ACS Nanoscience Au最新文献

{"title":"Mismatch-Tuned Plasmonic Nanogap Networks on Block Copolymers for Ultrasensitive Nucleic Acid Quantification","authors":"Yizhou Zhang,&nbsp;Ying Du,&nbsp;Martin Spillmann,&nbsp;Kazuto Akagi,&nbsp;Jiukai Tang,&nbsp;Shivaprakash N. Ramakrishna,&nbsp;Guangyu Qiu,&nbsp;Jing Wang","doi":"10.1021/acsnanoscienceau.5c00190","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.5c00190","url":null,"abstract":"<p>In localized surface plasmon resonance (LSPR), rationalnanogapengineering in metallic nanostructures enables strong plasmonic couplingand efficient confinement of incident electromagnetic fields, therebysignificantly enhancing optical responses for biosensing applications.Traditional approaches to fabricating small gaps have relied on localizingdielectric spacers between gold nanoparticles (AuNPs). However, doingso has encountered challenges in producing high-density, clean gapsacross large surface areas. Here, we demonstrate a straightforward,self-assembly-guided method for the consistent fabrication of topologicallyanchored AuNPs featuring sub-5 nm nanogaps, arranged on a nanostructuredblock copolymer template. The solution-based method enables time-dependenttuning toward high plasmonic coupling density, resulting in an extensivenumber of hotspots, with an equivalent sensing enhancement factor(ESEF) exceeding that of thermally annealed gold nanoisland chipsby 1 × 10⁵. Laser excitation of these densely packedAuNPs at their plasmonic resonance efficiently drives both nucleicacid hybridization and amplification-based cyclic fluorescence probecleavage, enabling SARS-CoV-2 viral sequence quantification down tothe attomolar level. Our results demonstrate that a carefully engineeredtemplate nanostructure and the AuNP diameter integrate plasmonic hotspots,target adsorption, thermoplasmonic heating, and signal transductionwithin a single platform. This facile strategy for densely packedhotspots offers a potentially scalable avenue for ultrasensitive biomolecularassays.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 4","pages":"570–581"},"PeriodicalIF":7.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148769451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inkjet-Printed Aqueous Graphene Suspensions on Flexible Substrates for Multimodal Wearable Continuous Health Monitoring","authors":"Seyed Sajjad Mirbakht,&nbsp;Faruk Ballipinar,&nbsp;Burcu Arman Kuzubasoglu,&nbsp;Melih Can Tasdelen,&nbsp;Saygun Guler,&nbsp;Murat Kaya Yapici","doi":"10.1021/acsnanoscienceau.5c00195","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.5c00195","url":null,"abstract":"<p>Flexible and gel-freedry electrophysiological electrodes offerexcellent alternatives to the benchmark with better skin conformalityand dispensing with the hydrogel electrolyte layer, where the integrityof recorded signals highly depends on the resilience of this layer.However, the implicit complex fabrication methods and resource-intensivenature of existing dry electrodes, designed for single use, necessitateadditional technological innovations. This paper presents an originalintegration of inkjet-printing, graphene, and poly(ethylene terephthalate)(PET) substrates to create flexible, inexpensive, and reusable dryelectrodes for monitoring human physiological biopotential signals,including ECG, EEG, EOG, and EMG. The electrodes exhibited high electricalconductivity (80 Ω/□) and maintained their performanceeven after 100 cyclic bends. Additionally, they demonstrated robustsignal collection even 90 days postfabrication, with reusability andstrong graphene-substrate bonding verified through Scotch tape experiments.Assessing against gel-based commercial electrodes, a 99.34% correlationratio was obtained from the recorded ECG signals. Similarly, a correlationratio of 95.14 ± 4.75% was achieved with 10 diverse participants.The capability of these electrodes to effectively record neural signalsin practical applications was demonstrated in real-time detectionof sleep and drowsiness in car drivers. These findings highlight thepotential of inkjet-printed graphene electrodes in advancing wearablehealth monitoring technologies.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 4","pages":"582–595"},"PeriodicalIF":7.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148769425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrophobic Ion Pairing Improves Protein Thermal Stability and Lipid Nanocarrier Integration through Controlled Surface Modification","authors":"Jiaming Mu,&nbsp;Daniel Sedough-Abbasian,&nbsp;Leran Mao,&nbsp;Sheiliza Carmali","doi":"10.1021/acsnanoscienceau.6c00033","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.6c00033","url":null,"abstract":"<p>Integrating therapeutic proteins into lipid-based nanocarriersremains challenging due to fundamental incompatibilities between hydrophilicprotein surfaces and lipophilic carrier matrices. Here, we demonstratethat controlled hydrophobic ion pairing (HIP) using lysozyme-sodiumdodecyl sulfate (SDS) at stoichiometric ratios simultaneously improvesthermal stability during pharmaceutical processing and lipid compatibilityfor nanocarrier integration. Building on our previous molecular characterizationof lysozyme-SDS complexes, we investigated their application in nanostructuredlipid carrier (NLC) formulations for oral protein delivery. SDS complexationpreserved lysozyme enzymatic activity at processing-relevant temperaturesand increased apparent lipid miscibility by 50% in both solid andliquid pharmaceutical lipid excipients. This enhanced compatibilitytranslated directly into superior NLC performance, with complexedlysozyme achieving a 4-fold higher encapsulation efficiency (79.6± 1.8% vs 18.4 ± 4.3% for native protein) with improvedbatch-to-batch reproducibility. In simulated gastrointestinal conditions,lysozyme-SDS NLCs demonstrated sustained intestinal release (87.2± 16.5% over 6 h) with 67.5 ± 7.5% enzymatic activity retainedcompared to only 15.2 ± 3.0% activity for native lysozyme formulations.Mechanistic analysis from differential scanning calorimetry and crystallinitymeasurements showed that SDS complexation induces a molten globule-likeprotein state that reduces lipid packing (56.8% vs 68.6% crystallinityfor native lysozyme), enabling superior matrix integration while maintainingbiological function. These findings establish that controlled surfacemodification through HIP provides a systematic approach to overcomeprotein–lipid incompatibilities, offering a generalizable frameworkfor developing lipid-based protein therapeutics.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 4","pages":"644–653"},"PeriodicalIF":7.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148769838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aligning van der Waals Heterostructures Using Electron Backscatter Diffraction","authors":"Ramachandra Bangari,&nbsp;Mehdi Mosayebi,&nbsp;John E. Buchner,&nbsp;Joshua D. Caldwell,&nbsp;Nabil D. Bassim,&nbsp;Thomas G. Folland","doi":"10.1021/acsnanoscienceau.6c00042","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.6c00042","url":null,"abstract":"<p>Precise and accurate determination of crystallographicorientationis crucial for engineering van der Waals heterostructures, where thetwist angle between layers controls emergent electronic and opticalproperties. While electron backscatter diffraction (EBSD) has beenextensively used for bulk materials, its application to van der Waalsmaterials remains largely unexplored. In this work, we demonstrateEBSD as a robust and versatile tool for determining crystallographicorientations of van der Waals materials with high precision. We showquantitative agreement between EBSD-determined orientations and facetorientations in orthorhombic α-MoO₃ flakes on siliconsubstrates. We use kernel average misorientation and grain referenceorientation distribution across the flakes to demonstrate angularprecision better than 0.2°. We extend this technique to otherlow-symmetry materials, specifically, monoclinic α-As₂Te₃, monoclinic GaTe, and triclinic ReSe₂,demonstrating broad applicability across van der Waals materials withdifferent crystal structures. Finally, as a proof-of-concept application,we leverage EBSD-determined orientations to engineer a twisted α-MoO₃ heterostructure with precisely controlled twist angle, enablingobservation of recently reported canalized phonon polaritons. Ourresults establish EBSD as a powerful characterization method for vander Waals materials, enabling precise orientation control essentialfor twistronics and twistoptics.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 4","pages":"654–661"},"PeriodicalIF":7.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148769856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction of Tunneling Oxide and Oxidation Process Effects for Reliable Si-Compatible Resistive-Switching Random-Access Memory","authors":"Yeji Lee,&nbsp;Soomin Kim,&nbsp;Seongmin Kim,&nbsp;Sungjun Kim,&nbsp;Seongjae Cho","doi":"10.1021/acsnanoscienceau.6c00003","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.6c00003","url":null,"abstract":"<p>Resistive-switching random-access memory (RRAM) has gaineda greatdeal of attention as an emerging memory suitable for massive datastorage media and synaptic device applications. For low-power operationcapability, eliminating the necessity of current compliance, tunnelingoxide can be inserted as a tunneling layer in the conventional RRAMdevices. In this work, we have systematically investigated the effectsof SiO₂ tunneling layer and its formation method on thereliability of a Si₃N₄-based RRAM device. Thetunneling oxide layers were deposited by plasma-enhanced chemicalvapor deposition (PECVD) and medium-temperature oxidation (MTO) andcompared to a single-layer reference device. The devices with tunnelinglayers demonstrated reduced state current, and the device preparedby MTO exhibited superior endurance and retention. All of the devicesdemonstrated space-charge-limited current conduction in the high-resistancestate. X-ray photoelectron spectroscopy revealed that the MTO oxidelayer was chemically more stable, resulting in a difference in endurancecharacteristics.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 4","pages":"537–548"},"PeriodicalIF":7.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148769449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence for Thermodynamically Stable “On-Top” Sulfur Divacancy in Monolayer WS2","authors":"Weiru Chen,&nbsp;John C. Thomas,&nbsp;Yihuang Xiong,&nbsp;Zhuohang Yu,&nbsp;Da Zhou,&nbsp;Shalini Kumari,&nbsp;Zhongwei Dai,&nbsp;Joshua A. Robinson,&nbsp;Mauricio Terrones,&nbsp;Archana Raja,&nbsp;Sinéad M. Griffin,&nbsp;Alexander Weber-Bargioni,&nbsp;Geoffroy Hautier","doi":"10.1021/acsnanoscienceau.5c00165","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.5c00165","url":null,"abstract":"<p>Chalcogenvacancies in monolayer transition metal dichalcogenides(TMDs), such as WS₂, play a crucial role in various applicationsranging from optoelectronics and catalysis to quantum informationscience (QIS), making their identification and control essential.This study focuses on the WS₂ single vacancy and vacancypairs. Using first-principles computations, we investigate their thermodynamicstabilities and electronic structures. We identify an ”on-top”divacancy configuration where two vacancies sit on top of each otherto be the only energetically stable complex with a binding energyof 160 meV. We compute a small difference in electronic structurewith a shift of the unoccupied state by 140 meV for the divacancycomplex and make note of a similar shift observed experimentally.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 4","pages":"517–522"},"PeriodicalIF":7.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148769841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removable Nanopore Sealing and In Situ Iron Oxide Nanoparticle Synthesis on Thin Silicon Nitride Membranes","authors":"Zehui Xia,&nbsp;Pia Bhatia,&nbsp;Celia Morral,&nbsp;Brian DiPaolo,&nbsp;Iryna Golovina,&nbsp;Adriana Buvač-Drndić,&nbsp;Chih-Yuan Lin,&nbsp;David Niedzwiecki,&nbsp;Marija Drndić","doi":"10.1021/acsnanoscienceau.6c00032","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.6c00032","url":null,"abstract":"<p>We report in situsynthesis of iron oxide particles inside siliconnitride nanopores via a chemical reaction, monitored by current readout.Nanopores were formed by electroporation on glass chips (diametersfrom 1.7 to 11.3 nm), transmission electron microscopy (TEM) drilling(diameters from 6.5 to 64.6 nm), or hydrofluoric acid etching (diametersfrom 12.6 to 36.2 nm) in 5–20 nm thick membranes. Nanoporesseal on time scales from ∼1 ms to ∼3.6 s, across a rangeof sizes and concentrations. We show single and ∼5-pore arrays,as fabricated, after sealing, and after cleaning and pore recovery.These results are independent of the fabrication method. Energy-dispersiveX-ray spectroscopy, aberration-corrected scanning TEM, and powderX-ray diffraction verify the synthesis of mixed magnetite and maghemiteiron oxide. This work advances nanoparticle–nanopore chipsfor applications in biosensing, plasmonics, and photonics, where positionand size control is required.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 4","pages":"633–643"},"PeriodicalIF":7.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148769441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Throughput SWCNT NIR-II Spectroscopy Enables Cell and In Vivo Applications","authors":"Atara R. Israel,&nbsp;Zachary Cohen,&nbsp;Nazifa Rahman,&nbsp;Anastasiia Vasylaki,&nbsp;Amelia K. Ryan,&nbsp;Syeda Rahman,&nbsp;Pratyusha Ghosh,&nbsp;Ryan M. Williams","doi":"10.1021/acsnanoscienceau.6c00053","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.6c00053","url":null,"abstract":"<p>Diagnostic sensor development and clinical translationlag, inpart, due to a lack of rapid, high-throughput screening methodologies.Optimization of high-throughput sensor development and deploymentwill likely help in expediting tools toward the clinic. To addressthis issue, we optimized high-throughput screening parameters usinga near-infrared (NIR-II) plate reader attached to an external probefor in vivo testing. We assessed spectroscopy parameters to improvethe speed and precision in screening a single-walled carbon nanotube(SWCNT)-based optical sensor. To do so, we assessed the appropriatewell-plate specifications, including laser power, excitation wavelength,exposure time, and focal height parameters for SWCNT-based opticalsensor development. We also used the plate reader to screen fluorescentSWCNTs that were endocytosed by a macrophage cell line. We then performedNIR probe spectroscopy to assess SWCNTs embedded within a methylcellulosehydrogel. Finally, we used the NIR probe to measure the SWCNT centerwavelength and intensity from live immunocompetent mice. We anticipatethat this framework may be broadly applicable to the development ofnear-infrared nanosensors with the potential for more rapid clinicaldiagnostic translation.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 4","pages":"674–684"},"PeriodicalIF":7.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148769688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cation Dopants in Ceria: A Perspective on Current Research and a Case Study Using CeO2 Aerogels","authors":"Travis G. Novak,&nbsp;Matthew R. Buck,&nbsp;Austin E. Herzog,&nbsp;Kyle A. Sendgikoski,&nbsp;Alejandro D. Tilley,&nbsp;Todd H. Brintlinger,&nbsp;Debra R. Rolison","doi":"10.1021/acsnanoscienceau.6c00059","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.6c00059","url":null,"abstract":"<p>Substitutional orinterstitial metal-cation dopants in CeO₂ play key rolesin catalytic, sensing, and energy applications.Cation dopants with a valency less than 4+ create charge-compensatingoxygen vacancies in the lattice that boost ionic conductivity andact as reactant adsorption/dissociation sites. These cation dopantsalso modify the optical properties of CeO₂, enabling thenormally high-bandgap oxide to more effectively harvest visible light.In this perspective, we highlight the key progress made using dopantsin CeO₂ and the challenges that remain. We briefly summarizecommon roles that cation dopants play in the CeO₂ lattice,including how their speciation and solubility affect materials properties.We also report how the structural and optical properties of CeO₂ aerogels vary when doped with transition metals (Co, Ni)or lanthanides (Y, La, Gd, Tb, Ho, and Er), thereby providing a rarelook at the effects of a diverse group of dopants on a single morphologicallyfixed system.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 4","pages":"505–516"},"PeriodicalIF":7.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148769802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solar Hydrogen Evolution Boosted by Cu and Pt Single-Atom Sites Anchored on g-C3N4 via Magnetron Sputtering Deposition","authors":"Niqab Khan,&nbsp;Erick Jo Prada,&nbsp;Mohammed A. M. Bajiri,&nbsp;Washington Santa Rosa,&nbsp;Flavio L. Souza,&nbsp;Gazi N. Aliev,&nbsp;Wolfgang Theis,&nbsp;Heberton Wender,&nbsp;Valmor R. Mastelaro,&nbsp;Jesum Alves Fernandes,&nbsp;Renato V. Gonçalves","doi":"10.1021/acsnanoscienceau.6c00011","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.6c00011","url":null,"abstract":"<p>Photocatalytic hydrogen (H₂) evolution offersa promisingsolution to environmental pollution and the global energy crisis.Among different photocatalysts, graphitic carbon nitride (g-C₃N₄), most known as melon in the literature, isdistinguished by its availability, large surface area, low cost, andunique optical and electrical properties. However, the efficiencyof pristine g-C₃N₄ is limited by rapid electron–holerecombination, presence of charged trapped states and high chargetransference resistance. To overcome these challenges, we used a facilemagnetron sputtering technique to load Cu and Pt single atoms ontog-C₃N₄, confirmed by AC-STEM, XPS, ICP-OES,and XAS characterizations. This approach not only overcomes the problemsrelated to the charge carrier dynamics of the pristine graphitic carbonnitride but also ensures uniform, contamination-free deposition andhigh distribution of single atoms, thereby optimizing photocatalyticperformance. Under solar irradiation (AM 1.5G) for 5 h, the Cu andPt-loaded g-C₃N₄ demonstrated significantlyimproved photocatalytic activity, achieving H₂ accumulatedvalues of 93 μmol and 173 μmol, respectively, comparedto only 0.3 μmol for pristine g-C₃N₄.For comparison, Pt and Cu nanoparticles (NPs)- loaded g-C₃N₄ samples were also prepared, achieving H₂ accumulation values of 86.3 and 24.3 μmol, respectively, comparedto pristine g-C₃N₄. However, these values arelower than those of Pt and Cu single-atom-loaded samples. The enhancedH₂ evolution performance is attributed to the depositionof metal single atoms acting as electron traps and active catalyticsites, thus improving electron–hole separation. These findingshighlight the potential of sputter depositing single-atom to overcomethe inherent limitations of g-C₃N₄, paving theway for more efficient and scalable hydrogen production systems.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":"6 4","pages":"596–605"},"PeriodicalIF":7.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148769826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}