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Application of ICP-MS to Examining the Utility of Skin as a Monitoring Tissue for Trace Elements in Bottlenose Dolphin, Tursiops Truncatus ICP-MS在宽吻海豚皮肤微量元素监测中的应用
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-03 DOI: 10.2174/1875038901003010169
Colleen E Bryan, S. Christopher, W. Mclellan, ames V. McFee, L. Schwacke, R. Wells
{"title":"Application of ICP-MS to Examining the Utility of Skin as a Monitoring Tissue for Trace Elements in Bottlenose Dolphin, Tursiops Truncatus","authors":"Colleen E Bryan, S. Christopher, W. Mclellan, ames V. McFee, L. Schwacke, R. Wells","doi":"10.2174/1875038901003010169","DOIUrl":"https://doi.org/10.2174/1875038901003010169","url":null,"abstract":"Collision cell technology inductively coupled plasma mass spectrometry (CCT-ICP-MS) was applied to answer fundamental questions about the utility of bottlenose dolphin skin as a monitoring tissue for trace element concentrations. Bottlenose dolphin skin samples were obtained from two freshly dead animals during necropsies. The samples were collected from twelve standardized locations across each animal, representing a significant spatial surface area to test among site trace element concentration variability. Skin biopsy samples were analyzed for As, Cd, Cu, Mn, Mo, Pb, Rb, Se, Sr, V and Zn concentrations by CCT-ICP-MS, and Hg concentrations were separately measured by atomic fluorescence spectrometry (AFS). Wet mass concentrations ranged from > 100 μg/g (Zn) to < 0.0100 μg/g (V, Mo, Cd, and Pb). Relative standard deviations of less than 20% among sample sites were observed for Cu, As, Se, and Hg, demonstrating that deposition of these elements may be tightly regulated in skin tissue. Multifactor mixed-effect analysis of variance analyses (ANOVA) showed significant effects (p < 0.05) longitudinally (dorsal-ventral) for Cu, Mo, Ru, Se, V, and Zn indicating that standardized sample collection sites may be needed for comparative evaluation of these elements between animals, due to relatively heterogeneous distribution in skin.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134005766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Elemental Analysis of Desert Varnish Samples in the Vicinity of Coal- Fired Power Plants and the Nevada Test Site Using Laser Ablation ICPMS 利用激光烧蚀ICPMS对燃煤电厂及内华达试验场附近沙漠清漆样品进行元素分析
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-03 DOI: 10.2174/1875038901003010153
P. Nowinski, V. Hodge, Kazumasa Lindley, J. Cizdziel
{"title":"Elemental Analysis of Desert Varnish Samples in the Vicinity of Coal- Fired Power Plants and the Nevada Test Site Using Laser Ablation ICPMS","authors":"P. Nowinski, V. Hodge, Kazumasa Lindley, J. Cizdziel","doi":"10.2174/1875038901003010153","DOIUrl":"https://doi.org/10.2174/1875038901003010153","url":null,"abstract":"Desert varnish is a thin manganese-iron rich dark coating that forms on rocks most often in arid climates. This coating may be up to a few hundred microns in thickness and is thought to grow by approximately one micron per thousand years. Recent research has shown that many elements are incorporated into this coating, and, in spite of its slow growth, it may serve as a passive environmental monitor for recent and historical air pollution. To test this hypothesis, small pieces of varnished rock were probed directly by laser ablation inductively coupled plasma mass spectrometry (LA- ICPMS). Results were obtained for 11 elements (13 isotopes: 9 Be, 107 Ag, 111 Cd, 118 Sn, 121 Sb, 138 Ba, 184 W, 205 Tl, 206 Pb, 207 Pb, 208 Pb, 232 Th, and 238 U) by magnetic sector ICPMS and for 23 elements (25 isotopes: same as before plus 51 V, 52 Cr, 59 Co, 60 Ni, 65 Cu, 66 Zn, 88 Sr, 98 Mo, 115 In, 133 Cs, 197 Au, and 209 Bi) by quadrupole ICPMS. Varnished rock samples were collected mainly in the fallout patterns of two coal-fired power plants and downwind from the Nevada Test Site (NTS). The LA-ICPMS data indicate that many of the elements commonly found in fly ash from coal-fired power plants (e.g., Cr, Co, Ni, Cu, Zn, Cd, Sn, Sb, Tl and Pb) were highly enriched in the rock coatings in relation to the upper continental crust (UCC). For one of the power plants, where tracer plume studies had been carried out, the highest concentrations in the rock varnish coincide with the peak tracer concentration locations. Thus, these elements in rock varnish hold promise for identifying those geographical regions impacted by nearby power plants. Overall, the results indicate that rock varnish can be used as a passive environmental monitor of relatively recent events, and that the trace element fingerprints held in rock varnish may also hold much potential in forensic air pollution studies.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124522741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Application of Electrochemical Methods for Analysis of Fluoroquinolones Antibacterial Agents and Fluoroquinolones-DNA Interactions 电化学方法在氟喹诺酮类抗菌剂及氟喹诺酮类与dna相互作用分析中的应用
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-01 DOI: 10.2174/1875038901003010027
A. Radi
{"title":"Application of Electrochemical Methods for Analysis of Fluoroquinolones Antibacterial Agents and Fluoroquinolones-DNA Interactions","authors":"A. Radi","doi":"10.2174/1875038901003010027","DOIUrl":"https://doi.org/10.2174/1875038901003010027","url":null,"abstract":"This mini review describes the results regarding the voltammetric determination of micromolar, submicromolar and nanomolar concentrations of various fluoroquinolones antibacterial agents using both traditional hanging mercury drop electrode, carbon paste electrode, glassy carbon paste electrode and chemically modified electrodes. We concentrate on the interaction of quinolones with DNA in solution and at electrode surface in the context of the general development in the field.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123391877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Editorial - Nanosized Analytical Devices for Biomedical and Pharmaceutical Applications 编辑-生物医学和制药应用的纳米分析装置
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-01 DOI: 10.2174/1875038901003010025
S. Ozkan
{"title":"Editorial - Nanosized Analytical Devices for Biomedical and Pharmaceutical Applications","authors":"S. Ozkan","doi":"10.2174/1875038901003010025","DOIUrl":"https://doi.org/10.2174/1875038901003010025","url":null,"abstract":"Analytical methods provide all the other disciplines such as biology, pharmaceutical chemistry, pharmaceutical technology, biotechnology and many other fields with data on the character and amount of chemical species contained in natural and manmade objects and on the distribution of these species in space and time. Within the last decade, very rapid changes have taken place in analytical sciences, nanomaterials and pharmaceutical industry activities. Among these, the impact of developments in analytical and computer sciences, nanotechnology and medical sciences have also added tremendous challenges to pharmaceuticals and their applications. We all know what we are facing new challenges everyday in our mutual applications. Developments in nanoscience and nanotechnology have already had a far-reaching impact in traditional analytical chemistry, opening a new era in analytical methodology and instrumentation. The new nano-sensors allow biological assays with a higher sensitivity and throughput than those for conventional analytical methods.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"51 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132359243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enantioselective Potentiometric Membrane Eectrodes Based on α-, β- and γ-Cyclodextrins as Chiral Selectors for the Assay of S-Deprenyl 基于α-、β-和γ-环糊精作为手性选择体的对映选择电位膜电极测定s -去戊烯基
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-01 DOI: 10.2174/1875038901003010086
Raluca-Ioana Stefan-van-Staden, Tumelo R. Mashile, J. F. Staden, H. Aboul‐Enein
{"title":"Enantioselective Potentiometric Membrane Eectrodes Based on α-, β- and γ-Cyclodextrins as Chiral Selectors for the Assay of S-Deprenyl","authors":"Raluca-Ioana Stefan-van-Staden, Tumelo R. Mashile, J. F. Staden, H. Aboul‐Enein","doi":"10.2174/1875038901003010086","DOIUrl":"https://doi.org/10.2174/1875038901003010086","url":null,"abstract":"Enantioselective, potentiometric membrane electrodes (EPMEs) based on � -, � - and � -cyclodextrins (CDs) as chiral selectors were proposed for the assay of S-deprenyl. The response characteristics proved that the proposed EPMEs could be reliably used in the assay of S-deprenyl. The best slope is exhibited by the EPME based on � -cyclodextrin. The limits of detection are very low: 10 -9 mol L -1 magnitude order for � -cyclodextrin based EPME, and 10 -11 mol L -1 magnitude order for � -, and � -cyclodextrins based EPMEs. The surfaces of the electrodes are stable and easily renewable by polishing on alumina paper.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"269 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133632647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radioactive Measurements as an Indicator of Metabolic Fluxes in Myocytes 放射性测量作为肌细胞代谢通量的指标
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-01 DOI: 10.2174/1875038901003010128
A. Onay-Beşikci
{"title":"Radioactive Measurements as an Indicator of Metabolic Fluxes in Myocytes","authors":"A. Onay-Beşikci","doi":"10.2174/1875038901003010128","DOIUrl":"https://doi.org/10.2174/1875038901003010128","url":null,"abstract":"Physiological, pathological and pharmacological alterations in energetic substrate metabolism have been known to contribute to effective functioning of an organ. Hence, pharmacological interventions have been shown to improve clinical symptoms of certain pathologies, such as ischemic heart disease. In order to manipulate metabolism, however, one has to be able to correctly measure and know the contribution of a particular pathway to energy production. Many methods have been developed and adapted to a wide range of techniques. Radioactive substrates have been utilized for many laboratories with success. We adapted, from well established radioactive techniques, measurements for glycolysis and glucose oxidation in C2C12 myocytes. We believe that the technique is straightforward and allows the researcher to manipulate according to the needs of the laboratory.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127151939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automated Determination of Pharmaceutically and Biologically Active Thiols by Sequential Injection Analysis: A Review 序进分析自动测定药用和生物活性硫醇的研究进展
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-01 DOI: 10.2174/1875038901003010037
P. Tzanavaras
{"title":"Automated Determination of Pharmaceutically and Biologically Active Thiols by Sequential Injection Analysis: A Review","authors":"P. Tzanavaras","doi":"10.2174/1875038901003010037","DOIUrl":"https://doi.org/10.2174/1875038901003010037","url":null,"abstract":"The present review article presents and discusses automated sequential injection (SI) based methods for the determination of pharmaceutically and biologically important thiols, namely cysteine, N-acetylcysteine, penicillamine, glutathione and captopril. The review intends to cover a range of ten years of published research on this topic (2000 - 2009). The methods are classified according to the detection systems in three categories, namely spectrophotometric, fluorimetric and electroanalytical. The determination principles of the methods are discussed and the main analytical figures of merit are tabulated.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"135 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114872975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
MEET THE GUEST EDITOR 认识一下特邀编辑
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-01 DOI: 10.2174/1875038901003010132
S. Ozkan
{"title":"MEET THE GUEST EDITOR","authors":"S. Ozkan","doi":"10.2174/1875038901003010132","DOIUrl":"https://doi.org/10.2174/1875038901003010132","url":null,"abstract":"Sibel A. Ozkan studied at Ankara University, from where she received her Pharmacy degree in 1985. She obtained her Master’s (1988) and PhD (1994) degrees in the same university, Analytical Chemistry Department. She has become full professor 2003. She has been involved in several analytical chemistry projects related to electroanalytical chemistry and separation techniques on drug active compounds and DNA-Drug interactions. She has organized and participated in organizing committees of a number of international meetings related to Pharmaceutical Sciences (Series of ISOPS-Ankara-Turkey). Her research interest focuses on the electrochemical investigations of pharmaceutically active compounds and their analysis using electroanalytical, chromatographic and spectrophotometric methods, and their validations. Her research area currently moves to the development of DNA biosensors and their interactions with drugs. She is currently a faculty member at the Analytical Chemistry Department at Faculty of Pharmacy, Ankara University.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131137384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chiral Analyses of Pollutants by Capillary Electrophoresis 毛细管电泳分析污染物的手性
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-01 DOI: 10.2174/1875038901003010046
I. Ali, T. Khan, H. Aboul‐Enein, I. B. Kuznetsov, Asim Mohd
{"title":"Chiral Analyses of Pollutants by Capillary Electrophoresis","authors":"I. Ali, T. Khan, H. Aboul‐Enein, I. B. Kuznetsov, Asim Mohd","doi":"10.2174/1875038901003010046","DOIUrl":"https://doi.org/10.2174/1875038901003010046","url":null,"abstract":"The determination of enantiomeric composition of chiral xenobiotics and pollutants is a very difficult job due to their low amounts and poor detection by commonly used UV detector. But this sort of analysis is an important issue from the health point of view. The chiral analyses of these notorious pollutants by capillary electrophoresis have been discussed in this article. This review discusses the new trends and advancements, which have been achieved in the analyses of chiral pollutants using capillary electrophoresis and the state-of-art of their enaniomeric resolution. This article focuses on sample treatment, applications, optimization, detection, mechanisms of chiral resolution and future perspectives of CE in chiral resolution of xenobiotics. Besides, efforts have also been made to suggest the improvement in CE machine to make it ideal for the analyses of chiral xenobiotics at trace levels.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128184963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
The Analytical Applications of Square Wave Voltammetry on Pharmaceutical Analysis 方波伏安法在药物分析中的应用
The Open Chemical and Biomedical Methods Journal Pub Date : 2010-11-01 DOI: 10.2174/1875038901003010056
B. DOĞAN-TOPAL, S. Ozkan, B. Uslu
{"title":"The Analytical Applications of Square Wave Voltammetry on Pharmaceutical Analysis","authors":"B. DOĞAN-TOPAL, S. Ozkan, B. Uslu","doi":"10.2174/1875038901003010056","DOIUrl":"https://doi.org/10.2174/1875038901003010056","url":null,"abstract":"Compared to other voltammetric techniques a square wave voltammetry (SWV), which is presented in this minireview, has a several advantages such as high speed, increased analytical sensitivity and relative insensitivity to the presence of dissolved oxygen. Also it is an electrochemical technique used in analytical applications and fundamental studies of electrode mechanism. This paper delivers both the underlying theory and the practical guidance needed to apply square wave techniques and also provides a wide collection of data for the description of diverse tendencies that characterize several electrochemical reactions analyzed by SWV. This review summarizes some of the recent developments and application of direct and stripping SWV for drug compounds in their dosage forms and biological samples as reported in the period from 1997 till 2010 year.","PeriodicalId":302199,"journal":{"name":"The Open Chemical and Biomedical Methods Journal","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121919202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 67
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