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Electrochemistry of Cyclodextrin Inclusion Complexes of Pharmaceutical Compounds 药物化合物环糊精包合物的电化学研究
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-01 DOI: 10.2174/1875038901003010074
A. Radi, Shimaa Eissa
{"title":"Electrochemistry of Cyclodextrin Inclusion Complexes of Pharmaceutical Compounds","authors":"A. Radi, Shimaa Eissa","doi":"10.2174/1875038901003010074","DOIUrl":"https://doi.org/10.2174/1875038901003010074","url":null,"abstract":"Electrochemistry of cyclodextrins (CDs) and cyclodextrin inclusion complexes with different pharmaceutical compounds is reviewed. The article highlights some electrochemical investigations of the CD-drugs interactions in solution. Cyclodextrin modified electrodes and their applications as electrochemical sensors in pharmaceutical analysis based on the self-assembly of CD derivatives on metal electrodes and nanoparticles, and cyclodextrin-modified multiwalled carbon nanotubes are also discussed.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115272125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
A Spectrophotometric Method for Diosmin Determination 分光光度法测定薯蓣皂苷
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-01 DOI: 10.2174/1875038901003010123
Z. Moldovan, A. Bunaciu, M. Al-Omar, H. Aboul‐Enein
{"title":"A Spectrophotometric Method for Diosmin Determination","authors":"Z. Moldovan, A. Bunaciu, M. Al-Omar, H. Aboul‐Enein","doi":"10.2174/1875038901003010123","DOIUrl":"https://doi.org/10.2174/1875038901003010123","url":null,"abstract":"A rapid and sensitive spectrophotometric method for the determination of diosmin (D) has been developed. The method is based on the reaction of D with 4-aminoantipyrine (AAP) in the presence of hexacyanoferrate (III) (HCF) in an alkaline medium and subsequent formation of a purple coloured product havingmax at 524.5 nm. The conditions affecting the reaction (reagents concentration, pH, order of addition of reagents, stability in time) were optimized. Under the optimum conditions, Beer's law was obeyed in the range of 0.3 - 35 μg mL -1 D with a correlation coefficient of 0.9993. The assay limits of detection and quantitation were 0.1 and 0.3 μg mL -1 , respectively. The proposed method was successfully applied to the analysis of the drug tablets formulation. The results were compared favorably with those obtained by other reported methods.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117181090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
Utilization of Cyclodextrins by Trichoderma Species 木霉对环糊精的利用
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-01 DOI: 10.2174/1875038901003010090
Gyula Oros, A. Jakab, T. Cserháti
{"title":"Utilization of Cyclodextrins by Trichoderma Species","authors":"Gyula Oros, A. Jakab, T. Cserháti","doi":"10.2174/1875038901003010090","DOIUrl":"https://doi.org/10.2174/1875038901003010090","url":null,"abstract":"The growth and the development of thallus of 17 Trichoderma species have been determined by using native � -, � - and � -cyclodextrins (CDs) and 8 different CD derivatives as a unique carbon source. The majority of species can use CD for growth, this ability was related to their intragenic taxonomic position in order of sections Trichoderma > Longibrachiatum > Pachybasium > Saturnisporum T. reesei being the most and T. virens the least active. All CDs have been utilized but their nutritional value was significantly influenced by the chemical structure, the size of molecules had major importance than the flexibility of their rings. Among natural derivatives of CDs Trichodermas preferred the � - and � -CD prior to � -CD, when carboxylation led to reduction of the biodegradation of � - and � -CDs and enhanced that of � - CD. Methylation or polymerization of � -CD also modified its decomposition rate by considered Trichoderma species. As supported by applied a three-way principal components analysis (3D-PCA) the studied here Trichoderma species showed considerable deviations in their capacity to decompose CDs and the stability of CDs towards biodegradation was highly dependent on the chemical structure of CDs.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133551408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Voltammetric Sensor Based on Nano TiO2 Powder Modified Glassy Carbon Electrode for Determination of Dopamine 纳米TiO2粉体修饰玻碳电极伏安传感器测定多巴胺
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-01 DOI: 10.2174/1875038901003010115
R. Goyal, D. Kaur, A. Pandey
{"title":"Voltammetric Sensor Based on Nano TiO2 Powder Modified Glassy Carbon Electrode for Determination of Dopamine","authors":"R. Goyal, D. Kaur, A. Pandey","doi":"10.2174/1875038901003010115","DOIUrl":"https://doi.org/10.2174/1875038901003010115","url":null,"abstract":"Synthesis of TiO2 nanopowder via a low cost ultrasonic spray pyrolysis technique is reported and the nanopowder is used for the surface modification of glassy carbon electrode. The structural characterization of nanopowder by high temperature XRD clearly shows the phase transformation from anatase to rutile phase on increasing temperature. The morphological structure is characterized by field emission scanning electron microscope and high resolution transmission electron microscope. The modified electrode is used for the determination of dopamine in the presence of excess of ascorbic acid/ uric acid using square-wave voltammetry. The voltammograms obtained during the oxidation studies revealed that nano TiO2 exhibits better catalytic function towards the oxidation of dopamine and ascorbic acid/uric acid. The overlapping voltammetric response of all the biomolecules at the bare electrode gets resolved into well defined voltammetric peaks with lowered oxidation potential and enhanced oxidation currents. Linear calibration curves for dopamine are obtained over the concentration range 75 nM - 2.5 μM in 0.1M phosphate buffer solution at pH 7.2 with a correlation coefficient of 0.9940 and the detection limit (3� ) is estimated to be 13.8 nM.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121079581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Development of Biomimetic Sensor for Fast and Sensitive Detection of Norfloxacin 快速灵敏检测诺氟沙星的仿生传感器研制
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-01 DOI: 10.2174/1875038901003010098
D. Gobatto, Ademar Wong, M. Lanza, M. Sotomayor
{"title":"Development of Biomimetic Sensor for Fast and Sensitive Detection of Norfloxacin","authors":"D. Gobatto, Ademar Wong, M. Lanza, M. Sotomayor","doi":"10.2174/1875038901003010098","DOIUrl":"https://doi.org/10.2174/1875038901003010098","url":null,"abstract":"A biomimetic sensor is proposed as a promising new analytical method for determination of norfloxacin (NF) in pharmaceuticals. The sensor was prepared by modifying a glassy carbon electrode surface with a Nafion ® membrane doped with poly(copper phthalocyanine) complex (poly-CuPc). Amperometric measurements carried out with the sensor under an applied potential of -0.05 V vs Ag|AgCl in 0.1 mol L -1 acetic acid containing 1.5 � 10 -3 mol L -1 hydrogen peroxide showed a linear response range from 2.0 � 10 -4 to 1.2 � 10 -3 mol L -1 . Selectivity and interference studies were also performed. A sensor response mechanism is proposed, based on the experimental evidence. Recovery studies were carried out using environmental samples, in order to evaluate the sensor's potential for use with these sample classes. Finally, sensor performance was evaluated using analyses of commercial formulations.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128049886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Anodic Voltammetry of Ciprofloxacin and its Analytical Applications 环丙沙星的阳极伏安法及其分析应用
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-01 DOI: 10.2174/1875038901003010108
B. Uslu, Burçin Bozal, Mehmet Emin Kuscu
{"title":"Anodic Voltammetry of Ciprofloxacin and its Analytical Applications","authors":"B. Uslu, Burçin Bozal, Mehmet Emin Kuscu","doi":"10.2174/1875038901003010108","DOIUrl":"https://doi.org/10.2174/1875038901003010108","url":null,"abstract":"The electrooxidative behavior and determination of ciprofloxacin at a glassy carbon electrode were investigated using cyclic, linear sweep, differential pulse and square wave voltammetric techniques. The dependence of the peak current and peak potentials on pH, concentration, nature of buffer, and scan rate were examined. The oxidation of ciprofloxacin gave a single and irreversible peak at glassy carbon electrode. The process was diffusion controlled. A linear response was obtained between 1.0 � 10 -6 and 4.0 � 10 -5 M in 0.1 M sulphuric acid for both techniques. The recovery studies were also achieved to check selectivity and accuracy of the methods. The proposed methods were applied for the determination of ciprofloxacin from pharmaceutical dosage forms without any time-consuming extraction, separation, adsorption steps. The repeatability, reproducibility, precision and accuracy of the proposed methods were investigated.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130748485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Development and Validation of a Gas Chromatographic Method forIdentification and Quantification of Terpene Trilactones in Ginkgo bilobaL. Extract and Pharmaceutical Preparations 银杏中萜烯三内酯的气相色谱鉴定与定量方法的建立与验证。提取物及药物制剂
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-06-09 DOI: 10.2174/1875038901003010018
Lotfi Sayadi, Inès Missaoui, B. Jamoussi, Abdelmanef Abderraba
{"title":"Development and Validation of a Gas Chromatographic Method forIdentification and Quantification of Terpene Trilactones in Ginkgo bilobaL. Extract and Pharmaceutical Preparations","authors":"Lotfi Sayadi, Inès Missaoui, B. Jamoussi, Abdelmanef Abderraba","doi":"10.2174/1875038901003010018","DOIUrl":"https://doi.org/10.2174/1875038901003010018","url":null,"abstract":"A gas chromatographic method was developed and validated for the determination of bilobalide and ginkgolides A, B, C and J in Ginkgo biloba L. The Ginkgo terpene trilactones have been dissolved in 57% of pure ethanol in purified water and separated by extraction with a mixture of toluene/ethyl acetate. After evaporation of the solvent with nitrogen and derivatization, these chemical markers have been quantified using GC-FID. The intra-day RSD was ranged from 1.13% for bilobalide to 2.34% in case of ginkgolides. The inter-day RSD was ranged from 2.54% and 3.68% for, bilobalide and ginkgolides respectively. Mean recoveries were 99.78% ± 0.82% and 99.48% ± 0.86% for ginkgolides and bilobalide, respectively. Based on chromatograms, the response of the terpene trilactones was linearly dependent on the terpene concentration, i.e. linear calibration curve was found in the range of the method and was applied to analyze standard extract (containing 5-7% total terpenoids and 22-25% total flavonoids) as working standard and for the analysis of six Ginkgo pharmaceutical products offered on the market.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"137 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126980824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Determination of Vanadium (IV) and (V) in Southern Nevada Groundwater by Ion Chromatography-Inductively Coupled Plasma Mass Spectrometry 离子色谱-电感耦合等离子体质谱法测定内华达州南部地下水中的钒(IV)和(V)
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-05-11 DOI: 10.2174/1875038901003010010
Sujanie Gamage, V. Hodge, J. Cizdziel, Kazumasa Lindley
{"title":"Determination of Vanadium (IV) and (V) in Southern Nevada Groundwater by Ion Chromatography-Inductively Coupled Plasma Mass Spectrometry","authors":"Sujanie Gamage, V. Hodge, J. Cizdziel, Kazumasa Lindley","doi":"10.2174/1875038901003010010","DOIUrl":"https://doi.org/10.2174/1875038901003010010","url":null,"abstract":"A rapid method is presented for measuring V(IV) and V(V) in groundwater, without preconcentration or complexing agents, using direct injection of the water samples (which were collected under an argon atmosphere) into an ion chromatograph-inductively coupled plasma mass spectrometer (ICPMS). The mobile phase is 1.5% v/v nitric acid, which minimizes the buildup of solids in the ultrasonic nebulizer, the torch, and on the entrance cones of the ICPMS - a problem with methods using organic complexing agents and inorganic salts. The result is much less instrument downtime for cleaning the affected parts. Limits of detection are 0.02 � g L -1 for V(IV) and 0.06 � g L -1 for V(V). The pentavalent form of vanadium represents 98% to 99% of the vanadium in these Southern Nevada groundwater samples and ranges from 3.7±0.1 � g L -1 to 82.1±0.5 � g L -1 . The remaining few percent is V(IV). Total vanadium was determined by ICPMS","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116059663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Development and Optimization of an Electrospraying Device for the Continuous Collection of Nano- and Microparticles~!2009-12-01~!2010-01-29~!2010-04-14~! 纳米和微粒连续收集电喷涂装置的研制与优化2010-12-01 2010-01-29 2010-04-14
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-05-04 DOI: 10.2174/1875038901003010001
Dirk Grafahrend, P. Jungbecker, G. Seide, H. Leonards, T. Gries, M. Möller, D. Klee
{"title":"Development and Optimization of an Electrospraying Device for the Continuous Collection of Nano- and Microparticles~!2009-12-01~!2010-01-29~!2010-04-14~!","authors":"Dirk Grafahrend, P. Jungbecker, G. Seide, H. Leonards, T. Gries, M. Möller, D. Klee","doi":"10.2174/1875038901003010001","DOIUrl":"https://doi.org/10.2174/1875038901003010001","url":null,"abstract":"","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"6 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124435727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Investigations on the Photo-Transformation of Retinol Acetate 醋酸视黄醇光转化的研究
The Open Chemical and Biomedical Methods Journal Pub Date : 2009-09-02 DOI: 10.2174/1875038900902030111
Z. Szabadai, B. Maranescu, D. Dragoș
{"title":"Investigations on the Photo-Transformation of Retinol Acetate","authors":"Z. Szabadai, B. Maranescu, D. Dragoș","doi":"10.2174/1875038900902030111","DOIUrl":"https://doi.org/10.2174/1875038900902030111","url":null,"abstract":"Taking into account the advanced photosensitivity of some pharmaceutical substances, there are several special requirements for their use, storage and even their assay in pharmaceutical formulations. Despite numerous attempts made in order to characterize the intrinsic photo-transformation tendency of drugs, the problem is far to be solved satisfactorily. In this paper a model study is performed in the concrete case of retinol acetate (vitamin A), a compound with well-known photosensitivity, using a photochemical reactor of original conception. In the case of vitamin A, a single dominant photochemical process seems to be takes place, as suggested by HPLC UV-spectroscopy and chemometric processing of spectrophotometric data. An adequate interpretation of kinetic data allows to define and determine a rate constant suitable to express the intrinsic photo-instability, irrespective of some experimental factors such as initial concentration, the nature of solvent etc. The processing technique we have been used is suitable even in the case when the spectroscopic behavior of reaction product is unknown. The described strategy is based on the monomolecular pathway supposition, successfully tested in the case of vitamin A.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121792677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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