Proceedings of 5th International Electronic Conference on Medicinal Chemistry最新文献

{"title":"Nutrient composition, antioxidant and antiproliferative activities of Clausena excavata and Murraya koenigii leaves","authors":"Wan Mohamad Zain, T. Yap, F. Othman, A. Rahmat","doi":"10.3390/ecmc2019-06332","DOIUrl":"https://doi.org/10.3390/ecmc2019-06332","url":null,"abstract":"","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126556213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of the emulsifier on the extraction process of flavonoids and carotenoids from Hypericum maculatum with a system of different polarity extractants","authors":"O. Protunkevych, K. Prysiazhniuk, T. Stetsenko","doi":"10.3390/ecmc2019-06301","DOIUrl":"https://doi.org/10.3390/ecmc2019-06301","url":null,"abstract":"","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126354380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the impact of tetrahydropyrido[2,1-b][1,3,5]thiadiazine derivatives on lepodova effects in the test of suspension by the tail","authors":"I. Nekrasa, H. Bibik, S. Krivokolysko, V. Dotsenko, K. Frolov, A. Startseva","doi":"10.3390/ecmc2019-06295","DOIUrl":"https://doi.org/10.3390/ecmc2019-06295","url":null,"abstract":"","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131853601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicated surgical braces","authors":"Dharmik Mehta","doi":"10.3390/ecmc2019-06279","DOIUrl":"https://doi.org/10.3390/ecmc2019-06279","url":null,"abstract":"In current scenario, several surgical braces are available for different body parts like knee, elbow, back etc. for several clinical conditions, especially pain in that part of the body. All these supportive treatments are aided by some medication through oral route, which produces several side effects on prolonged use. Present work endeavors to combine these different treatments: supportive and medicated treatments by incorporating sustained release medicated topical patch into the inner side of surgical braces through specially designed patch holder mechanism for easy incorporation and removal of patch. It not only eliminates need of oral medication but also gives localized administration of medication, thus resulting in more patient compliant treatment with improving overall safety profile. For developing model prototype of the same, combination of surgical knee brace and oral NSAID (diclofenac) was selected. In order to execute the working prototype, a pocket mechanism to incorporate a sustained release patch of 7 cm X 7 cm size was designed. Patch formulation was randomly selected based on trial batches for sustaining drug release up to 12 h, considering put on- put off phases of brace of 12 h each. The pocket was designed in such a way that in case of any discomfort or other unfavorable conditions, it can be easily removed from the brace. Flexibility in terms of size, shape and drug release profiles proves its versatility for other supportive braces and medications. Thus this innovation can be easily extended for other braces like elbow braces, shoulder braces, back braces etc. It not only enhances efficacy of the current treatments but also improves patient compliance significantly.","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127844122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a synthetic TLR4-agonistic peptide V77-E92 derived from breast-milk αS1‑casein","authors":"T. Saenger, S. Vordenbäumen, Juliana Bertelsbeck, E. Bleck, Matthias Schneider, J. Jose","doi":"10.3390/ecmc2019-06289","DOIUrl":"https://doi.org/10.3390/ecmc2019-06289","url":null,"abstract":"Breast-milk αS1-casein was suggested as an agonist of the Toll-like receptor 4 (TLR4).1 Pathogen recognition receptor TLR4 responds to lipopolysaccharides and a wide range of molecules, from proteins to metal ions. In consequence, three criteria are required to validate agonists which directly activate TLR4 and exclude TLR4-agonisticity through contaminants.2 Recently, we demonstrated that αS1-casein fulfilled two of these criteria. (i) αS1-Casein required TLR4/MD2 complex as well as cofactor CD14 to induce IL-8 secretion via TLR4 and (ii) αS1-casein bound TLR4, MD2 and CD14.3 Aim of this study was to (iii) identify a synthetic amino acid sequence derived from human αS1-casein responsible for TLR4-agonistic effects. \u0000For this, we analyzed the amino acid sequence (AAS) of αS1-casein in silico. αS1‑Casein showed to be α-helical and was likely to be intrinsically disordered in the region corresponding to R16-K99 of αS1-casein. Six truncated variants of αS1-casein coding for parts of the AAS were purified from Escherichia coli. These variants were tested for binding to HEK293 cells transfected with TLR4 (TLR4+) by flow cytometry and their induction of IL-8 secretion via TLR4. Variants of αS1-casein truncated at the N-terminus (E35-W185, R57-W185, V77-W185) bound TLR4+ induced lower IL-8 secretion with less AAS (7.5 ng/ml, 4.8 ng/ml, 3.6 ng/ml). Variant corresponding to E93-W185 of αS1-casein was neither binding TLR4+ nor inducing IL-8 secretion. Therefore, we postulated V77-E92 derived from αS1-casein as TLR4-agonist. This was confirmed by a synthetic peptide V77-E92 derived from αS1-casein, which induced an IL-8 secretion of 0.95 ng/ml. Hence, the third criteria of TLR4-agonists fulfilled and activation of TLR4 through contamination was excluded. \u0000In conclusion, αS1-casein was proofed as an agonist directly activating TLR4. This supported our postulate that αS1-casein has at least two functions, a nutritional and an immune active one. \u0000 \u0000 \u0000Vordenbaumen, S. et al. Human casein alpha s1 induces proinflammatory cytokine expression in monocytic cells by TLR4 signaling. Mol Nutr Food Res 60, 1079-89 (2016). \u0000Mancek-Keber, M. & Jerala, R. Postulates for validating TLR4 agonists. Eur J Immunol 45, 356-70 (2015). \u0000Saenger, T. et al. Human αS1-casein induces IL-8 secretion by binding to the ecto-domain of the TLR4/MD2 receptor complex. Biochim Biophys Acta Gen Subj 1863, 632-643 (2019).","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114233240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthetic cathinones: Chiral resolution and enantioselectivity studies","authors":"C. Fernandes, F. Remião, Bárbara Silva, P. Pinho","doi":"10.3390/ecmc2019-06331","DOIUrl":"https://doi.org/10.3390/ecmc2019-06331","url":null,"abstract":"","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"202 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124933319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of 4-chloro-5-[5-(2-arylvinyl)-1,3,4-oxadiazol-2-yl]benzenesulfonamide structure towards anticancer activity","authors":"Krzysztof Szafrański, J. Sławiński, A. Kawiak","doi":"10.3390/ecmc2019-06318","DOIUrl":"https://doi.org/10.3390/ecmc2019-06318","url":null,"abstract":"","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"234 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114993977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of microemulsions and sticks containing passion fruit seeds oil","authors":"K. Krambeck, D. Santos, J. S. Lobo, M. H. Amaral","doi":"10.3390/ecmc2019-06285","DOIUrl":"https://doi.org/10.3390/ecmc2019-06285","url":null,"abstract":"Passion fruit oil has been used on the skin as a moisturizer, antioxidant, and depigmenting, due to its high content of polyphenols. The objective of this work was to evaluate different methods of preparation of microemulsions containing passion fruit seeds oil. For this, we used sonication and high pressure homogenization (HPH) methods under different conditions. In order to characterize the microemulsions, accelerated stability tests, pH, and internal phase droplets size measurements were performed. Then, a double face hydrophilic and lipophilic stick was prepared from the microemulsion chosen and characterized according to their hardness and coloration. The results showed that the microemulsion did not change its internal phase droplets size throughout the study. The stick hydrophilic face had lower hardness and showed less color change than lipophilic face. This study showed that it is possible to develop sticks from microemulsions containing passion fruit seeds oil with good stability characteristics.","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132216340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial and anti-biofilm activity of quinazolinone derived Schiff base and its Cu(II) complex","authors":"Š. Pospíšilová, Jana Hricovíniová, A. Čížek, Z. Hricovíniová, J. Jampílek","doi":"10.3390/ecmc2019-06299","DOIUrl":"https://doi.org/10.3390/ecmc2019-06299","url":null,"abstract":"According to the last WHO report, the level of bacterial resistance is alarming all over the world. Drug resistant diseases cause at least 700 000 deaths a year [1]. The synthesis of new antibacterial compounds is an important step to overcome this problem.\u0000Shiff bases are a privileged structure possessing a wide spectrum of pharmacological activities such as anticancer, antioxidant and antibacterial [2]. The synthesis of 3‑[(2‑hydroxy‑5‑nitrobenzylidene)amino]‑2‑(2‑hydroxy‑5‑nitrophenyl)‑2,3‑dihydroquinazolin‑4(1H)‑one was described, and its spectral analysis, antioxidant and cytotoxic activities were presented [3]. The aim of this work was to study the antibacterial activity of this compound and its Cu(II) complex [4] against a spectrum of bacterial strains as well as the eradication activity against S. aureus biofilm.\u0000The compounds showed moderate antibacterial activity, which was slightly higher in the case of Cu(II) complex. The dynamics of activity against S. aureus was analyzed using the time-kill curve method, and the activity was considered as bacteriostatic. Minimum biofilm eradication activity (MBEC90) against staphylococcal biofilm was only twofold higher than MIC against planktonic cells, which shows a great potential of these derivatives as anti-biofilm active drugs.\u0000 \u0000This study was supported by the Ministry of Education of the Czech Republic (LO1305) and by project VEGA 2/0022/18.\u0000 \u0000References:\u0000\u0000No time to wait–securing the future from drug-resistant infections. Report to the Secretary General of the Nations, 2019, https://www.who.int/docs/default-source/documents/no-time-to-wait-securing-the-future-from-drug-resistant-infections-en.pdf?sfvrsn=5b424d7_6.\u0000 Sztanke, K.; Maziarka, A.; Osinka, A.; Sztanke, M. An insight into synthetic Schiff bases revealing antiproliferative activities in vitro. Med. Chem. 2013, 21(13):2648–3666.\u0000Hricoviniova, Z. Hricovini, M.; Kozics, K. New series of quinazolinone derived Schiff’s bases: synthesis, spectroscopic properties and evaluation of their antioxidant and cytotoxic activity. Pap. 2018, 72(4): 1041–1053.\u0000Hricoviniova, Z. et al. manuscript in preparation","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114242187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiproliferative and antibacterial activity of 3-arylbenzo[g]indazoles functionalized with nitro and amino groups at position 6","authors":"Viviana Cuartas, M. Crespo, E. Priego, L. Persoons, D. Daelemans, M. Camarasa, B. Insuasty, M. Pérez-Pérez","doi":"10.3390/ecmc2019-06312","DOIUrl":"https://doi.org/10.3390/ecmc2019-06312","url":null,"abstract":"1 Grupo de Investigación de Compuestos Heterocíclicos, Departamento de Química, Universidad del Valle, A. A. 25360 Cali, Colombia. 2 Centre for Bioinformatics and Photonics-CIBioFI, Calle 13 No. 100-00, Edificio E20, No. 1069, Cali, Colombia. 3 Grupo de Biotecnología e Infecciones Bacterianas, Departamento de Microbiología, Universidad del Valle, Cali, Colombia. 4 Instituto de Química Médica (IQM-CSIC), Juan de la Cierva 3, 28006-Madrid, Spain. 5 KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. Viviana Cuartas* 1,2, María del Pilar Crespo 3, Eva-María Priego 4, Leentje Persoons 5, Dirk Daelemans 5, María-José Camarasa 4, Braulio Insuasty 1,2","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"239 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114474683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}