Minerva Surgery最新文献

{"title":"Advances in minimally invasive diagnostic techniques for pulmonary diseases.","authors":"Wei Liu, Li Jian, Qiquan Zhao","doi":"10.23736/S2724-5691.25.10867-8","DOIUrl":"https://doi.org/10.23736/S2724-5691.25.10867-8","url":null,"abstract":"<p><p>Respiratory disorders can be broadly classified into two primary categories: those triggered by infectious agents and those stemming from noninfectious factors. The infectious group comprises a wide array of pathogens, including bacteria, viruses, and fungi. In contrast, the noninfectious category encompasses conditions such as immune system dysfunctions, as well as both malignant and benign tumors. Given the intricate and diverse nature of these diseases, accurate diagnosis often requires more than just routine clinical assessments and conventional imaging techniques. To address this complexity, the medical community has increasingly turned to minimally invasive diagnostic methods, which provide enhanced precision in managing complex cases. This comprehensive review delves into the utilization of these cutting-edge minimally invasive technologies within the field of respiratory medicine. It meticulously outlines their current applications, highlights their benefits and limitations, and also explores potential directions for future research endeavors, aiming to shed light on the evolving landscape of respiratory disease diagnosis and management.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of emergency resuscitative thoracotomy in blunt trauma: a systematic review.","authors":"Gaetano Poillucci, Pietro Fransvea, Angelo Serao, Annamaria Pronio, Edoardo Piras, Mauro Podda, Ennio A Adami","doi":"10.23736/S2724-5691.25.10839-3","DOIUrl":"https://doi.org/10.23736/S2724-5691.25.10839-3","url":null,"abstract":"<p><strong>Introduction: </strong>Emergency resuscitative thoracotomy (ERT) is a potentially life-saving procedure for selected trauma patients presenting in extremis with pending or already witnessed cardiopulmonary collapse. Outcome mostly in blunt trauma is believed to be poor. Our aim was to identify all studies reported over the past fourteen years and compare reported outcomes for blunt trauma.</p><p><strong>Evidence acquisition: </strong>We performed a systematic literature search according to PRISMA guidelines (from January 1^st, 2010 to May 31^st, 2024). Qualitative comparison of studies and outcomes was done.</p><p><strong>Evidence synthesis: </strong>A total of 22 articles were included for an overall number of 6315 ERT for blunt trauma. Male-to-female distribution was 3:1. The collectively reported overall survival was 4.5%. Mean age varied from lowest at 32.4 years to highest at 53 years. Neurological outcome was reported in 6 of 21 studies; among this six publications, just one reported neurological outcome using the Glasgow Outcome Scale (GOS). Heterogeneity in the studies prevented outcome analyses by formal quantitative meta-analysis.</p><p><strong>Conclusions: </strong>The reported outcome after ERT for blunt trauma is not favorable, with an extremely low survival rate highlighted in most studies. Multicenter, prospective, observational data are needed to validate the modern role of ERT in blunt trauma.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144508686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive subharmonic-aided pressure estimation for surgical management of portal hypertension: a clinical study in TIPS patients.","authors":"Ziyin Zhu, Si Liang, Linxue Qian","doi":"10.23736/S2724-5691.25.10917-9","DOIUrl":"https://doi.org/10.23736/S2724-5691.25.10917-9","url":null,"abstract":"<p><strong>Background: </strong>Portal hypertension (PH) is a critical condition often managed through surgical interventions such as transjugular intrahepatic portosystemic shunt (TIPS). Conventional portal pressure monitoring relies on invasive measurements, necessitating alternative approaches. Subharmonic-aided pressure estimation (SHAPE) technology offers a noninvasive method utilizing contrast-enhanced ultrasound, potentially reducing procedural risks. This study evaluated the clinical utility of SHAPE in assessing portal hypertension and monitoring hemodynamic changes pre- and post-TIPS placement.</p><p><strong>Methods: </strong>A total of 23 patients with PH underwent direct portal vein pressure (PVP) measurement, and SHAPE was performed for noninvasive estimation. Six patients who underwent TIPS received SHAPE evaluations before and after the procedure. Agreement and correlation between SHAPE and PVP were analyzed.</p><p><strong>Results: </strong>SHAPE demonstrated a strong correlation with PVP (P<0.001), with significant changes observed post-TIPS (P=0.011). These findings suggest SHAPE as a valuable tool for noninvasive monitoring of PH and evaluating TIPS efficacy.</p><p><strong>Conclusions: </strong>SHAPE technology presents a promising noninvasive alternative for assessing portal hypertension in surgical settings. It offers a safer and efficient approach to monitoring hemodynamic changes, particularly in patients undergoing TIPS, potentially reducing reliance on invasive procedures.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review assessing the significance of Body Mass Index as a contributing factor of outcomes in patients undergoing complex robotic pancreatic resections.","authors":"Garnet Vanterpool, Kristina Milivojev Covilo, Sharona B Ross","doi":"10.23736/S2724-5691.25.10806-X","DOIUrl":"https://doi.org/10.23736/S2724-5691.25.10806-X","url":null,"abstract":"<p><strong>Introduction: </strong>Pancreatic surgeries can be regarded as the most complex and high-risk procedures, with robotic approaches offering improved outcomes. This systematic review aimed to evaluate the impact of Body Mass Index (BMI) on perioperative outcomes in robotic pancreaticoduodenectomy (RPD) and robotic distal pancreatectomy (RDP).</p><p><strong>Evidence acquisition: </strong>Articles published from 2000 to 2024 were sourced from PubMed and Google Scholar using relevant keywords, with inclusion criteria focusing on robotic procedures involving at least 30 patients and BMI classification. Studies using non-robotic approaches were excluded unless used for comparison. Of 17,187 articles identified, 11 met the inclusion criteria. The risk of bias was minimized through dual independent reviewers, adhering to the PRISMA checklist.</p><p><strong>Evidence synthesis: </strong>Overall, 4645 patients (1501 RPD and 3144 RDP cases) were analyzed and highlighted some BMI-associated challenges, including longer operative times and increased postoperative complications in obese patients. However, robotic techniques were found to mitigate some of these issues, demonstrating reduced blood loss, lower conversion rates, and faster recovery compared to open or laparoscopic methods.</p><p><strong>Conclusions: </strong>Results showed that robotic approaches improved surgical safety and efficacy, even in patients with BMI >25 kg/m², supporting their use in high-risk populations. Despite limited available studies, findings highlight the need for further research on BMI's influence in robotic pancreatic surgeries to optimize patient outcomes and refine clinical practices.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common bacterial species and drug resistance of surgical site infection after upper gastrointestinal surgery.","authors":"Bingyou Yin, Xinjun Hu","doi":"10.23736/S2724-5691.25.10925-8","DOIUrl":"https://doi.org/10.23736/S2724-5691.25.10925-8","url":null,"abstract":"","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current evidence and new trends in anal fissure treatment.","authors":"Marta Domínguez-Muñoz, Andrea Balla, Juan Carlos Gómez-Rosado, Salvador Morales-Conde","doi":"10.23736/S2724-5691.25.10778-8","DOIUrl":"10.23736/S2724-5691.25.10778-8","url":null,"abstract":"<p><p>An anal fissure is a benign and painful ulcer extending from the pectinate line to the anal margin. It leads to an increase in the resting pressure of the internal anal sphincter and the pressure within the anal canal, resulting in local ischemia and impaired wound healing. Anal fissures are mostly located in the posterior midline. They are primarily caused by local trauma to the anoderm, often due to the passage of hard stools, irritation from diarrhea, or anorectal surgery. For both acute and chronic anal fissures, several treatment options are available, and surgery typically reserved as a second-line option. Recent trends in first-line therapy prefer calcium channel blockers (CCBs) over topical glyceryl trinitrate (GTN), as they offer similar healing rates but are associated with fewer side effects and better patient's compliance. Lateral internal sphincterotomy (LIS) remains the gold-standard surgical treatment for this condition. Additionally, emerging therapies, such as platelet-rich plasma (PRP) application, adipose-derived regenerative cells (ADRCs), and percutaneous tibial nerve stimulation (PTNS), have shown promising results and they are gaining attention as potential alternatives for managing chronic anal fissures. The present narrative review aims to provide a comprehensive overview of current therapeutic approaches for anal fissures, evaluating their effectiveness in promoting healing and comparing them with guideline-based recommendations.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":"258-265"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral Graves' disease: a case report with concomitant thyroid cancer and systematic review of literature.","authors":"Lorenzo Scappaticcio, Paola Caruso, Miriam Longo, Alessandra Volatile, Paolo Cirillo, Francesco Di Maio, Claudia Varro, Vanda Amoresano Paglionico, Sium Wolde Sellasie, Maria I Maiorino, Katherine Esposito, Giuseppe Bellastella","doi":"10.23736/S2724-5691.25.10685-0","DOIUrl":"10.23736/S2724-5691.25.10685-0","url":null,"abstract":"<p><strong>Introduction: </strong>Unilateral uptake (i.e., increased radiotracer in one lobe) on a thyroid scan in a patient with Graves' disease (GD) is the distinctive feature of unilateral GD (UGD), representing a rare entity and variant of GD with few documented cases to date. Considering the diagnostic and therapeutical implications of the knowledge of this form of GD, this study was designed to bring more light on the UGD entity within the bilobar thyroid gland.</p><p><strong>Evidence acquisition: </strong>The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed in reporting this systematic review. We developed a search strategy combining terms for Graves or Hyperthyroidism and unilateral systematically and searched PubMed from inception through August 25, 2024. The inclusion criteria were: 1) patients with Graves' hyperthyroidism due to a unilateral involvement in bilobar thyroid gland; 2) articles written in English or any language with an English abstract.</p><p><strong>Evidence synthesis: </strong>A total of 10 articles met inclusion criteria, in addition to our institutional experience (comprising 27 individual patients in total). All the included studies were case reports/series. Of the 27 patient cases, 20 (74.1%) were female and the mean age of patients was 44.5±10.6 years. 24 patients (88.9%) had overt hyperthyroidism, two (7.4%) subclinical hyperthyroidism, one (3.7%) had initially normal thyroid function. Orbitopathy was present in two cases out of ten (20%). thyrotropin receptor antibodies (TRAb) or thyroid stimulating immunoglobulin (TSI) were positive in 9 cases out of 12 (75%). Right thyroid lobe was involved in 17 cases (63.0%), while the left one in 10 cases (37.0%). Antithyroid drugs ATDs were adopted by 13 patients (68.4%). Four patients (21.1%) underwent surgery, while radioactive iodine (RAI) was performed in two cases. Two cases (15.4%) received a 12-month course of ATD therapy, one of whom recurred. In two out of three cases after hemithyroidectomy hyperthyroidism recurred due to the involvement of the contralateral lobe of the thyroid gland.</p><p><strong>Conclusions: </strong>Clinicians should be aware of the possibility that GD can present in the bilobar thyroid gland with unilateral gland involvement at scintigraphy. Ultrasound examination is indicated to detect the presence of contralateral thyroid tissue, and to exclude the possibility of a hyperfunctioning nodule or hemiagenesis. When choosing surgery, total thyroidectomy seems to be the appropriate treatment. Further investigation is needed to determine the natural course of UGD and its best management. Future guidelines should consider this form of GD.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":"274-281"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Centellicum® improves scarring of traumatic wounds with irregular edges (lacerations).","authors":"Bruno M Errichi, Gianni Belcaro, Edmondo Ippolito, Maria R Cesarone, David Cox, Claudia Scipione, Valeria Scipione, Umberto Cornelli, Marcello Corsi, Beatrice Feragalli, Francesca Coppazuccari, Roberto Cotellese","doi":"10.23736/S2724-5691.24.10711-3","DOIUrl":"10.23736/S2724-5691.24.10711-3","url":null,"abstract":"<p><strong>Background: </strong>Centellicum^®, a standardized Centella Asiatica extract, has been used orally for fibrosis and scar prevention. The main aim of this 2-month registry pilot study was the reduction of visible, significant scars and keloids after suturing traumatic wounds with irregular edges (lacerations), using Centellicum^®.</p><p><strong>Methods: </strong>The effects of oral Centellicum^® (450 mg/day; 2 capsules) and a standard management (SM) on wound healing were compared with the effects of a control group that used only the standard management.</p><p><strong>Results: </strong>Forty-eight otherwise healthy male subjects with lacerations requiring suturing were included in the study. 25 took Centellicum^® in addition to the standard management and 24 followed the standard management only. No side effects were observed with the supplement. Centellicum^® supplementation showed very good tolerability and compliance with 98% of the capsules correctly used. The two groups of otherwise healthy male subjects with lacerations were considered comparable at inclusion and there were no dropouts. No infections were observed. At 60 days, the scar dimensions were significantly smaller in the supplemented group (P<0.05). The elevation of the scar above the surrounding, non-affected skin, was also significantly reduced in the Centellicum^® group compared to controls (P<0.05). Local pain levels were significantly lower (P<0.05) in the supplement group at 60 days. Additionally, the scar redness score was significantly lower in the supplement group compared to controls (P<0.05) by the end of the study. The incidence of initial keloid formation was significantly lower in the supplemented subjects at 60 days, as determined by finger-point pressure palpation and high-resolution ultrasound (P<0.05). Skin flux, as measured by laser Doppler flowmetry (indicating hypervascularization due to local inflammation) was lower (P<0.05) with Centellicum^® at the end of the study. Inflammation, assessed via thermography (hot spots on the healing skin) was less visible and reduced in most areas in the supplement group (P<0.05) in comparison with the control group. Plasma oxidative stress was significantly lower in the Centellicum^® group at the end of the study (P<0.05).</p><p><strong>Conclusions: </strong>Oral Centellicum^® intake over 2 months improved healing of lacerations and reduced scarring, fibrosis and keloids at the level of the lesions. A larger study setup with more patients and with a prolonged study duration is needed to confirm these initial results.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":"231-235"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local flaps for partial breast reconstruction.","authors":"Fernando Rosatti, Dario Melita, Paolo Marchica, Isidoro Musmarra, Francesco Ciancio, Francesca De Lorenzi, Francesca Toia, Simone La Padula, Giuseppe A Lombardo","doi":"10.23736/S2724-5691.25.10805-8","DOIUrl":"10.23736/S2724-5691.25.10805-8","url":null,"abstract":"<p><strong>Introduction: </strong>Breast-conserving surgery (BCS) is often the first-line treatment for early-stage invasive breast cancer. Many studies claim that survival is non-inferior to radical treatments in selected cases. Although BCS preserves some breast tissue and often the nipple-areola complex, asymmetry and distortion of the breast contour may occur and reconstruction is sometimes required. The authors' aim is to conduct a review of main breast reconstruction options with local flaps after partial mastectomy.</p><p><strong>Evidence acquisition: </strong>A literature review was conducted on PubMed using the keywords: \"partial breast reconstruction,\" \"local flaps,\" \"LICAP,\" \"ICAP,\" \"AICAP,\" \"TDAP,\" \"MS-LD\" and \"SAAP.\" Reviews, meta-analyses, clinical trials, experimental studies and case reports focused on breast reconstruction with local flaps after partial mastectomy (quadrantectomy or lumpectomy) were included in the study. Only English-written studies published in the past 20 years were considered eligible. Older articles, non-English written articles or papers regarding random flaps/video assisted harvested flaps/combined flaps were excluded.</p><p><strong>Evidence synthesis: </strong>A cumulative number of 292 scientific articles was produced by the research. After screening by the two principal investigators, 73 articles were deemed eligible for full-text examination. In total, twenty-seven articles met the inclusions criteria.</p><p><strong>Conclusions: </strong>Local flaps are a safe and reliable option in breast reconstruction after partial mastectomy. They are associated with a low complication rate reported in the literature, with satisfactory aesthetic outcomes. Prospective multicenter clinical studies are desirable to confirm the results of this study.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":"266-273"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between serum albumin, exercise endurance, and pulmonary complications after lobectomy.","authors":"Xiaowei Liu, Su Wang, Xiujun Chen, Yan Zhang, Kun Zhang, Ci Tian, Bing Dong","doi":"10.23736/S2724-5691.25.10874-5","DOIUrl":"10.23736/S2724-5691.25.10874-5","url":null,"abstract":"<p><strong>Background: </strong>The aim of the article is to explore the relationship between serum albumin, exercise endurance, and pulmonary complications after lobectomy.</p><p><strong>Methods: </strong>Overall, 166 lung cancer patients who were treated in our hospital from January 2020 to June 2023 were selected to analyze the incidence of postoperative pulmonary complications and the differences in clinical data between patients with and without pulmonary complications. Logistic regression equations were used to analyze the influencing factors of postoperative pulmonary complications.</p><p><strong>Results: </strong>There were 46 patients with postoperative pulmonary complications, incidence rate was 27.71%; Among the 46 patients, eight had two or more complications. The age of patients with pulmonary complications was 69.29±6.65 years old, which was higher than that of patients without pulmonary complications (P<0.05). The proportions of surgical time ≥4 hours, intraoperative blood loss ≥50 mL, and preoperative albumin <35 g/L in patients with pulmonary complications were 58.70%, 65.22% and 76.09%, respectively, which were significantly higher than those in patients without pulmonary complications (P<0.05). Patients with pulmonary complications had peak expiratory flow rate (PEF), peak oxygen uptake as a percentage of expected value (VO<inf>2</inf>%P), kilogram oxygen uptake (VO<inf>2</inf>/kg), anaerobic threshold (AT), oxygen pulse as percentage of expected value (O<inf>2</inf>pulse%P), respiratory rate (BF), and 6-Minute Walking Test (6-MWT), which were 291.10±43.34 L/min, 55.54±12.21%, 16.21±4.32 mL, 44.45±10.02%, 71.18±15.56 L, 26.68±6.67 times and 410.04±45.54 m, which were significantly lower than patients without pulmonary complications (P>0.05). Logistic regression analysis showed that age, surgical time, preoperative albumin, VO<inf>2</inf>% P, and 6-MWT were the influencing factors for postoperative pulmonary complications (P<0.05).</p><p><strong>Conclusions: </strong>Serum albumin, cardiopulmonary motility indicators, and 6MWT are associated with the occurrence of pulmonary complications after lobectomy, and the occurrence of pulmonary complications is influenced by patient age and surgical time.</p>","PeriodicalId":29847,"journal":{"name":"Minerva Surgery","volume":" ","pages":"207-213"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}