Minerva SurgeryPub Date : 2025-02-13DOI: 10.23736/S2724-5691.25.10771-5
Gaetano Gallo, Mario Trompetto
{"title":"Clinical evidence and rationale of topical nifedipine and lidocaine ointment in the treatment of anal fissure and hemorrhoidal disease.","authors":"Gaetano Gallo, Mario Trompetto","doi":"10.23736/S2724-5691.25.10771-5","DOIUrl":"https://doi.org/10.23736/S2724-5691.25.10771-5","url":null,"abstract":"<p><strong>Introduction: </strong>Anorectal conditions such as hemorrhoidal disease and anal fissure are frequently painful and debilitating. Pain after hemorrhoidectomy is also common and distressing. These conditions are at least initially managed conservatively. An ointment formulation containing the calcium channel blocker nifedipine and the local anesthetic lidocaine has an established role in the treatment of rectal conditions, particularly conditions associated with anal sphincter hypertonia such as hemorrhoidal disease and anal fissure. This review aimed to compile the evidence for the use of nifedipine 0.3% and lidocaine 1.5% ointment in treating these common but bothersome anorectal diseases.</p><p><strong>Evidence acquisition: </strong>A comprehensive literature search was conducted, updated to 07 August 2024, using PubMed and MEDLINE databases to identify studies of lidocaine and nifedipine, alone or in combination, for the topical treatment of anal fissure or hemorrhoidal disease. Articles identified in the literature search were supplemented by ad hoc searches and supplemented by relevant literature known to the authors.</p><p><strong>Evidence synthesis: </strong>Nifedipine 0.3% and lidocaine 1.5% ointment is effective in relieving pain and aiding the resolution of thrombosed hemorrhoids, reducing resting anal pressure and healing chronic anal fissures, and controlling pain after hemorrhoidectomy. The ointment was significantly better than controls consisting of topical lidocaine 1.5% alone or in combination with hydrocortisone acetate 1%.</p><p><strong>Conclusions: </strong>Although the available literature on the topical application of nifedipine and lidocaine in anorectal diseases is limited, nifedipine 0.3% and lidocaine 1.5% ointment should be considered a valid treatment option for clinicians treating anorectal diseases. Further studies are warranted to confirm and extend the results reported.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143410982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva SurgeryPub Date : 2025-02-04DOI: 10.23736/S2724-5691.24.10392-9
Denglan Chu, Xueping Zhu, Xueping Zhang
{"title":"Cohort study of skin contact on growth and development of premature infants and mother-infant relationship in neonatal intensive care unit.","authors":"Denglan Chu, Xueping Zhu, Xueping Zhang","doi":"10.23736/S2724-5691.24.10392-9","DOIUrl":"https://doi.org/10.23736/S2724-5691.24.10392-9","url":null,"abstract":"","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva SurgeryPub Date : 2025-02-04DOI: 10.23736/S2724-5691.24.10650-8
Minglu Sun, Yuxin Hou, Yinyan Li
{"title":"True or false malignant features on breast mass lesions.","authors":"Minglu Sun, Yuxin Hou, Yinyan Li","doi":"10.23736/S2724-5691.24.10650-8","DOIUrl":"https://doi.org/10.23736/S2724-5691.24.10650-8","url":null,"abstract":"","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva SurgeryPub Date : 2025-02-04DOI: 10.23736/S2724-5691.24.10660-0
Yuyan Cao, Yingchun LE, Xiaofang Tan, Baoqin Lu, Yongqiang Xia, Wenjing Sun
{"title":"Comparison of effects of breast-conserving surgery and modified radical surgery on complications and survival prognosis of patients with breast cancer.","authors":"Yuyan Cao, Yingchun LE, Xiaofang Tan, Baoqin Lu, Yongqiang Xia, Wenjing Sun","doi":"10.23736/S2724-5691.24.10660-0","DOIUrl":"https://doi.org/10.23736/S2724-5691.24.10660-0","url":null,"abstract":"","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva SurgeryPub Date : 2025-02-04DOI: 10.23736/S2724-5691.24.10743-5
Manli DU, Junrong Tang, Wen Sun
{"title":"Enhancing postoperative care and nursing education through internet-based continuity of care for surgical patients.","authors":"Manli DU, Junrong Tang, Wen Sun","doi":"10.23736/S2724-5691.24.10743-5","DOIUrl":"https://doi.org/10.23736/S2724-5691.24.10743-5","url":null,"abstract":"","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143190788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva SurgeryPub Date : 2025-02-01DOI: 10.23736/S2724-5691.25.10731-4
Pier Paolo Brollo, Tommaso Stecca, Adriana DI Giacomo, Marco Massani, Vittorio Bresadola
{"title":"Near-infrared imaging with indocyanine green fluorescence for intraoperative lymphatic assessment in rectal cancer surgery: a systematic review.","authors":"Pier Paolo Brollo, Tommaso Stecca, Adriana DI Giacomo, Marco Massani, Vittorio Bresadola","doi":"10.23736/S2724-5691.25.10731-4","DOIUrl":"https://doi.org/10.23736/S2724-5691.25.10731-4","url":null,"abstract":"<p><strong>Introduction: </strong>At present, harvesting more lymph nodes is considered more conducive to the prognosis of colorectal cancer surgery. The recent development of enhanced surgical visualization has led to the wide employment of indocyanine green (ICG) to assist minimally invasive surgery. This systematic review aims to provide a wide and critical overview of the current state of the art of ICG lymphography during rectal surgery, by focusing on the most relevant literature on this topic.</p><p><strong>Evidence acquisition: </strong>After validation and registration in the PROSPERO international prospective register of systematic reviews on the 5<sup>th</sup> May 2024 (ID: CRD42024539426), 8 publications have been considered relevant for the research query and have been divided into two groups: lateral pelvic lymph node dissection (LPLND) and lateral pelvic sentinel lymph node biopsy (LPSLNB). A meta-analysis has not been performed due to the low statistical significance.</p><p><strong>Evidence synthesis: </strong>ICG lymphography seems to improve the number of harvested lateral pelvic lymph nodes, to reduce intraoperative blood loss and hospital length of stay during LPLND. In LPSLNB the detection rate of lateral pelvic sentinel lymph nodes ranged from 91.3% to 92%.</p><p><strong>Conclusions: </strong>ICG lymphography for fluorescence guidance for LLND is a feasible and safe technique, with promising application in terms of the number of harvested lymph nodes and post-operative outcomes improvement during rectal oncological surgery. As some of these benefits have been already suggested by the current literature, they need to be confirmed in larger and randomized clinical.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":"80 1","pages":"86-94"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minerva SurgeryPub Date : 2025-02-01DOI: 10.23736/S2724-5691.25.10712-0
Mohamed A Boukhlik, Mohamed A Daghmouri, Mohamed A Chaouch, François Depret, Benjamin Deniau
{"title":"Evaluation of efficacy and safety of perioperative albumin administration in major non-cardiac surgery: a systematic review and meta-analysis of randomized controlled trials.","authors":"Mohamed A Boukhlik, Mohamed A Daghmouri, Mohamed A Chaouch, François Depret, Benjamin Deniau","doi":"10.23736/S2724-5691.25.10712-0","DOIUrl":"https://doi.org/10.23736/S2724-5691.25.10712-0","url":null,"abstract":"<p><strong>Introduction: </strong>Studies suggested that restrictive fluid therapy during major surgery could be associated with better post-operative outcomes. The albumin uses in the perioperative period has been the subject of numerous studies with a still controversial efficacy and safety profile. This study aimed to assess the efficacy and safety of perioperative albumin use during major non-cardiac surgery.</p><p><strong>Evidence acquisition: </strong>This study was registered in PROSPERO (ID: CRD42022353278). We performed an electronic search of the relevant literature from 2000 until 2023. The primary endpoint was the incidence of moderate postoperative complications (defined by a Clavien-Dindo classification grade ≥2). Secondary endpoints were intraoperative fluid balance, intraoperative blood loss, postoperative wound infection and acute kidney injury (AKI).</p><p><strong>Evidence synthesis: </strong>We identified four relevant studies involving 426 patients (213 patients in the albumin group versus 213 patients in the control group). The meta-analysis did not reveal any significant difference between both group regarding the incidence of postoperative moderate complications even after subgroup analyses based on intraoperative or postoperative albumin administration (OR=1.23, 95% CI 0.73, 2.08, P=0.44). No difference was found for intraoperative fluid balance (MD=-190.83, 95% CI -408.67, 27.02, P=0.09), intraoperative blood loss (MD=-27.54, 95% CI -225.55, 170.48, P=0.79) and postoperative wound infection (OR=1.91, 95% CI 0.98, 3.73, P=0.06). Moreover, albumin administration was not associated with a significant increase of AKI incidence (OR=2.02, 95% CI 0.90, 4.53, P=0.09).</p><p><strong>Conclusions: </strong>Perioperative use of albumin during major non-cardiac surgery did not result in an increased incidence of moderate postoperative complications.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":"80 1","pages":"76-85"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}