{"title":"Feasibility and outcomes of colorectal cancer surgery in patients aged 85 and older.","authors":"Ryosuke Aoki, Hiroyuki Yamada, Ryoichiro Kobayashi, Tsuyoshi Shinohara, Yoshiro Fujimori","doi":"10.23736/S2724-5691.26.11111-3","DOIUrl":"https://doi.org/10.23736/S2724-5691.26.11111-3","url":null,"abstract":"<p><strong>Background: </strong>With the changing age distribution, the number of elderly patients with colorectal cancer is expected to increase. Postoperative morbidity and mortality rates are reported to be higher in elderly patients; however, surgical resection remains the only option to preserve quality of life and prolong survival. This study aimed to evaluate the feasibility of colorectal surgery in patients aged 85 years and older based on postoperative outcomes.</p><p><strong>Methods: </strong>A total of 477 patients who underwent surgery for colorectal cancer were categorized into two groups: the 75-84 years group (N.=362) and the ≥85 years group (N.=115). Preoperative comorbidities, operative outcomes, postoperative complications, and long-term survival were analyzed retrospectively.</p><p><strong>Results: </strong>Regarding preoperative comorbidities, dementia was significantly more prevalent in the ≥85 years group than in the 75-84 years group (P=0.002). In terms of laboratory findings, preoperative hemoglobin and serum albumin levels were significantly lower in the ≥85 years group than in the 75-84 years group (P=0.001 and P<0.001, respectively). The incidence of postoperative pneumonia and delirium was significantly higher in the ≥85 years group than in the 75-84 years group (P=0.001and P=0.011, respectively). The mean postoperative survival of patients aged ≥85 years exceeded six years.</p><p><strong>Conclusions: </strong>In colorectal cancer patients aged 85 and older with dementia, the incidence of postoperative pneumonia is high; therefore, cognitive function assessment is essential when considering surgery.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":"81 3","pages":"176-187"},"PeriodicalIF":1.3,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva SurgeryPub Date : 2026-04-01Epub Date: 2023-11-21DOI: 10.23736/S2724-5691.23.10102-X
Jiajun Gu, Lina Ji, Xiuling Lu, Jiefei Song
{"title":"Exploring the optimization of outpatient processes in the context of digitalization.","authors":"Jiajun Gu, Lina Ji, Xiuling Lu, Jiefei Song","doi":"10.23736/S2724-5691.23.10102-X","DOIUrl":"10.23736/S2724-5691.23.10102-X","url":null,"abstract":"","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":"146-149"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva SurgeryPub Date : 2026-04-01Epub Date: 2026-05-06DOI: 10.23736/S2724-5691.26.11078-8
Nasser Alrashidi
{"title":"Clinicopathologic characteristics and surgical outcomes of remnant gastric cancer: a comparative study of minimally invasive approaches.","authors":"Nasser Alrashidi","doi":"10.23736/S2724-5691.26.11078-8","DOIUrl":"10.23736/S2724-5691.26.11078-8","url":null,"abstract":"<p><strong>Background: </strong>Remnant gastric cancer (RGC), a malignancy arising in the gastric stump after partial gastrectomy, presents unique diagnostic and surgical challenges. The aim of the study is to recognize the clinicopathologic characteristics of the florescent (FL) and non-FL groups in RGC patients.</p><p><strong>Methods: </strong>This study retrospectively analyzed the clinicopathologic characteristics and surgical outcomes of 68 patients with RGC from 2014 to 2024 who underwent curative resection, comparing two distinct minimally invasive surgical approaches: the FL group (N.=31) and the non-FL group (N.=37). Baseline demographics, prior gastrectomy history, and tumor characteristics were comparable between the two cohorts.</p><p><strong>Results: </strong>The only statistically significant difference observed was in the operation method, with the FL group showing a significantly higher proportion of robotic-assisted surgery (61.3% vs. 24.3%, P=0.002). Although the FL group had a longer mean operation time (275.0 vs. 251.7 minutes, P=0.163), it demonstrated favorable trends toward lower estimated blood loss (100 vs. 120 mL, P=0.098) and shorter hospital stay (6 vs. 7 days, P=0.089). Postoperative complication rates and mortality were similar and acceptable in both groups.</p><p><strong>Conclusions: </strong>These findings suggest that while the FL approach, characterized by a higher utilization of robotic technology, is associated with a longer operative duration, it may offer marginal benefits in perioperative metrics for the complex surgery of RGC, underscoring the feasibility and safety of advanced minimally invasive techniques in this challenging patient population.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":"98-102"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva SurgeryPub Date : 2026-04-01DOI: 10.23736/S2724-5691.26.11116-2
Marco Palucci, Gabriela Del Angel-Millán, Fabio Giannone, Serena Penpa, Annalisa Roveta, Gianluca Cassese, Fabrizio Panaro
{"title":"Fully robotic liver transection using harmonic ACE curved shears: technical refinements, early insights, and challenges during the initial phase of robotic program implementation.","authors":"Marco Palucci, Gabriela Del Angel-Millán, Fabio Giannone, Serena Penpa, Annalisa Roveta, Gianluca Cassese, Fabrizio Panaro","doi":"10.23736/S2724-5691.26.11116-2","DOIUrl":"https://doi.org/10.23736/S2724-5691.26.11116-2","url":null,"abstract":"<p><strong>Background: </strong>Robotic liver surgery is rapidly evolving, but its standardization is limited by the lack of dedicated instruments for parenchymal transection. The Harmonic ACE Curved Shears are widely used; however, guidance on optimizing their use and a clear assessment of their advantages and limitations are lacking. This study evaluates the strengths and limitations of this transection method in a newly established robotic hepatopancreatobiliary (HPB) centre, based on surgical outcomes.</p><p><strong>Methods: </strong>Patients undergoing robotic liver resection between February and December 2024 were included. Parenchymal transection was performed using a \"one-surgeon, fully robotic technique\" with the Harmonic ACE Curved Shears. Intraoperative and postoperative data - including operative time, blood loss, clamping time, complications, and hospital stay - were prospectively collected and retrospectively analyzed.</p><p><strong>Results: </strong>Sixteen robotic hepatectomies were performed (15 minor, 1 major) for benign and malignant conditions. Median blood loss was 25 mL (IQR 0-325), mean operative time 341±120 minutes, and median clamping time was 8 minutes (IQR 0-56). Fifteen patients had an uneventful postoperative course, with a mean hospital stay of 5.2±2.8 days. One patient developed a grade B biliary fistula. No 30-day mortality or readmissions occurred.</p><p><strong>Conclusions: </strong>The fully robotic technique using Harmonic ACE Curved Shears is safe, effective, and reproducible. It replicates the crush-clamp technique and mimics other transection tools, facilitating precise dissection of biliary and vascular structures while minimizing blood loss and bile leaks. This approach may be particularly valuable in newly established robotic HPB centers, helping to achieve satisfactory surgical outcomes even during the early phase of program implementation. Nevertheless, these promising results require confirmation in larger cohorts and further studies, particularly to validate the safety and effectiveness of this technique in major hepatectomies and in procedures of greater complexity.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":"81 2","pages":"103-114"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148266401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva SurgeryPub Date : 2026-04-01Epub Date: 2023-10-18DOI: 10.23736/S2724-5691.23.10065-7
Xiaoxia Zhang, Wenfang Wang, Hongmei Ma, Yuying Ma, Juan Xue, Xiaoming Ju
{"title":"Effect of comprehensive nursing intervention on defecation time and incidence of urinary fistula in patients with neurogenic bladder at acute stage of stroke.","authors":"Xiaoxia Zhang, Wenfang Wang, Hongmei Ma, Yuying Ma, Juan Xue, Xiaoming Ju","doi":"10.23736/S2724-5691.23.10065-7","DOIUrl":"10.23736/S2724-5691.23.10065-7","url":null,"abstract":"","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":"144-146"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41239225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva SurgeryPub Date : 2026-04-01DOI: 10.23736/S2724-5691.26.11118-6
Iacopo Verbo, Mattia A Bez, Danilo DI Giorgio, Alessandro Verbo
{"title":"Feasibility and early patient-reported outcomes after elective laparoscopic sigmoid resection for diverticular disease: a pilot study.","authors":"Iacopo Verbo, Mattia A Bez, Danilo DI Giorgio, Alessandro Verbo","doi":"10.23736/S2724-5691.26.11118-6","DOIUrl":"https://doi.org/10.23736/S2724-5691.26.11118-6","url":null,"abstract":"<p><strong>Background: </strong>Patient-reported quality-of-life (QoL) outcomes are increasingly recognized as relevant endpoints in elective colorectal surgery. However, the feasibility and interpretability of systematic QoL assessment after elective laparoscopic sigmoid resection for diverticular disease remain incompletely defined, particularly in single-center settings.</p><p><strong>Methods: </strong>This retrospective single-center pilot study analyzed consecutive patients undergoing elective laparoscopic sigmoid resection for diverticular disease. The primary objective was to assess the feasibility and completeness of postoperative QoL assessment using EQ-5D, GIQLI, and LARS questionnaires. Secondary objectives included perioperative outcomes and early postoperative morbidity. Clinical and operative data were analyzed descriptively.</p><p><strong>Results: </strong>Thirty-six patients were included. Completion of postoperative QoL questionnaires was achieved in all cases. No floor or ceiling effects were observed across QoL instruments. Median postoperative length of stay was 7 (6-7) days. Minor postoperative complications (Clavien-Dindo <II) occurred in 8.4% of patients, with no major complications, anastomotic leaks, or reoperations. Mean EQ-5D and GIQLI scores indicated satisfactory early postoperative quality of life, while LARS scores suggested minimal bowel dysfunction.</p><p><strong>Conclusions: </strong>Systematic assessment of patient-reported outcomes after elective laparoscopic sigmoid resection for diverticular disease is feasible and yields interpretable early QoL signals. These pilot data support the integration of standardized QoL metrics in future prospective and comparative studies.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":"81 2","pages":"129-132"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148266324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva SurgeryPub Date : 2026-04-01Epub Date: 2026-05-06DOI: 10.23736/S2724-5691.26.11079-X
Subin Lee, Andrew Conner, Feredun Azari, Monisha Sudarshan, Sudish Murthy, Siva Raja
{"title":"Integrating adjuvant therapy as standard multimodal treatment for patients with esophageal cancer after neoadjuvant therapy.","authors":"Subin Lee, Andrew Conner, Feredun Azari, Monisha Sudarshan, Sudish Murthy, Siva Raja","doi":"10.23736/S2724-5691.26.11079-X","DOIUrl":"10.23736/S2724-5691.26.11079-X","url":null,"abstract":"<p><p>Recent developments in the treatment paradigm for esophageal cancer have brought major changes in our approach to caring for patients with this disease. Now, both neoadjuvant and adjuvant therapies have become integral components of the multimodal standard treatment delivered to these patients. While there has been a substantial body of evidence in the neoadjuvant realm, progress for adjuvant therapy has been slower. This review aims to provide a comprehensive summary of the current recommendations and newest evolutions in adjuvant treatment following neoadjuvant therapy for patients with esophageal and gastroesophageal cancers. A review of phase II-III randomized controlled trials on the use of adjuvant therapy has been performed. The latest clinical guidelines were examined to identify the evidence-based recommendations on the role of adjuvant therapy after neoadjuvant and surgical treatment for locally advanced esophageal and gastroesophageal cancers. The CheckMate 577 and MATTERHORN are landmark trials that established immunotherapy as standard adjuvant treatment for patients with resectable esophageal and gastroesophageal cancers who had previously received neoadjuvant therapy. In keeping with these advances, there have been ongoing developments to discover other immunotherapy and targeted treatment options to decrease recurrence and improve survival for these patients. Determining the optimal regimen and duration of treatment, as well as finding the appropriate patient selection for adjuvant therapy remains an active area of research. Adjuvant therapy offers patients with resectable esophageal and gastroesophageal cancers a chance for longer disease-free survival. The additions of PD-1/PD-L1 inhibitors have been instrumental in improving outcomes for patients with residual disease despite neoadjuvant therapy. Further work is needed to refine the current treatment regimens and incorporate novel systemic and immunotherapeutic options into our treatment armamentarium.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":"133-141"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva SurgeryPub Date : 2026-04-01DOI: 10.23736/S2724-5691.26.11067-3
Marco Visconti, Roberto Peltrini, Andrea G DI Santo Albini, Giuseppe Magno, Francesco Corcione
{"title":"Standardized laparoscopic approach for retroperitoneal tumors: a single-center preliminary experience.","authors":"Marco Visconti, Roberto Peltrini, Andrea G DI Santo Albini, Giuseppe Magno, Francesco Corcione","doi":"10.23736/S2724-5691.26.11067-3","DOIUrl":"https://doi.org/10.23736/S2724-5691.26.11067-3","url":null,"abstract":"<p><strong>Background: </strong>Retroperitoneal tumors are rare and heterogeneous lesions, and their surgical management remains challenging. Although laparoscopic techniques are increasingly adopted in abdominal surgery, a standardized minimally invasive approach for retroperitoneal pathology has not yet been clearly defined. The present study reports our preliminary single-center experience with a standardized laparoscopic management of retroperitoneal tumors.</p><p><strong>Methods: </strong>We retrospectively reviewed 36 patients treated for retroperitoneal tumors between 2017 and 2022. Patients were selected for a laparoscopic approach when lesion size was ≤10 cm and no vascular invasion was identified on preoperative imaging. Demographic, perioperative, histopathological, and follow-up data were analyzed. Postoperative complications were classified according to the Clavien-Dindo system.</p><p><strong>Results: </strong>Among the 36 patients, 22 underwent laparoscopic surgery, 14 open surgery, and 4 required conversion to an open approach. The mean operative time was 104 minutes for laparoscopic procedures and 168 minutes for open surgery. One patient in the laparoscopic group required postoperative blood transfusion (Clavien-Dindo grade II), with no other postoperative complications observed. Length of hospital stay was shorter after laparoscopy (3.2 vs. 8.8 days). Benign lesions were more frequently treated laparoscopically, whereas sarcomas and metastatic tumors were more commonly managed with an open approach. The laparoscopic technique was standardized by subdividing the retroperitoneum into defined anatomical regions, each associated with specific patient positioning, trocar placement, and surgical steps. R0 resection was achieved in all malignant cases, as confirmed by postoperative pathology. At a mean follow-up of 5 years, no recurrences were observed in either benign or malignant cases.</p><p><strong>Conclusions: </strong>Our preliminary experience suggests that a standardized laparoscopic approach for retroperitoneal tumors is feasible, safe, and reproducible in carefully selected patients. Nevertheless, the retrospective design, limited sample size, and exclusion of more complex cases represent important limitations. Larger multicenter studies are required to further validate these findings.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":"81 2","pages":"115-128"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148266373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}