results: In both groups, similar ROM values were obtained and no significant difference was observed. While the PRWE score was 17.5 ± 5.5 in the CRP group and 12.5 ± 4.8 in the VLP group, the MGOS score was 83.0 ± 7.4 in the CRP group and 86.8 ± 12.6 in the VLP group, and the scores were not significantly different (p = 0.802, p = 0.315). While there was almost no pain in both groups at rest, more pain was felt in the VKP group under stress. While grip strength was 20.9 ± 6.4 kg in the CRP group, it was 22.2 ± 6.8 kg in the VLP group, and there was no significant difference compared to the contralateral wrist. \u0000Conclusion: There is no clinical and functional difference between CRP and VLP in the one-year period after DRF treatment in the patient population aged > 60 years. Treatment should be planned according to the functional capacity of the patient.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49026578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evaluation of the neurocognitive development of the symptomatic West Syndrome patients","authors":"Esra Sarigecili, Khatuna Makharoblidze, Mustafa Kömür, Cengiz Okuyaz","doi":"10.19161/etd.1209083","DOIUrl":"https://doi.org/10.19161/etd.1209083","url":null,"abstract":"Aim: Our study was aimed to determine both demographic and clinical data of patients with symptomatic West Syndrome (WS) and to monitor their neurocognitive development with Bayley Scales of Infant and Toddler Development Screening Test, third edition (Bayley-III) test.\u0000Materials and Methods: Fourteen symptomatic WS patients were included in our study. Clinical and demographic data, electroencephalogram (EEG) findings, treatment response, Bayley III developmental test results were recorded before starting the treatment (T0) and in the 12th months of the treatment (T1 and T12).\u0000Results: Patients had a significant increase in Bayley-III test scores in all areas at the end of one year (p <0.05). As the patients' EEGs improved, a statistically significant increase was observed in Bayley-III test scores in all areas (p <0.05). However, when the correlation between seizure control and the Bayley-III test scores were evaluated, there was an improvement only in the language area (p< 0,05); but there was no statistically significant difference in other brain areas (p> 0.05).\u0000Conclusion: It has been shown that the neurocognitive level gradually improves even in symptomatic type WS with effective treatment during the follow-up of the disease or with the improvement of the EEG findings and seizure control.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48513330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic corticosteroid treatment response in hypersensitivity pneumonitis: a single center experience","authors":"Nilüfer Aylin Acet Öztürk, Funda Çoşkun, Ahmet Yurttaş, Nurlana İbrahi̇mova, Özge Aydın Güçlü, E. Demirdöğen, A. Görek Dilektaşlı, A. Ursavaş, E. Uzaslan, M. Karadağ","doi":"10.19161/etd.1208925","DOIUrl":"https://doi.org/10.19161/etd.1208925","url":null,"abstract":"Aim: Hypersensitivity pneumonitis (HP) is defined as an inflammatory and/or fibrotic immune reaction provoked by an inhalational exposure in susceptible individuals. Initial management of HP patients includes remediation of exposure and treatment with immunosuppressive agents. In this study we aimed to define clinical features and treatment modalities and to evaluate response to corticosteroids in HP patients followed in a single tertiary care setting.\u0000Materials and Methods: The patients with HP diagnosis followed between 1 January 2019 and 31 December 2020 were included in this retrospective study. Firstly, the candidate factors related with treatment response were evaluated by univariate analysis and then the possible factors with p values below 0.15 were evaluated by multiple linear regression model to identify independent predictors of systemic corticosteroid response.\u0000Results: The study population consisted of 50 HP patients and 20 of them (40%) had fibrotic HP. Forty-one (82.0%) patients were followed with a medical treatment for longer than 3 months. Within follow-up period 15 (36.5%) patients didn’t show clinical or radiological response to systemic corticosteroids. Patients without treatment response were presented as fibrotic HP (66.6% vs 26%, p=0.02), had radiological features of fibrosis (86.6% vs 30.7%, p=0.002) and had loss of pulmonary functions (60.0% vs 34.6%, p=0.03) more frequently. Uni-variable analysis revealed that radiological features of fibrosis (OR: 0.07 [95%CI: 0.01-0.42], p=0.003) and mosaic attenuation (OR: 7.0 [95%CI: 0.30-10.07], p=0.08) in HRCT related with corticosteroid treatment response.\u0000Conclusion: Our study suggests radiological features of fibrosis relate with worse clinical and radiological response to corticosteroid treatment. Prospective clinical trials are needed to clarify the role of immunosuppressive therapy in HP patients.","PeriodicalId":32499,"journal":{"name":"Ege Tip Dergisi","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48531803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}