European Polymer Journal最新文献_第9页

Kinetics and scale inhibition application studies towards bulk and RAFT copolymerization of maleic anhydride and acrylic acid 马来酸酐和丙烯酸的散装和 RAFT 共聚动力学和阻垢应用研究

IF 5.8 2区化学

European Polymer Journal Pub Date : 2024-10-12 DOI: 10.1016/j.eurpolymj.2024.113504

Mengyu Cao , Lei Wang , Aihua Li, Xiaolong Yang, Xiaole Gong, Jiang-Tao Xu, Jingquan Liu

{"title":"Kinetics and scale inhibition application studies towards bulk and RAFT copolymerization of maleic anhydride and acrylic acid","authors":"Mengyu Cao , Lei Wang , Aihua Li, Xiaolong Yang, Xiaole Gong, Jiang-Tao Xu, Jingquan Liu","doi":"10.1016/j.eurpolymj.2024.113504","DOIUrl":"10.1016/j.eurpolymj.2024.113504","url":null,"abstract":"<div><div>Poly(maleic anhydride) (PMA) is commonly reckoned as a better water scale inhibitor than poly(acrylic acid) (PAA) since each maleic anhydride unit can supply two carboxylic acid groups. However, pure PMA is difficult to achieve because the steric effect of its monomer MA. Herein, we synthesize copoly(MA-AA) copolymer by bulk polymerization method (bulk-copoly(MA-AA)), which avoids the use of any solvents which have to be removed afterwards. In addition, we also synthesize copoly(MA-AA) by reversible addition-fragmentation chain transfer (RAFT) polymerization method to afford RAFT-copoly(MA-AA) with low polydispersity index (PDI) less than 1.2, and the performance of RAFT-copoly(MA-AA) in water scale inhibition is more excellent relative to bulk-copoly(MA-AA). We also synthesize other copoly(MA-AA) copolymers by varying the molar ratio of MA to AA to study the polymerization mechanism. Through the static scale inhibition experiment, it is concluded that when the concentration of copoly(MA-AA) is 80 mg/L, the scale inhibition performance of RAFT-copoly(MA-AA) can reach 96.50 % which is the best among the control samples. It is also found that only 1:1 alternating copolymerization of MA and AA could be achieved as demonstrated by <sup>1</sup>H nuclear magnetic resonance spectra of the copolymers, evidencing the strong steric hindrance of MA for its homo-polymerization.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"220 ","pages":"Article 113504"},"PeriodicalIF":5.8,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High fire-safety epoxy resin with functional polymer/metal–organic framework hybrids 含功能聚合物/金属有机框架杂化物的高防火安全性环氧树脂

IF 5.8 2区化学

European Polymer Journal Pub Date : 2024-10-12 DOI: 10.1016/j.eurpolymj.2024.113505

Peiwen Xu , Chongyang Gao , Junchi Ma , Yuan Fang , Zhaodi Wang , Zongfu An , Uiseok Hwang , Xin Yang , Yahong Xu , Soochan Kim

引用次数: 0

Chain relaxation of carborane segments with tailored chain length at high temperatures 高温下具有定制链长的碳化硼段的链松弛

IF 5.8 2区化学

European Polymer Journal Pub Date : 2024-10-12 DOI: 10.1016/j.eurpolymj.2024.113509

Chongwen Yu , Jiaqi Sun , Xuejie Wang , Xingyao Liu , Tianhao Li , Xiao Hu , Gang Shao , Liu He , Jian Xu , Yujie Song

{"title":"Chain relaxation of carborane segments with tailored chain length at high temperatures","authors":"Chongwen Yu , Jiaqi Sun , Xuejie Wang , Xingyao Liu , Tianhao Li , Xiao Hu , Gang Shao , Liu He , Jian Xu , Yujie Song","doi":"10.1016/j.eurpolymj.2024.113509","DOIUrl":"10.1016/j.eurpolymj.2024.113509","url":null,"abstract":"<div><div>High-performance thermoset polymers have good thermal stability due to their highly crosslinked network, while also represent topological constraints that restrict cooperative segmental motion, making it difficult to relax stresses even at high temperatures. Failure of most thermoset polymers at high temperatures is due to ineffective stress relaxation, which limits the use of thermoset polymers in harsh environments. Herein, we employed a cyclosiloxane hybrid polymer (CHP) containing <em>o</em>-carborane segments with tailored carbon chain length to relieve internal stress. The introduction of <em>o</em>-carborane and lengthening of carbon chain both increased the CHP fractional free volume, and reduced the activation energy required in the later stages of the curing process. The carbon chain changed the conformation to achieve chain relaxation by stretching and rotating the carbon–carbon bonds at high temperatures, which avoided cracking and increased the failure temperature of the CHP. Furthermore, the adhesion strength of the <em>o</em>-carborane modified CHP reached a maximum of 2.15 MPa, surpassing 1.23 MPa of the neat CHP. The <em>o</em>-carborane modified CHP with the longest carbon chain exhibited good stability while supporting 1 kg load for 5 min when subjected to ablation, whereas the neat CHP failed after only 47 s. The <em>o</em>-carborane-modified CHP exhibited enhanced high-temperature properties through chain relaxation to inhibit cracking and in situ generation of boron oxide at high temperatures to protect the resin matrix.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"220 ","pages":"Article 113509"},"PeriodicalIF":5.8,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computer-aided design of thermosetting benzoxazoles containing bis-endoalkynyl groups: Low melting points and high thermal stability 含有双内炔基（bis-endoalkynyl）的热固性苯并恶唑的计算机辅助设计：低熔点和高热稳定性

IF 5.8 2区化学

European Polymer Journal Pub Date : 2024-10-12 DOI: 10.1016/j.eurpolymj.2024.113503

Jiahang Zhang, Zhengtao Jiang, Qixin Zhuang, Peiyuan Zuo, Xiaoyun Liu

{"title":"Computer-aided design of thermosetting benzoxazoles containing bis-endoalkynyl groups: Low melting points and high thermal stability","authors":"Jiahang Zhang, Zhengtao Jiang, Qixin Zhuang, Peiyuan Zuo, Xiaoyun Liu","doi":"10.1016/j.eurpolymj.2024.113503","DOIUrl":"10.1016/j.eurpolymj.2024.113503","url":null,"abstract":"<div><div>High-temperature-resistant polybenzoxazoles (PBOs) have recently become a prominent research area due to their potential applications in aviation and aerospace. However, achieving a balance between thermal stability and processability remains a significant challenge. In this study, a computer-aided method to develop PBOs with high thermal stability and processability is explored. First, thermoset benzoxazoles (CPBOs) are designed using a material genomic approach. Subsequently, their zero shear viscosity, temperature at 50 % thermal weight loss, dielectric constant and dielectric loss are predicted using a computer-aided method. Finally, two screened thermosetting benzoxazoles, CPBO-1 and CPBO-6, are synthesized and experimentally validated. The experiments indicate that their melting points are below 100 °C, with the lowest melt viscosities being 0.5 Pa•s and 1.5 Pa•s, respectively. The corresponding polymers, pCPBO-1 and pCPBO-6, feature high thermal stability. The 5 % weight loss temperature of pCPBO-1 in N<sub>2</sub> is 618.9 °C, while the dielectric constant and dielectric loss are 3.1 and 0.0063, respectively. These are excellent values for thermosetting resins. This computer-aided screening method is more efficient and cost-effective compared to conventional trial-and-error methods.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"220 ","pages":"Article 113503"},"PeriodicalIF":5.8,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142437911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CO2-based polyurethane elastomers with enhanced mechanical and tunable room-temperature damping performances 具有更强机械性能和可调室温阻尼性能的二氧化碳基聚氨酯弹性体

IF 5.8 2区化学

European Polymer Journal Pub Date : 2024-10-11 DOI: 10.1016/j.eurpolymj.2024.113499

Xin Wang , Dexian Yin , Zhi Chen , Yuqiong Hu , Shikai Hu , Xiuying Zhao

{"title":"CO2-based polyurethane elastomers with enhanced mechanical and tunable room-temperature damping performances","authors":"Xin Wang , Dexian Yin , Zhi Chen , Yuqiong Hu , Shikai Hu , Xiuying Zhao","doi":"10.1016/j.eurpolymj.2024.113499","DOIUrl":"10.1016/j.eurpolymj.2024.113499","url":null,"abstract":"<div><div>Elastomers provide excellent damping performance owing to their unique viscoelasticity, which are widely used as vibration and noise reduction materials. However, conventional rubber-based elastomers with a low glass transition temperature (<em>T<sub>g</sub></em>) and narrow damping range are difficult to adapt to room-temperature conditions. Additionally, most of petroleum-based elastomers hinder the sustainable development. In this work, a series of novel polyurethane elastomers was synthesized using carbon-fixed CO<sub>2</sub>-based polycarbonate propylene diol (PPCD). The impact of hard segment (HS) content on the thermal, mechanical, and damping properties of CO<sub>2</sub>-based polyurethane (PU) was comprehensively investigated. Increasing the HS content from 16 % to 44 % increased the <em>T<sub>g</sub></em> from −3.8 °C to 21.7 °C, covering the entire damping range at room temperature with an adjustable damping performance. Furthermore, the tensile strength increased from 7.2 MPa to 27.0 MPa. The synthesis of CO<sub>2</sub>-based PU can propel the utilization of PU in damping applications, enabling sustainable advancement of the PU industry.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"220 ","pages":"Article 113499"},"PeriodicalIF":5.8,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of linear and crosslinked isosorbide-containing poly(β-thioether ester) via amine-catalyzed thiol-Michael addition 通过胺催化硫醇-迈克尔加成法合成线性和交联的含异山梨醇的聚（β-硫醚酯

IF 5.8 2区化学

European Polymer Journal Pub Date : 2024-10-11 DOI: 10.1016/j.eurpolymj.2024.113498

Raouhi Sanaa , Daniel Portinha , Raouf Medimagh , Etienne Fleury

{"title":"Synthesis of linear and crosslinked isosorbide-containing poly(β-thioether ester) via amine-catalyzed thiol-Michael addition","authors":"Raouhi Sanaa , Daniel Portinha , Raouf Medimagh , Etienne Fleury","doi":"10.1016/j.eurpolymj.2024.113498","DOIUrl":"10.1016/j.eurpolymj.2024.113498","url":null,"abstract":"<div><div>In this work, the amine-catalyzed thiol-Michael reaction of isosorbide or isomannide-derived dithiols as Michael-donors, with some diacrylates and dimethacrylates as Michael-acceptors, is reported. In a first part, different amines (1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU), dimethylaminopyridine (DMAP), Amberlyst® A-21 and hexylamine (HA)) were tested as catalysts for reactions involving diacrylates and dimethacrylates in acetonitrile, respectively. Molecular weight taken as the relevant criterion, DBU and DMAP were found to be equally efficient for polymerization with acrylates while DBU was the most efficient one with methacrylates. A library of polymers differing from the structure of the used diacrylate (some of them derived from isosorbide or isomannide) or dimethacrylate was prepared, with fair molecular weights and Tg varying from –22 to +32 °C. Then oligomers with controlled molecular weight and good end group fidelity were prepared, and were further used in a two-stage crosslinking reaction to prepare soft and elastic biobased crosslinked polymers via thiol-Michael addition.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"220 ","pages":"Article 113498"},"PeriodicalIF":5.8,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of alternating polyesters using a dual catalytic system of alkali metal alkoxides and crown ether 使用碱金属烷氧基化合物和冠醚双重催化体系合成交替聚酯

IF 5.8 2区化学

European Polymer Journal Pub Date : 2024-10-11 DOI: 10.1016/j.eurpolymj.2024.113497

Yiru Li , Zhizhuang Li , Weihong Zeng , Yuxin Shen , Yanian Fang , Yunliang Wang , Heng Li

{"title":"Synthesis of alternating polyesters using a dual catalytic system of alkali metal alkoxides and crown ether","authors":"Yiru Li , Zhizhuang Li , Weihong Zeng , Yuxin Shen , Yanian Fang , Yunliang Wang , Heng Li","doi":"10.1016/j.eurpolymj.2024.113497","DOIUrl":"10.1016/j.eurpolymj.2024.113497","url":null,"abstract":"<div><div>In this study, a dual catalytic system that merges crown ether with alkali metal alkoxides (AMA) is utilized in the ring-opening alternating polymerization (ROAP) of phthalic anhydride (PA) and propylene oxide (PO). This method streamlines the production of polyesters characterized by a fully alternating sequence, a modifiable molar mass (achieving up to 59.3 kg mol<sup>−1</sup>), and a narrow molar mass distribution (<em>Ð</em><sub>M</sub> < 1.26). Analysis of various commercially available AMAs, notably sodium ethoxide (EtONa), sodium methoxide, and lithium ethoxide, in tandem with crown ethers (15-crown-5 and 18-crown-6), underscores the superior catalytic efficacy of the EtONa and 18-crown-6 pairing. This heightened efficiency is attributed to the coordination of crown ether with alkali metal ions, thereby boosting the nucleophilicity of terminal alkoxide anions. The methodology has been successfully deployed in the ROAP of PA, norbornene anhydride, and multiple epoxides, while also simplifying the creation of aliphatic–aromatic block polyesters from a mixture of PA, PO, and lactide. This strategy presents a straightforward approach to polyester production, thus making significant contributions to the evolution of polyester synthesis technology.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"220 ","pages":"Article 113497"},"PeriodicalIF":5.8,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photo and pH dual stimuli-responsive block copolymer micelles with defined incorporation of o-nitrobenzyl units in poly(ɛ-caprolactone) block for controlled release 在聚(ɛ-己内酯)嵌段中明确加入邻硝基苄基单元的光和 pH 双刺激响应嵌段共聚物胶束用于控释

IF 5.8 2区化学

European Polymer Journal Pub Date : 2024-10-10 DOI: 10.1016/j.eurpolymj.2024.113501

Shankarrao V. Avhad , Shakeb N. Choudhari , Ashootosh V. Ambade

{"title":"Photo and pH dual stimuli-responsive block copolymer micelles with defined incorporation of o-nitrobenzyl units in poly(ɛ-caprolactone) block for controlled release","authors":"Shankarrao V. Avhad , Shakeb N. Choudhari , Ashootosh V. Ambade","doi":"10.1016/j.eurpolymj.2024.113501","DOIUrl":"10.1016/j.eurpolymj.2024.113501","url":null,"abstract":"<div><div>A series of dual stimuli-responsive block copolymers with varying content of photocleavable o-nitrobenzyl (ONB) ester group pendent in the hydrophobic poly(ɛ-caprolactone) block and pH-cleavable acetal linkage at the junction with hydrophilic poly(ethylene glycol) block is synthesized. The hydrophobic block is a random copolymer synthesized by ring-opening copolymerization of ɛ-caprolactone and ONB-substituted ɛ-caprolactone containing varying compositions of the two monomers. Kinetics of polymerization shows that ONB-functionalized monomer has lower reactivity than that of the unsubstituted monomer. The series of block copolymers shows self-assembly into well-defined spherical micelles of average size of 150–200 nm in aqueous solution. Photocleavage of ONB groups is studied by NMR and UV–vis spectroscopy, and its extent is determined. The two stimuli <em>viz</em>. UV light and pH are used individually as well as simultaneously to study the controlled release of the encapsulated drug Camptothecin and the synergistic effect of the two stimuli is demonstrated. The effect of varying content of ONB groups is observed on drug release profile. MTT assay showed non-cytotoxic nature of the polymer. Cell uptake and photoinduced release of doxorubicin (DOX) from the micelles in MDA-MB-231 cells is demonstrated.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"220 ","pages":"Article 113501"},"PeriodicalIF":5.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of Fe2+ on the self-assembly of a bipyridine containing homopolymer: From bowl-shaped nanoparticles to vesicles Fe2+对含双吡啶均聚物自组装的影响：从碗状纳米颗粒到囊泡

IF 5.8 2区化学

European Polymer Journal Pub Date : 2024-10-10 DOI: 10.1016/j.eurpolymj.2024.113502

Yirong Fan, Tao Wang, Hui Sun

{"title":"The influence of Fe2+ on the self-assembly of a bipyridine containing homopolymer: From bowl-shaped nanoparticles to vesicles","authors":"Yirong Fan, Tao Wang, Hui Sun","doi":"10.1016/j.eurpolymj.2024.113502","DOIUrl":"10.1016/j.eurpolymj.2024.113502","url":null,"abstract":"<div><div>Metal ion coordination has critical influence on the self-assembly behavior of amphiphilic polymers and the morphology of the obtained assemblies. Herein, an amphiphilic homopolymer with 2,2′-bipyridine (BPy) as side chain is synthesized (noted as PBPyAA), which can self-assemble into bowl-shaped nanoparticles (BNPs) in tetrahydrofuran (THF)/water. Taking advantage of the coordination interaction between BPy and metal ions, Fe<sup>2+</sup> is chosen to regulate the self-assembly behavior and the morphology of the assemblies of PBPyAA in two pathways. (Ⅰ) The aqueous solution of Fe<sup>2+</sup> with various concentrations is added to the THF solution of PBPyAA during self-assembly. (Ⅱ) Fe<sup>2+</sup> is added into the THF solution of PBPyAA before self-assembly, followed by the addition of deionized water to promote the self-assembly. The results show that the pathway Ⅰ facilitates the coordination of BPy and Fe<sup>2+</sup>. With the increase of the concentration of Fe<sup>2+</sup> aqueous solution, the coordination efficiency of BPy increases from 0.419 % to 7.789 %, leading to the transformation of BNPs to vesicles. Though the coordination efficiency of BPy also increases with the concentration of Fe<sup>2+</sup> in pathway Ⅱ, which is still quite low of 0.274 % to 0.366 %, and the morphology of the BNPs barely changes. In addition, ethylene diamine tetraacetic acid (EDTA), a strong chelating agent, is also added to promote the competitive complexation with BPy, resulting in the dissociation of BPy and Fe<sup>2+</sup> and the reversible transformation from vesicles to BNPs. Overall, the effect of Fe<sup>2+</sup> coordination on the self-assembly behavior of PBPyAA in two pathways is investigated and the reversible transformation of BNPs to vesicles is also achieved.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"220 ","pages":"Article 113502"},"PeriodicalIF":5.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal–phenolic nanozyme based microneedle patch with antibacterial and antioxidant for infected wound healing 基于金属酚类纳米酶的微针贴片具有抗菌和抗氧化作用，可促进感染伤口愈合

IF 5.8 2区化学

European Polymer Journal Pub Date : 2024-10-10 DOI: 10.1016/j.eurpolymj.2024.113500

Qi Dong , Siyu Xiong , Junjie Ai , Zhaowei Zhang , Yingshan Zhou

{"title":"Metal–phenolic nanozyme based microneedle patch with antibacterial and antioxidant for infected wound healing","authors":"Qi Dong , Siyu Xiong , Junjie Ai , Zhaowei Zhang , Yingshan Zhou","doi":"10.1016/j.eurpolymj.2024.113500","DOIUrl":"10.1016/j.eurpolymj.2024.113500","url":null,"abstract":"<div><div>Chronic bacterial-infected wound healing is becoming increasingly severe, with high rates of mortality and disability, owing to bacterial film, excessive accumulation of reactive oxygen species (ROS), inflammatory, and traditional therapeutics with poor drug permeability. Herin, a functional Zn-gallic acid nanozyme (Zn-NM) with excellent antibacterial and antioxidant capacity was incorporated with a gelatin-based microneedle patch (Zn-NM@MN) to achieve transdermal and sustained release of the drug at the infected wound site. The Zn-NM displayed the concentration-dependent antibacterial capacity, and 250 μg/mL of Zn-NM simultaneously possessed excellent antibacterial (89.36 ± 0.95 % for Escherichia coli, 92.44 ± 11.03 % for Staphylococcus aureus, and 95.03 ± 1.06 % for Methicillin-resistant Staphylococcus aureus), antioxidant properties and negligible cytotoxicity. After that, Zn-NM@MN could transdermal the epidermis or biofilm to sustain the release of Zn-NM for 3 h (release of 80 % drug). Systematic tissue regeneration assessment on rats’ infected full-thickness skin wounds demonstrated an enhanced wound healing rate. Zn-NM@MN could efficiently kill the bacteria (about 85 %), alleviate oxidant stress, reduce bacterial-induced inflammation, and promote vascular regeneration. This synergetic therapy strategy will pave the way for treating complicated infection wounds.</div></div>","PeriodicalId":315,"journal":{"name":"European Polymer Journal","volume":"220 ","pages":"Article 113500"},"PeriodicalIF":5.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0