ACS Nanoscience Au最新文献

{"title":"Orally Administered Silver Nanoparticles Are Absorbed and Migrate to Testes in Mice","authors":"Yuma Saeki, Kazuma Higashisaka, Rina Izutani, Jiwon Seo, Kazuki Miyaji, Yuya Haga, Yasuo Tsutsumi","doi":"10.1021/acsnanoscienceau.4c00021","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00021","url":null,"abstract":"Given that daily exposure to nanoparticles is now unavoidable, there are concerns that nanoparticles have unexpected biological effects due to their small size. Here, we examined the biodistribution of silver nanoparticles, which are the most frequently used nanoparticles owing to their antibacterial activity, with a diameter of 10 nm (nAg10) to the male genital tract, and the effects of paternal treatment with nAg10 on fetal development. Male Slc:ICR male mice were orally treated with nAg10 for 14 consecutive days. Inductively coupled plasma mass spectrometry analysis detected silver in the blood and testis of male mice, but no general toxicological effects were induced. Moreover, there were no significant changes in fetal development when these treated male mice were mated with nontreated female mice. This implies that although orally ingested nAg10 is distributed to the male genital tract, it does not affect fetal development under the present treatment conditions.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142192240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Electrocatalytic Semihydrogenation of Alkynes via Weakening Alkene Adsorption over Electron-Depleted Cu Nanowires","authors":"Dan Luo, Zhiheng Xie, Shuangqun Chen, Tianyi Yang, Yalin Guo, Ying Liu, Zhouhao Zhu, Liyong Gan, Lingmei Liu, Jianfeng Huang","doi":"10.1021/acsnanoscienceau.4c00030","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00030","url":null,"abstract":"Electrochemical semihydrogenation (ESH) of alkynes to alkenes is an appealing technique for producing pharmaceutical precursors and polymer monomers, while also preventing catalyst poisoning by alkyne impurities. Cu is recognized as a cost-effective and highly selective catalyst for ESH, whereas its activity is somewhat limited. Here, from a mechanistic standpoint, we hypothesize that electron-deficient Cu can enhance ESH activity by promoting the rate-determining step of alkene desorption. We test this hypothesis by utilizing Cu–Ag hybrids as electrocatalysts, developed through a welding process of Ag nanoparticles with Cu nanowires. Our findings reveal that these rationally engineered Cu–Ag hybrids exhibit a notable enhancement (2–4 times greater) in alkyne conversion rates compared to isolated Ag NPs or Cu NWs, while maintaining over 99% selectivity for alkene products. Through a combination of operando and computational studies, we verify that the electron-depleted Cu sites, resulting from electron transfer between Ag nanoparticles and Cu nanowires, effectively weaken the adsorption of alkenes, thereby substantially boosting ESH activity. This work not only provides mechanistic insights into ESH but also stimulates compelling strategies involving hybridizing distinct metals to optimize ESH activity.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"2011 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141937714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CO2 Hydrogenation to Methanol over Mesoporous SiO2-Coated Cu-Based Catalysts","authors":"Luiz H. Vieira, Marco A. Rossi, Letícia F. Rasteiro, José M. Assaf, Elisabete M. Assaf","doi":"10.1021/acsnanoscienceau.4c00016","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00016","url":null,"abstract":"Although chemical promotion led to essential improvements in Cu-based catalysts for CO₂ hydrogenation to methanol, surpassing structural limitations such as active phase aggregation under reaction conditions remains challenging. In this report, we improved the textural properties of Cu/In₂O₃/CeO₂ and Cu/In₂O₃/ZrO₂ catalysts by coating the nanoparticles with a mesoporous SiO₂ shell. This strategy limited particle size up to 3.5 nm, increasing metal dispersion and widening the metal–metal oxide interface region. Chemometric analysis revealed that these structures could maintain high activity and selectivity in a wide range of reaction conditions, with methanol space-time yields up to 4 times higher than those of the uncoated catalysts.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141745570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CO2 Hydrogenation to Methanol over Mesoporous SiO2-Coated Cu-Based Catalysts","authors":"Luiz H. Vieira*,&nbsp;Marco A. Rossi,&nbsp;Letícia F. Rasteiro,&nbsp;José M. Assaf and Elisabete M. Assaf*,&nbsp;","doi":"10.1021/acsnanoscienceau.4c0001610.1021/acsnanoscienceau.4c00016","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00016https://doi.org/10.1021/acsnanoscienceau.4c00016","url":null,"abstract":"<p >Although chemical promotion led to essential improvements in Cu-based catalysts for CO₂ hydrogenation to methanol, surpassing structural limitations such as active phase aggregation under reaction conditions remains challenging. In this report, we improved the textural properties of Cu/In₂O₃/CeO₂ and Cu/In₂O₃/ZrO₂ catalysts by coating the nanoparticles with a mesoporous SiO₂ shell. This strategy limited particle size up to 3.5 nm, increasing metal dispersion and widening the metal–metal oxide interface region. Chemometric analysis revealed that these structures could maintain high activity and selectivity in a wide range of reaction conditions, with methanol space-time yields up to 4 times higher than those of the uncoated catalysts.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"4 4","pages":"235–242 235–242"},"PeriodicalIF":4.8,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.4c00016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomics Analysis for Unveiling the Toxicological Mechanism of Silver Nanoparticles Using an In Vitro Gastrointestinal Digestion Model","authors":"Yongjiu Chen, Ruixia Wang, Ming Xu","doi":"10.1021/acsnanoscienceau.4c00012","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00012","url":null,"abstract":"The increasing use of silver nanoparticles (AgNPs) in consumer products has led to concerns about potential health risks after oral exposure as a result of the transformation and absorption in the gastrointestinal tract (GIT). However, the intricate condition of the GIT poses challenges in understanding the fate and toxicity of AgNPs as they traverse from the mouth to the rectum. For an in-depth understanding of the nanobio interactions, we employed a simulated digestion model to investigate alterations in the physicochemical properties of AgNPs <i>in vitro</i>. Meanwhile, we investigated the underlying toxicological mechanisms of digested AgNPs in enterocytes through metabolomics analysis. In contrast to route means that primarily apply salt solutions to mimic dietary digestion, this <i>in vitro</i> model is a semidynamic sequential digestion system that includes artificial oral, gastric, and intestinal fluids, which are similar to those under physiological conditions including electrolytes, enzymes, bile, pH, and time of digestion. Our results suggest that the formation of Ag–Cl and Ag–S species within the simulated digestion model can lead to an increase in the size of digested AgNPs and that the acidic condition promotes the release of Ag⁺ from particles. More critically, the presence of digestive enzymes and high concentrations of salt enhances the uptake of Ag by human colon enterocytes, ultimately promoting ROS generation and exacerbating cytotoxicity. Metabolomics analysis further reveals that the sequentially digested AgNPs may disorder lipid metabolism, including the biosynthesis of unsaturated fatty acids and arachidonic acid metabolism, thus increasing the possibility of ferroptosis activation in enterocytes. These findings offer significant insights into the fate and potential adverse effects of AgNPs in the GIT, providing important implications for assessing the health risks of AgNPs via oral exposure.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141510132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuning Chemical DNA Ligation within DNA Crystals and Protein–DNA Cocrystals","authors":"Abigail R. Orun, Caroline K. Slaughter, Ethan T. Shields, Ananya Vajapayajula, Sara Jones, Rojina Shrestha, Christopher D. Snow","doi":"10.1021/acsnanoscienceau.4c00013","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00013","url":null,"abstract":"Biomolecular crystals can serve as materials for a plethora of applications including precise guest entrapment. However, as grown, biomolecular crystals are fragile in solutions other than their growth conditions. For crystals to achieve their full potential as hosts for other molecules, crystals can be made stronger with bioconjugation. Building on our previous work using carbodiimide 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide (EDC) for chemical ligation, here, we investigate DNA junction architecture through sticky base overhang lengths and the role of scaffold proteins in cross-linking within two classes of biomolecular crystals: cocrystals of DNA-binding proteins and pure DNA crystals. Both crystal classes contain DNA junctions where DNA strands stack up end-to-end. Ligation yields were studied as a function of sticky base overhang length and terminal phosphorylation status. The best ligation performance for both crystal classes was achieved with longer sticky overhangs and terminal 3′phosphates. Notably, EDC chemical ligation was achieved in crystals with pore sizes too small for intracrystal transport of ligase enzyme. Postassembly cross-linking produced dramatic stability improvements for both DNA crystals and cocrystals in water and blood serum. The results presented may help crystals containing DNA achieve broader application utility, including as structural biology scaffolds.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141530001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Light-Responsive and Antibacterial Graphenic Materials as a Holistic Approach to Tissue Engineering","authors":"Andrea Ferreras,&nbsp;Ana Matesanz,&nbsp;Jabier Mendizabal,&nbsp;Koldo Artola,&nbsp;Yuta Nishina,&nbsp;Pablo Acedo,&nbsp;José L. Jorcano,&nbsp;Amalia Ruiz*,&nbsp;Giacomo Reina* and Cristina Martín*,&nbsp;","doi":"10.1021/acsnanoscienceau.4c0000610.1021/acsnanoscienceau.4c00006","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00006https://doi.org/10.1021/acsnanoscienceau.4c00006","url":null,"abstract":"<p >While the continuous development of advanced bioprinting technologies is under fervent study, enhancing the regenerative potential of hydrogel-based constructs using external stimuli for wound dressing has yet to be tackled. Fibroblasts play a significant role in wound healing and tissue implants at different stages, including extracellular matrix production, collagen synthesis, and wound and tissue remodeling. This study explores the synergistic interplay between photothermal activity and nanomaterial-mediated cell proliferation. The use of different graphene-based materials (GBM) in the development of photoactive bioinks is investigated. In particular, we report the creation of a skin-inspired dressing for wound healing and regenerative medicine. Three distinct GBM, namely, graphene oxide (GO), reduced graphene oxide (rGO), and graphene platelets (GP), were rigorously characterized, and their photothermal capabilities were elucidated. Our investigations revealed that rGO exhibited the highest photothermal efficiency and antibacterial properties when irradiated, even at a concentration as low as 0.05 mg/mL, without compromising human fibroblast viability. Alginate-based bioinks alongside human fibroblasts were employed for the bioprinting with rGO. The scaffold did not affect the survival of fibroblasts for 3 days after bioprinting, as cell viability was not affected. Remarkably, the inclusion of rGO did not compromise the printability of the hydrogel, ensuring the successful fabrication of complex constructs. Furthermore, the presence of rGO in the final scaffold continued to provide the benefits of photothermal antimicrobial therapy without detrimentally affecting fibroblast growth. This outcome underscores the potential of rGO-enhanced hydrogels in tissue engineering and regenerative medicine applications. Our findings hold promise for developing game-changer strategies in 4D bioprinting to create smart and functional tissue constructs with high fibroblast proliferation and promising therapeutic capabilities in drug delivery and bactericidal skin-inspired dressings.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"4 4","pages":"263–272 263–272"},"PeriodicalIF":4.8,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.4c00006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142010490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making the Most of Nothing: One-Class Classification for Single-Molecule Transport Studies","authors":"William Bro-Jørgensen,&nbsp;Joseph M. Hamill,&nbsp;Gréta Mezei,&nbsp;Brent Lawson,&nbsp;Umar Rashid,&nbsp;András Halbritter*,&nbsp;Maria Kamenetska*,&nbsp;Veerabhadrarao Kaliginedi* and Gemma C. Solomon*,&nbsp;","doi":"10.1021/acsnanoscienceau.4c0001510.1021/acsnanoscienceau.4c00015","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00015https://doi.org/10.1021/acsnanoscienceau.4c00015","url":null,"abstract":"<p >Single-molecule experiments offer a unique means to probe molecular properties of individual molecules–yet they rest upon the successful control of background noise and irrelevant signals. In single-molecule transport studies, large amounts of data that probe a wide range of physical and chemical behaviors are often generated. However, due to the stochasticity of these experiments, a substantial fraction of the data may consist of blank traces where no molecular signal is evident. One-class (OC) classification is a machine learning technique to identify a specific class in a data set that potentially consists of a wide variety of classes. Here, we examine the utility of two different types of OC classification models on four diverse data sets from three different laboratories. Two of these data sets were measured at cryogenic temperatures and two at room temperature. By training the models solely on traces from a blank experiment, we demonstrate the efficacy of OC classification as a powerful and reliable method for filtering out blank traces from a molecular experiment in all four data sets. On a labeled 4,4′-bipyridine data set measured at 4.2 K, we achieve an accuracy of 96.9 ± 0.3 and an area under the receiver operating characteristic curve of 99.5 ± 0.3 as validated over a fivefold cross-validation. Given the wide range of physical and chemical properties that can be probed in single-molecule experiments, the successful application of OC classification to filter out blank traces is a major step forward in our ability to understand and manipulate molecular properties.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"4 4","pages":"250–262 250–262"},"PeriodicalIF":4.8,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.4c00015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142010489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterials Research at a Primarily Undergraduate Institution: Transforming Nanorods, Undergraduate Research Communities, and Infrastructure","authors":"Katherine E. Plass*,&nbsp;J. Kenneth Krebs,&nbsp;Jennifer L. Morford,&nbsp;Raymond E. Schaak,&nbsp;Joshua J. Stapleton and Adri C. T. van Duin,&nbsp;","doi":"10.1021/acsnanoscienceau.4c0000510.1021/acsnanoscienceau.4c00005","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00005https://doi.org/10.1021/acsnanoscienceau.4c00005","url":null,"abstract":"<p >Undergraduate research transforms student’s conceptions of themselves as scientists and encourages participation and retention in science, technology, engineering, and mathematics (STEM) fields. Many barriers exist to carrying out scientifically impactful undergraduate research in nanomaterials at primarily undergraduate institutions (PUIs). Here, we share several practices and design principles that demonstrate pathways to overcome these barriers. Design of modular research projects with low entry barriers is essential. Postsynthetic transformation of nanoparticles is a field that enables such design and has been used successfully to advance nanoscience research while being achievable within undergraduate laboratories. Relatively large, inclusive research communities can be supported through the creation of opportunities with peer- and near-peer mentoring. We also share emerging strategies for enabling routine undergraduate access to transmission electron microscopy, which is one of the most mainstream characterization techniques in nanoscience yet is frequently absent from the infrastructure at undergraduate-focused institutions.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"4 4","pages":"223–234 223–234"},"PeriodicalIF":4.8,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.4c00005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142010446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anodic Electrodeposition of IrOx Nanoparticles from Aqueous Nanodroplets","authors":"Saptarshi Paul,&nbsp;Joshua Reyes-Morales,&nbsp;Kingshuk Roy and Jeffrey E. Dick*,&nbsp;","doi":"10.1021/acsnanoscienceau.3c00061","DOIUrl":"10.1021/acsnanoscienceau.3c00061","url":null,"abstract":"<p >Electrodeposition has been used for centuries to create new materials. However, synthetic platforms are still necessary to enrich a variety of nanomaterials that can be electrodeposited. For instance, IrO_<i>x</i> is a popular material for the water oxidation reaction, but electrodeposition strategies for the controlled growth of IrO_<i>x</i> nanoparticles are lacking. Here, we demonstrate the anodic electrodeposition of IrO_<i>x</i> nanoparticles from aqueous nanodroplets. Field emission scanning electron microscopy (FESEM) and scanning transmission electron microscopy (STEM) images confirm the macro- and microstructure of the resulting nanoparticles. IrO_<i>x</i> nanoparticles of 43 ± 10 nm in diameter were achieved. X-ray photoelectron spectroscopy (XPS) showed the presence of Ir(III) and Ir(IV) hydrated oxyhydroxide species. The synthesis of IrO_<i>x</i> nanoparticles under anodic conditions using water nanodroplets expands the capabilities of our technique and provides a tunable platform for IrO_<i>x</i> nanoparticle electrodeposition.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"4 3","pages":"216–222"},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.3c00061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140608889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}