Precision Radiation Oncology最新文献_第7页

Comparing concurrent chemoradiotherapy, 125I seed implantation combined with chemotherapy, and chemotherapy alone efficacy in treating unresectable locally advanced pancreatic cancer 同期放化疗、125I粒子植入联合化疗和单纯化疗治疗不可切除的局部晚期癌症的疗效比较

Precision Radiation Oncology Pub Date : 2022-06-01 DOI: 10.1002/pro6.1156

Ya-Qin Zheng, Rui Huang, Wen-Lu Zou, Chao Liu, H. Niu, J. Yue

引用次数: 0

Patient-specific synthetic magnetic resonance imaging generation from cone beam computed tomography for image guidance in liver stereotactic body radiation therapy. 根据锥形束计算机断层扫描生成患者特异性合成磁共振成像，用于肝脏立体定向体放射治疗的图像引导。

Precision Radiation Oncology Pub Date : 2022-06-01 Epub Date: 2022-06-11 DOI: 10.1002/pro6.1163

Zeyu Zhang, Zhuoran Jiang, Hualiang Zhong, Ke Lu, Fang-Fang Yin, Lei Ren

{"title":"Patient-specific synthetic magnetic resonance imaging generation from cone beam computed tomography for image guidance in liver stereotactic body radiation therapy.","authors":"Zeyu Zhang, Zhuoran Jiang, Hualiang Zhong, Ke Lu, Fang-Fang Yin, Lei Ren","doi":"10.1002/pro6.1163","DOIUrl":"10.1002/pro6.1163","url":null,"abstract":"Objective: Despite its prevalence, cone beam computed tomography (CBCT) has poor soft-tissue contrast, making it challenging to localize liver tumors. We propose a patient-specific deep learning model to generate synthetic magnetic resonance imaging (MRI) from CBCT to improve tumor localization.Methods: A key innovation is using patient-specific CBCT-MRI image pairs to train a deep learning model to generate synthetic MRI from CBCT. Specifically, patient planning CT was deformably registered to prior MRI, and then used to simulate CBCT with simulated projections and Feldkamp, Davis, and Kress reconstruction. These CBCT-MRI images were augmented using translations and rotations to generate enough patient-specific training data. A U-Net-based deep learning model was developed and trained to generate synthetic MRI from CBCT in the liver, and then tested on a different CBCT dataset. Synthetic MRIs were quantitatively evaluated against ground-truth MRI.Results: The synthetic MRI demonstrated superb soft-tissue contrast with clear tumor visualization. On average, the synthetic MRI achieved 28.01, 0.025, and 0.929 for peak signal-to-noise ratio, mean square error, and structural similarity index, respectively, outperforming CBCT images. The model performance was consistent across all three patients tested.Conclusion: Our study demonstrated the feasibility of a patient-specific model to generate synthetic MRI from CBCT for liver tumor localization, opening up a potential to democratize MRI guidance in clinics with conventional LINACs.","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ad/88/nihms-1842255.PMC10103741.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9603128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of functional magnetic resonance imaging in the assessment of nasopharyngeal carcinoma treatment response 功能磁共振成像评估鼻咽癌治疗反应的研究进展

Precision Radiation Oncology Pub Date : 2022-05-30 DOI: 10.1002/pro6.1161

K. Wong, Katarina Cheng, Saikit Lam, Chenyang Liu, Jing Cai

{"title":"Review of functional magnetic resonance imaging in the assessment of nasopharyngeal carcinoma treatment response","authors":"K. Wong, Katarina Cheng, Saikit Lam, Chenyang Liu, Jing Cai","doi":"10.1002/pro6.1161","DOIUrl":"https://doi.org/10.1002/pro6.1161","url":null,"abstract":"Nasopharyngeal carcinoma (NPC) is a common malignancy endemic in South‐East Asia. Functional magnetic resonance imaging (fMRI) has been used for prompt detection of treatment response before visible morphological changes in NPC treatment. Among different fMRI techniques, diffusion‐weighted imaging (DWI) and dynamic contrast enhancement (DCE) were proved to be more successful in NPC treatment response assessment whilst the application of magnetic resonance spectroscopy (MRS) remains questionable. Apart from discussing the imaging technique, time points for post‐treatment response assessments are recommended. Four instead of three months is recommended for prompt identification of non‐ or partial responders and 6–9 months post‐treatment multiparametric MRI is also recommended for effective confirmation of complete responding individuals to avoid residual disease. For future advancement, in addition to the post‐treatment response assessment, continuous or longitudinal assessment on the treatment response with the use of magnetic resonance simulator (MR‐simulator) or magnetic resonace imaging guided linear accelerator (MR‐Linac) tailor‐made for radiotherapy (RT) maybe feasible. Longitudinal assessments or predictive radiomics modeling allow spotting out the possibility of treatment failure before the completion or even before the start of treatments. Adaptive instead of salvage treatments can then be prepared, thus reducing the damage and side effects of consecutive cytotoxic treatments.","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47389966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of planning target volume margins in 1.5 T magnetic resonance‐guided stereotactic body radiation therapy for localized prostate cancer 1.5 T磁共振引导立体定向放射治疗局限性前列腺癌规划靶体积边界的评估

Precision Radiation Oncology Pub Date : 2022-05-12 DOI: 10.1002/pro6.1155

Bin Yang, J. Yuan, D. Poon, H. Geng, W. Lam, K. Cheung, S. Yu

引用次数: 0

Effect of radiotherapy and chemotherapy on the survival rate of Asian Americans with nasopharyngeal carcinoma 放化疗对亚裔鼻咽癌患者生存率的影响

Precision Radiation Oncology Pub Date : 2022-05-08 DOI: 10.1002/pro6.1154

A. M. Chen, L. Qi, R. Cress, Yueju Li, L. Beckett, Baoqing Li

引用次数: 0

A pilot study of respiratory motion characterization in the abdomen using a fast volumetric 4D‐MRI for MR‐guided radiotherapy 一项使用快速体积4D - MRI进行MR引导放射治疗的腹部呼吸运动特征的初步研究

Precision Radiation Oncology Pub Date : 2022-05-08 DOI: 10.1002/pro6.1153

O. Wong, M. Law, D. Poon, R. W. H. Yung, S. Yu, K. Cheung, J. Yuan

引用次数: 0

Magnetic resonance imaging‐only‐based radiation treatment planning for simultaneous integrated boost of multiparametric magnetic resonance imaging‐defined dominant intraprostatic lesions 仅基于磁共振成像的放射治疗计划，用于同时综合增强多参数磁共振成像定义的主要瓣内病变

Precision Radiation Oncology Pub Date : 2022-04-19 DOI: 10.1002/pro6.1152

M. Dumas, Marisa Leney, Joshua Kim, P. Sevak, M. Elshaikh, M. Pantelic, B. Movsas, I. Chetty, N. Wen

引用次数: 0

Anti‐proliferative and metastasis‐inhibiting effect of carbon ions on non‐small cell lung adenocarcinoma A549 cells 碳离子对非小细胞肺腺癌A549细胞的抗增殖和转移抑制作用

Precision Radiation Oncology Pub Date : 2022-04-15 DOI: 10.1002/pro6.1151

Zhen Yang, Hongtao Luo, Shuangwu Feng, Y. Geng, Xueshan Zhao, Chengcheng Li, Ruifeng Liu, Qiuning Zhang, Xiaohu Wang

引用次数: 0

Radiotherapy guidelines for rectal cancer in China (2020 Edition) 中国癌症放射治疗指南（2020年版）

Precision Radiation Oncology Pub Date : 2022-03-01 DOI: 10.1002/pro6.1141

Shixin Liu, Jing Jin

{"title":"Radiotherapy guidelines for rectal cancer in China (2020 Edition)","authors":"Shixin Liu, Jing Jin","doi":"10.1002/pro6.1141","DOIUrl":"https://doi.org/10.1002/pro6.1141","url":null,"abstract":"Rectal cancer is one of the most common malignant tumors. In China, rectal cancer has been the third most frequently diagnosed cancer and the fifth leading cause of cancer death, with changes of residents’ lifestyle factors and diets. The best treatment for rectal cancer depends on many factors. Multidisciplinary Treatment has become the basis for improving the therapeutic effect, in which radiology is increasingly necessary for treating patients with rectal cancer. For patients who have extensive, fixed, bulky tumors or obvious nodal disease, radiotherapy and chemotherapy combined with surgery has emerged as the standard of care. For patients with metastatic disease, the reasonable combination of local and systemic therapy might be an alternative. Improvements in imaging, pathological diagnosis and radiation techniques provide a solid foundation for promoting the level of clinical practice in rectal cancer. High‐quality magnetic resonance imaging distinguishing risk stratification, molecular markers predicting therapeutic effect and prognosis, magnetic resonance imaging in delineating target volumes drawn, intensity‐modulated radiation therapy, and image‐guides radiation therapy for precision treatment delivery are all being widely applied in multiple centers. Furthermore, as the role of targeted therapy and immune therapy has become increasingly prominent, the attempt of combined radiotherapy is also ongoing. In view of the characteristics and current situation of diagnosis and treatment of rectal cancer in China, the guidelines will present the basis and reference for combined treatment and standardized treatments. Meanwhile, there may be continuous new advances in clinical practice, and that will be a new basis to update the guidelines, directly benefiting all rectal cancer patients and facilitating discipline developments.","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49473368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The role of stereotactic body radiation therapy in the management of pulmonary metastases: a systematic review 立体定向放射治疗在肺转移瘤治疗中的作用:系统综述

Precision Radiation Oncology Pub Date : 2022-03-01 DOI: 10.1002/pro6.1148

Yung Lee, Y. Samarasinghe, Nadeesha Samarasinghe, Janhavi Patel, T. McKechnie, C. Finley, W. Hanna, A. Swaminath, J. Agzarian

{"title":"The role of stereotactic body radiation therapy in the management of pulmonary metastases: a systematic review","authors":"Yung Lee, Y. Samarasinghe, Nadeesha Samarasinghe, Janhavi Patel, T. McKechnie, C. Finley, W. Hanna, A. Swaminath, J. Agzarian","doi":"10.1002/pro6.1148","DOIUrl":"https://doi.org/10.1002/pro6.1148","url":null,"abstract":"While pulmonary metastases are often managed through metastasectomies, stereotactic body radiation therapy (SBRT) is a relatively novel treatment that has shown promise for this disease. This review aimed to summarize the current findings of SBRT in the treatment of pulmonary metastases. MEDLINE, EMBASE, and CENTRAL were searched for articles that examined the use of SBRT for patients with pulmonary metastases. Primary outcomes included overall survival, disease‐free survival, and progression‐free survival. Results were pooled where appropriate. Risk of bias was assessed through the Methodological Index for Non‐Randomized Studies tool. After screening, 13 studies with 545 patients conducted between 2006 and 2020 were included in this review. Primary tumor localizations included gastrointestinal, pulmonary, and bone, among others. Pooled overall survival at 1 year was 81%, 41% at 3 years, 34% at 4 years, and 26% at 5 years. Pooled progression‐free survival at 1, 2, and 3 years was 60%, 41%, and 31% respectively. Local control at 1, 2, and 3 years were 90%, 79%, and 77%, respectively. Preliminary evidence regarding SBRT for treatment of pulmonary metastases shows promising benefits for overall survival and local control. Further high‐quality prospective trials are required to investigate the effectiveness and treatment‐related adverse effects of SBRT, and should compare it with metastasectomy.","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43628990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0