Global Medical Health Communication最新文献

{"title":"Hyperferritinemia Correlated with Activated Population of Natural Killer Cells in Pediatric Major β-Thalassemia Patients","authors":"Adi Imam Cahyadi, M. Ghozali, R. Ghrahani, L. Reniarti, R. Panigoro","doi":"10.29313/GMHC.V9I1.6346","DOIUrl":"https://doi.org/10.29313/GMHC.V9I1.6346","url":null,"abstract":"Natural killer (NK) cells act both as cytotoxic and cytokine producers in the innate immune response. Hyperferritinemia resulting from a routine blood transfusion as a specific treatment in major β-thalassemia patients may disturb the cellular immune system’s harmony. This study aims to investigate the correlation between hyperferritinemia and the NK cell subsets in major β-thalassemia settings. Pediatric major β-thalassemia patients who routinely received a blood transfusion at Dr. Hasan Sadikin General Hospital in 2016 were included in this cross-sectional study. Blood samples were treated with the monoclonal antibody of CD3, CD56, and CD16 to count the NK cells subsets as CD56 bright , CD56 dim , and CD16 + using flowcytometry. CD69 + used as an activation marker. The median fluorescence intensity (MFI) of CD56, CD16, and CD69 was measured. Total iron-binding capacity (TiBC), ferritin, and serum iron level examined as iron status. A Spearman correlation test was used for statistical analysis. Fifty-five blood samples were obtained for analysis. This study reveals that the percentage of CD3 − lymphocyte population was correlated with the ferritin levels (r=−0.45, p=0.0009). Positive correlation was revealed between activated population (CD69 + ) of CD56 bright and CD56 dim NK cell subsets and hyperferritinemia [(r=0.353, p=0.008) and (r=0.355, p=0.008)]. The activated CD56 bright cells was associated with ferritin level (r=0.353, p=0.008) and TiBC (r=0.334, p=0.018). Hyperferritinemia in pediatric major β-thalassemia patients may influence NK cell subsets' balance population, particularly the CD56 bright and CD56 dim NK cell subsets, then alter their immune response to pathogens. KORELASI ANTARA HIPERFERITINEMIA DAN SEL NATURAL KILLER TERAKTIVASI PADA ANAK DENGAN TALASEMIA BETA MAYOR Sel-sel natural killer (NK) telah diketahui memiliki peran sitotoksik dan dalam produksi sitokin pada respons imun bawaan. Hiperferitinemia merupakan hasil dari transfusi darah rutin yang dijalani sebagai terapi utama pada talasemia mayor. Penelitian ini bertujuan mempelajari hubungan hiperferitinemia dan sel NK pada talasemia beta mayor. Penelitian potong lintang ini melibatkan anak dengan talasemia beta mayor yang secara rutin menerima transfusi darah di RSUP Dr. Hasan Sadikin selama tahun 2016. Sampel darah diberi marker CD3, CD56, dan CD16 untuk menghitung subset sel NK sebagai CD56 bright , CD56 dim , dan CD16 + menggunakan flowcytometry . CD69 + digunakan sebagai penanda aktivasi. M edian fluorescence intensity (MFI) CD56, CD16, dan CD69 diukur. Kadar TiBC, ferritin, dan Fe serum diperiksa sebagai status besi. Uji korelasi Spearman digunakan pada analisis statistik. Analisis dilakukan terhadap 55 sampel darah anak dengan talasemia. Penelitian ini mendapatkan populasi limfosit CD3 berkorelasi dengan kadar feritin (r=−0,45; p=0,0009). Korelasi positif didapatkan pada populasi teraktivasi (CD69 + ) dari subset sel CD56 bright dan CD56 dim NK serta hiperferitinem","PeriodicalId":31502,"journal":{"name":"Global Medical Health Communication","volume":"9 1","pages":"14-22"},"PeriodicalIF":0.0,"publicationDate":"2021-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48825447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Number of Valve Lesion in Rheumatic Heart Disease Severity","authors":"S. R. Desita, A. Lefi, M. A. Rahman, Y. Oktaviono","doi":"10.29313/GMHC.V9I1.6609","DOIUrl":"https://doi.org/10.29313/GMHC.V9I1.6609","url":null,"abstract":"Rheumatic heart disease (RHD) occurs due to sequelae in the form of damage to the heart valves from the failure of acute rheumatic fever (ARF) therapy. Heart valve damage can cause various complications such as congestive heart failure, arrhythmias, pulmonary hypertension, atrial fibrillation, endocarditis, which can cause death. The study aimed to assess the association between clinical characteristics and valve lesion and rheumatic heart disease severity. The study was an analytic observational with a cross-sectional design of 73 patients with definite RHD from September 2019 to March 2020 in Dr. Soetomo Regional General Hospital. The majority of patients were female (80%, p=0.235) 30–39 years old (34%, p=0.157). The mean age was 42.08±12.16 years. The majority of patients have low socioeconomic status (78%, p=0.025) and rural dwelling location (70%, p=0.138) over three-quarters of patients living with more than four people in the same house (75%). Multivalvular lesions (90%, p=0.003) and severe RHD (77%) were present predominantly. In conclusion, low socioeconomic status and multivalvular lesions are associated with rheumatic heart disease severity. KARAKTERISTIK KLINIS DAN JUMLAH LESI KATUP PADA DERAJAT KEPARAHAN PENYAKIT JANTUNG REUMATIK Penyakit jantung reumatik (PJR) adalah penyakit yang terjadi akibat gejala sisa berupa kerusakan katup jantung dari kegagalan terapi demam reumatik akut (DRA). Kerusakan katup jantung pada PJR dapat menimbulkan berbagai komplikasi seperti gagal jantung kongesti, aritmia, hipertensi pulmonal, atrial fibrilasi, dan endokarditis yang dapat menyebabkan kematian. Penelitian ini bertujuan mencari hubungan karakteristik klinis dan jumlah lesi katup dengan derajat keparahan PJR. Penelitian ini merupakan analitik observasional menggunakan pendekatan cross-sectional . Sampel penelitian ini adalah pasien yang terdiagnosis definitif PJR berdasar atas ekokardiografi pada bulan Sepetember 2019–Maret 2020 di RSUD Dr. Soetomo Surabaya. Didapatkan 73 pasien sesuai dengan kriteria inklusi. Mayoritas pasien berjenis kelamin perempuan (80%; p=0,235), dengan kelompok usia 30–39  (34%; p=0,157). Usia rerata 42,08±12,16 tahun. Sebagian besar pasien berstatus sosial ekonomi rendah (78%, p=0,025) dan lokasi tinggal pedesaan (70%; p=0,138). Lebih dari tiga perempat pasien tinggal dengan ≤4 orang di satu atap (75%). Lesi multivalvular (90%; p=0,003) dan PJR berat (77%) ditemukan secara dominan. Simpulan, status sosial ekonomi rendah dan lesi katup multivalvular berhubungan dengan derajat keparahan penyakit jantung reumatik.","PeriodicalId":31502,"journal":{"name":"Global Medical Health Communication","volume":"9 1","pages":"36-41"},"PeriodicalIF":0.0,"publicationDate":"2021-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46853504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatoprotective Effect of Sun Chlorella as an Antioxidant in Rattus norvegicus Induced Carbon Tetrachloride","authors":"W. Siswandari, F. Arjadi, Hernayanti Hernayanti, V. Indriani","doi":"10.29313/GMHC.V9I1.6341","DOIUrl":"https://doi.org/10.29313/GMHC.V9I1.6341","url":null,"abstract":"Carbon tetrachloride (CCl₄) is a chemical that can cause damage to liver cells. One of the natural ingredients developed to reduce liver damage due to chemicals and infections is Chlorella sp. The research aimed to explore the hepatoprotective effect of the antioxidant superoxide dismutase (SOD) by administering Sun Chlorella in Rattus norvegicus CCl₄ induced rats. The study design used a post-test with a control group design with a completely randomized design trial on 30 male rats of Wistar strains, aged 2–3 months, 200–250 grams in weight. The research was conducted in November 2016–January 2017 in Purwokerto. Rats were divided into five groups and treated for four weeks as follows: K1 group was given aquades; K2 was given CCl₄; K3, K4, K5 were given CCl₄ and Sun Chlorella 3.6 mg/200 gBW, 7.2 mg/200 gBW, and 14.4 mg/200 gBW respectively, by the gastric probe. Statistical analysis with correlation test and one way ANOVA multivariate test showed that Sun Chlorella 7.2 and 14.4 mg/200 gBW significantly increased SOD levels in rats induced CCl₄ (p=0.004, p=0.009). SOD rates were significantly strong associated with aspartate aminotransferase/AST (r=−0.685, p=0.000) and alanine aminotransferase/ALT (r=−0.659, p=0.000). The conclusion is Sun Chlorella increases SOD levels in CCl₄-induced rats. Increased SOD levels may decrease AST and ALT levels. EFEK HEPATOPROTEKTIF SUN CHLORELLA SEBAGAI ANTIOKSIDAN PADA RATTUS NORVEGICUS YANG DIINDUKSI KARBON TETRAKLORIDA Karbon tetraklorida (CCl₄) merupakan bahan kimia yang dapat menyebabkan kerusakan sel hati. Berbagai bahan alami telah dikembangkan untuk mengurangi kerusakan hati baik akibat bahan kimia maupun infeksi, salah satunya adalah Chlorella sp. Penelitian ini bertujuan melihat efek hepatoprotektif  dengan pemberian Sun Chlorella pada tikus Rattus norvegicus yang diinduksi CCl₄. Desain penelitian menggunakan post-test with a control group dengan rancangan percobaan rancangan acak lengkap pada 30 tikus jantan galur Wistar, usia 2–3 bulan, dan berat 200–250 gram. Penelitian ini dilakukan di Purwokerto pada periode November 2016–Januari 2017. Tikus dibagi menjadi lima kelompok dan mendapatkan perlakuan per oral dengan sonde lambung selama 4 minggu sebagai berikut: kelompok K1 sebagi kontrol negatif diberikan aquades; kelompok control positif K2 diberikan CCl₄; kelompok perlakuan K3, K4, dan K5 diberikan CCl4 dan Sun Chlorella 3,6 mg/200 gBB; 7,2 mg/200 gBB; 14,4 mg/200 gBB tikus berurutan. Uji statistik dengan menggunakan uji korelasi dan ANOVA satu arah menunjukkan bahwa pemberian Sun Chlorella 7,2 mg dan 14,4 mg meningkatkan kadar SOD pada tikus yang diinduksi CCl₄ secara bermakna (p=0,004; p=0,009). Kadar SOD berhubungan kuat dengan kadar aspartat aminotransferase/AST (r=−0,685; p=0,000) dan alanin aminotransferase/ALT (r=−0,659; p=0,000). Kesimpulan penelitian ini adalah pemberian Sun Chlorella meningkatkan kadar SOD pada tikus yang diinduksi CCl₄. Peningkatan kadar SOD menyebabkan penurunan kadar AST ","PeriodicalId":31502,"journal":{"name":"Global Medical Health Communication","volume":"9 1","pages":"8-13"},"PeriodicalIF":0.0,"publicationDate":"2021-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47361933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of Knowledge Levels about Organ Topography and Structure among Grade IV Medical Students","authors":"Y. Yuniarti, R. Perdana, Ariko Rahmat Putra, F. A. Yulianto, Muhammad Agie Najibullah Wijaya, Wendy Darmawan","doi":"10.29313/GMHC.V9I1.4440","DOIUrl":"https://doi.org/10.29313/GMHC.V9I1.4440","url":null,"abstract":"One of the competencies the students of the graduate medical education is to apply the basic principles of the science of biomedicine, epidemiology, clinical, and behavior in the practice of medicine. Anatomy is one of the biomedicine sciences learned in medical education, including learning about the body's structure and organ topography. This research aims to describe the organ's structure and topography knowledge among the faculty of medicine students. This survey with 88 students was conducted in a faculty of medicine in Bandung city from October to December 2018 using a random sampling method. Statistical analysis using frequency distribution, percentage proportions, and Wald's statistics in the 95% confidence interval. The instrument for validity analysis is Pearsons's correlation, and the instrument for reliability analysis is Kappa's percent agreement. The results showed the average level of knowledge on organ structure and topography. It shows anatomical teaching and learning about the organ's structure, and the topography still needs to be optimized. GAMBARAN TINGKAT PENGETAHUAN TENTANG STRUKTUR DAN TOPOGRAFI ORGAN PADA MAHASISWA TINGKAT IV KEDOKTERAN Salah satu kompetensi lulusan mahasiswa pendidikan kedokteran adalah mampu mengaplikasikan prinsip ilmu dasar biomedik, epidemiologi, klinis, dan perilaku dalam praktik profesi kedokteran. Anatomi merupakan salah satu ilmu biomedik dalam pendidikan kedokteran yang mempelajari struktur dan topografi organ. Penelitian ini bertujuan mengetahui tingkat pengetahuan mahasiswa tingkat IV fakultas kedokteran mengenai struktur dan topografi organ. Survei terhadap 88 mahasiswa ini dilaksanakan di sebuah fakultas kedokteran di Kota Bandung dari bulan Oktober hingga Desember 2018 menggunakan metode random sampling . Analisis statistik menggunakan distribusi frekuensi, persentase proporsi, dan Wald’s statistic dalam 95% interval kepercayaan. Analisis validitas menggunakan Pearson’s correlation, sedangkan analisis reliabilitas menggunakan Kappa’s percent agreement . Hasil penelitian menunjukkan tingkat pengetahuan rerata tentang struktur organ dan topografi dalam kategori cukup. Hal ini menunjukkan pembelajaran anatomi tentang struktur organ dan topografi masih perlu dioptimalkan.","PeriodicalId":31502,"journal":{"name":"Global Medical Health Communication","volume":"9 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2021-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45062391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sigi's Response to the Disaster Program: Nutrition, Sanitation, and Food Fulfillment","authors":"Hilda Carmitha Panjaitan, T. P. Sanubari, Fiane de Fretes","doi":"10.29313/GMHC.V9I1.6820","DOIUrl":"https://doi.org/10.29313/GMHC.V9I1.6820","url":null,"abstract":"The earthquake occurring in Indonesia caused various problems, especially the decreased degree of human health caused by insufficient food availability. It makes victims of natural disasters need assistance from government programs. One case of a natural disaster in 2018 was an earthquake in Central Sulawesi. Unfortunately, disaster survival has the challenge to continue their living caused by program absences from the government in post-disaster. This study aimed to explore disaster survival's resilience after one year of the earthquake disaster in Sidera village, Sigi regency, in response to government programs, especially nutrition, sanitation, and food fulfillment response. This research used mixed-method approaches with a cross-sectional design. Data collection was done with questionnaires, in-depth interviews, and anthropometric measurements. The study was conducted from February to April 2020 with 30 refugees in the temporary shelter in Sidera village as respondents. The study results found that people still need to initiate countermeasures related to sanitation and fulfillment of food. Government programs in health services produce good conditions related to normal nutritional status at the age of 5 years (40%), 5–18 years (100%), and 18 years (41%). The conclusion is that the government program is not sustainable, which makes the community still need to initiate countermeasures related to sanitation and food fulfillment. The program recommendations are to ensure clean water availability and guide the community to fulfill their food need. TANGGAPAN SIGI TERHADAP PROGRAM BENCANA: GIZI, SANITASI, DAN PEMENUHAN PANGAN Gempa bumi yang terjadi di Indonesia menyebabkan berbagai masalah, secara khusus penurunan derajat kesehatan manusia dikarenakan oleh ketersediaan pangan yang tidak tercukupi. Hal tersebut membuat korban bencana alam membutuhkan bantuan dari program pemerintah. Salah satu kasus bencana alam tahun 2018 adalah gempa bumi di Sulawesi Tengah. Namun, hingga pascabencana, korban bencana alam masih tinggal di pengungsian tanpa program. Tujuan penelitian ini adalah mengeksplorasi daya lenting pengungsi pasca-satu tahun bencana gempa bumi di Desa Sidera, Kabupaten Sigi sebagai tanggapan dari program pemerintah khususnya gizi, air bersih, dan pemenuhan pangan. Penelitian ini menggunakan pendekatan mixed-method  dengan desain cross-sectional . Teknik pengumpulan data dilakukan melalui pengisian kuesioner, in depth interview , serta pengukuran antropometri. Penelitian dilakukan pada 30 responden yang merupakan pengungsi di hunian sementara (huntara) Desa Sidera. Penelitian dilakukan selama bulan Februari hingga April 2020. Hasil penelitian menemukan bahwa masyarakat masih perlu melakukan inisiasi penanggulangan terkait air bersih dan pemenuhan pangan. Program pemerintah terkait pelayanan kesehatan menghasilkan kondisi yang baik terkait status gizi normal pada usia ≤5 tahun (40%), 5–18 tahun (100%), dan ≥18 tahun (41%). Simpulan dari peneli","PeriodicalId":31502,"journal":{"name":"Global Medical Health Communication","volume":"9 1","pages":"48-54"},"PeriodicalIF":0.0,"publicationDate":"2021-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46609919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Al-Qur'an Tadabbur Therapy on Nulliparous Women’s Anxiety Level during Labor","authors":"Nurul Kamila, Rosa Mutianingsih","doi":"10.29313/GMHC.V9I1.6914","DOIUrl":"https://doi.org/10.29313/GMHC.V9I1.6914","url":null,"abstract":"The process of pregnancy affects psychological aspects significantly. This process may lead to anxiety and inconveniences. The previous research showed that anxiety might be contributing to the labor process. These can decreased baby birth weight and increased hypothalamic-pituitary-adrenal (HPA) hormone levels which cause changes in steroid hormone production and adult fertility rates. Besides, anxiety during pregnancy impacts emotional problems, disorders of hyperactivity, decentralization, and impaired child development. Nonpharmacological therapy that has been approved in reducing anxiety is religious copings. One of the religious copings is to contemplate ( tadabbur ) Al-Qur'an . Al-Qur'an can treat all kinds of diseases, including anxiety disorders. This study aims to examine the effect of Al-Qur'an tadabbur therapy on reducing nulliparous anxiety levels during labor. A quasi-experimental study was conducted with a pretest-postest control group design. The sampling technique was consecutive sampling. The number of 30 third trimester nulliparous women experienced moderate-severe anxiety levels in Tanjung Karang Community Health Center, Mataram was selected to participate in this study during July–September 2020. They were divided into two groups, the intervention and control groups. The intervention group received Al-Qur'an tadabbur therapy, while the control group was not. The statistical analysis used was univariate and bivariate analyses with an independent t-test. The instrument was used as the Zung Self-Rating Anxiety Scale (SAS) questionnaire. This study showed that the decrease of anxiety score in the intervention group was 26.1% higher than the control group p=0.001 (p<0.05). In conclusion, Al-Qur'an tadabbur therapy is effective in reducing anxiety levels during labor. EFEKTIVITAS TERAPI TADABBUR AL-QUR’AN UNTUK MENURUNKAN TINGKAT KECEMASAN IBU PRIMIGRAVIDA DALAM MENGHADAPI PERSALINAN Proses kehamilan sering kali memengaruhi aspek psikologis yang dapat menyebabkan berbagai permasalahan seperti kecemasan dan ketidaknyamanan. Selain berdampak pada proses persalinan, kecemasan juga dapat mengakibatkan penurunan berat lahir dan peningkatan aktivitas hipotalamus-hipofisis-adrenal (HHA) yang menyebabkan perubahan produksi hormon steroid dan angka fertilitas saat dewasa. Selain itu, kecemasan pada masa kehamilan berkaitan dengan masalah emosional, gangguan hiperaktivitas, desentralisasi, dan gangguan perkembangan kognitif pada anak. Terapi nonfarmakologis yang telah disetujui dalam mengurangi kecemasan adalah religious coping . Salah satu religious coping adalah dengan tadabbur Al-Qur’an . Al-Qur’an merupakan pedoman yang mampu mengobati segala macam penyakit termasuk gangguan kecemasan. Penelitian ini bertujuan menguji efek terapi tadabbur Al-Qur’an terhadap penurunan kecemasan ibu hamil primigravida dalam menghadapi persalinan. Penelitian quasi-experiment dilakukan dengan pretest-postest with control group design , teknik pengambilan sam","PeriodicalId":31502,"journal":{"name":"Global Medical Health Communication","volume":"9 1","pages":"55-60"},"PeriodicalIF":0.0,"publicationDate":"2021-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43604409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiviness of Lime Peel Extract (Citrus aurantifolia Swingle) against C-Reactive Protein Levels in Alloxan-Induced Wistar Rats","authors":"R. V. Suryadinata, Amelia Lorensia, Kezia Sefania","doi":"10.29313/GMHC.V9I1.6227","DOIUrl":"https://doi.org/10.29313/GMHC.V9I1.6227","url":null,"abstract":"Hyperglycemia is a metabolic disease that is most often found and continuously increasing. Various complications due to hyperglycemia in the blood can cause tissue damage. It will increase free radicals that can trigger an inflammatory response characterized by an increased  C-reactive protein  in the blood. Prevention can be done by administering flavonoid antioxidant and lime peel containing high flavonoid. This study aims to analyze the efficacy of lime peel extract against C-reactive protein level with hyperglycemia through alloxan-induced Wistar rats (140 mg/kgBW). It is an experimental study using a post-test control group design that was carried out at the Pharmacology Laboratory of the Universitas Surabaya for the period July–August 2020. Experimental Wistar rats were divided into a negative control group, a positive control group, and three groups with different doses of lime peel extract (2.35 mg, 4.7 mg, and 9.4 mg). Treatment was carried out for 30 days before measuring the C-reactive protein levels in the blood using ELISA. The results showed a difference in C-reactive protein level between groups (Man-Whitney, p=0.004). The increase in the dose of lime peel extract (9.4 mg) showed the lowest C-reactive protein level. Therefore, it can be concluded that the administration of lime peel extract in hyperglycemia conditions can reduce the inflammatory process in the body. EFEK EKSTRAK KULIT JERUK NIPIS ( CITRUS AURANTIFOLIA SWINGLE) TERHADAP KADAR C-REACTIVE PROTEIN PADA TIKUS WISTAR YANG DIINDUKSI ALOKSAN Hiperglikemia merupakan penyakit metabolik yang paling sering dijumpai dan terus mengalami peningkatan dari tahun ke tahun. Berbagai komplikasi akibat hiperglikemia dalam darah dapat menyebabkan kerusakan jaringan. Hal ini dikarenakan hiperglikemia akan meningkatkan radikal bebas sehingga memicu respons inflamasi yang ditandai dengan peningkatan C-reactive protein dalam darah. Pencegahan dapat dilakukan dengan pemberian asupan antioksidan flavonoid. Kulit jeruk nipis memiliki kandungan flavonoid yang tinggi. Penelitian ini bertujuan menganalisis efikasi ekstrak kulit jeruk nipis terhadap kadar C-reactive protein pada tikus Wistar dengan kondisi hiperglikemia melalui induksi aloksan (140 mg/kgBB). Metode pada penelitian ini adalah eksperimental dengan menggunakan post-test control group  yang dilaksanakan di Laboratorium Farmakologi Universitas Surabaya periode Juli–Agustus 2020. Hewan coba tikus Wistar dibagi menjadi kelompok kontrol negatif, kelompok kontrol positif, dan tiga kelompok perlakuan dengan pemberian dosis ekstrak jeruk nipis yang berbeda (2,35 mg; 4,7 mg; dan 9,4 mg). Pemberian perlakuan dilakukan selama 30 hari, selanjutnya akan dilakukan pengukuran kadar C-reactive protein dalam darah dengan menggunakan ELISA. Hasil penelitian memperlihatkan perbedaan kadar C-reactive protein antarkelompok (Mann-Whitney, p=0,004). Peningkatan pemberian dosis ekstrak kulit jeruk nipis (9,4 mg) menunjukkan penurunan kadar C-reactive protei","PeriodicalId":31502,"journal":{"name":"Global Medical Health Communication","volume":"9 1","pages":"23-28"},"PeriodicalIF":0.0,"publicationDate":"2021-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44497929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Android-based Stunting Child Nutrition Application (GiAS) to Assess Macro-nutrients, Zinc, and Calcium in Stunting and Non-stunting Under Two Children","authors":"Fajarini Putri Hidayat, Ma’mun Sutisna, Roni Rowawi, H. Wijayanegara, H. Garna, A. Rachmiatie","doi":"10.29313/GMHC.V9I1.6708","DOIUrl":"https://doi.org/10.29313/GMHC.V9I1.6708","url":null,"abstract":"Stunted children will have normal cognitive ability if nutrition is improved. The rapid brain growth in the first 1,000 days of life means that children should not be malnourished. Stunting is generally caused by a lack of macronutrients (carbohydrates, protein, and fat) and micronutrients (calcium and zinc). The mobile application called stunting child nutrition (GiAS) has features that can detect stunting, monitor toddler growth, recommend daily menus for toddlers, nutritional adequacy rate (RDA) in 2019, and others. The purpose of this study was to make it easier to distinguish macronutrients, zinc, and calcium from stunting and non-stunting children aged 12–24 months using the GiAS android application. It is conducted at the Citeureup Community Health Center, Cimahi city, for June–July 2020. The sampling technique was a simple random sampling of 88 respondents. This type of research is an observational analytic with a statistical test is a cross-sectional design. The results of the study using the Mann-Whitney test showed differences in carbohydrates (84.99±26.31 vs 151.16±68.43, p=0.001), protein (30.81±11.03 vs 60.55±38.43, p=0.001), fat (32.80±15.39 vs 64.84±47.81, p=0.001), and calcium (0.55±0.40 vs 1.43±1.16, p=0.001) and there is similarity of zinc (0.005±0.004 vs 0.010±0.016, p=0.084) after 7 days of using the GiAS application between stunting and non-stunting children. The probability value <0.05 means that the application can compare macronutrients, zinc, and calcium between stunted and non-stunted children on the 7 th day. Chi-square analysis showed an increase in children's weight and height under five at two weeks and one month (p=0.001). In conclusion, the comparison of macronutrients, zinc, calcium in stunting and non-stunting children aged 12–24 months can be differentiated using the GiAS application. APLIKASI GIZI ANAK STUNTING (GIAS) BERBASIS ANDROID UNTUK MENILAI ZAT GIZI MAKRO, ZINC , DAN KALSIUM PADA ANAK STUNTING DAN NON-STUNTING Anak stunting akan memiliki kognitif yang normal jika dilakukan perbaikan gizi yang optimal. Pertumbuhan otak yang pesat di 1.000 hari pertama kehidupan menjadikan anak tidak boleh kekurangan nutrisi. Stunting umumnya kekurangan zat gizi makro (karbohidrat, protein, dan lemak) serta zat gizi mikro (kalsium dan zinc ). Aplikasi mobile bernama gizi anak stunting (GiAS) memiliki fitur yang dapat mendeteksi stunting , memantau pertumbuhan balita, merekomendasikan menu harian untuk balita, angka kecukupan gizi (AKG) tahun 2019, dan lainnya. Tujuan penelitian ini adalah kemudahan membedakan zat gizi makro, zinc , dan kalsium anak stunting dengan non-stunting usia 12–24 bulan menggunakan aplikasi android GiAS di Puskesmas Citeureup Kota Cimahi periode Juni–Juli 2020. Teknik pengambilan sampel adalah simpel random sampling sebanyak 88 responden. Jenis penelitian ini adalah analitik observasional dengan uji statistik adalah desain cross-sectional (α=0,05). Hasil penelitian  menggunakan Uji Mann-Whitney te","PeriodicalId":31502,"journal":{"name":"Global Medical Health Communication","volume":"9 1","pages":"61-68"},"PeriodicalIF":0.0,"publicationDate":"2021-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43747376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Gooseberry (Physalis angulata) Ethanol Extract in Wistar Rats Carrageenan-Induced Paw Oedema","authors":"Ami Nurlatifah, E. Hendryanny, Y. Yuniarti","doi":"10.29313/GMHC.V9I1.6336","DOIUrl":"https://doi.org/10.29313/GMHC.V9I1.6336","url":null,"abstract":"Gooseberry is an herbaceous plant that contains flavonoids. Flavonoid is one of the secondary metabolites that have an anti-inflammatory effect. This study aims to determine the effect of using ethanol extract of gooseberry as an anti-inflammatory in carrageenan-induced paw edema. This study was in vivo experimental laboratory using a completely randomized design of 25 Wistar rats and divided into five groups. The negative control group was given carboxymethylcellulose. The positive control group has given diclofenac sodium 27 mg/200 gBW. The sample test group has given ethanol extract of gooseberry with 3.6 mg/200 gBW, 5.4 mg/200 gBW, and 7.2 mg/200 gBW dosage. Paw rat’s inflammation induced by injecting carrageenan and measured from 1 st to 6 th hour using a pletismometer. This study has conducted at Pharmacology Laboratory, Universitas Islam Bandung, and the Laboratory of Therapy and Pharmacology, Universitas Padjajaran, from June to September 2019. The result of average edema volume paw rats using the Kruskal-Wallis test on the 6 th hour was p=0.02 (p<0.05). The Mann-Whitney test was p<0.05, showing differences between negative control and positive control and sample test groups. One-way ANOVA test on the percentage of edema inhibition between positive control and sample test group had p=0.107. It shows no significant difference. An effect of ethanol of extract of gooseberries as an anti-inflammatory with the highest percentage of edema inhibition is 5.4 mg/200 gBW dosage. The flavonoid content in gooseberries is thought to inhibit the formation of prostaglandins by inhibiting the cyclooxygenase enzyme. In conclusion, the ethanol extract of gooseberry can be anti-inflammatory. EFEK EKSTRAK ETANOL CIPLUKAN ( PHYSALIS ANGULATA ) TERHADAP EDEMA TELAPAK KAKI TIKUS GALUR WISTAR YANG DIINDUKSI KARAGENAN Ciplukan adalah tanaman herbal yang mengandung flavonoid. Flavonoid merupakan salah satu metabolit sekunder yang dapat memberikan efek antiinflamasi. Penelitian ini bertujuan mengetahui pengaruh penggunaan ekstrak etanol ciplukan sebagai antiinflamasi pada tikus yang diinduksi karagenan. Penelitian ini merupakan penelitian laboratorium eksperimental in vivo menggunakan desain rancangan acak lengkap pada 25 ekor tikus galur Wistar yang terbagi ke dalam lima kelompok. Kelompok kontrol negatif diberi carboxymethilcellulose . Kontrol positif diberi sodium diklofenak 27 mg/200 gBB. Kelompok uji diberi ekstrak etanol ciplukan dengan dosis 3,6 mg/200 gBB; 5,4 mg/200 gBB; dan 7,2 mg/200 gBB. Induksi inflamasi dilakukan dengan menginjeksikan karagenan pada telapak kaki tikus, lalu diukur menggunakan pletismometer dari jam ke-1 hingga jam ke-6. Penelitian ini dilakukan di Laboratorium Farmasi, Universitas Islam Bandung dan Laboratorium Farmasi dan Terapi, Universitas Padjajaran dari bulan Juni hingga September 2019. Volume rerata telapak kaki tikus pada jam ke-6 menggunakan Kruskal-Wallis adalah p=0,02 (p<0,05). Hasil uji Mann-Whitney diperoleh p<0,05 yang me","PeriodicalId":31502,"journal":{"name":"Global Medical Health Communication","volume":"9 1","pages":"29-35"},"PeriodicalIF":0.0,"publicationDate":"2021-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43120344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential of Strawberry, Rome Beauty Apple, and New Combination on Fasting Blood as Supporting Diet Therapy in Patients with Type II Diabetes Mellitus","authors":"Niken Yuliwati, Riezky Faisal Nugroho","doi":"10.29313/GMHC.V9I1.6409","DOIUrl":"https://doi.org/10.29313/GMHC.V9I1.6409","url":null,"abstract":"Strawberries ( Fragaria x ananassa ) and Rome beauty apples ( Malus sylvestris ) contain high antioxidants to reduce oxidative stress and improve the glycemic response with diabetes mellitus type 2. This study aimed to analyze the effect of strawberries, Rome beauty apples, and their combination to decrease fasting blood glucose levels of type 2 diabetes mellitus patients. This experimental research used a randomized pre-post-test with a control group design. Subjects were 44 patients divided into four groups: K (control, not given the fruit), P1 (strawberries 200 g/day), P2 (apples 300 g/day), and P3 (the combination strawberries 100 g/day, apples 150 g/day) for 14 days in February–March 2019 in Surakarta. The inclusion criteria were DM patients aged 40–55 years who received oral antidiabetic drug therapy. Exclusion criteria were type 2 DM patients who, based on the doctor's diagnosis, had complications such as gastritis, hypertension, chronic renal failure, heart disease, liver disease, stroke, cancer, patients with consumption of antioxidant supplements. Mean of blood glucose level on K (149.82±39.125), P1 (141.00±38.079), P2 (128.73±31.841), and P3 (177.73±50.176). Analysis paired t test results showed a significant difference between before and after treatment (p=0.045). To find out which group was the most meaningful, the Bonferroni post hoc test. Decrease of fasting blood glucose levels with group K (−10.55, p>0.05), P1 (−30.18, p 0.05 in P1 and P3. In conclusion, strawberries, Rome beauty apples, and their combination significantly decreased fasting blood glucose levels of type 2 diabetes mellitus patients, with the highest and most significant decrease in Rome beauty apples. POTENSI STROBERI, APEL ROME BEAUTY , DAN KOMBINASI BARU TERHADAP GULA DARAH PUASA SEBAGAI PENUNJANG TERAPI DIET PADA PASIEN DIABETES MELITUS TIPE II Stroberi ( Fragaria x ananassa ) dan apel Rome beauty ( Malus sylvestris ) mengandung antioksidan tinggi untuk mengurangi stres oksidatif dan memperbaiki respons glikemik pada diabetes mellitus tipe 2. Tujuan penelitian adalah menganalisis pengaruh buah stroberi, apel rome beauty , dan kombinasinya terhadap penurunan kadar glukosa darah puasa pasien diabetes melitus tipe 2. Jenis penelitian eksperimen dengan rancangan randomized  pre-post-test dengan control group design . Subjek penelitian 44 pasien yang dibagi empat kelompok, yaitu K (kontrol tidak diberi buah), P1 (stroberi 200 g/hari), P2 (apel Rome beauty 300 g/hari) dan P3 (kombinasi stroberi 100 g/hari dan apel 150 g/hari) selama 14 hari pada bulan Februari–Maret 2020 di Surakarta. Kriteria inklusi adalah pasien diabetes melitus (DM) usia 40–55 tahun yang mendapat terapi obat antidiabetik oral. Kriteria eksklusi adalah pasien DM tipe 2 yang berdasar atas diagnosis dokter mengalami komplikasi seperti mag, hipertensi, gagal ginjal kronik, penyakit jantung, penyakit hati, strok, kanker, dan pasien dengan konsumsi suplemen antioksidan. Kadar glukosa darah rerata pada ","PeriodicalId":31502,"journal":{"name":"Global Medical Health Communication","volume":"9 1","pages":"69-75"},"PeriodicalIF":0.0,"publicationDate":"2021-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44932283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}