Proceedings of the Nigerian Academy of Science最新文献_第3页

Acalypha wilkesiana acid extract as a potential green inhibitor for corrosion of mild steel in acidic medium: Thermodynamics and kinetics study 果胶酸提取物在酸性介质中对低碳钢的潜在缓蚀剂:热力学和动力学研究

Proceedings of the Nigerian Academy of Science Pub Date : 2023-01-20 DOI: 10.57046/lpmi5583

T. Adedayo, E. Olasehinde, O. Oluwasina

{"title":"Acalypha wilkesiana acid extract as a potential green inhibitor for corrosion of mild steel in acidic medium: Thermodynamics and kinetics study","authors":"T. Adedayo, E. Olasehinde, O. Oluwasina","doi":"10.57046/lpmi5583","DOIUrl":"https://doi.org/10.57046/lpmi5583","url":null,"abstract":"The use of synthetic compounds as corrosion inhibitor is diminishing due to strict environmental regulations and toxic effects of the compounds on human beings and the environment. Consequently, there exists the need to develop a new class of corrosion inhibitors with low toxicity, eco-friendliness and good efficiency. Therefore, this study investigates the inhibitory potential of Acalypha wilkesiana (AWAE) extract on mild steel in 1M HCl using weight loss method. Experiments were performed by varying immersion period, concentration of the inhibitor and temperature. The results obtained showed a decrease in the corrosion rate of mild steel as the extract concentration increases while the inhibition efficiency increases with extract concentration. Effect of temperature on the inhibition efficiency showed an increase in inhibition efficiency with rise in temperature. The adsorption of the inhibitor on the mild steel surface in acid solution was found to obey the Langmuir adsorption isotherm. Calculated thermodynamic parameters revealed that the mechanism of the corrosion inhibition may be due to the chemical adsorption of the phyto-constituents on the surface of mild steel. Kinetic treatment of the data followed a first order reaction and the half-life values of the metal increase with increase in the extract concentration. Preliminary investigation of the phytochemical constituents showed that Acalypha wilkesiana contains tannin, flavonoid, saponin, alkaloid, steroid , terpenoid and some other compounds in trace quantity. FTIR results indicate that AWAE contains O and N atoms in functional groups and aromatic ring which meet the general consideration of a typical corrosion inhibitor.","PeriodicalId":312312,"journal":{"name":"Proceedings of the Nigerian Academy of Science","volume":"358 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125647139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental and chemical risk factors for breast cancer 乳腺癌的环境和化学危险因素

Proceedings of the Nigerian Academy of Science Pub Date : 2022-10-30 DOI: 10.57046/parf4610

M. Akanji, O. Adeyemi

{"title":"Environmental and chemical risk factors for breast cancer","authors":"M. Akanji, O. Adeyemi","doi":"10.57046/parf4610","DOIUrl":"https://doi.org/10.57046/parf4610","url":null,"abstract":"In Nigeria, breast cancer (BC) is currently the leading cause of cancer mortality, accounting for approximately 23% of all cancer diagnoses and 18% of all cancer deaths. Although the fundamental etiology of BC is still unknown, a number of risk factors, including age, lifestyle, menarche, menopause, and environmental exposures, among others, have been linked to the disease. There is mounting evidence that hazardous compounds that are part of our everyday environment are important risk variables. Exposure to these BC-predisposing chemicals happens through the items we use, the food we eat, the air we breathe, and the water we drink. Mostly, these are endocrine disrupting chemicals (EDCs) capable of mimicking hormones such as estrogen and progesterone with links to BC initiation and progression. EDCs, which include bisphenol A, dichlorodiphenyltrichloroethane, and polychlorinated biphenyls, among others, can be found in everyday items including plastic and metal containers, cosmetics, detergents, and insecticides. In addition, exposure to polycyclic aromatic hydrocarbons (PAHs), which are formed during the burning of organic materials and fuel, is another significant risk factor for BC. While BC initiation and pathogenesis are multifaceted with links to various contributing risk factors, a deeper understanding of the environmental and chemical conundrum will aid mitigating and prevention initiatives in Nigeria and elsewhere.","PeriodicalId":312312,"journal":{"name":"Proceedings of the Nigerian Academy of Science","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129624380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could the high incidence of breast cancers in Nigerian women be related to 1,4-Dioxane in skin lightening products? 尼日利亚妇女乳腺癌的高发病率是否与美白产品中的1,4-二恶烷有关?

Proceedings of the Nigerian Academy of Science Pub Date : 2022-10-30 DOI: 10.57046/jzru1180

Y. Olumide, O. Ayanlowo, A. Akinkugbe, E. Otrofanowei, Sherifat Adeniyi, O. Peters, Omotola Olumodeji, Macaulay Iduma, Abba Gabriel

{"title":"Could the high incidence of breast cancers in Nigerian women be related to 1,4-Dioxane in skin lightening products?","authors":"Y. Olumide, O. Ayanlowo, A. Akinkugbe, E. Otrofanowei, Sherifat Adeniyi, O. Peters, Omotola Olumodeji, Macaulay Iduma, Abba Gabriel","doi":"10.57046/jzru1180","DOIUrl":"https://doi.org/10.57046/jzru1180","url":null,"abstract":"Two monstrous female health-related issues are currently engaging the attention of the global community. These are the chemical skin-lightening issue and the rising female breast cancer issue. Nigeria has the highest prevalence of chemical skin lightening practice with 77.3% of traders in Lagos using such products and one of the highest incidences of breast cancer globally of 50.5 per 100,000 women. 1,4-Dioxane, a possible contaminant in toiletries and cosmetics, is an IARC group 2B carcinogen and a potential breast carcinogen. It is generated when ethylene oxide -a known breast carcinogen is added to other chemicals during manufacturing. The skin lightening procedure is most conducive for optimal per-cutaneous absorption and inhalation of Dioxane. The research question entertained was if there is a link in the increasing prevalence of skin lightening practice and the rising breast cancer burden in Nigeria. One hundred skin lightening products procured from across Lagos, Nigeria had their listed contents scrutinized and entered onto a spreadsheet, then they were analyzed for Dioxane using Scalia’s Solid Phase Extraction gas chromatography procedure. Water (Aqua) 66%, Glycerin 60% and Tocopherol or Vitamin E 41% were found to be the most listed ingredients on the package labels, with Vitamin C 28%, Kojic acid 26%, Citric acid 22% and Carrot oil seen in 20% of products. All the analyzed samples were negative for Dioxane. The study brought to the fore the need to explore other potential breast carcinogens in skin lightening cosmetics and environmental chemicals.","PeriodicalId":312312,"journal":{"name":"Proceedings of the Nigerian Academy of Science","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130139961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental chemical risk factors of breast cancer in Nigeria I: Broad overview 尼日利亚乳腺癌的环境化学危险因素1:概览

Proceedings of the Nigerian Academy of Science Pub Date : 2022-10-30 DOI: 10.57046/pnrg7615

Y. Olumide, O. Ayanlowo, A. Akinkugbe, E. Otrofanowei

{"title":"Environmental chemical risk factors of breast cancer in Nigeria I: Broad overview","authors":"Y. Olumide, O. Ayanlowo, A. Akinkugbe, E. Otrofanowei","doi":"10.57046/pnrg7615","DOIUrl":"https://doi.org/10.57046/pnrg7615","url":null,"abstract":"Nigeria is currently experiencing a most disturbing level of incidence rate, morbidity and mortality from the ravages of female breast cancer, with its attendant burden of emotional, social and financial consequences. Tens of thousands of chemicals make their way into our everyday products and environment, with little regard for safety. The need to explore the impact of adverse environmental chemical exposures to breast health in Nigeria informed this study as there is need for public health approach to long term prevention. After exploring the robust scientific database on environmental chemical risk factors for female breast cancer, we found that many mammary toxicants are ubiquitous in our environment in Nigeria but have been taken for granted as inevitable in normal life exposures. This study identifies some of the potential environmental chemical risk factors of breast cancer in Nigeria. We describe the special exposure scenarios in Nigeria and prescribe some modest but practical ways to mitigate exposures. The factors that constitute risk to breast cancer could potentially be modified either through community education or government action and regulation. The subject is discussed in multiple Parts before releasing the manuscripts for publication to prevent criminalizing only a few chemicals if discussed and published to the exclusion of others. To our knowledge, this is the first ever comprehensive work on the subject in the African continent and is useful to typical developing countries as are found in sub-Saharan countries and elsewhere since findings and recommendations are usually generic in nature and mutually beneficial.","PeriodicalId":312312,"journal":{"name":"Proceedings of the Nigerian Academy of Science","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131681590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental chemical risk factors of breast cancer in Nigeria II: Adolescent hormonal contraceptives use 尼日利亚乳腺癌的环境化学危险因素II:青少年激素避孕药的使用

Proceedings of the Nigerian Academy of Science Pub Date : 2022-10-30 DOI: 10.57046/buwn9159

Y. Olumide, O. Ayanlowo, A. Akinkugbe, E. Otrofanowei

{"title":"Environmental chemical risk factors of breast cancer in Nigeria II: Adolescent hormonal contraceptives use","authors":"Y. Olumide, O. Ayanlowo, A. Akinkugbe, E. Otrofanowei","doi":"10.57046/buwn9159","DOIUrl":"https://doi.org/10.57046/buwn9159","url":null,"abstract":"Globocan’s 2018 cancer statistics show increasing rates of breast cancer in Nigeria. There is sufficient evidence in humans that hormonal contraceptive is a breast cancer risk factor particularly among African American women who begin use before 20 years of age or before first pregnancy. Nigerian breast cancer patients have identical subtypes as African Americans i.e triple negative tumors, early age of onset, clinically aggressive, and poor prognosis. Data from Nigeria show that 37.4% adolescent girls engage in high-risk sexual behaviour. For adolescent girls, dual use of condom and other hormonal contraceptives have been recommended to prevent pregnancy and acquisition of STI/HIV. Adolescents in Nigeria have uncensored access to all the contraceptive mix including hormonal contraceptives. There are also some ethical concerns. There are extremely harmful socio-cultural and socio-economic determinants that promote early sexual debut, Teenage Pregnancy, and Child Marriage. There are also grave health related, social and economic consequences for mother and child, and the community. Both Teenage Pregnancy and Child Marriage undermine nearly every Millennium Development Goal. The notable reason given by some fathers for embracing Child Marriage was to protect daughters from what was perceived as “unwholesome” Western values that permit loss of virginity, pre-marital sex and high adolescent sexual networking, necessitating the use of contraceptives. Hormonal contraceptive is a modifiable risk factor of breast cancer. Appropriate early pre-adolescent and adolescent parental care and nurturing before the crisis stage in godly principles is the gold standard for preventing adolescents’ use of contraceptives. Adolescent pregnancy and Child Marriage are not safe options.","PeriodicalId":312312,"journal":{"name":"Proceedings of the Nigerian Academy of Science","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126684186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental and chemical risk factors for breast cancer: A review of the current understanding of environmental toxic metal-induced breast malignancies, Nigeria perspective 乳腺癌的环境和化学危险因素:目前对环境有毒金属诱发的乳房恶性肿瘤的认识综述，尼日利亚的观点

Proceedings of the Nigerian Academy of Science Pub Date : 2022-10-30 DOI: 10.57046/cftm8615

O. Sonuga, A. Sonuga, Elvis Awah, Temitope O. Ogunsanya

{"title":"Environmental and chemical risk factors for breast cancer: A review of the current understanding of environmental toxic metal-induced breast malignancies, Nigeria perspective","authors":"O. Sonuga, A. Sonuga, Elvis Awah, Temitope O. Ogunsanya","doi":"10.57046/cftm8615","DOIUrl":"https://doi.org/10.57046/cftm8615","url":null,"abstract":"Breast cancer is the most commonly diagnosed cancer in women worldwide, with an increasing number of new cases each year. The incidence of breast cancer is sadly increasing at the same time as environmental toxicants, particularly in Africa nations like Nigeria. Toxic metals are significant environmental pollutants and their toxicity results in harmful health effects. Numerous studies have described environmental exposure of humans to toxic metals in African populations, and the most commonly implicated toxic metals include arsenic, cadmium, chromium, copper, lead and nickel, all of which impact negatively on human health and the environment. Recently some of these toxic metals have been linked to the development of different types of cancers including breast cancer. Given the large burden of the morbidity and mortality associated with breast cancer, it is of the upmost importance to identify predisposing risk factors so that appropriate preventive strategies that could reduce cancer incidence can be developed and implemented. Therefore, this review aims at elucidating the role of environmental toxic metals in the development of breast cancer.","PeriodicalId":312312,"journal":{"name":"Proceedings of the Nigerian Academy of Science","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125731897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental chemical risk factors of breast cancer in Nigeria IV: Pesticides 尼日利亚乳腺癌的环境化学危险因素IV:农药

Proceedings of the Nigerian Academy of Science Pub Date : 2022-10-30 DOI: 10.57046/kwzm9450

Y. Olumide, O. Ayanlowo, A. Akinkugbe, E. Otrofanowei

{"title":"Environmental chemical risk factors of breast cancer in Nigeria IV: Pesticides","authors":"Y. Olumide, O. Ayanlowo, A. Akinkugbe, E. Otrofanowei","doi":"10.57046/kwzm9450","DOIUrl":"https://doi.org/10.57046/kwzm9450","url":null,"abstract":"Pesticides are widely used to protect pests in agricultural production and in homes. Women, like men, are heavily involved in Nigerian Agriculture. Since pesticides are essentially poison meant to kill or ward off unwanted living organisms, it is not surprising that they could produce adverse health impacts in people. The pesticides identified as potential breast cancer risk factors discussed in this study are DDT, Lindane, Formaldehyde, Naphthalene/ Mothballs, 2,2-Dichlorovinyl dimethyl phosphate/Aluminium phosphate, Calcium carbide and Diphenylamine. DDT continues to be used against vectors of malaria parasites. Lindane is used by agricultural workers, sprayed in homes by pesticide applicators, used for treating head lice or scabies as shampoos and lotions, and transferred to household members by clothing of workers who are occupationally exposed to Lindane. Formaldehyde is largely released into the air by cosmetics/nail polish, detergents, household furniture, from control of fish parasites and preservation of frozen fish and poultry. The main source of naphthalene is from mothballs sometimes used when storing clothing against moths like Tineola bisselliella. Mothballs are also used as a recreational drug – “Bagging” (sniffing mothballs fumes) particularly among adolescent girls. Dichlorovinyl dimethyl phosphate/Aluminium phosphate are used to protect beans from weevils. Calcium carbide is used as a ripening agent, and Dipheylamine is used as a coating agent on fruit and vegetables to preserve moisture. These chemicals are among the pesticides banned/restricted under the auspices of UNEP but continued to be used in Nigeria because they are cheap. Recommendations are proffered on how to rid pesticides from food.","PeriodicalId":312312,"journal":{"name":"Proceedings of the Nigerian Academy of Science","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115079677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental chemical risk factors of breast cancer in Nigeria III: Metal: Lead 尼日利亚乳腺癌的环境化学危险因素III:金属:铅

Proceedings of the Nigerian Academy of Science Pub Date : 2022-10-30 DOI: 10.57046/lhhr2272

Y. Olumide, O. Ayanlowo, A. Akinkugbe, E. Otrofanowei

{"title":"Environmental chemical risk factors of breast cancer in Nigeria III: Metal: Lead","authors":"Y. Olumide, O. Ayanlowo, A. Akinkugbe, E. Otrofanowei","doi":"10.57046/lhhr2272","DOIUrl":"https://doi.org/10.57046/lhhr2272","url":null,"abstract":"Lead (Pb) is a metalloestrogen and a notable breast cancer risk factor. Lead is an International Agency for Research on Cancer (IARC) group 2A carcinogen. There is no level of exposure to lead that is known to be without harmful effects. Nigeria has literally every known environmental risk factor for lead exposure. Notable sources of lead exposure in Nigeria are lead in contaminated water, paints, artisanal gold ore processing, incineration of lead-containing waste and electronic waste (e-waste). Other sources of lead exposure are ‘tiro’—a lead-laden eye cosmetic, smoked fish particularly those displayed near highways with high vehicular traffic density, vegetables and root crops grown in mining communities, fruit exposed to lead-laden ripening agents, “Calabar chalk”—a lead-laden pica mostly consumed by pregnant women, and children’s toys. Prenatal vitamins supplements, paediatric medication syrups, traditional alcoholic and non-alcoholic drinks such as Kunnu and Zobo were also found as notable sources of lead consumption. Studies in Nigeria on blood lead (Pb) levels in children, pregnant women, and breast milk of nursing women were found to contain high lead levels. Lead exposure is preventable. Hitherto, the neurotoxicity of lead has been the dominant concern as regards lead exposure in children. The breast cancer risk factor now reinforces the zero tolerance for lead exposure.","PeriodicalId":312312,"journal":{"name":"Proceedings of the Nigerian Academy of Science","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126293232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect of Ocimum basilicum essential oil on Dimethylbenz[a]anthracene-induced breast tumor in mice 罗勒精油对二甲苯[a]蒽致小鼠乳腺肿瘤的保护作用

Proceedings of the Nigerian Academy of Science Pub Date : 2022-10-30 DOI: 10.57046/qbzz2983

A. Ayuba, M. Salawu, H. Oloyede

{"title":"Protective effect of Ocimum basilicum essential oil on Dimethylbenz[a]anthracene-induced breast tumor in mice","authors":"A. Ayuba, M. Salawu, H. Oloyede","doi":"10.57046/qbzz2983","DOIUrl":"https://doi.org/10.57046/qbzz2983","url":null,"abstract":"Background: Breast cancer is one of the most common cancers worldwide.7,12-dimethylbenz[a]anthracene (DMBA) is one of the xenobiotics that are implicated in various toxicological conditions including carcinogenesis. This study was conducted to assess the protective effect of Ocimum basilicum essential oil on Dimethylbenz[a]anthracene-induced breast tumor in mice. Method: Sixty (60) adult female mice were randomized into five groups (A-E) each containing twelve (12) mice: Group A- Control received distilled water, Group B- DMBA induced only, Group C- DMBA induced+100mg/kg bodyweight (bwt) essential oil, Group D- DMBA induced+200mg/kg bwt essential oil and Group E- DMBA induced + Tamoxifen, respectively. The animals were treated with Ocimum basilicum essential oil for 14 days. At the end of 14 days, assays for serum catalase, superoxide dismutase, malondialdehyde, reduced glutathione and glutathione-s- transferase also IL-1β, TNF-α, NF-κB and fragmented DNA were done. Result: Histopathology analysis of the skin of the mammary gland shows that DMBA-induced mice possessed enlarged skin tissue with epidermal necrosis and disruption of the entire layers of the skin, this suggesting tissue damage and cancer while positive control and group administered with Ocimum basilicum essential oil showed preserved epidermal, dermal and subcutaneous layers. There is increase in levels of IL-1β, TNF-α, NF-κB, fragmented DNA, SOD,CAT, GST activities and GSH level in the group administered with Ocimum basilicum essential oil when compared with the negative control.","PeriodicalId":312312,"journal":{"name":"Proceedings of the Nigerian Academy of Science","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130987247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiplasmodial effects of aqueous leaf extracts of Senna alata and Dennettia tripetalla in chloroquine-sensitive Plasmodium berghei berghei (NK65) infected mice 番泻叶和三叶草叶水提物对氯喹敏感的伯氏疟原虫(NK65)感染小鼠的抗疟原虫作用

Proceedings of the Nigerian Academy of Science Pub Date : 2022-06-30 DOI: 10.57046/weda5828

B. Onyegeme-okerenta, Godspower Dickson, B. Amadi, E. Essien

{"title":"Antiplasmodial effects of aqueous leaf extracts of Senna alata and Dennettia tripetalla in chloroquine-sensitive Plasmodium berghei berghei (NK65) infected mice","authors":"B. Onyegeme-okerenta, Godspower Dickson, B. Amadi, E. Essien","doi":"10.57046/weda5828","DOIUrl":"https://doi.org/10.57046/weda5828","url":null,"abstract":"The antiplasmodial effects of Senna alata and Dennettia tripetalla on chloroquine-sensitive Plasmodium berghei berghei (NK65) were analysed. P. berghei was obtained from National Institute for Medical Research, Lagos, Nigeria, and maintained in the laboratory by serial passage in mice. Chemosuppressive, prophylactic, and curative procedures were used to evaluate the antiplasmodial potentials of the extracts against established infection. A total of 320 albino mice were used for this study. Twenty-five albino mice were divided into 5 groups and used for D. tripetalla acute toxicity study. Eighty-five albino mice were divided into 15 groups of five albino mice each and used for chemosuppressive tests while two hundred and ten mice were used for prophylactic and curative tests. The infected mice were orally treated daily with 5mg/kg chloroquine 500 mg/kg, 1000 mg/kg, 1500 mg/kg, and 2000 mg/kg body weight of S. alata, D. tripetalla, and S. alata + D. tripetalla respectively. The in vivo antiplasmodial effect of the extracts against P. berghei infection showed a significant (p?0.05) dose-dependent schizontocidal activity for the chemosuppressive, and prophylactic test. Results of the curative study showed that the combination of both S. alata and D. tripetalla exhibited a strong curative effect on malaria parasitaemia. There was a significant clearance (p?0.05) in parasiteamia level from day 1 to day 5 of treatment in a dose-dependent manner with a corresponding significant (p?0.05) percentage suppression. It was therefore concluded that the leaf extracts of S. alata and D. tripetalla possess antimalarial potencies which could be exploited for antimalarial therapy.","PeriodicalId":312312,"journal":{"name":"Proceedings of the Nigerian Academy of Science","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123044078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1