Eco-Environment & Health最新文献_第9页

Soil metabolomics: Deciphering underground metabolic webs in terrestrial ecosystems 土壤代谢组学：解密陆地生态系统的地下代谢网

Eco-Environment & Health Pub Date : 2024-03-20 DOI: 10.1016/j.eehl.2024.03.001

Yang Song , Shi Yao , Xiaona Li , Tao Wang , Xin Jiang , Nanthi Bolan , Charles R. Warren , Trent R. Northen , Scott X. Chang

{"title":"Soil metabolomics: Deciphering underground metabolic webs in terrestrial ecosystems","authors":"Yang Song , Shi Yao , Xiaona Li , Tao Wang , Xin Jiang , Nanthi Bolan , Charles R. Warren , Trent R. Northen , Scott X. Chang","doi":"10.1016/j.eehl.2024.03.001","DOIUrl":"10.1016/j.eehl.2024.03.001","url":null,"abstract":"<div><p>Soil metabolomics is an emerging approach for profiling diverse small molecule metabolites, i.e., metabolomes, in the soil. Soil metabolites, including fatty acids, amino acids, lipids, organic acids, sugars, and volatile organic compounds, often contain essential nutrients such as nitrogen, phosphorus, and sulfur and are directly linked to soil biogeochemical cycles driven by soil microorganisms. This paper presents an overview of methods for analyzing soil metabolites and the state-of-the-art of soil metabolomics in relation to soil nutrient cycling. We describe important applications of metabolomics in studying soil carbon cycling and sequestration, and the response of soil organic pools to changing environmental conditions. This includes using metabolomics to provide new insights into the close relationships between soil microbiome and metabolome, as well as responses of soil metabolome to plant and environmental stresses such as soil contamination. We also highlight the advantage of using soil metabolomics to study the biogeochemical cycles of elements and suggest that future research needs to better understand factors driving soil function and health.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 2","pages":"Pages 227-237"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772985024000255/pdfft?md5=9df12501966a6e448d231e6e3cd4b6f1&pid=1-s2.0-S2772985024000255-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140279306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determining soil conservation strategies: Ecological risk thresholds of arsenic and the influence of soil properties 确定土壤保护战略：砷（As）的生态风险阈值和土壤特性的影响

Eco-Environment & Health Pub Date : 2024-03-12 DOI: 10.1016/j.eehl.2024.02.007

Yihang Huang , Naichi Zhang , Zixuan Ge , Chen Lv , Linfang Zhu , Changfeng Ding , Cun Liu , Peiqin Peng , Tongliang Wu , Yujun Wang

{"title":"Determining soil conservation strategies: Ecological risk thresholds of arsenic and the influence of soil properties","authors":"Yihang Huang , Naichi Zhang , Zixuan Ge , Chen Lv , Linfang Zhu , Changfeng Ding , Cun Liu , Peiqin Peng , Tongliang Wu , Yujun Wang","doi":"10.1016/j.eehl.2024.02.007","DOIUrl":"10.1016/j.eehl.2024.02.007","url":null,"abstract":"<div><p>The establishment of ecological risk thresholds for arsenic (As) plays a pivotal role in developing soil conservation strategies. However, despite many studies regarding the toxicological profile of As, such thresholds varying by diverse soil properties have rarely been established. This study aims to address this gap by compiling and critically examining an extensive dataset of As toxicity data sourced from existing literature. Furthermore, to augment the existing information, experimental studies on As toxicity focusing on barley-root elongation were carried out across various soil types. The As concentrations varied from 12.01 to 437.25 mg/kg for the effective concentrations that inhibited 10% of barley-root growth (EC<sub>10</sub>). The present study applied a machine-learning approach to investigate the complex associations between the toxicity thresholds of As and diverse soil properties. The results revealed that Mn-/Fe-ox and clay content emerged as the most influential factors in predicting the EC<sub>10</sub> contribution. Additionally, by using a species sensitivity distribution model and toxicity data from 21 different species, the hazardous concentration for x% of species (HCx) was calculated for four representative soil scenarios. The HC5 values for acidic, neutral, alkaline, and alkaline calcareous soils were 80, 47, 40, and 28 mg/kg, respectively. This study establishes an evidence-based methodology for deriving soil-specific guidance concerning As toxicity thresholds.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 2","pages":"Pages 238-246"},"PeriodicalIF":0.0,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772985024000243/pdfft?md5=3ebe391bc5038ba05c156560f6904102&pid=1-s2.0-S2772985024000243-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140282075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between exposure to a mixture of organochlorine pesticides and hyperuricemia in U.S. adults: A comparison of four statistical models 美国成年人接触有机氯农药混合物与高尿酸血症之间的关系：四种统计模型的比较

Eco-Environment & Health Pub Date : 2024-03-05 DOI: 10.1016/j.eehl.2024.02.005

Yu Wen , Yibaina Wang , Renjie Chen , Yi Guo , Jialu Pu , Jianwen Li , Huixun Jia , Zhenyu Wu

{"title":"Association between exposure to a mixture of organochlorine pesticides and hyperuricemia in U.S. adults: A comparison of four statistical models","authors":"Yu Wen , Yibaina Wang , Renjie Chen , Yi Guo , Jialu Pu , Jianwen Li , Huixun Jia , Zhenyu Wu","doi":"10.1016/j.eehl.2024.02.005","DOIUrl":"https://doi.org/10.1016/j.eehl.2024.02.005","url":null,"abstract":"<div><p>The association between the exposure of organochlorine pesticides (OCPs) and serum uric acid (UA) levels remained uncertain. In this study, to investigate the combined effects of OCP mixtures on hyperuricemia, we analyzed serum OCPs and UA levels in adults from the National Health and Nutrition Examination Survey (2005–2016). Four statistical models including weighted logistic regression, weighted quantile sum (WQS), quantile g-computation (QGC), and bayesian kernel machine regression (BKMR) were used to assess the relationship between mixed chemical exposures and hyperuricemia. Subgroup analyses were conducted to explore potential modifiers. Among 6,529 participants, the prevalence of hyperuricemia was 21.15%. Logistic regression revealed a significant association between both hexachlorobenzene (HCB) and trans-nonachlor and hyperuricemia in the fifth quintile (OR: 1.54, 95% CI: 1.08–2.19; OR: 1.58, 95% CI: 1.05–2.39, respectively), utilizing the first quintile as a reference. WQS and QGC analyses showed significant overall effects of OCPs on hyperuricemia, with an OR of 1.25 (95% CI: 1.09–1.44) and 1.20 (95% CI: 1.06–1.37), respectively. BKMR indicated a positive trend between mixed OCPs and hyperuricemia, with HCB having the largest weight in all three mixture analyses. Subgroup analyses revealed that females, individuals aged 50 years and above, and those with a low income were more vulnerable to mixed OCP exposure. These results highlight the urgent need to protect vulnerable populations from OCPs and to properly evaluate the health effects of multiple exposures on hyperuricemia using mutual validation approaches.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 2","pages":"Pages 192-201"},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277298502400022X/pdfft?md5=f9089c53011019fcb0674c6ca9082bac&pid=1-s2.0-S277298502400022X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140550894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adsorption and separation technologies based on supramolecular macrocycles for water treatment 基于超分子大环的水处理吸附和分离技术

Eco-Environment & Health Pub Date : 2024-03-04 DOI: 10.1016/j.eehl.2024.02.002

{"title":"Adsorption and separation technologies based on supramolecular macrocycles for water treatment","authors":"","doi":"10.1016/j.eehl.2024.02.002","DOIUrl":"10.1016/j.eehl.2024.02.002","url":null,"abstract":"<div><p>The escalating challenges in water treatment, exacerbated by climate change, have catalyzed the emergence of innovative solutions. Novel adsorption separation and membrane filtration methodologies, achieved through molecular structure manipulation, are gaining traction in the environmental and energy sectors. Separation technologies, integral to both the chemical industry and everyday life, encompass concentration and purification processes. Macrocycles, recognized as porous materials, have been prevalent in water treatment due to their inherent benefits: stability, adaptability, and facile modification. These structures typically exhibit high selectivity and reversibility for specific ions or molecules, enhancing their efficacy in water purification processes. The progression of purification methods utilizing macrocyclic frameworks holds promise for improved adsorption separations, membrane filtrations, resource utilization, and broader water treatment applications. This review encapsulates the latest breakthroughs in macrocyclic host-guest chemistry, with a focus on adsorptive and membrane separations. The aim is to spotlight strategies for optimizing macrocycle designs and their subsequent implementation in environmental and energy endeavors, including desalination, elemental extraction, seawater energy harnessing, and sustainable extraction. Hopefully, this review can guide the design and functionality of macrocycles, offering a significantly promising pathway for pollutant removal and resource utilization.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 3","pages":"Pages 381-391"},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772985024000140/pdfft?md5=e927183433590a39b0a4a38d4ac40475&pid=1-s2.0-S2772985024000140-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140268730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dihalogenated nitrophenols in drinking water: Prevalence, resistance to household treatment, and cardiotoxic impact on zebrafish embryo 饮用水中的二卤代硝基苯酚：普遍性、对家庭处理的耐受性以及对斑马鱼胚胎的心脏毒性影响

Eco-Environment & Health Pub Date : 2024-03-04 DOI: 10.1016/j.eehl.2024.02.004

Hongjie Sun , Yingying Liu , Chunxiu Wu , Lena Q. Ma , Dongxing Guan , Huachang Hong , Haiying Yu , Hongjun Lin , Xianfeng Huang , Peng Gao

{"title":"Dihalogenated nitrophenols in drinking water: Prevalence, resistance to household treatment, and cardiotoxic impact on zebrafish embryo","authors":"Hongjie Sun , Yingying Liu , Chunxiu Wu , Lena Q. Ma , Dongxing Guan , Huachang Hong , Haiying Yu , Hongjun Lin , Xianfeng Huang , Peng Gao","doi":"10.1016/j.eehl.2024.02.004","DOIUrl":"10.1016/j.eehl.2024.02.004","url":null,"abstract":"<div><p>Dihalogenated nitrophenols (2,6-DHNPs), an emerging group of aromatic disinfection byproducts (DBPs) detected in drinking water, have limited available information regarding their persistence and toxicological risks. The present study found that 2,6-DHNPs are resistant to major drinking water treatment processes (sedimentation and filtration) and households methods (boiling, filtration, microwave irradiation, and ultrasonic cleaning). To further assess their health risks, we conducted a series of toxicology studies using zebrafish embryos as the model organism. Our findings reveal that these emerging 2,6-DHNPs showed lethal toxicity 248 times greater than that of the regulated DBP, dichloroacetic acid. Specifically, at sublethal concentrations, exposure to 2,6-DHNPs generated reactive oxygen species (ROS), caused apoptosis, inhibited cardiac looping, and induced cardiac failure in zebrafish. Remarkably, the use of a ROS scavenger, N-acetyl-l-cysteine, considerably mitigated these adverse effects, emphasizing the essential role of ROS in 2,6-DHNP-induced cardiotoxicity. Our findings highlight the cardiotoxic potential of 2,6-DHNPs in drinking water even at low concentrations of 19 μg/L and the beneficial effect of N-acetyl-l-cysteine in alleviating the 2,6-DHNP-induced cardiotoxicity. This study underscores the urgent need for increased scrutiny of these emerging compounds in public health discussions.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 2","pages":"Pages 183-191"},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772985024000164/pdfft?md5=3b92f75046a7ef3c9d94cdbf5e9f02a4&pid=1-s2.0-S2772985024000164-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140083821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging concern on air pollution and health: Trade-off between air pollution exposure and physical activity 新出现的空气污染与健康问题：空气污染暴露与体育锻炼之间的权衡

Eco-Environment & Health Pub Date : 2024-03-04 DOI: 10.1016/j.eehl.2024.01.012

Pengpeng Wu , Qian Guo , Yuchen Zhao , Mengyao Bian , Suzhen Cao , Junfeng (Jim) Zhang , Xiaoli Duan

引用次数: 0

Understanding the role of manganese oxides in retaining harmful metals: Insights into oxidation and adsorption mechanisms at microstructure level 了解锰氧化物在吸附有害金属方面的作用：从微观结构层面洞察氧化和吸附机制

Eco-Environment & Health Pub Date : 2024-03-01 DOI: 10.1016/j.eehl.2024.01.002

Feng Li , Hui Yin , Tianqiang Zhu , Wen Zhuang

{"title":"Understanding the role of manganese oxides in retaining harmful metals: Insights into oxidation and adsorption mechanisms at microstructure level","authors":"Feng Li , Hui Yin , Tianqiang Zhu , Wen Zhuang","doi":"10.1016/j.eehl.2024.01.002","DOIUrl":"10.1016/j.eehl.2024.01.002","url":null,"abstract":"<div><p>The increasing intensity of human activities has led to a critical environmental challenge: widespread metal pollution. Manganese (Mn) oxides have emerged as potentially natural scavengers that perform crucial functions in the biogeochemical cycling of metal elements. Prior reviews have focused on the synthesis, characterization, and adsorption kinetics of Mn oxides, along with the transformation pathways of specific layered Mn oxides. This review conducts a meticulous investigation of the molecular-level adsorption and oxidation mechanisms of Mn oxides on hazardous metals, including adsorption patterns, coordination, adsorption sites, and redox processes. We also provide a comprehensive discussion of both internal factors (surface area, crystallinity, octahedral vacancy content in Mn oxides, and reactant concentration) and external factors (pH, presence of doped or pre-adsorbed metal ions) affecting the adsorption/oxidation of metals by Mn oxides. Additionally, we identify existing gaps in understanding these mechanisms and suggest avenues for future research. Our goal is to enhance knowledge of Mn oxides' regulatory roles in metal element translocation and transformation at the microstructure level, offering a framework for developing effective metal adsorbents and pollution control strategies.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 1","pages":"Pages 89-106"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772985024000036/pdfft?md5=9e1f464e07765eaf1d04377675dc1390&pid=1-s2.0-S2772985024000036-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139631614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do wearing masks and preservatives have a combined effect on skin health? 敷面膜和使用防腐剂会对皮肤健康产生综合影响吗？

Eco-Environment & Health Pub Date : 2024-03-01 DOI: 10.1016/j.eehl.2024.01.003

Yu Liu , Leijian Chen , Shuyi Zhang , Xiaoxiao Wang , Yuanyuan Song , Hongwen Sun , Zongwei Cai , Lei Wang

{"title":"Do wearing masks and preservatives have a combined effect on skin health?","authors":"Yu Liu , Leijian Chen , Shuyi Zhang , Xiaoxiao Wang , Yuanyuan Song , Hongwen Sun , Zongwei Cai , Lei Wang","doi":"10.1016/j.eehl.2024.01.003","DOIUrl":"10.1016/j.eehl.2024.01.003","url":null,"abstract":"<div><p>Chemical exposure and local hypoxia caused by mask-wearing may result in skin physiology changes. The effects of methylparaben (MeP), a commonly used preservative in personal care products, and hypoxia on skin health were investigated by HaCaT cell and ICR mouse experiments. MeP exposure resulted in lipid peroxidation and interfered with cellular glutathione metabolism, while hypoxia treatment disturbed phenylalanine, tyrosine, and tryptophan biosynthesis pathways and energy metabolism to respond to oxidative stress. A hypoxic environment increased the perturbation of MeP on the purine metabolism in HaCaT cells, resulting in increased expression of proinflammatory cytokines. The synergistic effects were further validated in a mouse model with MeP dermal exposure and “mask-wearing” treatment. CAT, PPARG, and MMP2 were identified as possible key gene targets associated with skin health risks posed by MeP and hypoxia. Network toxicity analysis suggested a synergistic effect, indicating the risk of skin inflammation and skin barrier aging.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 1","pages":"Pages 107-115"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772985024000048/pdfft?md5=30a83f8f2b5d92c8c2369df5c48aa094&pid=1-s2.0-S2772985024000048-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139631288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic fields promote electrocatalytic CO2 reduction via subtle modulations of magnetic moments and molecular bonding 磁场通过对磁矩和分子键的微妙调节促进电催化二氧化碳还原

Eco-Environment & Health Pub Date : 2024-02-29 DOI: 10.1016/j.eehl.2024.02.003

Shilin Wei, Weiqi Liu, Peiyao Bai, Chuangchuang Yang, Xiao Kong, Lang Xu

{"title":"Magnetic fields promote electrocatalytic CO2 reduction via subtle modulations of magnetic moments and molecular bonding","authors":"Shilin Wei, Weiqi Liu, Peiyao Bai, Chuangchuang Yang, Xiao Kong, Lang Xu","doi":"10.1016/j.eehl.2024.02.003","DOIUrl":"10.1016/j.eehl.2024.02.003","url":null,"abstract":"<div><p>Introducing a magnetic-field gradient into an electrically driven chemical reaction is expected to give rise to intriguing research possibilities. In this work, we elaborate on the modes and mechanisms of electrocatalytic activity (from the perspective of alignment of magnetic moments) and selectivity (at the molecular level) for the CO<sub>2</sub> reduction reaction in response to external magnetic fields. We establish a positive correlation between magnetic field strengths and apparent current densities. This correlation can be rationalized by the formation of longer-range ordering of magnetic moments and the resulting decrease in the scattering of conduction electrons and charge-transfer resistances as the field strength increases. Furthermore, aided by the magnetic-field-equipped <em>operando</em> infrared spectroscopy, we find that applied magnetic fields are capable of weakening the C–O bond strength of the key intermediate ∗COOH and elongating the C–O bond length, thereby increasing the faradaic efficiency for the electroreduction of CO<sub>2</sub> to CO.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 2","pages":"Pages 247-255"},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772985024000152/pdfft?md5=2d20ebee471e7163b020ece83e84d0bb&pid=1-s2.0-S2772985024000152-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140468358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface property and in vitro toxicity effect of insoluble particles given by protein corona: Implication for PM cytotoxicity assessment 蛋白电晕不溶性颗粒的表面特性和体外毒性效应：对 PM 细胞毒性评估的启示

Eco-Environment & Health Pub Date : 2024-02-28 DOI: 10.1016/j.eehl.2024.01.011

Sisi Chen , Yexuan Zhang , Hongjuan Chen , Weijuan Zheng , Xin Hu , Li Mao , Xuewen Guo , Hongzhen Lian

{"title":"Surface property and in vitro toxicity effect of insoluble particles given by protein corona: Implication for PM cytotoxicity assessment","authors":"Sisi Chen , Yexuan Zhang , Hongjuan Chen , Weijuan Zheng , Xin Hu , Li Mao , Xuewen Guo , Hongzhen Lian","doi":"10.1016/j.eehl.2024.01.011","DOIUrl":"10.1016/j.eehl.2024.01.011","url":null,"abstract":"<div><p><em>In vitro</em> toxicological assessment helps explore key fractions of particulate matter (PM) in association with the toxic mechanism. Previous studies mainly discussed the toxicity effects of the water-soluble and organic-soluble fractions of PM. However, the toxicity of insoluble fractions is relatively poorly understood, and the adsorption of proteins is rarely considered. In this work, the formation of protein corona on the surface of insoluble particles during incubation in a culture medium was investigated. It was found that highly abundant proteins in fetal bovine serum were the main components of the protein corona. The adsorbed proteins increased the dispersion stability of insoluble particles. Meanwhile, the leaching concentrations of some metal elements (e.g., Cu, Zn, and Pb) from PM increased in the presence of proteins. The toxicity effects and potential mechanisms of the PM insoluble particle–protein corona complex on macrophage cells RAW264.7 were discussed. The results revealed that the PM insoluble particle–protein corona complex could influence the phagosome pathway in RAW264.7 cells. Thus, it promoted the intracellular reactive oxygen species generation and induced a greater degree of cell differentiation, significantly altering cell morphology. Consequently, this work sheds new light on the combination of insoluble particles and protein corona in terms of PM cytotoxicity assessment.</p></div>","PeriodicalId":29813,"journal":{"name":"Eco-Environment & Health","volume":"3 2","pages":"Pages 137-144"},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772985024000127/pdfft?md5=ecc56aae2013054e7163fb80f7ebf6d2&pid=1-s2.0-S2772985024000127-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140465281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0