Perspectives In Medical Research最新文献_第8页

Efficacy of Methylprednisolone and Etoricoxib Combination to attenuate Post-operative Pain and Nausea/Vomiting in Laparoscopic Surgeries 甲强的松龙联合依托昔布减轻腹腔镜手术后疼痛和恶心/呕吐的疗效

Perspectives In Medical Research Pub Date : 2022-05-06 DOI: 10.47799/pimr.1001.08

V. Sharma, K. Lakhina, Rahul Bankapur, P. Lamba

{"title":"Efficacy of Methylprednisolone and Etoricoxib Combination to attenuate Post-operative\u0000 Pain and Nausea/Vomiting in Laparoscopic Surgeries","authors":"V. Sharma, K. Lakhina, Rahul Bankapur, P. Lamba","doi":"10.47799/pimr.1001.08","DOIUrl":"https://doi.org/10.47799/pimr.1001.08","url":null,"abstract":"Abstract\u0000 Background and Aims:Pain and PONV (postoperative nausea and vomiting) are common complaints in the period following surgery. A multimodal approach targeting the reduction of postoperative pain with an opioid-sparing analgesic along with an antiemetic medication would minimize opioid consumption and its associated side effects. We evaluated the efficacy of methylprednisolone 125 mg IV taken along with oral 120 mg etoricoxib on postoperative pain and PONV in patients undergoing laparoscopic surgeries\u0000 Material and methods:A prospective, randomized, double-blind study was conducted on 70 patients aged between 18 and 60 years with ASA grade 1 and 2 posted for elective laparoscopic surgeries. The test group was given a combination of methylprednisolone 125mgIV (given just before induction)& etoricoxib120mg oral (given 1 hr before surgery). (Group A, n=35) while control group received normal saline IV and a placebo per oral(Group B, n=35). Duration and quality of analgesia was assessed by visual analogue scale (VAS) score at 2,4,6,8,10,12,16,20 and 24hr as primary objective. Total dose of rescue analgesic(injection Fentanyl 50 mcg) in first 24 hours, peri-operative hemodynamic change and post op nausea vomiting (PONV) were observed as secondary objective.\u0000 Result:Demographic profiles were comparable. Duration of postoperative analgesia was significantly prolonged(p<0.05) in Group A(7.57±1.04hrs) as compared to Group B(3.05±0.5hrs). Group A showed a significant reduction in postoperative fentanyl consumption in the form of rescue analgesic(p<0.05). Group A also showed significant reduction in the incidence of PONV(p<0.05).\u0000 Conclusion:We conclude that single-dose administration of methylprednisolone IV along with oral etoricoxib has better analgesic efficacy in comparison to placebo for patients undergoing laparoscopic surgeries.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42021585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A proposed scoring system for fast triage of COVID 19 patients using basic clinical parameters: Simple Clinical Parameter (SCIP) Score 一种基于基本临床参数的新型冠状病毒肺炎患者快速分诊评分系统:简单临床参数(SCIP)评分

Perspectives In Medical Research Pub Date : 2022-05-06 DOI: 10.47799/pimr.1001.10

Satish Chandel, Geeta Rai, Vandana Tayal, Niket Rai, S. Singhal, Parag Sharma

{"title":"A proposed scoring system for fast triage of COVID 19 patients using basic clinical parameters: Simple Clinical Parameter (SCIP) Score","authors":"Satish Chandel, Geeta Rai, Vandana Tayal, Niket Rai, S. Singhal, Parag Sharma","doi":"10.47799/pimr.1001.10","DOIUrl":"https://doi.org/10.47799/pimr.1001.10","url":null,"abstract":"Abstract\u0000 \u0000 Introduction\u0000 : Globally healthcare systems are jeopardized due to the COVID-19 pandemic. A fast and simple triage is very important for effective utilization of health care resources. We propose a new tool is for severity assessment of patients at the initial point of care.\u0000 \u0000 Objective: To propose a scoring method for fast triage of COVID 19 patients in predicting the level of care required by the patient \u0000 \u0000 Methods: The SCIP score is for patients who have been tested positive for COVID-19. This scoring system is useful to segregate the patients into different level of care based on values of clinical parameters like Pulse rate (PR), Respiratory rate (RR) and arterial blood oxygen saturation. The risk score ranges from 1 to 10. Lower the score more severe is the disease and hence more intense care is warranted.\u0000 Result: Preliminary observation of SCIP scoring criteria is based on ten patients. On retrospective analysis it was observed that the level of care required by the patients was in correspondence with the score obtained by the SCIP formula.\u0000 \u0000 Conclusion: SCIP scoring system is an easy and rapid tool which may be helpful in early detection of severity and taking fast decision in the time of crisis due to COVID 19. Validation in more number of patients is required to establish the findings.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46461157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histomorphological spectrum of Phyllodes Tumours: A Restrospective Study 叶状肿瘤的组织形态学谱:回顾性研究

Perspectives In Medical Research Pub Date : 2022-05-06 DOI: 10.47799/pimr.1001.07

Udita Singhal, Q. Mahapatra, U. Kumar, Annu Nanda, Pooja Jain, Shalini Trivedi

{"title":"Histomorphological spectrum of Phyllodes Tumours: A Restrospective\u0000 Study","authors":"Udita Singhal, Q. Mahapatra, U. Kumar, Annu Nanda, Pooja Jain, Shalini Trivedi","doi":"10.47799/pimr.1001.07","DOIUrl":"https://doi.org/10.47799/pimr.1001.07","url":null,"abstract":"Abstract\u0000 \u0000 Introduction: Phyllodes tumours are rare fibroepithelial lesions of breast. Clinical examination, ultrasound, cytology and histopathology are the mainstay of the diagnosis. The present research was undertaken with the aim of studying the clinicopathological features of Phyllodes tumour reported in the past seven years in a Delhi government hospital. \u0000 \u0000 Method: A retrospective study of phyllodes tumour was carried out in females from 225 diagnosed cases of breast lesion reported in the pathology department of a government hospital in Delhi during the period of January 2013 to December2019. All the relevant history, findings of clinical examination and investigations performed were assessed from files of the patient.\u0000 \u0000 Results: Out of 225 cases of breast lesions reported in the pathology department 8 tumours were reported as phyllodes in the study period. The most common affected age group was 41- 50yrs. 5 (62.5 %) of 8 tumours were benign,2 (25) %) were borderline and only 1 was malignant. The tumour size was 15mm to 200mm. All the 8 cases (100%) presented with breast lump; 3 cases (30%) complained of pain in the lump. 2 cases developed ulceration and Peau D’ orange and in 1 case typical nipple retraction was seen. FNAC was done in 5 patients. No preoperative investigations were done in 2cases.\u0000 \u0000 Conclusion: Phyllodes tumour is a rare neoplasm of the breast. Histopathology plays an important role in differentiating it from fibroadenoma. Strict histologic assessment is definitely required for the diagnosis of the PT and for its treatment and management","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44937773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A S tudy of the Effectiveness of Lidocaine to Treat S evere P ulmonary Vascular Constriction induced by Protamine 利多卡因治疗鱼精蛋白引起的严重肺血管收缩的疗效研究

Perspectives In Medical Research Pub Date : 2022-05-06 DOI: 10.47799/pimr.1001.03

Sanjeev Singh, I. Okyere, Anbarasu Annamalai, Arti Singh

{"title":"A\u0000 S\u0000 tudy of the Effectiveness of Lidocaine\u0000 to Treat S\u0000 evere P\u0000 ulmonary Vascular Constriction \u0000 induced by Protamine","authors":"Sanjeev Singh, I. Okyere, Anbarasu Annamalai, Arti Singh","doi":"10.47799/pimr.1001.03","DOIUrl":"https://doi.org/10.47799/pimr.1001.03","url":null,"abstract":"Abstract\u0000 \u0000 Background: Protamine neutralises heparin after separation from cardiopulmonary bypass. This study aimed to evaluate the effects of lidocaine on protamine induced pulmonary vascular constriction in paediatric cardiothoracic surgery. Methods: This was a single-centre, prospective, double-blind and randomised study conducted among eighty pediatric patients with acyanotic congenital cardiac disease, scheduled for elective on-pump cardiac surgery under general anaesthesia. In the study, the participants were divided into four groups: Group NPHL- nonpulmonary hypertension with lidocaine preconditioning, group NPHS- nonpulmonary hypertension with normal saline (as placebo), group PHL- pulmonary hypertension with lidocaine preconditioning, and group PHS- pulmonary hypertension with normal saline (as placebo). Results: Pulmonary vasoconstriction occurred in 11.25% of cases after protamine administration. Both the NPHS and PHS groups exhibited an increase in mean airway pressure (Paw), Respiratory index (RI), alveolar-arterial oxygen difference (A-aDO2), pulmonary artery pressure (PAP) and decreased dynamic pulmonary compliance (Cydn) and oxygen index (OI) after protamine administration. However, these changes were not observed in the NPHL and PHL groups with lidocaine preconditioning. Plasma levels of TXB2 in the NPHS and PHS groups were higher than the NPHL and PHL groups, but 6-keto-PGF1 alpha levels were lower in the NPHS and PHS groups than in the NPHL and PHL groups. Conclusion: In congenital heart disease, repair without cardiopulmonary bypass is not possible in most cases. Prior to reversing heparin with protamine, preconditioning lidocaine reverses protamine-induced pulmonary vasoconstriction and improves lung function.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49317093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Class of Central Renin Angiotensin Aldosterone System Inhibitor: Firibastat 新型中枢肾素-血管紧张素-醛固酮系统抑制剂：Firibastat

Perspectives In Medical Research Pub Date : 2022-05-06 DOI: 10.47799/pimr.1001.02

Nidhi Maheshwari, Vandana Tayal

{"title":"Novel Class of Central Renin Angiotensin Aldosterone System Inhibitor: Firibastat","authors":"Nidhi Maheshwari, Vandana Tayal","doi":"10.47799/pimr.1001.02","DOIUrl":"https://doi.org/10.47799/pimr.1001.02","url":null,"abstract":"Abstract\u0000 Hypertension is one of the most important risk factors for the development of ischemic heart diseases, stroke, disability, vascular dementia, heart failure, renal dysfunction, retinopathy, and premature death. Despite the use of two or more blood pressure lowering medications, a considerable proportion of patients show poor control. Current antihypertensive medications show the limitation of use and effect in obese population, certain races like black population and also in renal impairment. Thus, there is an impending need to develop novel classes of antihypertensive agents acting on new targets with diversified mechanisms of action to more effectively manage raised blood pressure. With the introduction of the recent concept of overactive brain renin angiotensin system in cardiovascular disorders, attempts have been made to identify a molecule with the potential of inhibiting aminopeptidases involved in the formation of Angiotensin III. A novel aminopeptidase A inhibitor, also a prodrug Firibastat is currently undergoing development in Phase III clinical trials for hypertension as well as chronic heart failure. We hereby, provide an updated summary of evidence generated so far with Firibastat and also a glimpse into the therapeutic potential of this novel candidate extending beyond the spectrum of essential hypertension","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46029752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary advice in the Indian context- A critical Assessment 饮食建议在印度的背景下-一个关键的评估

Perspectives In Medical Research Pub Date : 2022-05-06 DOI: 10.47799/pimr.1001.20

M. Mudgalkar

引用次数: 0

Giant Bullae In Lung Parenchyma — A Case Series 肺实质巨大大泡-一个病例系列

Perspectives In Medical Research Pub Date : 2022-05-06 DOI: 10.47799/pimr.1001.16

Nagender Prasad Chenimilla, Ramya Krishna B, Ramulu Madire

引用次数: 0

Computed Tomography (CT)guided Fine Needle Aspiration Cytology of Intrathoracic Lesions CT引导下胸内病变细针穿刺细胞学检查

Perspectives In Medical Research Pub Date : 2022-05-06 DOI: 10.47799/pimr.1001.11

Sridhar Pulluri, Ramulu Madire

{"title":"Computed Tomography (CT)guided Fine Needle Aspiration Cytology of Intrathoracic Lesions","authors":"Sridhar Pulluri, Ramulu Madire","doi":"10.47799/pimr.1001.11","DOIUrl":"https://doi.org/10.47799/pimr.1001.11","url":null,"abstract":"Abstract\u0000 \u0000 B\u0000 ackground: Diagnosis of intrathoracic masses is a difficult challenge for clinicians. The compact anatomical arrangement of the mediastinum with diverse pathologies is usually encountered. The present study was done to determine the efficiency of computed tomography (CT) guided Fine-Needle Aspiration Cytology (FNAC) in the evaluation of various thoracic mass lesions\u0000 \u0000 Methods\u0000 : A total of n=46 patients presenting as intrathoracic mass lesions, confirmed on contrast-enhanced CT, were included in the study. A commercially available CT (Ingenuity 128 slices, Philips) was used for biopsy. All patients were subjected to detailed clinical history and physical examination. Investigations: Complete blood count, Erythrocyte sedimentation rate, bleeding time, clotting time, Prothrombin time, Activated partial thromboplastin time, HIV and HbsAg, Chest X-ray postero Anterior view, and Lateral view done in all cases. Chest X-ray AP view and Ultrasound was done wherever needed. Plain and contrast CT was done in all cases before FNAC.\u0000 \u0000 Results: The positive diagnostic yield in our study is noted in 45 of the 46 patients(97.82%); the positive yield for malignancy was 89.13% (41 of 46 patients), benign in8.69 % (4/46), and undiagnosed in 1/46 (2.17%). Out of 46, 40(86.96%) were parenchymal lesions and 6(13.04%) were mediastinal lesions. Out of 40 parenchymal lesions, 38/40(95%) were malignant, which consisted of 55.3% Squamous cell carcinoma, 28.9% Adenocarcinoma. \u0000 \u0000 Conclusion: FNAC is useful for obtaining samples for the diagnosis of focal pulmonary infections, even in immunocompromised patients, and planning appropriate chemotherapy options in lung cancer and metastatic lesions.CT-guided FNAC is an initial approach for the diagnosis of small pulmonary nodules of less than 20mm, aiding in early diagnosis and treatment interventions improving prognosis.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45831129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of Vaginal pH as Point of Care Test for Detection of Bacterial Vaginosis 阴道pH值作为检测细菌性阴道病的护理点试验的应用

Perspectives In Medical Research Pub Date : 2022-05-06 DOI: 10.47799/pimr.1001.06

Shridevi Metgud, Spurthi Gangigute, S. Metgud

{"title":"Utility of Vaginal pH as Point of Care Test for Detection of Bacterial Vaginosis","authors":"Shridevi Metgud, Spurthi Gangigute, S. Metgud","doi":"10.47799/pimr.1001.06","DOIUrl":"https://doi.org/10.47799/pimr.1001.06","url":null,"abstract":"Abstract\u0000 \u0000 Background & objectives: Bacterial vaginosis (BV) is a Reproductive tract infection (RTI) among young sexually active women with high prevalence. It is associated with complications related to pregnancy and an increased risk of acquiring STDs. This poses a need for cost-effective detection of BV in low resource settings. Hence, we propose to study the utility of vaginal pH determination for the detection of BV. \u0000 \u0000 Material & Methods: This is a single center, 1 year cross-sectional study. Swabs were collected from 250 non-pregnant women attending the out-patient department of Obstetrics and Gynecology with vaginal discharge as a predominant symptom with or without backache and abdominal pain. Vaginal pH determination, Gram stain, wet mount, Whiff test, and Amsel’s criteria were used for BV detection.\u0000 \u0000 Results: 250 study participants with vaginal discharge suggestive of BV were analyzed. Vaginal pH was significantly higher in women with BV with the mean pH being 6.2. Vaginal pH >4.5 had a sensitivity of 85% and specificity of 66% to detect BV. The Whiff test had the least sensitivity. Clue cells and Amsel’s criteria of ≥ 3 were significant for BV. A combination of pH and Whiff test performed better had high sensitivity and specificity.\u0000 \u0000 Conclusions: A combination of pH determination and the Whiff test serves as a low-cost alternative in resource-poor settings for detection of BV. Though Clue cells and Amsel’s criteria ≥ 3 were most sensitive and specific, they cannot be used in low resource settings. Vaginal pH alone can be used to detect BV in areas of low prevalence.","PeriodicalId":30624,"journal":{"name":"Perspectives In Medical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48134548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence :Dawn of New Era in Medicine 人工智能:医学新时代的曙光

Perspectives In Medical Research Pub Date : 2022-05-06 DOI: 10.47799/pimr.1001.01

Shireesha Gugloth, R. Kasturi, Khasim Shaik

引用次数: 0