Cytokine最新文献

{"title":"MiR-125b suppresses bladder Cancer cell growth and triggers apoptosis by regulating IL-6/IL-6R/STAT3 axis in vitro and in vivo","authors":"Fang Lin ,&nbsp;Shaorun Hu ,&nbsp;Jinxiang Chen ,&nbsp;Haiyang Li ,&nbsp;Mengting Li ,&nbsp;Rong Li ,&nbsp;Min Xu ,&nbsp;Mao Luo","doi":"10.1016/j.cyto.2025.156926","DOIUrl":"10.1016/j.cyto.2025.156926","url":null,"abstract":"<div><div>Bladder cancer (BLCA) is an aggressive malignancy characterized by limited therapeutic options and a poor prognosis. Research has indicated that abnormally expressed miRNAs play a significant role in the pathogenesis of BLCA, although the specific mechanisms remain unclear. MiR-125b plays a tumor suppressor role in a variety of cancers and affects the biological processes of cancer cells such as proliferation, invasion, migration and apoptosis by regulating different signaling pathways. Elucidation of the molecular mechanisms underlying miR-125b may provide clinical therapeutic strategies for bladder cancer. Here, miR-125b was downregulated whereas its targets IL-6R and STAT3 were upregulated in BLCA, as evidenced by bioinformatics analysis. Kaplan-Meier analysis confirmed that miR-125b serves as an independent prognostic factor linked to overall survival (OS) in patients with bladder cancer. Furthermore, overexpression of miR-125b significantly inhibited BLCA cell proliferation, migration, and invasion, while promoting apoptosis, as evidenced by an increased Bax/Bcl-2 ratio and activated cleaved caspase-3. Further investigations demonstrated that miR-125b directly targets and downregulates both IL-6R and STAT3. In a xenograft model, miR-125b overexpression effectively inhibited tumor growth in bladder cancer by blocking IL-6/IL-6R and STAT3 signaling pathways. Collectively, these findings broaden our understanding of the mechanism by which miR-125b acting as a BLCA suppressor in apoptotic regulation by targeting the IL-6/IL-6R/STAT3 signaling pathway, providing novel insights regarding the design of novel miRNA based therapeutic strategies against BLCA.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"190 ","pages":"Article 156926"},"PeriodicalIF":3.7,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory cytokine profile in non-small cell lung Cancer (NSCLC) patients during early enhanced recovery after surgery (ERAS) period and its relation to hospital length of stay","authors":"Yongxia SONG ,&nbsp;Chengcheng LI ,&nbsp;Yan FANG ,&nbsp;Ziyi SHEN ,&nbsp;Xiaoling GE ,&nbsp;Rui WANG ,&nbsp;Wanli XIA ,&nbsp;Ruoyu HUANG ,&nbsp;Huan QIU ,&nbsp;Huaguang PAN ,&nbsp;Jingfang HONG","doi":"10.1016/j.cyto.2025.156918","DOIUrl":"10.1016/j.cyto.2025.156918","url":null,"abstract":"<div><h3>Purpose</h3><div>Immunoregulatory cytokines may play a fundamental role in tumor growth and the acute surgical stress response. Inflammatory cytokine profiles have the potential to serve as biomarkers. This study aimed to correlate tumor- or surgery-related inflammatory cytokine profile, derived from data mining, with clinical data and the hospital length of stay for non-small cell lung cancer (NSCLC) patients during the early enhanced recovery after surgery (ERAS) period.</div></div><div><h3>Methods</h3><div>A multi-phase detection approach was used, involving pre- and post-operative NSCLC patients and matched healthy controls. In the screening phase, plasma levels of 48 cytokines were quantified using a Luminex multiplex bead array to identify tumor- or surgery-related cytokine profiles. In the confirmation phase, differentially expressed cytokines were validated using ELISA with a new set of samples. Tumor-related cytokines were identified by comparing preoperative NSCLC patients with controls, while tumor or surgery-related cytokines were determined by comparing with the same cohort before and after surgery, as well as postoperative patients with controls. We then searched cancer genomics databases and protein atlas resources to investigate cytokine-related RNA expression and RNA-protein interactions. Finally, we integrated and standardized our results, conducting correlation analysis to explore relationships between cytokines, hospital length of stay, and clinical data.</div></div><div><h3>Results</h3><div>During the initial phase of the ERAS, a comprehensive array of differential cytokines associated with tumors or surgery, including Eotaxin, IL-1β, IL-1Ra, IL-6, IL-13, IL-16, IP-10, MCP-1, PDGF-BB, RANTES, SCF, and TRAIL, were identified. Preoperative levels of RANTES, urea nitrogen, prognostic-nutritional index, and age may serve as potential indicators for predicting hospital length of stay.</div></div><div><h3>Conclusion</h3><div>The multi-phase detection analysis has identified a plasma cytokine signature for NSCLC patients during the early ERAS period. Assessment of cytokine profiles and clinical data may reveal unique insights into short-term survival outcome under ERAS.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"190 ","pages":"Article 156918"},"PeriodicalIF":3.7,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “An update on the association between metabolic syndrome and osteoarthritis and on the potential role of leptin in osteoarthritis” [Cytokine 129 (2020) 155043]","authors":"Yu-Hang Gao ,&nbsp;Cheng-Wu Zhao ,&nbsp;Bo Liu ,&nbsp;Ning Dong ,&nbsp;Lu Ding ,&nbsp;Ye-Ran Li ,&nbsp;Jian-Guo Liu ,&nbsp;Wei Feng ,&nbsp;Xin Qi ,&nbsp;Xian-Hua Jin","doi":"10.1016/j.cyto.2025.156923","DOIUrl":"10.1016/j.cyto.2025.156923","url":null,"abstract":"","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"190 ","pages":"Article 156923"},"PeriodicalIF":3.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytokine immune profiles among COVID 19 patients with different disease severities seeking treatment at Moi teaching and referral hospital, Kenya","authors":"Jenniffer C. Sang ,&nbsp;Stanslaus K. Musyoki ,&nbsp;Wilfred E. Injera ,&nbsp;Lucy W. Karani ,&nbsp;Geoffrey K. Maiyoh","doi":"10.1016/j.cyto.2025.156917","DOIUrl":"10.1016/j.cyto.2025.156917","url":null,"abstract":"<div><h3>Background</h3><div>COVID-19 manifests with a wide range of severities, from asymptomatic to critical conditions. Immunological profiles in patients positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may serve as early indicators of disease severity, aiding in prioritizing patient care.</div></div><div><h3>Methodology</h3><div>Archived patient plasma samples were retrieved from the Molecular Lab Bio-repository, ensuring equal representation of males, females, and various disease severities. Socio-demographic and disease severity data were obtained from patient health records. Levels of pro-inflammatory cytokines (interferon-gamma [IFN-γ], tumor necrosis factor-alpha [TNF-α], interleukin-2 [IL-2], and interleukin-17 [IL-17]) and anti-inflammatory cytokines (interleukin-4 [IL-4], interleukin-6 [IL-6], and interleukin-10 [IL-10]) were measured using the BD FACSCalibur flow cytometer. Data analysis involved comparing cytokine levels across different disease severities, with demographic data expressed as means ± standard deviation (SD). Statistical significance was set at <em>P</em> ≤ 0.05.</div></div><div><h3>Findings</h3><div>The mean ages for males and females were 49.6 ± 22.7 and 48.4 ± 23.7, respectively. Mean ages for disease severity categories were 33 ± 19 (asymptomatic), 45.2 ± 21.5 (moderate), 56.8 ± 18.7 (severe), and 61.95 ± 22 (critical). Comorbidities were present in 25 % of patients, with cardiovascular disease (41 %) and pulmonary disease (31 %) being the most common. Predominant symptoms in critical patients included dyspnea (63 %) and myalgia (60 %), while rhinorrhea (46.2 %) and chest pain (45.7 %) were common in severe cases. Gastrointestinal symptoms were observed only in severe and critical groups. Levels of the pro-inflammatory cytokines (IFN-γ, TNF-α, and IL-17) increased linearly with disease severity. Among anti-inflammatory cytokines, IL-6 and IL-10 levels also rose significantly with increasing severity.</div></div><div><h3>Conclusion</h3><div>Levels of TNF-α, IL-17, and IL-6 correlated with disease severity and may serve as prognostic biomarkers. Advanced age and underlying comorbidities were independently associated with higher disease severity.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"190 ","pages":"Article 156917"},"PeriodicalIF":3.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChREBP drives fibroblast proliferation and promotes pulmonary fibrosis development","authors":"Jian Zheng ,&nbsp;Yang Zhang ,&nbsp;Yan Chen ,&nbsp;Li Tian","doi":"10.1016/j.cyto.2025.156906","DOIUrl":"10.1016/j.cyto.2025.156906","url":null,"abstract":"<div><h3>Objective</h3><div>The study aimed to investigate the role of carbohydrate-responsive element-binding protein (ChREBP) in the pathogenesis of pulmonary fibrosis (PF) by assessing its impact on fibrotic protein expression, fibroblast proliferation, and apoptosis in lung tissues.</div></div><div><h3>Method</h3><div>The PF model was established using bleomycin, and pathological changes in lung tissues were assessed through histopathological analysis. Expression levels of inflammatory markers and fibrotic proteins, including ChREBP, were measured using Western blot and ELISA. Additionally, human embryonic lung fibroblasts (MRC-5) were transfected with ChREBP overexpression or silencing vectors following TGF-β1 induction to examine changes in cellular behavior, including viability, apoptosis, and fibrotic protein expression.</div></div><div><h3>Results</h3><div>The PF model group showed significant alveolar structural abnormalities and elevated levels of TNF-α, MMP-7 and TGF-β1. ChREBP expression was markedly increased in fibrotic tissues (<em>P</em> &lt; 0.05). In vitro<em>,</em> ChREBP overexpression in MRC-5 cells enhanced fibrotic protein levels, increased cell viability, and reduced apoptosis rates. Conversely, silencing ChREBP reduced fibrotic protein expression, inhibited fibroblast proliferation, and increased apoptosis (<em>P</em> &lt; 0.05). These findings suggest that ChREBP plays a key role in modulating fibrosis-related pathways in PF.</div></div><div><h3>Conclusions</h3><div>ChREBP is substantially upregulated in PF and plays a key role in promoting fibroblast proliferation and inhibiting apoptosis. These findings suggest that targeting ChREBP may present a novel therapeutic strategy for treating pulmonary fibrosis by modulating fibrotic and apoptotic pathways.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"190 ","pages":"Article 156906"},"PeriodicalIF":3.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of genetic variants in TNF and PTPRT genes in goats and correlation with the risk of brucellosis infections","authors":"Zhengxuan Zhang ,&nbsp;Congliang Wang ,&nbsp;Minying Ju ,&nbsp;Zhaofei Ren ,&nbsp;Xiaoyu Liu ,&nbsp;Yanyan Li ,&nbsp;Xiaomin Du ,&nbsp;Rongrong Li ,&nbsp;Wangye Liu ,&nbsp;Haijing Zhu","doi":"10.1016/j.cyto.2025.156913","DOIUrl":"10.1016/j.cyto.2025.156913","url":null,"abstract":"<div><div><em>Brucella</em>, an intracellular facultative coccidia, causes brucellosis, which poses a significant threat to livestock farming and public health, and screening for candidate genes associated with resistance to brucellosis is considered an effective strategy for controlling the transmission and infection of this disease. In this context, we detected InDel genetic variants of the tumor necrosis factor (TNF) and protein tyrosine phosphatase receptor T (PTPRT) genes in the Shaanbei White Cashmere (SWBC) goat and analyzed the correlation between their polymorphisms and the risk of brucellosis infection in goats. The results indicated that the TNF rs669191919 and PTPRT rs639317914 loci were polymorphic in the examined goat populations. Both loci exhibited a 13 bp InDel deletion and resulted in three genotypes: insertion/insertion (II), insertion/deletion (ID), and deletion/deletion (DD), with II genotypes and I alleles occurring at higher frequencies. The polymorphism information content (PIC) values suggested that both InDel variant loci were moderately polymorphic (0.25 &lt; PIC &lt;0.50). Furthermore, association analysis revealed that none of the four established genetic models codominant, dominant, recessive, and allele showed an association between the polymorphisms at the rs669191919 and rs639317914 loci and the risk of brucellosis in goats (<em>P</em> &gt; 0.05). Bioinformatics analyses indicated that the rs669191919 and rs639317914 loci specifically bind to the transcription factors upstream transcription factor 1 (USF1) and nescient helix-loop-helix 1 (NHLH1), respectively. In summary, our findings suggest that polymorphisms at the TNF rs669191919 and PTPRT rs639317914 loci do not influence resistance to brucellosis in goats. However, investigations into the specific binding of these polymorphic loci to transcription factors may represent a novel avenue for exploring the mechanisms underlying resistance to brucellosis in livestock.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"190 ","pages":"Article 156913"},"PeriodicalIF":3.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CCL19/MIP-3β as a key mediator in the production of anti-GPIIb/IIIa antibody-producing B cells in patients with chronic hepatitis C","authors":"Junki Iida ,&nbsp;Haruki Uojima ,&nbsp;Takashi Satoh ,&nbsp;Masaya Sugiyama ,&nbsp;Akira Take ,&nbsp;Yoshihiko Sakaguchi ,&nbsp;Kazuyoshi Gotoh ,&nbsp;Hisashi Hidaka ,&nbsp;Shunji Hayashi ,&nbsp;Yasuhito Tanaka ,&nbsp;Makoto Otsu ,&nbsp;Chika Kusano","doi":"10.1016/j.cyto.2025.156915","DOIUrl":"10.1016/j.cyto.2025.156915","url":null,"abstract":"<div><div>The roles of specific cytokines and chemokines in modulating the production of anti-GPIIb/IIIa antibody-producing B cells remain poorly understood. We aimed to assess key mediators that influence the number of anti-glycoprotein (GP) IIb/IIIa antibody-producing B cells in patients with hepatitis C virus (HCV). This study used a subset of a previously reported cohort in Japan. We first evaluated the number of anti-GPIIb/IIIa antibody-producing B cells using an enzyme-linked immunospot assay in samples from 22 patients who received direct-acting antivirals (DAA)-based therapy and achieved a sustained virological response (SVR). To identify the key mediators, we then analyzed levels of cytokines, chemokines, and inflammation markers in serum samples obtained from the same cohort using Bio-Plex Multiplex Immunoassays. The analysis revealed a significant correlation between the frequency of anti-GPIIb/IIIa antibody-producing B cells and CCL19/macrophage inflammatory protein-3 beta (MIP-3β) (<em>r</em> = 0.590, <em>p</em> = 0.006). After DAA treatment for HCV, both the frequency of these B cells and the levels of CCL19/MIP-3β significantly decreased. Furthermore, the frequency of anti-GPIIb/IIIa antibody-producing B cells and levels of CCL19/MIP-3β were significantly higher in the thrombocytopenia group compared to the non-thrombocytopenia group (<em>p</em> = 0.001 and <em>p</em> = 0.029, respectively). These results suggest that CCL19/MIP-3β may be a key mediator in the production of anti-GPIIb/IIIa antibody-producing B cells in patients with HCV.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"190 ","pages":"Article 156915"},"PeriodicalIF":3.7,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric mucosal CD8+TRM cells are recruited through CXCR5-CXCL13 axis in Helicobacter pylori infected subjects","authors":"Tingting Xia ,&nbsp;Zelin Zhang ,&nbsp;Jia Xie,&nbsp;Hanmei Yuan,&nbsp;Yayi Ren,&nbsp;Yue Xu,&nbsp;Jie Ning,&nbsp;Bin Li,&nbsp;Chao Wu","doi":"10.1016/j.cyto.2025.156904","DOIUrl":"10.1016/j.cyto.2025.156904","url":null,"abstract":"<div><div>Gastric mucosal CD8⁺ tissue-resident memory T (CD8⁺T_RM) cells are increased in <em>Helicobacter pylori</em> (<em>H. pylori</em>) infected subjects, but the characteristics and chemotactic mechanism of CD8⁺T_RM cells remain unknown. We demonstrated that C-X-C chemokine receptor 5 (CXCR5) was upregulated on gastric mucosal CD8⁺T_RM cells, and gastric CXCL13 was dominantly secreted by dendritic cells and macrophages in <em>H. pylori</em> infected subjects. Gastric mucosal CD8⁺T_RM cells from CagA+ <em>H. pylori</em> infected subjects was increased and could secrete more IFN-γ and TNF-α to engage in local immune response. The number of gastric mucosal CD8⁺T_RM cells and the expression of CXCL13 was elevated in <em>H. pylori</em> infected individuals with the development of gastric diseases. In conclusion, gastric mucosal CD8⁺T_RM cells are increased from CagA+ <em>H. pylori</em> infected subjects and could be recruited through CXCL13-CXCR5 axis, which mainly release IFN-γ and TNF-α in <em>H. pylori</em> related immune response.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"190 ","pages":"Article 156904"},"PeriodicalIF":3.7,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soluble tumour necrosis factor receptor 1 predicts hospitalization in children and young adults with dengue virus infection in the Philippines","authors":"Vanesse Li ,&nbsp;Hridesh Mishra ,&nbsp;Michelle Ngai ,&nbsp;Valerie M. Crowley ,&nbsp;Vanessa Tran ,&nbsp;Maria Salome Siose Painaga ,&nbsp;James Yared Gaite ,&nbsp;Patrick Hamilton ,&nbsp;Andrea L. Conroy ,&nbsp;Kevin C. Kain ,&nbsp;Michael T. Hawkes","doi":"10.1016/j.cyto.2025.156911","DOIUrl":"10.1016/j.cyto.2025.156911","url":null,"abstract":"<div><h3>Background</h3><div>Dengue fever is a common cause of acute febrile illness in the tropics and requires hospitalization for intravenous (IV) fluid therapy in a minority of patients. Predicting which patients will progress to severe disease is challenging. Soluble tumour necrosis factor receptor 1 (sTNFR1) is associated with severe dengue and may have prognostic value.</div></div><div><h3>Methods</h3><div>Prospective cohort study of outpatients in the Philippines with dengue fever, confirmed by NS1 antigenemia or IgM seropositivity. sTNFR1 was measured at presentation and patients were followed for 14–21 days for hospitalization (primary outcome), duration of stay, IV fluid resuscitation, hemoconcentration, and thrombocytopenia (secondary outcomes).</div></div><div><h3>Results</h3><div>244 patients (median age 9 years, 40 % female, 26 % uncomplicated dengue, 73 % dengue with warning signs, 0.82 % severe dengue) were included. The median sTNFR1 plasma concentration was 3000pg/mL (IQR 2400–3700) at clinic presentation, decreasing to 1800 (IQR 1600–2100) after recovery. 181 patients (74 %) required hospitalization. Plasma sTNFR1 concentration &gt; 2800 pg/mL, measured at clinic presentation, was associated with subsequent hospitalization (relative risk 1.5, 95 %CI 1.2–1.7, <em>p</em> &lt; 0.0001). Elevated sTNFR1 was also associated with longer duration of stay, IV fluid requirement, hemoconcentration, and thrombocytopenia. sTNFR1 was also associated with a marker of systemic inflammation (procalcitonin), and circulating markers of endothelial activation (Ang2, sTie-2, sVCAM-1, and endoglin).</div></div><div><h3>Conclusion</h3><div>Elevated sTNFR1 is predictive of subsequent hospitalization among outpatients with DENV infection. It shows promise as a marker that could guide triage to reduce the large healthcare burden of dengue in resource-constrained settings.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"190 ","pages":"Article 156911"},"PeriodicalIF":3.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosome-mediated communication between T cells and dendritic cells: Implications for therapeutic strategies","authors":"Tahereh Kashkoulinejad Kouhi","doi":"10.1016/j.cyto.2025.156914","DOIUrl":"10.1016/j.cyto.2025.156914","url":null,"abstract":"<div><div>Cell communication is crucial for coordinating physiological functions in multicellular organisms, with exosomes playing a significant role. Exosomes mediate intercellular communication by transporting proteins, lipids, and nucleic acids between cells. These small, membrane-bound vesicles, derived from the endosomal pathway, are integral to various biological processes, including signal transmission and cellular behavior modulation. Recent advances highlight the potential of exosomes, especially dendritic cell-derived exosomes (DEXs), for diagnostic and therapeutic applications, particularly in cancer immunotherapy. DEXs are distinguished by their ability to present antigens and stimulate immune responses more effectively than exosomes from other cell types. They carry a cargo rich in immunostimulatory molecules and MHC-peptide complexes, which facilitate robust T-cell activation and enhance tumor-specific immune responses. The unique properties of DEXs, such as their ability to cross biological barriers and resist tumor-induced immunosuppression, position them as promising candidates for therapeutic applications. Here, I review the reports on the bidirectional interaction between dendritic cells and T cells through exosomes and their role in medicine.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"189 ","pages":"Article 156914"},"PeriodicalIF":3.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143591585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}