Precision Radiation Oncology最新文献

{"title":"Activity-dependent transit dose assessment in ¹⁹²Ir high-dose-rate brachytherapy surface applicator using GafChromic^TM EBT4 film.","authors":"Daniel Liu, Emily Draeger, Christopher J Tien, Fada Guan","doi":"10.1002/pro6.70033","DOIUrl":"10.1002/pro6.70033","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the newly released GafChromic^TM EBT4 film for transit dose measurement in high-dose rate brachytherapy (HDR-BT) surface applicators and to systematically investigate the relationship between transit dose and ¹⁹²Ir source activity.</p><p><strong>Methods: </strong>EBT4 film was used to measure dose at 3 mm depth from a horizontally oriented Leipzig-style surface applicator connected to a ¹⁹²Ir HDR-BT remote afterloading unit. Transit dose was systematically characterized across eight different source activities ranging from 3.372 to 9.716 Ci (13,724 U to 39,544 U) using measurements with seven nominal dwell times (5-100 seconds, scaled to 10 Ci (40,700 U)). Transit dose was derived from linear extrapolation to zero dwell time and compared with dose calculated (10-Ci source with 100-s nominal dwell time, excluding transit contributions) using the treatment planning system (TPS) Eclipse (Version 16.1).</p><p><strong>Results: </strong>EBT4 film demonstrated excellent dose-response linearity with nominal dwell time (adjusted R² > 0.99) across all source activities, confirming its suitability for transit dose measurement. Transit dose contributions ranged from 0.3% to 4.3% of TPS dose (100-s nominal dwell time at 10 Ci), with maximum contribution from the 9.543 Ci source (0.225±0.040 Gy) and minimum from the 5.502 Ci source (0.017±0.025 Gy). Transit dose showed poor linear correlation with source activity (adjusted R² = 0.497), indicating that factors beyond source activity influence transit dose magnitude.</p><p><strong>Conclusions: </strong>This study validates EBT4 film as a reliable tool for transit dose measurement in surface brachytherapy. The observed non-linear relationship between transit dose and source activity reveals the critical influence of experimental setup variables, particularly source guide tube geometry, which affects the source-to-target distance during transit. These findings demonstrate that transit dose is impacted by multiple interdependent factors including source activity, guide tube configuration, and setup geometry. For clinical applications, this highlights the importance of standardized setup protocols and empirical measurement for accurate transit dose assessment.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"9 4","pages":"242-250"},"PeriodicalIF":3.6,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12750306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145878962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical application of boron neutron capture therapy for cancer treatment: A systematic review.","authors":"Ling Zhou, Yuming Chen, Meng Peng, Xiumao Yin, Huanqing Liang, Jieming Mo, Wan Zhang, Zhigang Liu","doi":"10.1002/pro6.70031","DOIUrl":"10.1002/pro6.70031","url":null,"abstract":"<p><p>Boron neutron capture therapy (BNCT) combines boron drug delivery and heavy-ion therapy. The key factors in the application of BNCT are high-quality neutron beams and boron-containing compounds. It can be used to treat gliomas, meningiomas, melanomas, and recurrent head and neck cancers. To promote the research and development of accelerator-based neutron sources, increase the tumor targeting capability of boron drugs, and improve BNCT efficacy in treating malignancies, this review provides an overview of the development of boron-containing compounds and the progress made in clinical studies using BNCT.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"9 4","pages":"304-313"},"PeriodicalIF":3.6,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12750318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"V_15(Gy) as a predictor of asymptomatic radiation pneumonitis in patients with lung cancer: A retrospective dosimetric analysis.","authors":"Weixing Ji, Tao Jiang, Zhihan Chen, Gang Chen, Yang Zhang, Shisuo Du","doi":"10.1002/pro6.70029","DOIUrl":"10.1002/pro6.70029","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the dose dependency of asymptomatic radiation pneumonitis (aRP) in patients with lung cancer following radiotherapy, focusing on the predictive value of dosimetric parameters.</p><p><strong>Methods: </strong>This study included 72 patients with primary lung cancer who underwent radiotherapy between January 2019 and June 2022. The patients were divided into an aRP group (<i>n</i> = 30) and a non-RP group (<i>n</i> = 42). The physical dose was converted to an equivalent dose using the Linear-Quadratic (LQ) model, with an α/β value of 3. Three lung structures were defined, and the corresponding dose-volume histogram parameters were collected. The Mann-Whitney U test was used to compare dose parameters between the two groups, and multivariate logistic regression was performed to remove correlations among different parameters. A logistic function and receiver operating characteristic curve were constructed to predict aRP. This study analyzed the impact of different clinical characteristics on the aRP incidence.</p><p><strong>Results: </strong>The lungs-planning target volume (PTV) V_15(Gy) was ultimately identified as the best predictive parameter. Significant dose-response relationships were observed, with V_15(Gy) achieving an area under the curve of 0.666 ± 0.067 (<i>P</i> = 0.017). The optimal cutoff value for lungs-PTV V_15(Gy) was 21.1%, below which the incidence of aRP decreased significantly. Immunotherapy has been identified as an independent risk factor for aRP.</p><p><strong>Conclusion: </strong>The occurrence of aRP in patients with lung cancer after radiotherapy has a clear dose dependency, with lungs-PTV, V_15(Gy) being the best dose parameter for prediction, and the optimal cutoff value based on this study was 21.1%.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"9 3","pages":"185-191"},"PeriodicalIF":3.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12559912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145402131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral T-cell lymphoma with central nervous system involvement and elevated interleukin-10 levels in the cerebrospinal fluid: A case report.","authors":"Xin Wang, Haichen Wei, Dan Liu, Hui Wang, Zengjun Li, Lijie Xing","doi":"10.1002/pro6.70018","DOIUrl":"10.1002/pro6.70018","url":null,"abstract":"<p><p>Central nervous system (CNS) involvement in peripheral T-cell lymphoma (PTCL) is rare and is associated with poor prognosis. This report presents two pathologically confirmed PTCL cases. Although cerebrospinal fluid (CSF) flow cytometry did not detect tumor cells, CSF analysis revealed significantly elevated interleukin (IL)-10 levels and an increased IL-10/IL-6 ratio, suggesting CNS involvement. Following effective chemotherapy, which crossed the blood-brain barrier, IL-10 levels and the IL-10/IL-6 ratio decreased significantly, with clinical improvement. These findings suggest that IL-10 is a valuable supplementary diagnostic marker for CNS involvement in PTCL. Whole-brain radiation therapy, as a consolidative treatment, may be effective for residual or refractory lesions and improve prognosis. We review these patients' clinical and diagnostic features and discuss the role of radiotherapy in the treatment of CNS involvement in PTCL.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"9 3","pages":"223-227"},"PeriodicalIF":3.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12559901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145402163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential benefits of multi-field IMPT for stage I NSCLC SBRT: An in silico dosimetric comparison to IMRT and CyberKnife.","authors":"ZhangMing Chen, Xianrui Yan, Shu Xie, Pinjing Cheng, Dong Xiang, Cheng Tao, Qingtao Qiu, Tengxiang Li, Chengqiang Li, Huazhong Shu, Antoine Simon, Jian Zhu","doi":"10.1002/pro6.70027","DOIUrl":"10.1002/pro6.70027","url":null,"abstract":"<p><strong>Purpose: </strong>Multi-field intensity-modulated proton therapy (IMPT) is a novel treatment protocol design method proposed to reduce range uncertainty. This study aimed to investigate whether multi-field IMPT has a dose distribution advantage over photon intensity-modulated radiation therapy (IMRT) and CyberKnife in stereotactic body radiotherapy (SBRT) for stage I non-small cell lung cancer (NSCLC).</p><p><strong>Methods: </strong>Twenty-nine patients who underwent photon SBRT from February 2021 to September 2022 at Shandong Cancer Hospital were included. Their Computed Tomography (CT) images were used to design CyberKnife and multi-field IMPT plans. For the photon plan (IMRT and CyberKnife), the planning target volume (PTV), which was extended from the internal gross target volume (IGTV), was prescribed at 50 Gy. For the proton plans, the planning beam-specific target volume (PBSTV) based on the IGTV was created to meet the same area as the photon PTV. Multi-field IMPT was simulated by adding additional beam angles to conventional IMPT. Dose distribution assessment factors included D_mean and dose gradient index (GI) for PTV/PBSTV, and D_mean and the hottest 0.1 cm³ dose (D_0.1cc) for organs at risk (OARs).</p><p><strong>Results: </strong>With each patient receiving 7-11 beams, multi-field IMPT had a better target GI than IMRT. For the lung, heart, spinal cord, chest wall, and ribs doses, the D_mean of the multi-field IMPT was smaller than that of the other two plans for all metrics. CyberKnife was significantly less protective of the OARs than the other two planning modalities, owing to the presence of a high target center dose.</p><p><strong>Conclusion: </strong>Multi-field IMPT achieves favorable target coverage and OAR protection compared to IMRT and CyberKnife for SBRT of NSCLC.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"9 3","pages":"156-166"},"PeriodicalIF":3.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12559922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145402128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosimetric assessment of conventional and advanced algorithms in clinical stereotactic radiotherapy.","authors":"Abhay Kumar Singh, Anuj Vijay, Manindra Bhushan","doi":"10.1002/pro6.70028","DOIUrl":"10.1002/pro6.70028","url":null,"abstract":"<p><strong>Purpose: </strong>To systematically compare the dosimetric performance of conventional (Ray Tracing, AAA) and advanced (Monte Carlo, Acuros XB) dose calculation algorithms across homogeneous and heterogeneous tissues in stereotactic radiotherapy (SRT) and stereotactic body radiotherapy (SBRT).</p><p><strong>Methods: </strong>A retrospective analysis of 125 SRT cases (brain: 50, lung: 20, liver: 20, spine: 35) was conducted using CyberKnife and Varian systems. Plans were originally created using Type B (Anisotropic Analytical Algorithm [AAA] and Ray Tracing) algorithms and were subsequently recalculated using Type C (Acuros XB and Monte Carlo) algorithms, while maintaining identical beam geometry and monitor units. Dosimetric parameters (D_95%, D_mean, D_max, CI, HI, GI) were evaluated. Validation included point dose measurements with Cheese Phantom and gamma index analysis using the PTW 1600 SRS Phantom.</p><p><strong>Results: </strong>In lung cases, Type B algorithms overestimated D_95% by 14% compared to Monte Carlo, which reduced D_mean by 13.7% and CI by 25.8%. In liver, Acuros XB lowered D_mean by 21.4% with a 0.8% CI reduction. For spine, Monte Carlo reduced D_95% by 3.4%, with a 1.1% drop in D_mean and stable CI. Brain cases showed minimal differences, with Monte Carlo increasing CI by 2.5% (1.19 vs. 1.16). Gamma pass rates exceeded 98% for Monte Carlo and Acuros XB, surpassing Ray Tracing and AAA (≤96%).</p><p><strong>Conclusion: </strong>Advanced algorithms demonstrated superior dose accuracy, homogeneity, and organs at risk (OAR) sparing in heterogeneous anatomical regions. Despite higher computational requirements, their clinical implementation is justified for SRT/SBRT planning. This study supports a site-specific approach, advocating for advanced algorithm use in anatomically complex scenarios.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"9 3","pages":"192-201"},"PeriodicalIF":3.6,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12559905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145402171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, risk factors, and CT characteristics of radiation recall pneumonitis induced by COVID-19 infection in lung cancer.","authors":"Wenhua Yun, Junxu Wen, Xueying Zhai, Xiaoyan Yin, Xiangjiao Meng","doi":"10.1002/pro6.70025","DOIUrl":"10.1002/pro6.70025","url":null,"abstract":"<p><strong>Objective: </strong>Radiation recall pneumonitis (RRP) is a localized inflammatory reaction occurring in previously irradiated lung regions, typically triggered by certain anticancer agents. In clinical settings, we have observed that COVID-19 infection may also act as a precipitating factor for RRP. However, its true incidence and possible risk factors remain poorly defined.</p><p><strong>Methods: </strong>Lung cancer patients who received radiotherapy and were diagnosed with COVID-19 between November 2022 and February 2023 were included. RRP was defined as pulmonary changes limited to the previously irradiated regions, occurring at least 6 months after radiotherapy. Patients medical records and radiation dose distribution data were analyzed to identify potential contributing factors to RRP.</p><p><strong>Results: </strong>The study included 140 patients who underwent thoracic radiotherapy with a minimum six-month interval before COVID-19 diagnosis. Among these, 62 patients (44.2%) developed RRP, and 45% of these experienced grade ≥ 2 pneumonitis. No radiotherapy dose-related factors were significantly associated with RRP. However, statistical analysis showed that RRP incidence was significantly associated with baseline T-stage (<i>P</i> = 0.034) and the time interval from radiotherapy completion to COVID-19 infection (<i>P</i> < 0.001).</p><p><strong>Conclusions: </strong>A 44.2% incidence of COVID-19-related RRP was identified, which is notably higher than previously reported. While radiotherapy dosimetry did not correlate with RRP risk, baseline T-stage and timing of COVID-19 infection after radiotherapy were significantly associated with its occurrence.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"9 3","pages":"177-184"},"PeriodicalIF":3.6,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12559899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145402134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating intra-fraction motion and its dosimetric impact in ethos online adaptive radiotherapy for prostate cancer.","authors":"Yoganathan Sa, Ahamed Basith, Rajeev Choudary Apsani, Venkada Manickam Gurusamy, Amine Khemissi, Satheesh Paloor, Saju Divakar, Sarah McCabe, Rabih Hammoud, Noora Al-Hammadi","doi":"10.1002/pro6.70013","DOIUrl":"10.1002/pro6.70013","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the geometric and dosimetric uncertainties during online adaptive radiotherapy (ART) for prostate cancer.</p><p><strong>Methods: </strong>Sequential cone beam computed tomography (CBCT) scans from 52 sessions involving 13 patients were analyzed. An ART plan was generated using CBCT1, followed by a verification scan (CBCT2) acquired 13.1 ± 3.0 minutes before treatment delivery. New contours (prostate, seminal vesicles, bladder, rectum, and bowel) were delineated on CBCT2 and transferred to CBCT1 for dose distribution analysis. Three dimensional contour variations were quantified, new planning target volume (PTV) margins were calculated, and their dosimetric benefits were assessed.</p><p><strong>Results: </strong>No significant differences were observed in the high-dose volumes (V60 Gy and V57 Gy) of the bladder and rectum (<i>P</i> > 0.05). PTV margins were 2.6 mm, 2.4 mm, and 2.6 mm in the lateral, vertical, and longitudinal directions for the prostate, and 3.9 mm, 3.8 mm, and 4.3 mm for the seminal vesicles, respectively. These margin reductions led to a 37% reduction in the dose to the surrounding critical organs, while maintaining consistent target coverage.</p><p><strong>Conclusion: </strong>This study supports symmetric PTV margins of 3 mm for the prostate and 4.5 mm for the seminal vesicles in online ART, thereby contributing to the development of optimized treatment strategies for prostate cancer.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"9 3","pages":"202-209"},"PeriodicalIF":3.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12559917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145402187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"On the significance of peak dose in normal tissue toxicity in spatially fractionated radiotherapy: The case of proton minibeam radiation therapy\".","authors":"Zhaoning Wang, Linlin Wang","doi":"10.1002/pro6.70026","DOIUrl":"10.1002/pro6.70026","url":null,"abstract":"","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"9 3","pages":"221-222"},"PeriodicalIF":2.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12559893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145402082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Multi-sequence MRI-based clinical-radiomics models for the preoperative prediction of microsatellite instability-high status in endometrial cancer\".","authors":"","doi":"10.1002/pro6.70023","DOIUrl":"10.1002/pro6.70023","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1002/pro6.70000.].</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"9 3","pages":"228"},"PeriodicalIF":2.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12559911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145402167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}