{"title":"A study of Proximal Humerus Fractures treated by Locking Compression plating","authors":"Varun Krishna Komuravalli, N. Reddy","doi":"10.47799/pimr.1002.08","DOIUrl":"https://doi.org/10.47799/pimr.1002.08","url":null,"abstract":"Abstract\u0000 \u0000 Background: The treatment of proximal humerus fractures is always a challenge for the Orthopedic surgeon. Proximal humeral fractures are a regular presence in clinics. In the past, the standard treatment method was conservative. The results and functional outcomes, on the other hand, were not favorable. The functional outcomes have been known to improve after the development of locking compression plates. The purpose of this study was to see how functional proximal humerus fractures were treated with locking compression plates fared.\u0000 \u0000 Methods: This cross-sectional interventional prospective study was carried out in the Department of Orthopedics, Prathima Institute of Medical Sciences. The study included all adult patients with closed two-part and three-part proximal humerus fractures who were reported within a week after the incident. Based on the sample size calculations and inclusion and exclusion criteria a total of n=35 patients were included in the study. Patients were followed up for 12months after surgery using a typical surgical method with a locking compression plate.\u0000 \u0000 Results: n=35 patients out of which n=19(54.2%) were males and n=16 (45.7%) were females. The distribution based on age involved in patients with fractures showed equal preponderance among 31-35 years and 20-25 years with n=9(25.71%).Neer's classification of fractures of proximal humerus was followed in this study. Most of the patients in n=25 (71.42%) cases were having Neer's Two-part fractures and three-part fractures were found in n=8(22.8%) and four-part in n=2(5.7%). The overall results in the study were 65.71% of patients had excellent results,20% had good results,8.5% had satisfactory results and 5.7% had poor results. \u0000 \u0000 Conclusion: Locking plates are a preferable therapeutic choice for proximal humerus fractures, particularly when the bone quality is poor and the fracture is comminuted. Complication rates can be reduced by using good surgical techniques and selecting the right situations. Proximal humeral internal locking plates continue to provide strong overall functionality.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47647133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pattern Of Nicotine Use And Dependence In Psychiatric Patients","authors":"R. Pattabhi, Preeti Gudlavallety, Ruthika Radham","doi":"10.47799/pimr.1002.06","DOIUrl":"https://doi.org/10.47799/pimr.1002.06","url":null,"abstract":"Abstract\u0000 \u0000 Background: Tobacco use is an epidemic known as “the brown plague” affecting one billion lives in the 21st century and 80% in developing countries. Prevalence of smoking is especially high in patients with psychiatric illness with an ongoing debate over which comes first. Studies about nicotine consumption in psychiatric patients are few from developing countries. Hence, this study is designed to identify socio-demographic and diagnostic correlates of nicotine use.\u0000 \u0000 Aims and Objectives:- To estimate the pattern of nicotine use and determine the association between socio-demographic profile, onset of nicotine use, it’s use as a coping mechanism, psychological association with nicotine use in psychologically ill patients.\u0000 \u0000 Material and methods:- A cross-sectional study including 101 patients with nicotine use and psychiatric illness were administered a semi structured questionnaire, Fagerstrom Test for Nicotine Dependence(FTND) and nicotine dependence syndrome scale. Data analyzed with mean, standard deviation, chi- square, ANOVA\u0000 \u0000 Results:-Nicotine use was more common in middle age group with alcohol dependence followed by depression. Nicotine use was not associated with background, socioeconomic status, gender. Majority tried to quit for health but what kept them with nicotine were drive, stereotypy, continuity, priority.\u0000 \u0000 Conclusions:- Nicotine is a commonly abused substance in psychiatric patients without a clear demarcation about the cause effect relationship. The existing study gives few insights into reasons for nicotine intake which was more so among the productive age group. Hence, there is a need for further research about psychotropic drug interactions with nicotine use and focus on integration of nicotine cessation into treatment of other psychiatric disorders rather than separate deaddiction clinics to alleviate the illness burden.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49001687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Iron Profile in Patients with Type II Diabetes Mellitus in — A study in a Tertiary Care Hospital","authors":"Lavanya Lagisetty","doi":"10.47799/pimr.1002.09","DOIUrl":"https://doi.org/10.47799/pimr.1002.09","url":null,"abstract":"Abstract\u0000 \u0000 Background: The most prevalent metabolic condition, type 2 diabetes mellitus, is characterized by persistent hyperglycemia caused by abnormalities in insulin production, insulin action, or both. Iron, a transitional metal, has been demonstrated to play a key role in the pathophysiology of Type 2 Diabetes Mellitus, with a bidirectional link in which iron influences glucose metabolism, which in turn influences the iron metabolic pathways. The current study aimed to estimate the iron profile in Type 2 diabetes mellitus cases.\u0000 \u0000 Methods: This cross-sectional study was done in the Department of Biochemistry, Prathima Institute of Medical Sciences, Naganoor, Karimnagar. A total of n=100 cases of type II diabetes mellitus were included in the study and age and sex-matched healthy controls were also included in the study. Laboratory investigations included Fasting Blood glucose, Serum ferritin, Total iron-binding capacity, serum iron, and serum transferrin saturation. \u0000 \u0000 Results: The fasting blood glucose was found to be significantly higher in the diabetes mellitus cases. The serum ferritin mean values were 105.32 µgm/dl. In the controls, the range of ferritin levels was 145 µgm/dl. The serum ferritin levels were found to be significantly reduced in the study cases as compared to the controls. Similarly, the total iron-binding capacity (TIBC) of the cases was found to be significantly increased as compared to the controls. The serum transferrin levels were also found to be elevated in the study cases as compared to the controls.\u0000 \u0000 Conclusion: Iron is closely related to the development of diabetes mellitus. Elevated iron and ferritin levels are risk factors for diabetes and can lead to a variety of problems. Conversely in chronic diabetics, there is a tendency to develop iron deficiency anemia and other nutritional deficiency anemias as observed by the results of the current study. As a result, iron profile evaluation can be a valuable output of the expected investigations on diabetes and related problems.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49477834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factors Influencing Depression In Patients Of Cerebrovascular Accidents-A Study","authors":"Jagadish Gorre, Preeti Gudlavallety, Uttam Kishan Porandla, Nagender Rao Y, Kishan Porandla","doi":"10.47799/pimr.1001.17","DOIUrl":"https://doi.org/10.47799/pimr.1001.17","url":null,"abstract":"Abstract\u0000 \u0000 Background:\u0000 Post Stroke Depression (PSD) is one of the most frequent Neuropsychiatric consequences of stroke. It affects almost 29%-70% of Stroke Survivors (SS). There is paucity of research data in determining the risk factors and especially severity and association of depression with site of lesion location in Indian community.\u0000 \u0000 Aim \u0000 and\u0000 Objectives: To determine factors associated with PSD and association between Socio-demographic profiles, Stroke symptoms, Site of lesion with depression.\u0000 \u0000 Materials and Methods: It’s a cross-sectional study including participants from the outpatients section of Department of Neurology at Prathima Institute of Medical Sciences. A predetermined sample size of 60 patients with CVA patients was enrolled in the study and their socio demographic details are collected along with administering Beck’s Depression Inventory for Depression. Neuro-imaging provided information on lesion location. Collected data was analysed using SPSS version 19 and using descriptive and inferential statistics.\u0000 \u0000 Results: In this study 18 out of 60 subjects with stroke were diagnosed with PSD. Risk factors found to be mainly associated with PSD are lack of family support, Joint family types, Stroke with Aphasia, Cranial Nerve involvement and Motor System weakness whereas, Substance use is found to be a protective factor. Significant numbers of subjects were found to have left-anterior-sub-cortical lesions associated with PSD.\u0000 \u0000 Conclusion: This study highlights the variables which are to be considered in the recognition of PSD for Neurologists and Mental health care workers for early intervention and a better outcome in view of stroke recovery.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47608099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serum Uric Acid as an Independent Risk Factor for Acute Ischemic Stroke","authors":"Hari Shankar Akula, U. Cheeti","doi":"10.47799/pimr.1001.12","DOIUrl":"https://doi.org/10.47799/pimr.1001.12","url":null,"abstract":"Abstract\u0000 \u0000 Background: Stroke is a neurological deficit due to acute focal injury of the central nervous system due to any vascular cause. The role of serum uric acid as a risk factor for acute stroke is an area of importance to many researchers. We in the current study tried to determine the levels of serum uric acid in cases of acute ischemic stroke and compare them with those in age and sex-matched controls.\u0000 \u0000 Methods: This hospital-based case-control study was performed in the Department of General Medicine, Prathima Institute of Medical Sciences, Naganoor, Karimnagar. All the subjects were interviewed, examined, and investigated as per the predesigned and pre-tested proforma. Biochemical investigations included estimation of serum uric acid, serum triglycerides, fasting blood glucose, Renal function tests, and Liver function tests. \u0000 \u0000 Results: Mean Serum Uric Acid level was lower in the patients with lacunar stroke as compared to the patients with larger infarcts (6.16 ± 1.68 mg/dl vs. 6.73 ± 2.07 mg/dl). Butthisdifference was not statistically significant as the p-value is >0.05.The correlation between SUA and NIHSS score was studied with the help of Spearman rank correlation. It was found that there was a significant positive correlation between SUA and NIH stroke scale score on admission as well as at the time of discharge (p<0.05 for both).\u0000 \u0000 Conclusion: Elevated serum uric acid level is independently associated with acute ischemic stroke. It was observed that serum uric acid levels were correlated with hypertension, diabetes mellitus, smoking, obesity, and metabolic syndrome. It was found that cases with elevated serum acid levels had poor prognosis and overall mortality rate.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45093871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intra-abdominal Pressure as a Prognostic Factor in Severe Acute Pancreatitis","authors":"Madan Popuri, Vpl Chandrakumar Sistla","doi":"10.47799/pimr.1001.19","DOIUrl":"https://doi.org/10.47799/pimr.1001.19","url":null,"abstract":"Abstract\u0000 \u0000 Objective:To assess the prognostic value of Intra-abdominal Pressure in severe acute pancreatitis, compare it to APACHE II, to determine when to intervene based on intra abdominal pressure.\u0000 \u0000 Materials and Methods:We studied the role of intra-abdominal pressure measurement as a prognostic index and its applicability to determine the timing of intervention in cases of severe acute pancreatitis as a prospective cohort study from 2010- 2012, at Kamineni Hospital, L.B Nagar, Hyderabad. All patients who were admitted with severe acute pancreatitis and consented to take part in the study were enrolled. All patients were evaluated clinically, radiologically, biochemically and by the prognostic indices – APACHE II, Ranson criteria and intra-abdominal pressure measurement. A total of 55 patients were enrolled in this study. Intra-abdominal pressure was measured by intravesical technique using a Foley catheter.Intra-abdominal pressure was measured every 12 hours. Within 24 hours of admission, APACHE II score was obtained. Multivariate analysis was utilised for statistics.\u0000 \u0000 Results:Males comprised 73% of study population. Mean age was 41.23± 13.74 years (17- 83 years). Ten patients (18.81%) died. Among the non-survivors, the intra-abdominal pressure (20.1± 3.1073 Vs 8.97± 4.39) and the APACHE II (17.5 ±4.09 Vs3.93 ±4.345),were significantly greater, P value <0.0001. The AUC for intra-abdominal pressureat 24 hours and at 72 hours was >0.7, which is highly significant. The sensitivity for intra-abdominal pressure(>13 mm Hg) at 72 hours as a marker for mortality was 100%.\u0000 \u0000 Conclusion:The Intra-abdominal pressure monitoring is rapid, reproducible, inexpensive and minimally invasive, and can be used as a marker of the severity and prognosis of severe acute pancreatitis. Intra-abdominal pressure could potentially be used to guide the timing of intervention. Compared to APACHE II, which is inclusive of multiple parameters, intra-abdominal pressure can serve the same purpose as a single prognostic index. Further, we recommend a large, multicentric studies to conclusively establish the predictive power of intra-abdominal pressure in acute pancreatitis and whether interventions known to reduce intra-abdominal pressure, can alter the ultimate outcome.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44007275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Syed, Prenika Shangloo, B. Gupte, Sangeeta Gupta
{"title":"Effect Of AJI-NO-MOTO On Kidney Of Adult Albino Rat: A\u0000 \u0000 Histopathological Evaluation","authors":"M. Syed, Prenika Shangloo, B. Gupte, Sangeeta Gupta","doi":"10.47799/pimr.1001.04","DOIUrl":"https://doi.org/10.47799/pimr.1001.04","url":null,"abstract":"Abstract\u0000 \u0000 Introduction: Aji-No-Moto (MSG), the wonder flavoring agent, has been reportedly overused in all packed food products and the cuisines being served in restaurants. This salt effect almost all the organs of the body but the evidences regarding its ill effects are very limited. Thus, no guidelines are there for the safe limits of Aji-No-Moto use. In current study we planned to analyses the histopathological effects of Aji-No-Moto on kidney.\u0000 \u0000 Methods: The study was conducted on 18 inbred adult albino rats of either sex. The rats of control group (C) received only standard diet with distilled water, low dose test group (T₁) rats received 0.5mg/kg of MSG dissolved in distilled water and high dose test group (T₂) rats received 1.5mg/kg of MSG dissolved in distilled water per orally for 28 days. After the experimental period, the rats were sacrificed to dissect out the renal tissue which was later subjected to histological processing and tissue sectioning.\u0000 \u0000 Observations: The kidney tissue sections of the control group (C) revealed normal renal architecture consisting of cortical labyrinth and medulla. The cortical labyrinth consisted of glomeruli, PCT and DCT whereas the medulla consisted of the ascending and descending limbs of loop of henle and collecting ducts. On the other hand, renal sections of low dose group (T₁) showed focal shrinkage of renal glomerulus and widening of the Bowman’s space. Furthermore, these changes were more pronounced in high dose group (T₂) along with hypercellularity of glomeruli, dilatation, hyperaemia and congestion in the intertubular cortical blood vessels and mononuclear cell infiltrate.\u0000 \u0000 Conclusion: Aji-No-Moto is the most widely used flavoring agent whose minimal dose for use has to be evaluated. The current study was planned to access the minimal low dose limit of MSG for use. The results of aforementioned study revealed that even small dose of 0.5mg/kg/day is capable of producing histopathological effects on kidney.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44286598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}