Recent advances in the construction, imaging and phototherapy applications of NIR-II J-aggregates based on different fluorophores

IF 4.1 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2025-07-22 DOI:10.1016/j.dyepig.2025.113054

Gan Sun , Yurong Zhang , Na Zhou , Fangjun Huo , Caixia Yin

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引用次数: 0

Abstract

With the development of various near-infrared imaging technologies, near-infrared-II (NIR-II) (1000–1700 nm) dyes have attracted extensive attention from scientific researchers. NIR-II radiation exhibits superior tissue penetration capability, reduced tissue scattering effects, lower tissue autofluorescence, and minimized photodamage. These advantages provide possibilities for deeper in vivo imaging and promote advancements in biomedicine. Among them, J-aggregates are fluorescent materials composed of highly ordered organic dye molecules. In J-aggregates, the arrangement of monomer molecules' transition dipole moments in "head-to-tail" or "slip-stacked" configurations, almost parallel to the connecting central line, reduces excitonic state energy and induces strong interactions between intermolecular transition dipole moments, forming exciton coupling. Consequently, compared with monomers, J-aggregates exhibit longer absorption and emission wavelengths. Currently reported J-aggregate fluorescent dyes are mainly constructed from small organic fluorescent monomers such as cyanine and BODIPY. This review discusses strategies for constructing J-aggregates by different monomer molecules and their biological applications, and provides perspectives on future development strategies and potential application directions.

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基于不同荧光团的NIR-II j聚集体的构建、成像和光疗应用的最新进展

随着各种近红外成像技术的发展，近红外- ii (NIR-II) （1000-1700 nm）染料受到了科研人员的广泛关注。NIR-II辐射表现出优越的组织穿透能力，减少组织散射效应，降低组织自身荧光，并将光损伤降至最低。这些优点为更深入的体内成像提供了可能，促进了生物医学的进步。其中j聚集体是由高度有序的有机染料分子组成的荧光材料。在j -聚集体中，单体分子的跃迁偶极矩以“头对尾”或“滑叠”的方式排列，几乎平行于连接的中心线，降低了激子态能量，并诱导分子间跃迁偶极矩之间的强相互作用，形成激子耦合。因此，与单体相比，j -聚集体具有更长的吸收和发射波长。目前报道的j聚集体荧光染料主要由小的有机荧光单体构成，如花青素和BODIPY。本文综述了不同单体分子构建j聚集体的策略及其生物学应用，并对未来的发展策略和潜在的应用方向进行了展望。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.