Chemical Research in Toxicology最新文献_第2页

Bisphenol A in Disposable Face Masks: A Novel Human Exposure Pathway and Impact on the Aquatic Environment.

IF 3.7 3区医学

Chemical Research in Toxicology Pub Date : 2025-02-17 Epub Date: 2025-02-03 DOI: 10.1021/acs.chemrestox.4c00535

Hei-Tak Tse, Chun-Kit Au, Wan Chan

{"title":"Bisphenol A in Disposable Face Masks: A Novel Human Exposure Pathway and Impact on the Aquatic Environment.","authors":"Hei-Tak Tse, Chun-Kit Au, Wan Chan","doi":"10.1021/acs.chemrestox.4c00535","DOIUrl":"10.1021/acs.chemrestox.4c00535","url":null,"abstract":"We identified and quantified bisphenol A (BPA), a known estrogen-like endocrine disruptor, in disposable face mask samples collected in Hong Kong. Results revealed that BPA is a common contaminant in face masks, with concentrations reaching up to 2 μg/mask. Although polypropylene, the primary material used in mask production, is generally considered to be BPA-free, the contaminant likely originates from additives, such as flame retardants, added during manufacturing. With a dermal absorption coefficient of 0.59 for BPA, the data indicate that mask-borne BPA is readily absorbed by the skin. Notably, 8 of 85 samples could cause the user to exceed the tolerable daily BPA intake set by the European Food Safety Agency (0.0002 μg/kg body weight per day). Additionally, BPA dissolves completely in landfill leachate in less than 70 days, which poses previously unrecognized health and environmental hazards. Given the extensive use of face masks during the pandemic, their role as personal protective equipment for medical practitioners, and the fact that there are currently no regulations regarding BPA contents in masks, it is imperative to investigate the need for regulations in order to safeguard face mask users and the environment.","PeriodicalId":31,"journal":{"name":"Chemical Research in Toxicology","volume":" ","pages":"347-352"},"PeriodicalIF":3.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Evaluation of the Interaction and Gender Differences in Combination of Apatinib and Metoprolol Using Humanized CYP2D6 Model. 应用人源化CYP2D6模型早期评价阿帕替尼与美托洛尔联合用药的相互作用及性别差异。

IF 3.7 3区医学

Chemical Research in Toxicology Pub Date : 2025-02-17 Epub Date: 2025-01-15 DOI: 10.1021/acs.chemrestox.4c00433

Yahui Wang, Qihui Kong, Huiyan Chai, Haidan Hu, Qianwen Zhang, Jianchang Qian, Bingbing Chen

{"title":"Early Evaluation of the Interaction and Gender Differences in Combination of Apatinib and Metoprolol Using Humanized CYP2D6 Model.","authors":"Yahui Wang, Qihui Kong, Huiyan Chai, Haidan Hu, Qianwen Zhang, Jianchang Qian, Bingbing Chen","doi":"10.1021/acs.chemrestox.4c00433","DOIUrl":"10.1021/acs.chemrestox.4c00433","url":null,"abstract":"Apatinib, a commonly used tyrosine kinase inhibitor in cancer treatment, can cause adverse reactions such as hypertension. Hypertension, in turn, can increase the risk of certain cancers. The coexistence of these diseases makes the use of combination drugs more common in clinical practice, but the potential interactions and regulatory mechanisms in these drug combinations are poorly understood. We used the humanized CYP2D6 mouse model to predict the effect of apatinib on the pharmacokinetics and pharmacodynamics of metoprolol and investigated the interactional mechanism. The inhibitory effects and mechanisms of apatinib on metoprolol were investigated in vitro by using wild-type mouse liver microsomes (WT MLMs), humanized CYP2D6 mouse liver microsomes (hCYP2D6 MLMs), and human liver microsomes (HLMs). Molecular docking was utilized to explore the structural basis of the observed inhibitory mode. And in vivo interaction between apatinib and metoprolol was assessed by pharmacokinetics study using the humanized CYP2D6 mice. In vitro studies and molecular docking experiments indicated that apatinib competitively inhibited the metabolism of metoprolol. In vivo findings revealed that the administration of apatinib combined with metoprolol resulted in a significant increase in the AUC(0-t), AUC(0-∞) and Cmax of metoprolol; additionally, there was a reduction in the CLz/F and heart rate, indicating that apatinib strongly inhibited metoprolol metabolism. And the homologous CYP2D6 protein in WT mice was more sensitive to apatinib compared to the hCYP2D6 mice. Gender analysis revealed that metoprolol accumulation was more pronounced in male mice when combined with apatinib, indicating a higher susceptibility to cardiotoxicity in males.","PeriodicalId":31,"journal":{"name":"Chemical Research in Toxicology","volume":" ","pages":"296-306"},"PeriodicalIF":3.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A High-Affinity and Selective DNA Aptamer for the N-Linked C8-Deoxyguanosine Adduct Produced by the Arylamine Carcinogen 4-Aminobiphenyl.

IF 3.7 3区医学

Chemical Research in Toxicology Pub Date : 2025-02-17 Epub Date: 2025-02-05 DOI: 10.1021/acs.chemrestox.4c00496

Yijing Chen, Ryan E Johnson, Richard A Manderville, Juewen Liu

{"title":"A High-Affinity and Selective DNA Aptamer for the N-Linked C8-Deoxyguanosine Adduct Produced by the Arylamine Carcinogen 4-Aminobiphenyl.","authors":"Yijing Chen, Ryan E Johnson, Richard A Manderville, Juewen Liu","doi":"10.1021/acs.chemrestox.4c00496","DOIUrl":"10.1021/acs.chemrestox.4c00496","url":null,"abstract":"4-Aminobiphenyl (4-ABP) is a known human carcinogen that is implicated in the development of bladder cancers in smokers. The amine substituent undergoes bioactivation to generate nitrenium ions capable of covalently modifying DNA nucleobases. The primary adduct of 4-ABP, N-(deoxyguanosin-8-yl)-4-aminobiphenyl (dG-C8-ABP), is a bulky N-linked C8-dG adduct that serves as a biomarker for assessing the cancer risk associated with aromatic amine exposure. In this study, the capture-SELEX method was utilized to isolate DNA aptamers for dG-C8-ABP with high affinity and specificity. Using thioflavin T fluorescence spectroscopy and isothermal titration calorimetry, the parent aptamer PdG-1 has a Kd value below 100 nM and over 50-fold selectivity for dG-C8-ABP against competing analytes. A turn-on fluorescent sensor for dG-C8-ABP diagnostics, developed using a strand displacement assay, is also presented with a limit of detection of 68 nM. Our work represents the first selection of a DNA aptamer for a bulky DNA adduct produced by a known human carcinogen and sets the stage for the creation of ultrasensitive aptasensor platforms to meet the challenge of dG-C8-ABP detection in clinical settings.","PeriodicalId":31,"journal":{"name":"Chemical Research in Toxicology","volume":" ","pages":"340-346"},"PeriodicalIF":3.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabidiol Toxicity Driven by Hydroxyquinone Formation.

IF 3.7 3区医学

Chemical Research in Toxicology Pub Date : 2025-02-17 Epub Date: 2025-01-29 DOI: 10.1021/acs.chemrestox.4c00448

Metzli I Montero, Pravien S Rajaram, Jose E Zamora Alvarado, Kara E McCloskey, Ryan D Baxter, Roberto C Andresen Eguiluz

引用次数: 0

PFOS-Induced Perturbations in Trophoblast Functions through the Oip5os1/miR-155/Rnd3 Axis in PE. pfos通过PE中Oip5os1/miR-155/Rnd3轴诱导的滋养细胞功能的扰动

IF 3.7 3区医学

Chemical Research in Toxicology Pub Date : 2025-02-17 Epub Date: 2025-01-14 DOI: 10.1021/acs.chemrestox.4c00184

Xiaomin Ye, Peiqu Zhong, Qiongfang Chen, Dongmei Zhou, Jieyu Luo, Youcai Liang, Jiayuan Zhang, Lijian Zhao

引用次数: 0

Interview with Professor Alanna Schepartz, 2024 Keynote Speaker, American Chemical Society Division of Chemical Toxicology. 采访Alanna Schepartz教授，2024年主讲人，美国化学学会化学毒理学分部。

IF 3.7 3区医学

Chemical Research in Toxicology Pub Date : 2025-02-17 Epub Date: 2025-01-17 DOI: 10.1021/acs.chemrestox.4c00429

Sadia S Disha, Temilade R Adeniran, Chinenye P Nwike

引用次数: 0

Characterizing the Transient Emission of Particles and Gases from a Single Puff of Electronic Cigarette Smoke. 表征单吸电子烟烟雾中粒子和气体的瞬态发射。

IF 3.7 3区医学

Chemical Research in Toxicology Pub Date : 2025-02-17 Epub Date: 2025-01-17 DOI: 10.1021/acs.chemrestox.4c00420

Kashala Fabrice Kapiamba, Steven Achterberg, Ta-Chun Lin, Philip D Whitefield, Yue-Wern Huang, Yang Wang

{"title":"Characterizing the Transient Emission of Particles and Gases from a Single Puff of Electronic Cigarette Smoke.","authors":"Kashala Fabrice Kapiamba, Steven Achterberg, Ta-Chun Lin, Philip D Whitefield, Yue-Wern Huang, Yang Wang","doi":"10.1021/acs.chemrestox.4c00420","DOIUrl":"10.1021/acs.chemrestox.4c00420","url":null,"abstract":"This study employed high-time-resolution systems to examine the transient properties of aerosols and gases emitted from electronic cigarette (EC) puffs. Using a fast aerosol sizer, we measured particle size distributions (PSDs) across various EC brands (JUUL, VUSE, VOOPOO), revealing sizes ranging from 5 to 1000 nm at concentrations of 107 to 1010 cm-3. Most aerosols were found to be in the ultrafine range (below 100 nm), with JUUL-, VUSE-, and VOOPOO-producing aerosols with geometric mean sizes of 19.9, 47.3, and 29.4 nm, respectively. Applying the International Commission on Radiological Protection (ICRP) deposition model and assuming no further evolution of aerosols in the respiratory system, we estimated particle deposition in different respiratory regions: 45-60% in the alveolar region, 10-25% in the tracheobronchial region, and 20-35% in the extrathoracic region. The highest single-puff deposition was observed with the VOOPOO device at 60 W, depositing 180.1 ± 7.6 μg in the alveolar region. The gas emissions (CO2, NOx, CO, and total hydrocarbons) were measured at different power settings of the VOOPOO EC. Single-puff NOx and CO levels exceeded the permissible exposure limits of the Occupational Safety and Health Administration, indicating potential acute exposure risks. Higher power settings were correlated with increased gas mixing ratios, suggesting more e-liquid vaporization and possible chemical transformations at higher temperatures. These findings demonstrated significant health risks associated with ultrafine particles from high-power ECs and emphasize the need for advanced measurements to accurately assess their physicochemical properties and potential health implications.","PeriodicalId":31,"journal":{"name":"Chemical Research in Toxicology","volume":" ","pages":"270-280"},"PeriodicalIF":3.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibitory Effects of Alkaloids on OATP1B1 In Vitro and In Vivo: Prediction for Food/Herb-Drug Interactions and Hepatoprotective Effects Based on Structure-Activity Relationships.

IF 3.7 3区医学

Chemical Research in Toxicology Pub Date : 2025-02-17 Epub Date: 2025-02-03 DOI: 10.1021/acs.chemrestox.4c00418

Yanhong Sun, Huixin Tan, Fenghe Wang, Jiahuan Hu, Xiaoyan Duan, Wanting Bai, Jinjin Wu, Jie Bai, Jinping Hu

{"title":"Inhibitory Effects of Alkaloids on OATP1B1 In Vitro and In Vivo: Prediction for Food/Herb-Drug Interactions and Hepatoprotective Effects Based on Structure-Activity Relationships.","authors":"Yanhong Sun, Huixin Tan, Fenghe Wang, Jiahuan Hu, Xiaoyan Duan, Wanting Bai, Jinjin Wu, Jie Bai, Jinping Hu","doi":"10.1021/acs.chemrestox.4c00418","DOIUrl":"10.1021/acs.chemrestox.4c00418","url":null,"abstract":"Alkaloids, a class of low-molecular-weight nitrogenous compounds, attract a great deal of interest because of their biological activities and therapeutic potential. Yet, surprisingly little is known about their interactions with drug transporters, especially Organic Anion Transporting Polypeptide 1B1 (OATP1B1), a liver-specific uptake transporter, which is closely associated with drug-induced liver injury (DILI). This study aims to investigate the inhibitory effects of 160 alkaloids on OATP1B1, assess the hepatoprotective effects against bosentan-induced liver injury, and elucidate the structure-activity relationships of alkaloids with OATP1B1. Four alkaloids, including dihydroberberine, deacetyltaxol, dihydrocapsaicin, and tetrahydropalmatine, significantly inhibited OATP1B1 transport activity in OATP1B1-HEK293 cells (>50%), which reduced the OATP1B1-mediated uptake of methotrexate and microcystin-LR, and consequently decreased their cell toxicity. In bosentan-induced liver injury models, 4 alkaloids reduced serum total bile acid (TBA) levels and liver concentration of bosentan to different degrees, especially deacetyltaxol, which exhibited the most potent hepatoprotective effect against bosentan. The pharmacophore model suggested that the critical pharmacophores of alkaloid inhibitors are hydrogen bond acceptors and hydrophobic groups. Our findings pave the way for predicting the potential risks of alkaloids-containing food/herb-drug interactions in humans and optimizing the alkaloid structure for alleviating OATP1B1-related DILI.","PeriodicalId":31,"journal":{"name":"Chemical Research in Toxicology","volume":" ","pages":"281-295"},"PeriodicalIF":3.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxic Effects of Cobalt on Erythroid Progenitor Cells. 钴对红系祖细胞的毒性作用。

IF 3.7 3区医学

Chemical Research in Toxicology Pub Date : 2025-02-17 Epub Date: 2025-01-15 DOI: 10.1021/acs.chemrestox.4c00441

Yao Li, Qingjiang Ding, Hailin Wang

{"title":"Toxic Effects of Cobalt on Erythroid Progenitor Cells.","authors":"Yao Li, Qingjiang Ding, Hailin Wang","doi":"10.1021/acs.chemrestox.4c00441","DOIUrl":"10.1021/acs.chemrestox.4c00441","url":null,"abstract":"Cobalt is a crucial trace element that widely exists in natural environments and is necessary for normal physiological function. However, excessive cobalt exposure leads to various adverse health effects, especially hematological and endocrine dysfunctions. Here, we investigated the toxicity of cobalt on early erythropoiesis by using ex vivo cultured erythroid progenitor cells (EPCs). We exposed EPCs to cobalt chloride (CoCl2) and observed that their proliferation was significantly reduced after treatment with 50 μM CoCl2 for 3 days and 10 μM CoCl2 for 4 days. Furthermore, CoCl2 exposure reduced the proportion of S phase cells and induced apoptosis of EPCs in a dose-dependent manner (20-100 μM). Notably, further studies revealed that CoCl2 exposure inhibited the expression and phosphorylation of the erythroid proliferation master gene c-Kit. During EPC differentiation, treatment with CoCl2 hindered the enucleation of erythrocytes. Consistent with these findings, the RNA-seq results revealed that CoCl2 treatment inhibited the expression of several genes related to both proliferation and differentiation. The gene responsible for nucleoprotein export during enucleation, Xpo7, was also downregulated. Gene ontology analysis revealed that CoCl2 treatment inhibited a variety of biological processes, including DNA replication and ribosome synthesis. In summary, we demonstrated that sustained excessive CoCl2 exposure impaired the function of the EPCs.","PeriodicalId":31,"journal":{"name":"Chemical Research in Toxicology","volume":" ","pages":"307-313"},"PeriodicalIF":3.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Berberine Inhibits KLF4 Promoter Methylation and Ferroptosis to Ameliorate Diabetic Nephropathy in Mice".

IF 3.7 3区医学

Chemical Research in Toxicology Pub Date : 2025-02-17 Epub Date: 2025-01-24 DOI: 10.1021/acs.chemrestox.5c00022

Shengyu Cai, Huizheng Zhu, Lingling Chen, Congcong Yu, Liyuan Su, Kaihua Chen, Yousheng Li

引用次数: 0