Comparison of [68Ga]Ga-PSMA-HBED-CC PET versus Whole-Body BoneScintigraphy for the Detection of Bone Metastases in Patients with ProstateCancer

Journal of Nuclear Medicine and Radiation Therapy Pub Date : 2016-08-16 DOI:10.4172/2155-9619.1000302

Schreiter, M. Gericke, Uwe Heimann, I. Steffen, L. Stelter, M. Maurer, B. Hamm, W. Brenner, D. Theilig, J. Kahn, Schreiter Nf

引用次数: 6

Abstract

Aim: To compare [68Ga]Ga-PSMA-HBED-CC PET and (99m)Tc-DPD bone scintigraphy for the detection of bone metastases from prostate cancer. Methods: [68Ga]Ga-PSMA-HBED-CC PET/CT and (99m)Tc-DPD bone scintigraphy in 19 men with histopathological proven prostate cancer were compared to each other for the sensitivity/specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) for the detection of bone metastases. Results: According to the standard of reference lesion-based analysis of [68Ga]Ga-PSMA-HBED-CC PET and (99m)Tc-DPD bone scintigraphy reached a sensitivity of 45.6%/34%, specificity of 86.4%/81.4%, accuracy of 60.5%/ 51.2%, positive predictive value of 85.5%/76.1%, and negative predictive value of 47.7%/41.4%, respectively. Conclusion: [68Ga]Ga-PSMA-HBED-CC PET could detect significantly more bone metastases in prostate cancer than (99m)Tc-DPD bone scintigraphy.

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[68Ga]Ga-PSMA-HBED-CC PET与全身骨显像检测前列腺癌骨转移的比较

目的:比较[68Ga]Ga-PSMA-HBED-CC PET与(99m)Tc-DPD骨显像对前列腺癌骨转移的检测效果。方法:比较[68Ga] ga - psma - hbead - cc PET/CT和(99m)Tc-DPD骨显像对19例经组织病理学证实的前列腺癌患者骨转移检测的敏感性/特异性、准确性、阳性预测值(PPV)和阴性预测值(NPV)。结果:根据参考病灶分析标准，[68Ga]Ga-PSMA-HBED-CC PET和(99m)Tc-DPD骨显像的敏感性为45.6%/34%，特异性为86.4%/81.4%，准确率为60.5%/ 51.2%，阳性预测值为85.5%/76.1%，阴性预测值为47.7%/41.4%。结论:[68Ga]Ga-PSMA-HBED-CC PET对前列腺癌骨转移的检出率明显高于(99m)Tc-DPD骨显像。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Nuclear Medicine and Radiation Therapy

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