Dyes and Pigments最新文献

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A fluorescent chlorin based metal organic framework for rapid and selective sensing of fluoride ions 用于氟离子快速和选择性传感的荧光氯基金属有机框架
IF 4.1 3区 工程技术
Dyes and Pigments Pub Date : 2025-04-17 DOI: 10.1016/j.dyepig.2025.112845
Xinyi Zhang , Zhezhen Qi , Weiyi Dai , Xueying Hao , Qiliang Deng , Futai Lu
{"title":"A fluorescent chlorin based metal organic framework for rapid and selective sensing of fluoride ions","authors":"Xinyi Zhang ,&nbsp;Zhezhen Qi ,&nbsp;Weiyi Dai ,&nbsp;Xueying Hao ,&nbsp;Qiliang Deng ,&nbsp;Futai Lu","doi":"10.1016/j.dyepig.2025.112845","DOIUrl":"10.1016/j.dyepig.2025.112845","url":null,"abstract":"<div><div>Metal organic frameworks (MOFs) have emerged as a highly promising platform for a range of sensing applications due to their tunable structures and diverse functionalities. In this study, we have developed and synthesized a novel chlorin luminescent MOF (TCPC-224), which is composed of 5,10,15,20-tetrakis(4-carboxyphenyl) chlorin ligand and zirconium clusters. TCPC-224 was utilized as a “turn-on” sensing probe for the detection of fluoride ions. The proposed sensing approach demonstrates a strong linear relationship in the range of 0.3–50 μM with a low detection limit of 0.029 μM toward fluoride ions. Furthermore, TCPC-224 has also been applied to detect fluoride ions in complex samples (river and tap water). These findings indicate that TCPC-224 holds great potential to serve as a rapid (less than 3 min), sensitive and selective fluorescent sensing platform for the detection and quantification of fluoride ions.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"240 ","pages":"Article 112845"},"PeriodicalIF":4.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dibutylated Si-fluorescein: enhanced hydrophobicity for fluorogenic labeling in vivo 二丁基硅荧光素:增强疏水性,用于体内荧光标记
IF 4.1 3区 工程技术
Dyes and Pigments Pub Date : 2025-04-17 DOI: 10.1016/j.dyepig.2025.112841
Ning Wang , Haoyang Li , Demei Kong , Xiaoyue Feng , Chen Li , Xiaoyan Cui , Ting Wang
{"title":"Dibutylated Si-fluorescein: enhanced hydrophobicity for fluorogenic labeling in vivo","authors":"Ning Wang ,&nbsp;Haoyang Li ,&nbsp;Demei Kong ,&nbsp;Xiaoyue Feng ,&nbsp;Chen Li ,&nbsp;Xiaoyan Cui ,&nbsp;Ting Wang","doi":"10.1016/j.dyepig.2025.112841","DOIUrl":"10.1016/j.dyepig.2025.112841","url":null,"abstract":"<div><div>Fluorescein derivatives, characterized by a xanthene backbone, represent a prominent class of organic molecular dyes. Through silicon atom substitution, silicon-substituted fluoresceins (SiFs) exhibit bathochromic emission spectra with high quantum yields. However, the anionic configuration significantly restricts their application <em>in vivo</em>. Herein, we reported dibutylated silicon fluorescein, <strong>SiFC4</strong> and <strong>HSiFC4</strong>. With increased hydrophobicity by dibutylation, <strong>SiFC4</strong> tends to convert into the neutral lactone form and enables its aggregation (150 nm in diameter) with substantially reduced background fluorescence at physiological pH. Notably, <strong>HSiFC4</strong> demonstrates 4.3-fold enhanced fluorogenicity in HaloTag labeling systems and robust fluorescence response (4.1-fold) in living cell imaging compared to its dimethyl derivative, <strong>HSiFC1</strong>. This approach underscores the potential of alkylation in modulating the properties of fluorophores, offering a promising strategy for advanced applications in the future.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"240 ","pages":"Article 112841"},"PeriodicalIF":4.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thermally activated delayed fluorescence material based on phthalonitrile for versatile applications as host and sensitizer in OLEDs 基于邻苯二腈的热激活延迟荧光材料在oled中作为宿主和敏化剂的广泛应用
IF 4.1 3区 工程技术
Dyes and Pigments Pub Date : 2025-04-16 DOI: 10.1016/j.dyepig.2025.112843
Yli Peng , Wenle Wang , Xinyu Li , Yuqin Du , Feng Wang , Kang Chen , Huixia Xu , Huijun Sun , Yanqin Miao , Hua Wang
{"title":"Thermally activated delayed fluorescence material based on phthalonitrile for versatile applications as host and sensitizer in OLEDs","authors":"Yli Peng ,&nbsp;Wenle Wang ,&nbsp;Xinyu Li ,&nbsp;Yuqin Du ,&nbsp;Feng Wang ,&nbsp;Kang Chen ,&nbsp;Huixia Xu ,&nbsp;Huijun Sun ,&nbsp;Yanqin Miao ,&nbsp;Hua Wang","doi":"10.1016/j.dyepig.2025.112843","DOIUrl":"10.1016/j.dyepig.2025.112843","url":null,"abstract":"<div><div>To enhance and stabilize the performance of organic light emitting diodes (OLEDs), it is essential to design the host to converse dark triplet excitons to emissive singlet. Herein, we developed a host material with thermally activated delayed fluorescence (TADF) characteristics based on phthalonitrile and carbazole derivatives, namely Me-2CzPN. This TADF molecule derived from a typical TADF emitter of 2CzPN through featuring double methyls groups on 3- and 6- positions of carbazole. Me-2CzPN exhibits a high triplet energy of 2.47 eV and a large rate constant of reverse intersystem crossing (RISC), ensuring efficient energy transfer from host to guest, and improve the utilization of triplet exciton. Consequently, the corresponding blue TADF-OLED achieved a high maximum external quantum efficiency (<span><math><mrow><msub><mrow><mi>E</mi><mi>Q</mi><mi>E</mi></mrow><mi>max</mi></msub></mrow></math></span>) of 20.8 %. When employed Me-2CzPN as a host material in red phosphorescent OLED, the device displayed an <span><math><mrow><msub><mrow><mi>E</mi><mi>Q</mi><mi>E</mi></mrow><mi>max</mi></msub></mrow></math></span> of 12.4 %. Furthermore, Me-2CzPN was used sensitizer in hyperfluorescent OLEDs (HF-OLEDs), exhibiting an <span><math><mrow><msub><mrow><mi>E</mi><mi>Q</mi><mi>E</mi></mrow><mi>max</mi></msub></mrow></math></span> of 7.1 % accompanied with full width at half maximum (FWHM) values of 34 nm. These findings reveal the versatile applications of Me-2CzPN as emitter, host and sensitizer for fluorescent emitters, respectively.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"240 ","pages":"Article 112843"},"PeriodicalIF":4.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel fluorescent probe with a large Stokes shift for rapidly monitoring hypochlorous acid in living cells, zebrafish, and tobacco seedlings 一种具有大斯托克斯位移的新型荧光探针,用于快速监测活细胞、斑马鱼和烟草幼苗中的次氯酸
IF 4.1 3区 工程技术
Dyes and Pigments Pub Date : 2025-04-15 DOI: 10.1016/j.dyepig.2025.112836
Lin Wang , Ning Zhang , Jian-Yong Wang
{"title":"A novel fluorescent probe with a large Stokes shift for rapidly monitoring hypochlorous acid in living cells, zebrafish, and tobacco seedlings","authors":"Lin Wang ,&nbsp;Ning Zhang ,&nbsp;Jian-Yong Wang","doi":"10.1016/j.dyepig.2025.112836","DOIUrl":"10.1016/j.dyepig.2025.112836","url":null,"abstract":"<div><div>Hypochlorous acid (HClO), as a kind of reactive oxygen species, was produced in the normal aerobic metabolism of organisms. The right amount of HClO can kill invading organisms and fight infection. However, when the amount of HClO is too high, the homeostasis within cells could be disrupted, resulting in irreversible damage to the body. Therefore, HClO plays an important role in normal physiological activities. In this study, a fluorescent probe BTD-TM for monitoring HClO was designed and developed based on benzothiadiazole. When HClO was recognized, the atom S in the thiomorpholine group was oxidized to the sulfoxide structure. Probe BTD-TM showed the advantages of large Stokes shift (120 nm) with low detection limit (LOD = 0.414 μM), high sensitivity, and good stability. Probe BTD-TM was able to achieve the precise detection of endogenous hypochlorous acid with high sensitivity, covering the intracellular homeostasis response induced by n-acetylcysteine and the inflammatory model system triggered by lipopolysaccharide stimulation. At the same time, excellent detection performance was also demonstrated for the tracking of the addition of exogenous hypochlorous acid. In addition, bioimaging showed that BTD-TM could also be used to detect HClO in zebrafish and tobacco seedlings.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"240 ","pages":"Article 112836"},"PeriodicalIF":4.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An indole-fused quinacridone-based fluorescent probe with high photostability and specificity for cellular lipid droplets 一种基于吲哚融合喹吖啶酮的荧光探针,具有高光稳定性和细胞脂滴特异性
IF 4.1 3区 工程技术
Dyes and Pigments Pub Date : 2025-04-14 DOI: 10.1016/j.dyepig.2025.112835
Yutong Ouyang , Haonan Xiong , Huanlong Zheng , Chenguang Wang , Chuandong Dou , Yufei Gao
{"title":"An indole-fused quinacridone-based fluorescent probe with high photostability and specificity for cellular lipid droplets","authors":"Yutong Ouyang ,&nbsp;Haonan Xiong ,&nbsp;Huanlong Zheng ,&nbsp;Chenguang Wang ,&nbsp;Chuandong Dou ,&nbsp;Yufei Gao","doi":"10.1016/j.dyepig.2025.112835","DOIUrl":"10.1016/j.dyepig.2025.112835","url":null,"abstract":"<div><div>Lipid droplets (LDs) are critical organelles that participate in numerous biological processes in eukaryotic cells. However, the unsatisfying specificity to LDs and poor photostability of previous fluorescent probes (<em>e.g.</em> BODIPY 493/503, Nile Red) have substantially limited the in-depth investigations into LDs, particularly for the small and nascent LDs. Herein, inspired by the outstanding photophysical properties of the classical pigment quinacridone (QA), QA was chosen as an excellent π-skeleton to constitute superior fluorescent probe. The indole cores and ether chains were successfully incorporated into its π-skeleton to construct a novel fluorescent probe <strong>IQA1</strong>. Compared to conventional fluorescent probes, <strong>IQA1</strong> not only demonstrates innate superb photostability, but also exhibits superior specificity to LDs. The long ether chains effectively reversed the insolubility of QA in lipids, endowing <strong>IQA1</strong> with appropriate lipophilicity to traverse the cell membrane and target LDs. These advantages are conductive to the application of <strong>IQA1</strong> in various LDs fluorescence imaging, <em>e.g.</em> 3D confocal imaging of the quantification and dimensions of LDs in the ferroptosis HeLa cells and the oleic acid stimulated HeLa cells, time-lapse structured illumination microscopy (SIM) imaging to observe the dynamics of LDs at nanoscale (178 nm). This study thus not only provides a fascinating fluorescent probe <strong>IQA1</strong> for LDs advanced imaging, but also explores a new area for quinacridone pigment application.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"240 ","pages":"Article 112835"},"PeriodicalIF":4.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microwave-assisted synthesis of base modified Furo[3,2-c]quinolone nucleosides and insights into their photophysical properties 微波辅助合成碱修饰呋喃[3,2-c]喹诺酮类核苷及其光物理性质研究
IF 4.1 3区 工程技术
Dyes and Pigments Pub Date : 2025-04-12 DOI: 10.1016/j.dyepig.2025.112826
Sumit Kumar , Aditi Arora , Gautam Deo , Mrityunjay K. Tiwari , Jyotirmoy Maity , Brajendra K. Singh
{"title":"Microwave-assisted synthesis of base modified Furo[3,2-c]quinolone nucleosides and insights into their photophysical properties","authors":"Sumit Kumar ,&nbsp;Aditi Arora ,&nbsp;Gautam Deo ,&nbsp;Mrityunjay K. Tiwari ,&nbsp;Jyotirmoy Maity ,&nbsp;Brajendra K. Singh","doi":"10.1016/j.dyepig.2025.112826","DOIUrl":"10.1016/j.dyepig.2025.112826","url":null,"abstract":"<div><div>A green, catalyst free, one-pot, gram scale microwave-assisted synthesis of fluorescent furo [3,2-<em>c</em>]quinolone nucleoside analogues has been successfully developed using 2-Me-THF as a greener solvent. This method, employing 3′,5′-di-<em>O</em>-acetyl-5-formyl-2′-deoxyuridine, alkyl isocyanides, and differently substituted 4-hydroxyquinolones, achieved product yield up to 92 %, which offers high atom economy, reduced reaction time and simple work-up procedure. The products were fully characterized by spectroscopic techniques and single crystal X-ray analysis with DFT analysis conforming the electronic structures. Fluorescence studies revealed strong emission (∼450 nm), large Stokes shifts (59–98 nm), and high quantum yields (0.053–0.595). Solvatochromism studies highlighted their environmental sensitivity, indicating potential applications in nucleic acid research and bio-imaging.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"240 ","pages":"Article 112826"},"PeriodicalIF":4.1,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optical detection of hydrogen sulfide by Turn-ON chemosensors based on 2-nitro-5,10,15,20-tetraphenylporphyrins 基于2-硝基-5,10,15,20-四苯基卟啉的Turn-ON化学传感器光学检测硫化氢
IF 4.1 3区 工程技术
Dyes and Pigments Pub Date : 2025-04-11 DOI: 10.1016/j.dyepig.2025.112801
Carla I.M. Santos , Ana M. Santiago , Cristina J. Dias , Ana R. Araújo , Daniel Cavaco , Gonçalo Justino , Manuel Melle-Franco , M. Amparo F. Faustino , M. Graça P.M. S. Neves , JoséM.G. Martinho , Ermelinda M.S. Maçôas
{"title":"Optical detection of hydrogen sulfide by Turn-ON chemosensors based on 2-nitro-5,10,15,20-tetraphenylporphyrins","authors":"Carla I.M. Santos ,&nbsp;Ana M. Santiago ,&nbsp;Cristina J. Dias ,&nbsp;Ana R. Araújo ,&nbsp;Daniel Cavaco ,&nbsp;Gonçalo Justino ,&nbsp;Manuel Melle-Franco ,&nbsp;M. Amparo F. Faustino ,&nbsp;M. Graça P.M. S. Neves ,&nbsp;JoséM.G. Martinho ,&nbsp;Ermelinda M.S. Maçôas","doi":"10.1016/j.dyepig.2025.112801","DOIUrl":"10.1016/j.dyepig.2025.112801","url":null,"abstract":"<div><div>The sensing ability of 2-nitro-5,10,15,20-tetraphenylporphyrin <strong>(P–NO<sub>2</sub>)</strong> and of the corresponding Zn(II) complex <strong>(ZnP–NO<sub>2</sub>)</strong> towards hydrogen sulfide (H<sub>2</sub>S) was investigated using UV–vis absorption and emission spectroscopy. The presence of H<sub>2</sub>S induced strong alterations in the excited state of <strong>P–NO<sub>2</sub></strong> and <strong>ZnP–NO<sub>2</sub></strong>. Specifically, the originally broad fluorescence emission observed around 700 nm was strongly quenched, while new sharp bands emerged at lower wavelengths. Both <strong>P–NO<sub>2</sub></strong> and <strong>ZnP–NO<sub>2</sub></strong> showed a clear sensitive and turn-ON response to the presence of H<sub>2</sub>S, with detection limits (LOD) of 3 μM for <strong>P–NO<sub>2</sub></strong> and 7 μM for <strong>ZnP–NO<sub>2</sub></strong>. In the case of <strong>ZnP–NO<sub>2</sub></strong>, the spectral shift enables a ratiometric sensing of H<sub>2</sub>S, making this approach particularly robust against variations in sensor concentration, environmental effects and instrumentation errors. Interestingly, the spectral changes induced by H<sub>2</sub>S were reversible suggesting that it is possible to reuse the sensor. The sensing mechanism was evaluated by <sup>1</sup>H NMR and HRMS-ESI experiments and corroborated by density functional theory (DFT) calculations. Overall, the results emphasized that the β-nitroporphyrins based probes are a powerful tool for the detection of H<sub>2</sub>S and present potential as a new sensing approach.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"240 ","pages":"Article 112801"},"PeriodicalIF":4.1,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polycatenar mesogens based on phenothiazine imine: Liquid crystal and photophysical properties 基于吩噻嗪亚胺的多链链间质:液晶和光物理性质
IF 4.1 3区 工程技术
Dyes and Pigments Pub Date : 2025-04-10 DOI: 10.1016/j.dyepig.2025.112817
Yixian Li , Shibo Chen , Yuantang Duan , Zilong Guo , Wenyong Xiong , Hongmei Zhao , Xiaohong Cheng
{"title":"Polycatenar mesogens based on phenothiazine imine: Liquid crystal and photophysical properties","authors":"Yixian Li ,&nbsp;Shibo Chen ,&nbsp;Yuantang Duan ,&nbsp;Zilong Guo ,&nbsp;Wenyong Xiong ,&nbsp;Hongmei Zhao ,&nbsp;Xiaohong Cheng","doi":"10.1016/j.dyepig.2025.112817","DOIUrl":"10.1016/j.dyepig.2025.112817","url":null,"abstract":"<div><div>The first phenothiazine (PT) imine polycatenar columnar mesogens consisting of a PT central core with 4′-substituted biphenylene-4-imino units at both wings and connecting with two terminal 2,4,5-trialkoxyphenyl groups via ester or ether links have been synthesized. These compounds self-assemble into hexagonal columnar liquid crystalline (LC) mesophases. They exhibit green to yellow fluorescence emission with large stokes shift in their LC, solution and solid states. They show aggregation-induced enhanced emission (AIEE) and mechanofluorochromic (MFC) behavior. The influences of ester or ether links on their properties have been discussed. Ether compound <strong>PT-E,</strong> with more planar conformation and higher electron density on the PT core, forms gel in an organic solution and shows stronger solid-state fluorescence emission, AIEE and MFC effects. The applications of <strong>PT-E</strong> as a chemosensor towards Al (III) and in white light emission diode (WLED) have been explored. In addition, using <em>Caenorhabditis elegans</em> as an animal model, the bioimaging of these fluorescence materials has been investigated. The results show that <em>Caenorhabditis elegans (C. elegans)</em> exhibits greater fluorescence in the <strong>PT-E</strong> solution.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"240 ","pages":"Article 112817"},"PeriodicalIF":4.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a novel near-infrared fluorescent probe based on nile blue for the detection of leucine aminopeptidase as a cancer biomarker 开发基于尼罗河蓝的新型近红外荧光探针,用于检测作为癌症生物标记物的亮氨酸氨肽酶
IF 4.1 3区 工程技术
Dyes and Pigments Pub Date : 2025-04-10 DOI: 10.1016/j.dyepig.2025.112827
Marcia Domínguez , David Azorín-Soriano , Jessie García-Fleitas , Jennifer Soler-Beatty , Andrea Bernardos , Alba García-Fernández , Juan F. Blandez , Félix Sancenón , Ramón Martínez-Máñez
{"title":"Development of a novel near-infrared fluorescent probe based on nile blue for the detection of leucine aminopeptidase as a cancer biomarker","authors":"Marcia Domínguez ,&nbsp;David Azorín-Soriano ,&nbsp;Jessie García-Fleitas ,&nbsp;Jennifer Soler-Beatty ,&nbsp;Andrea Bernardos ,&nbsp;Alba García-Fernández ,&nbsp;Juan F. Blandez ,&nbsp;Félix Sancenón ,&nbsp;Ramón Martínez-Máñez","doi":"10.1016/j.dyepig.2025.112827","DOIUrl":"10.1016/j.dyepig.2025.112827","url":null,"abstract":"<div><div>We report herein the design and synthesis of a near-infrared fluorescent probe (<strong>NB–SO<sub>3</sub>-Leu</strong>) derived from the Nile Blue (NB) fluorophore scaffold, modified with sulfonic groups to improve solubility and biocompatibility. The mechanism of action of the <strong>NB-SO<sub>3</sub>-Leu</strong> probe was successfully validated in the presence of leucine aminopeptidase (LAP), a widely known cancer biomarker. The fluorescence signal of <strong>NB-SO<sub>3</sub>-Leu</strong>, which was initially low, increased 4-fold after incubation with the LAP enzyme after 15 min. In addition, the <strong>NB-SO<sub>3</sub>-Leu</strong> probe was validated <em>in vitro</em> in 4T1 (mouse mammary carcinoma cells), HeLa (human cervical cancer cells), and SK-Mel-103 (human melanoma cells) with high endogenous LAP levels. This work aims to advance in the development of a new generation of reliable and sensitive cancer detection methods.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"240 ","pages":"Article 112827"},"PeriodicalIF":4.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
External heavy atom effect in brominated carbazole/oxadiazole hybrid hosts for enhanced efficiency in phosphorescence and TADF OLEDs 外重原子效应对溴化咔唑/恶二唑杂交寄主磷光和TADF oled效率的影响
IF 4.1 3区 工程技术
Dyes and Pigments Pub Date : 2025-04-10 DOI: 10.1016/j.dyepig.2025.112822
Jingsheng Wang , Shiying Hu , Yuying Wu, Yaotian Zhang, Yeting Tao, Youtian Tao
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