Journal of Nuclear Medicine and Radiation Therapy最新文献

{"title":"Osteoblastic Changes During Non-Small Cell Lung Cancer (NSCLC) Treatment:How to Distinguish between Objective Response and Progressive Disease","authors":"F. Gelsomino, V. Ambrosini, M. Tiseo, F. Sperandi, B. Melotti, A. Ardizzoni","doi":"10.4172/2155-9619.1000296","DOIUrl":"https://doi.org/10.4172/2155-9619.1000296","url":null,"abstract":"Bone metastases are common in disseminated NSCLC, occurring in approximately 30% to 40% of patients [2]. In the majority of cases, they present an osteolytic imaging pattern, even though osteoblastic or mixed-type patterns have also been reported in nearly 8% of cases [3,4]. Generally, in the assessment of objective response to anticancer agents, bone metastases are classified as non-target lesions and therefore “not evaluable” for response. However, according to the revised Response Evaluation Criteria in Solid Tumors guideline (RECIST version 1.1) [5], the appearance of new non-target lesions, including lytic or osteoblastic bone metastases, is a criterion for defining progressive disease. Sometimes, the evaluation of bone lesion response may be challenging and misinterpreted.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124466152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of [68Ga]Ga-PSMA-HBED-CC PET versus Whole-Body BoneScintigraphy for the Detection of Bone Metastases in Patients with ProstateCancer","authors":"Schreiter, M. Gericke, Uwe Heimann, I. Steffen, L. Stelter, M. Maurer, B. Hamm, W. Brenner, D. Theilig, J. Kahn, Schreiter Nf","doi":"10.4172/2155-9619.1000302","DOIUrl":"https://doi.org/10.4172/2155-9619.1000302","url":null,"abstract":"Aim: To compare [68Ga]Ga-PSMA-HBED-CC PET and (99m)Tc-DPD bone scintigraphy for the detection of bone metastases from prostate cancer. Methods: [68Ga]Ga-PSMA-HBED-CC PET/CT and (99m)Tc-DPD bone scintigraphy in 19 men with histopathological proven prostate cancer were compared to each other for the sensitivity/specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) for the detection of bone metastases. Results: According to the standard of reference lesion-based analysis of [68Ga]Ga-PSMA-HBED-CC PET and (99m)Tc-DPD bone scintigraphy reached a sensitivity of 45.6%/34%, specificity of 86.4%/81.4%, accuracy of 60.5%/ 51.2%, positive predictive value of 85.5%/76.1%, and negative predictive value of 47.7%/41.4%, respectively. Conclusion: [68Ga]Ga-PSMA-HBED-CC PET could detect significantly more bone metastases in prostate cancer than (99m)Tc-DPD bone scintigraphy.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"113 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121898338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodistribution of Novel 68Ga-Radiolabelled HER2 Aptamers in Mice","authors":"M. Gijs, G. Becker, A. Plenevaux, M. Bahri, A. Aerts, N. Impens, S. Baatout, A. Luxen","doi":"10.4172/2155-9619.1000300","DOIUrl":"https://doi.org/10.4172/2155-9619.1000300","url":null,"abstract":"Background: Two novel HER2 aptamers were recently selected with great potential for the in vitro diagnosis of HER2-positive cancer. The goal of this study was to examine the in vivo diagnostic potential of these HER2 aptamers. Methods: Both HER2 aptamers were radiolabelled with 68Ga, injected in mice bearing a HER2-positive and HER2-negative tumour and evaluated by PET/MRI. Results: Ex vivo bio distribution analysis revealed high uptake in the blood, tissues and organs, except the brain. Interestingly, this high uptake was explained by the slow blood clearance due to non-specific aptamer binding to blood proteins. We observed accumulation of radioactivity in both tumours in time. Although higher uptake in the HER2-positive tumour compared to the HER2-negative tumour was observed, this was accompanied with more necrosis in the HER2-negative tumour, which was observed by 18FDG PET/CT. Conclusion: This work presents a first step towards the development of 68Ga-labelled aptamers for molecular cancer imaging.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"2013 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127425250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonunion of the Posteromedial Tubercle of the Talus: Interest of SPECT/CT","authors":"D. Olivier, G. Florent, R. Philippe, Abgral Ronan, Querellou Solène","doi":"10.4172/2155-9619.1000299","DOIUrl":"https://doi.org/10.4172/2155-9619.1000299","url":null,"abstract":"We report the case of an isolated fracture of the posteromedial tubercle of the talar process caused by a posterior tackle in a football player, which is an unusual and misdiagnosed fracture leading to a nonunion causing a chronic ankle pain. To our knowledge, this is the first reported case demonstrating the major interest of SPECT/CT to diagnose an unusual nonunion of the posteromedial tubercle of the talus.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131387723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novelties and New Potentials in the Clinical Application of SPECT/CT Imaging","authors":"Sarolta Szekeres, E. Schmidt, Z. Szabó, Zsuzsanna Bán, K. Zámbó","doi":"10.4172/2155-9619.1000298","DOIUrl":"https://doi.org/10.4172/2155-9619.1000298","url":null,"abstract":"The application of hybrid devices that is fused technologies is getting more and more important in the field of imaging diagnostics. The greatest advantage of this method is the combined use of several modalities, which can provide data about the morphological, functional and possibly molecular changes in different diseases simultaneously. In this paper the potentials, advantages and applicabilities of SPECT/CT (single photon emission computer tomograph/computer tomograph) are summarized mainly in oncological diseases but in other diseases as well. Multimodality devices detecting functional and morphological abnormalities simultaneously increase the specificity and diagnostic accuracy of nuclear medicine methods and therefore the effectiveness of therapy too.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126452904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Intravesical Prostatic Protrusion on Continence Outcomes afterRobotic-Assisted Laparoscopic Radical Prostatectomy","authors":"Sheng-Chun Hung, Y. Ou, Cheng-kuang Yang, Chen-Li Cheng, H. Ho, K. Chiu, C. Su, Wen-ming Chen, Shian-Shiang Wang, Chuan-Shu Chen, Jian-Ri Li","doi":"10.4172/2155-9619.1000294","DOIUrl":"https://doi.org/10.4172/2155-9619.1000294","url":null,"abstract":"Purpose: We try to evaluate the influence of intravesical prostatic protrusion (IPP) in the postoperative continence of patient who received robotic assisted laparoscopic radical prostatectomy. Methods: A total 600 patients who underwent robotic assisted laparoscopic radical prostatectomy were included in the study. Preoperative MRI was performed in all patients and the vertical distance from the tip of the protruding prostate to the base of the urinary bladder was measured in all sagittal plane. The degree of intravesical prostatic protrusion were divided into three groups (IPP<5 mm, 5 mm<IPP<10 mm, 10 mm<IPP). Surgical procedure was mentioned. Continence was defined as no pad use or only one safety pad per day and assessed at 1, 3 and 12 months postoperatively. The result was examined. Results: The overall continence rate at 1, 3 and 12 month was 69.2%, 91.33% and 95.5%. Among the three groups, there is significant difference in 1 month, 3 months and 12 months continence rate (IPP<5 mm: 82.5%, 96.3%, 97.7%; 5 mm<IPP<10 mm: 61.9%, 89.4%, 94.4%; 10 mm<IPP: 30%, 75.6%, 88.9%, p<0.001). At first month, 415 patients achieved continence but 195 patients still incontinence and the length of IPP among the two groups were 4.43 mm ± 3.74 mm and 8.69 mm ± 6.63 mm, p<0.001. There is also significant difference in IPP length among continence and incontinence group. Conclusions: To our result, both of intravesical prostatic protrusion and prostate volume was correlated with recovery of early and one year continence after robotic assisted laparoscopic radical prostatectomy and with inferior outcome.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129475512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics of Patients with Acute Pancreatitis Coexisting withOrgan Failure: A Retrospective Cohort Study","authors":"Chunyi Gui, Weidong Wu, R. Lei, Min Wang","doi":"10.4172/2155-9619.1000297","DOIUrl":"https://doi.org/10.4172/2155-9619.1000297","url":null,"abstract":"Purpose: Acute pancreatitis is a systemic disease, and is usually closely associated with organ failures. This study was to investigate the pattern of organ failure in the course of acute pancreatitis. Recent Findings: A total of 783 severe acute pancreatitis (SAP) and moderately severe acute pancreatitis (MSAP) patients who were sequentially treated in Department of Surgery, Ruijin Hospital from January 2001 to December 2008 were retrospectively analyzed. All the patients were divided according to their outcomes into two groups: deceased group and survival group. The relationship between the happening of organ failure and outcome of the patients were observed. Then peripheral blood level of endotoxin core antibody and TNF-α between SAP and MSAP groups were compared. Among the 783 patients, the numbers of MSAP patients and SAP patients were 573 and 210 respectively. Overall, 698 patients were survived, which represents 89.1% of the total patients. Furthermore, 273 patients or 34.9% of the total were diagnosed with organ failure. There were 109 patients with single organ failure, 2 of which died; 81 and 60 patients with 2 organs failure and 3 organs failure respectively. In each group 30 patients died. Finally there were 23 patients with 4 or more organs failure and none of them survived. The rate is 15.3% (107/698) of the patients with single organ failure in survival group, while the corresponding number is only 2.4% (2/85) in deceased group. On the contrary, only 11.6% (81/698) patients in the survival group had multiple organ failure, while the number is 97.6% (83/85) in the deceased group. Respiratory, renal, cardiovascular, neurological, hematologic and hepatic failure occurred in 206, 80, 103, 92, 41, and 27 patients, with the incidence of 26.3%, 10.2%, 13.2%, 11.7%, 5.2%, and 3.4%; and the mortality rates were 38.8%, 63.8%, 49.5%, 37.0%, 53.7%, and 44.4% respectively. Peripheral blood levels of TNF-α and endotoxin core antibody in patients with SAP were significantly different with that of MSAP. Summary: In the course of acute pancreatitis, respiratory and cardiovascular failure has the highest incidence, and renal, hematologic failure is associated with poorest prognosis.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121142423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occult Breast Carcinoma with Axillary Lymph Node Metastasis in a MalePatient â An Evidence Based Approach","authors":"V. Pai, V. Manohar, K. Kattimani, Padmanabh B. Deshp, Satish Tumbal","doi":"10.4172/2155-9619.1000293","DOIUrl":"https://doi.org/10.4172/2155-9619.1000293","url":null,"abstract":"Occult primary breast carcinoma (OPBC) with axillary lymph node metastasis is a rare disorder accounting for 0.1% to 0.8% of all the cases of breast cancer in females. Such a presentation in males is even rarer with only isolated case reports noted in English literature. Magnetic resonance imaging (MRI) of the breast detects primary tumor in nearly 2/3rd patients. Role of mastectomy is considered controversial. There is no consensus on the role of adjuvant therapy owing to the rarity of these tumors. We are presenting an elderly man who presented with axillary lymph node metastasis of ductal carcinoma and was treated with surgery followed by adjuvant chemotherapy.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124701869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Application of Technetium-99m-Labeled Red Blood Cells SubcutaneousRadionuclide Venography and Abdominal/Pelvic Hybrid SPECT/CT Imaging inPatients with Suspicion of Proximal Deep Vein Thrombosis","authors":"Chih-Ting Liu, Hsiu-Lan Chu, I-Hsin Tsai, Yi-Ling Chang, Chia-Yang Lin","doi":"10.4172/2155-9619.1000295","DOIUrl":"https://doi.org/10.4172/2155-9619.1000295","url":null,"abstract":"Technetium-99m-labeled red blood cells subcutaneous radionuclide venography can apply to evaluate deep venous flow of lower extremities. We introduce additional abdominal/pelvic hybrid SPECT/CT (single-photon emission computed tomography with computed tomography) to scrutinize the proximal deep venous flow defects in the iliac vein. SPECT/CT imaging is collected when disturbed or asymmetrical iliac venous flow is noted on the planar imaging of Tc-99m-labeled red blood cells subcutaneous radionuclide venography. The region of SPECT/CT imaging includes abdominal aorta, inferior vena cava and bilateral iliac vessels. We present three cases with suspicion of deep vein thrombosis in the iliac vein. Tc-99m-labeled red blood cells subcutaneous radionuclide venography with SPECT/CT revealed not only provides us the venous flow but also other information including abnormal vessel structure, space-occupying lesion and abnormality in other organs. In conclusion, if disturbed or asymmetrical iliac venous flow and abnormal collateral venous drainage in the abdomen are noted on the Tc-99mlabeled red blood cells subcutaneous radionuclide venography, SPECT/CT imaging may arrange for further information and differential diagnosis of lower extremities swelling; not only in detecting deep vein thrombosis.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123916596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salvage Therapy for Prostate Cancer: Which is Best? Brachytherapyversus Open and Robotic Prostatectomy","authors":"S. Goonewardene","doi":"10.4172/2155-9619.1000290","DOIUrl":"https://doi.org/10.4172/2155-9619.1000290","url":null,"abstract":"No standard salvage therapy exists. The objective of salvage therapy is oncological control with minimum toxicity. Advances in functional imaging, including multi parametric prostate MRI and abdominopelvic lymphangio- MRI, have paved the way for salvage therapy in localised recurrence. To date there are no randomized clinical trials comparing HDR-BT with radical prostatectomy. Methods: We conduct as retrospective review over 20 years comparing outcomes of salvage brachytherapy compared to open and robotic radical prostatectomy, searching Embase and Medline. Results: Whilst robotic radical prostatectomy is a clear winner, there is also a role for salvage brachytherapy. Conclusions: The role of salvage therapies such as brachytherapy need to be further explored.","PeriodicalId":302578,"journal":{"name":"Journal of Nuclear Medicine and Radiation Therapy","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132896776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}