The Open Chemical and Biomedical Methods Journal最新文献

Ratio of Dense to Buoyant LDL Subclass is Associated with LDL Density Phenotype (VLDL-5) 高密度与浮力LDL亚类之比与LDL密度表型(VLDL-5)相关

The Open Chemical and Biomedical Methods Journal Pub Date : 2013-07-23 DOI: 10.2174/1875038901306010001

Haitham M Ahmed, M. Elshazly, S. Martin, M. Blaha, K. Kulkarni, S. Jones

{"title":"Ratio of Dense to Buoyant LDL Subclass is Associated with LDL Density Phenotype (VLDL-5)","authors":"Haitham M Ahmed, M. Elshazly, S. Martin, M. Blaha, K. Kulkarni, S. Jones","doi":"10.2174/1875038901306010001","DOIUrl":"https://doi.org/10.2174/1875038901306010001","url":null,"abstract":"Background: Dense LDL phenotypes are associated with increased atherogenicity, and are commonly evaluated for the purposes of atherosclerosis research and cardiovascular risk discrimination. Objective: To examine the ability of LDL subclasses, expressed as a ratio of dense-to-buoyant subclass, to predict LDL density phenotype. Methods: LDL subclasses and density phenotypes were measured with vertical auto profile ultracentrifugation in 1,339,898 consecutive lipid profiles between 2009 and 2011 from a clinical sample of US adults. Logarithmic LDL density ratio (LLDR) was calculated as ratio of dense-to-buoyant LDL subclasses, ln((LDL3-C + LDL4-C) / (LDL1-C +LDL2-C)); normally distributed after log-transformation. LLDR was compared to density phenotype using ROC C- statistic with optimum sensitivity and specificity cutpoints determined. Results: There was a strong, highly significant, monotonic increase in LLDR across progressively higher density phenotypes (p 0.905, sensitivity 81%, specificity 86%. There was also a positive correlation between LLDR and LDL Max Time (R 2 =0.802). Conclusion: LLDR is a convenient, easily calculated, and continuous variable that is strongly associated with LDL density phenotype and LDL Max Time. Further research is needed to investigate the relationship between lipoprotein density and size, and whether LLDR provides more cardiovascular risk discrimination than LDL density phenotype.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121201701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Potentiometric Method for Evaluating the Oxidant/Antioxidant Activity of Seminal and Follicular Fluids and Clinical Significance of this Parameter for Human Reproductive Function 评价精液和卵泡液氧化/抗氧化活性的电位法及其对人类生殖功能的临床意义

The Open Chemical and Biomedical Methods Journal Pub Date : 2012-03-19 DOI: 10.2174/1875038901205010001

K. Brainina, E. Gerasimova, D. P. Varzakova, S. Balezin, I. Portnov, V. A. Makutina, E. V. Tyrchaninova

引用次数: 18

A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples 分子印迹聚合物用于选择性固相萃取尿液样品中的布洛芬

The Open Chemical and Biomedical Methods Journal Pub Date : 2011-12-02 DOI: 10.2174/1875038901004010007

A. Lagha

{"title":"A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples","authors":"A. Lagha","doi":"10.2174/1875038901004010007","DOIUrl":"https://doi.org/10.2174/1875038901004010007","url":null,"abstract":"A molecularly imprinted polymer (MIP) was synthesized and evaluated to selectively extract ibuprofen, a non- steroidal anti-inflammatory drug (NSAID), from human urine. The synthesis of the MIP was performed in dimethylformamide with acrylamide as functional monomer, ethylene glycol dimethacrylate as the cross linker and ibuprofen template as the target drug. The performance of the synthesized MIP as solid phase extraction (SPE) packing to recognize and bind ibuprofen was evaluated against other structurally related NSAIDs such as naproxen and ketoprofen. Using a mixture of acetonitrile-water (1/9 v/v) as a solvent for ibuprofen the binding recovery at approximately 90% was obtained for developed MIP in optimized conditions. Batch rebinding capacity of ibuprofen was determined from the derived Freundlich isotherm and was found to be 1.45 � mol g -1 . Furthermore, a higher selectivity of developed MIP for ibuprofen over structurally related analogues was observed. The synthesized MIP has enabled the direct percolation of humane urine and the easy elimination of endogenous compounds from it with simple aqueous washing of the MIP-SPE packing. HPLC analysis has confirmed the high extraction recovery (ca. 85 %) of ibuprofen from such urine samples with use of proposed MIP-SPE system.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122322071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Possible Association of Altered Serum Lipids in Obese Adult Females with Adenoviral Infection 肥胖成年女性血脂改变与腺病毒感染的可能关联

The Open Chemical and Biomedical Methods Journal Pub Date : 2011-09-12 DOI: 10.2174/1875038901004010001

A. Jaworowska

{"title":"Possible Association of Altered Serum Lipids in Obese Adult Females with Adenoviral Infection","authors":"A. Jaworowska","doi":"10.2174/1875038901004010001","DOIUrl":"https://doi.org/10.2174/1875038901004010001","url":null,"abstract":"The aim of this pilot study was to investigate the possible role of adenovirus infection in etiology of obesity. Antibodies (IgG, IgA, IgM) to adenovirus were determined in a total of 71 Caucasian, apparently healthy, middle aged (mean 45.9 ± 13.6 years), living in urban area, cohort of women - including overweight/obese (OW/OB, n = 50) and normal weight (NW, n = 21) group - by using serotype non-specific enzyme linked immunosorbent assay (ELISA). Triglycerides (TG), total- (TChol) and HDL-cholesterol (HDLChol) concentrations in collected serum samples were performed by standard enzymatic methods. The level of LDL cholesterol (LDLChol) was calculated using the Friedewald formula. Anthropometric measurements were taken and body mass index (BMI), percentage of fat mass (%FM) and waist-to-hip ratio (WHR) were calculated. There were no associations (p > 0.05) observed between IgG + or IgA + seropositivity for adenovirus and measured obesity indicators as BMI, %FM, WHR in studied female groups. However, in the group of OW/OB subjects with combined seropositivity (IgG + /IgA + ) - both for IgG and IgA antibodies to adenovirus - which suggest chronic adenoviral infection the significantly (p < 0.05) lower serum TG, TChol and LDLChol concentrations have been observed in comparison with the seronegative (IgG - /IgA - ) females from the OW/OB and NW group of females. Findings of our pilot study suggest that infection of some adenoviruses may predispose to altered serum lipids in some adult OW/OB females. Further studies should be made to critically evaluate this association and its possible consequences to currently accepted protocols for obesity prevention and treatment. Especially, in this group of OW/OB females, the involvement of measurements of the serotype-specific neutralizing antibodies to adenovirus or isolation/identification of specific adenovirus like particles in serum and adipose tissue using convective interaction media (CIM) monolithic column technology should be advisable.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124057307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluvial Transport of Chernobyl Plutonium (Pu) to the Black Sea: Evidence from 240Pu/239Pu Atom Ratios in Danube Delta Sediments 切尔诺贝利钚(Pu)向黑海的河流输送:多瑙河三角洲沉积物中240Pu/239Pu原子比的证据

The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-03 DOI: 10.2174/1875038901003010197

M. Ketterer, S. Gulin, Gary D. MacLellan, W. J. Hartsock

引用次数: 12

Editorial Inductively Coupled Plasma Mass Spectrometry (ICP-MS)for Environmental Monitoring and Fingerprinting 电感耦合等离子体质谱(ICP-MS)用于环境监测和指纹识别

The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-03 DOI: 10.2174/1875038901003010133

J. Cizdziel

{"title":"Editorial Inductively Coupled Plasma Mass Spectrometry (ICP-MS)for Environmental Monitoring and Fingerprinting","authors":"J. Cizdziel","doi":"10.2174/1875038901003010133","DOIUrl":"https://doi.org/10.2174/1875038901003010133","url":null,"abstract":"This Hot Topic issue of “The Open Chemical and Biomedical Methods Journal” is devoted to applications of Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in environmental monitoring and fingerprinting. ICP-MS has become a common method for monitoring environmental quality and processes, and for fingerprinting of natural and anthropogenic pollution sources because of its multi-elemental capability, high sensitivity, low detection limits and capability to measure isotopes. The papers herein span a wide range of interesting applications, from monitoring trace elements in atmospheric particulate matter and biota to fingerprinting sources of naturally occurring radioactive material (NORM) and historical air pollution to determining the provenance of food supply to improving sample preparation and analysis schemes. As is always the case, knowledge of the fundamentals of the instrument and technique (i.e., ICP-MS) is invaluable to obtain accurate data and avoid many of the pitfalls (e.g., matrix effects, isobaric interferences, instrumental drift) that can lead to poor data quality and misleading information. Thus, another objective of this issue is to show how different researchers effectively use ICP-MS, both solutionand laser-based, for diverse environmental samples and applications.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114068428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Combining Helium Collision Mode, Aerosol Dilution and Discrete Sampling to Maximize Matrix Tolerance and Productivity in ICP-MS Analysis of Environmental Samples 结合氦碰撞模式，气溶胶稀释和离散采样，以最大限度地提高ICP-MS分析环境样品的基质容忍度和生产率

The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-03 DOI: 10.2174/1875038901003010135

S. Wilbur, L. Jones

引用次数: 10

The application of solution and laser ablation based ICP-MS and solution based AES for the provenance determination of selected food and drink produce 采用溶液和激光烧蚀等离子体质谱法和溶液原子发射光谱法测定食品饮料产品的来源

The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-03 DOI: 10.2174/1875038901003010179

R. Watling, Garry S. H. Lee, C. Scadding, Tamara S. Pilgrim, R. Green, Alexander E. Martin, C. D. May, Jenna L. Valentin

{"title":"The application of solution and laser ablation based ICP-MS and solution based AES for the provenance determination of selected food and drink produce","authors":"R. Watling, Garry S. H. Lee, C. Scadding, Tamara S. Pilgrim, R. Green, Alexander E. Martin, C. D. May, Jenna L. Valentin","doi":"10.2174/1875038901003010179","DOIUrl":"https://doi.org/10.2174/1875038901003010179","url":null,"abstract":"The provenance identification of selected types of food and drink was undertaken from data obtained using both solution and laser ablation based inductively coupled plasma mass spectrometry (ICP-MS) and solution based inductively coupled plasma atomic emission spectroscopy (ICP-AES) analysis of selected food and drink materials (pork, wine, tea, coffee and olive oil). Quantitative determination of up to 55 elements was undertaken using solution based ICP- MS and AES while counts per second data for 49 elements was used for samples analyzed using Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS). ICP-AES was used to determine the concentrations of Na, K, Ca, Mg and Fe where appropriate. A quantitative analytical methodology for LA-ICP-MS analysis of olive oil was also developed and preliminary trials undertaken. Additional information, to establish more detailed geographic resolution in provenance determination, especially for tea and coffee (plantation of origin), was provided by the incorporation of data for light stable isotope distribution patterns ( 2 H (D), 13 C and 15 N). LA-ICP-MS was used for the direct analysis of olive oil and coffee beans. The use of laser ablation for the analysis of olive oil has the potential to overcome problems associated with both acid dissolution and thermal oxidation of this material, which are the traditional methods of sample dissolution and which either introduce significant contamination or cause the loss of volatile organo-metallic compounds that may be indicative for provenance determination. Results from the overall study indicated that it was possible not only to establish country of origin of the study materials but also in some cases to improve resolution of provenance to state of origin (wine and pork), and even plantation of origin (tea and coffee).","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126471775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Unusually Radiogenic Lead (Pb) in Ashtabula River Sediments: An Isotopic Tracing Case Study Using Quadrupole ICP-MS Ashtabula河沉积物中异常放射性成因铅(Pb):四极ICP-MS同位素示踪案例研究

The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-03 DOI: 10.2174/1875038901003010202

M. Ketterer, David A. Lane, James A Jordan

{"title":"Unusually Radiogenic Lead (Pb) in Ashtabula River Sediments: An Isotopic Tracing Case Study Using Quadrupole ICP-MS","authors":"M. Ketterer, David A. Lane, James A Jordan","doi":"10.2174/1875038901003010202","DOIUrl":"https://doi.org/10.2174/1875038901003010202","url":null,"abstract":"Unusually radiogenic Pb has been found in sediments of a portion of the Ashtabula River (80 o 48' W, 41 o 54' N) near its confluence with Lake Erie. Pb isotopic compositions have been determined by quadrupole ICPMS, revealing that the Pb results from mixing of three sources: crustal Pb, common Pb from industrial pollutant sources, and highly radiogenic Pb associated with U-containing accessory minerals in a Ti ore refining process discharge. Crustal Pb and anthropogenic pollutant common Pb exhibit 206 Pb/ 204 Pb ratios of ~ 19, in agreement with findings from published Lake Erie sediment studies. Horizons containing > 10 ppm U exhibit elevated 206 Pb/ 204 Pb ratios (23.88 ± 2.57, n = 11) which cannot be accounted for by anthropogenic common Pb sources. Increases in 206 Pb/ 204 Pb are not accompanied by corresponding increases in 208 Pb/ 204 Pb, with the exception of one horizon that contains 96 ppm Th. The 206 Pb/ 204 Pb is correlated with the U concentration (r 2 = 0.902). A small tributary of the Ashtabula River, Fields Brook, is the apparent point of origin of the U, Th and radiogenic Pb in the Ashtabula River sediments. These findings demonstrate that the Pb isotopic composition in the environment is subject to local influences from naturally occurring radioactive material sources.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116848105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Validation of a Simple Microwave-Assisted Acid Digestion Method Using Microvessels for Analysis of Trace Elements in Atmospheric PM2.5 in Monitoring and Fingerprinting Studies 微波辅助酸消化方法在大气PM2.5微量元素监测和指纹分析中的应用验证

The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-03 DOI: 10.2174/1875038901003010143

V. Celo, E. Dabek-Zlotorzynska, David Mathieu, Irina Okonskaia

{"title":"Validation of a Simple Microwave-Assisted Acid Digestion Method Using Microvessels for Analysis of Trace Elements in Atmospheric PM2.5 in Monitoring and Fingerprinting Studies","authors":"V. Celo, E. Dabek-Zlotorzynska, David Mathieu, Irina Okonskaia","doi":"10.2174/1875038901003010143","DOIUrl":"https://doi.org/10.2174/1875038901003010143","url":null,"abstract":"Two microwave-assisted digestion procedures, followed by inductively coupled plasma mass spectrometry (ICP-MS) analysis, were evaluated for the determination of trace elements in fine atmospheric aerosols (PM2.5) for air monitoring purposes. The first procedure used 40%(v/v) HNO3 and a digestion program with a maximum temperature of 175 o C. The second digestion procedure provided the dissolution of silicate matrix through the use of a mixture of HNO3/HF/H3BO3 at 200 o C. Both digestion procedures employed microvessels (MicroVessel TM ), which significantly reduced the amount of reagents needed, and increased the sample throughput by two-fold. The effectiveness of both digestion procedures was studied through the analysis of NIST standard reference materials (SRM), namely SRM 2783 (PM2.5 Air Particulate Matter deposited on a polycarbonate filter membrane), and SRM 1648 (Urban Particulate Matter). The accuracy was also checked through the analysis of co-located ambient PM2.5 samples collected within the Canadian National Air Pollution Surveillance (NAPS) network. Comparison of analytical results for PM2.5 samples showed that 40% (v/v) HNO3 could dissolve most of the metals of interest to the same degree as the HNO3/HF/H3BO3 mixture. Good agreement was also obtained by comparison with Energy Dispersive X-ray Fluorescence Spectrometry (ED-XRF). The efficiency of the simple microwave digestion procedure (no HF) was not dependent on the origin, mass loading, or elemental composition of the analyzed samples, thus it is quite suitable for monitoring purposes. However, the total dissolution of several trace elements such as Ti, Cr and U in PM2.5, and Ti, Cr, Al, lanthanides, and Sb in coarse fractions of PM (PM10-2.5) would require digestion in the presence of HF.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"262 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122930893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45