ACS Nanoscience Au最新文献

{"title":"Light-Responsive and Antibacterial Graphenic Materials as a Holistic Approach to Tissue Engineering","authors":"Andrea Ferreras,&nbsp;Ana Matesanz,&nbsp;Jabier Mendizabal,&nbsp;Koldo Artola,&nbsp;Yuta Nishina,&nbsp;Pablo Acedo,&nbsp;José L. Jorcano,&nbsp;Amalia Ruiz*,&nbsp;Giacomo Reina* and Cristina Martín*,&nbsp;","doi":"10.1021/acsnanoscienceau.4c0000610.1021/acsnanoscienceau.4c00006","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00006https://doi.org/10.1021/acsnanoscienceau.4c00006","url":null,"abstract":"<p >While the continuous development of advanced bioprinting technologies is under fervent study, enhancing the regenerative potential of hydrogel-based constructs using external stimuli for wound dressing has yet to be tackled. Fibroblasts play a significant role in wound healing and tissue implants at different stages, including extracellular matrix production, collagen synthesis, and wound and tissue remodeling. This study explores the synergistic interplay between photothermal activity and nanomaterial-mediated cell proliferation. The use of different graphene-based materials (GBM) in the development of photoactive bioinks is investigated. In particular, we report the creation of a skin-inspired dressing for wound healing and regenerative medicine. Three distinct GBM, namely, graphene oxide (GO), reduced graphene oxide (rGO), and graphene platelets (GP), were rigorously characterized, and their photothermal capabilities were elucidated. Our investigations revealed that rGO exhibited the highest photothermal efficiency and antibacterial properties when irradiated, even at a concentration as low as 0.05 mg/mL, without compromising human fibroblast viability. Alginate-based bioinks alongside human fibroblasts were employed for the bioprinting with rGO. The scaffold did not affect the survival of fibroblasts for 3 days after bioprinting, as cell viability was not affected. Remarkably, the inclusion of rGO did not compromise the printability of the hydrogel, ensuring the successful fabrication of complex constructs. Furthermore, the presence of rGO in the final scaffold continued to provide the benefits of photothermal antimicrobial therapy without detrimentally affecting fibroblast growth. This outcome underscores the potential of rGO-enhanced hydrogels in tissue engineering and regenerative medicine applications. Our findings hold promise for developing game-changer strategies in 4D bioprinting to create smart and functional tissue constructs with high fibroblast proliferation and promising therapeutic capabilities in drug delivery and bactericidal skin-inspired dressings.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.4c00006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142010490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making the Most of Nothing: One-Class Classification for Single-Molecule Transport Studies","authors":"William Bro-Jørgensen, Joseph M. Hamill, Gréta Mezei, Brent Lawson, Umar Rashid, András Halbritter, M. Kamenetska, Veerabhadrarao Kaliginedi, Gemma C. Solomon","doi":"10.1021/acsnanoscienceau.4c00015","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00015","url":null,"abstract":"","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141379331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making the Most of Nothing: One-Class Classification for Single-Molecule Transport Studies","authors":"William Bro-Jørgensen,&nbsp;Joseph M. Hamill,&nbsp;Gréta Mezei,&nbsp;Brent Lawson,&nbsp;Umar Rashid,&nbsp;András Halbritter*,&nbsp;Maria Kamenetska*,&nbsp;Veerabhadrarao Kaliginedi* and Gemma C. Solomon*,&nbsp;","doi":"10.1021/acsnanoscienceau.4c0001510.1021/acsnanoscienceau.4c00015","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00015https://doi.org/10.1021/acsnanoscienceau.4c00015","url":null,"abstract":"<p >Single-molecule experiments offer a unique means to probe molecular properties of individual molecules–yet they rest upon the successful control of background noise and irrelevant signals. In single-molecule transport studies, large amounts of data that probe a wide range of physical and chemical behaviors are often generated. However, due to the stochasticity of these experiments, a substantial fraction of the data may consist of blank traces where no molecular signal is evident. One-class (OC) classification is a machine learning technique to identify a specific class in a data set that potentially consists of a wide variety of classes. Here, we examine the utility of two different types of OC classification models on four diverse data sets from three different laboratories. Two of these data sets were measured at cryogenic temperatures and two at room temperature. By training the models solely on traces from a blank experiment, we demonstrate the efficacy of OC classification as a powerful and reliable method for filtering out blank traces from a molecular experiment in all four data sets. On a labeled 4,4′-bipyridine data set measured at 4.2 K, we achieve an accuracy of 96.9 ± 0.3 and an area under the receiver operating characteristic curve of 99.5 ± 0.3 as validated over a fivefold cross-validation. Given the wide range of physical and chemical properties that can be probed in single-molecule experiments, the successful application of OC classification to filter out blank traces is a major step forward in our ability to understand and manipulate molecular properties.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.4c00015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142010489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tutorial on Describing, Classifying, and Visualizing Common Crystal Structures in Nanoscale Materials Systems","authors":"Katelyn J. Baumler,&nbsp; and ,&nbsp;Raymond E. Schaak*,&nbsp;","doi":"10.1021/acsnanoscienceau.4c0001010.1021/acsnanoscienceau.4c00010","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00010https://doi.org/10.1021/acsnanoscienceau.4c00010","url":null,"abstract":"<p >Crystal structures underpin many aspects of nanoscience and technology, from the arrangements of atoms in nanoscale materials to the ways in which nanoscale materials form and grow to the structures formed when nanoscale materials interact with each other and assemble. The impacts of crystal structures and their relationships to one another in nanoscale materials systems are vast. This Tutorial provides nanoscience researchers with highlights of many crystal structures that are commonly observed in nanoscale materials systems, as well as an overview of the tools and concepts that help to derive, describe, visualize, and rationalize key structural features. The scope of materials focuses on the elements and their compounds that are most frequently encountered as nanoscale materials, including both close-packed and nonclose-packed structures. Examples include three-dimensionally and two-dimensionally bonded compounds related to the rocksalt, nickel arsenide, fluorite, zincblende, wurtzite, cesium chloride, and perovskite structures, as well as layered perovskites, intergrowth compounds, MXenes, transition metal dichalcogenides, and other layered materials. Ordered versus disordered structures, high entropy materials, and instructive examples of more complex structures, including copper sulfides, are also discussed to demonstrate how structural visualization tools can be applied. The overall emphasis of this Tutorial is on the ways in which complex structures are derived from simpler building blocks, as well as the similarities and interrelationships among certain classes of structures that, at first glance, may be interpreted as being very different. Identifying and appreciating these structural relationships is useful to nanoscience researchers, as it allows them to deconstruct complex structures into simpler components, which is important for designing, understanding, and using nanoscale materials.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.4c00010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142436544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tutorial on Describing, Classifying, and Visualizing Common Crystal Structures in Nanoscale Materials Systems","authors":"Katelyn J. Baumler, R. Schaak","doi":"10.1021/acsnanoscienceau.4c00010","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00010","url":null,"abstract":"","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140965801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterials Research at a Primarily Undergraduate Institution: Transforming Nanorods, Undergraduate Research Communities, and Infrastructure","authors":"Katherine E. Plass*,&nbsp;J. Kenneth Krebs,&nbsp;Jennifer L. Morford,&nbsp;Raymond E. Schaak,&nbsp;Joshua J. Stapleton and Adri C. T. van Duin,&nbsp;","doi":"10.1021/acsnanoscienceau.4c0000510.1021/acsnanoscienceau.4c00005","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00005https://doi.org/10.1021/acsnanoscienceau.4c00005","url":null,"abstract":"<p >Undergraduate research transforms student’s conceptions of themselves as scientists and encourages participation and retention in science, technology, engineering, and mathematics (STEM) fields. Many barriers exist to carrying out scientifically impactful undergraduate research in nanomaterials at primarily undergraduate institutions (PUIs). Here, we share several practices and design principles that demonstrate pathways to overcome these barriers. Design of modular research projects with low entry barriers is essential. Postsynthetic transformation of nanoparticles is a field that enables such design and has been used successfully to advance nanoscience research while being achievable within undergraduate laboratories. Relatively large, inclusive research communities can be supported through the creation of opportunities with peer- and near-peer mentoring. We also share emerging strategies for enabling routine undergraduate access to transmission electron microscopy, which is one of the most mainstream characterization techniques in nanoscience yet is frequently absent from the infrastructure at undergraduate-focused institutions.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.4c00005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142010446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterials Research at a Primarily Undergraduate Institution: Transforming Nanorods, Undergraduate Research Communities, and Infrastructure","authors":"Katherine E. Plass, J. K. Krebs, Jennifer L. Morford, R. Schaak, Joshua J. Stapleton, A. V. van Duin","doi":"10.1021/acsnanoscienceau.4c00005","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00005","url":null,"abstract":"","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140660860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anodic Electrodeposition of IrOx Nanoparticles from Aqueous Nanodroplets","authors":"Saptarshi Paul,&nbsp;Joshua Reyes-Morales,&nbsp;Kingshuk Roy and Jeffrey E. Dick*,&nbsp;","doi":"10.1021/acsnanoscienceau.3c00061","DOIUrl":"10.1021/acsnanoscienceau.3c00061","url":null,"abstract":"<p >Electrodeposition has been used for centuries to create new materials. However, synthetic platforms are still necessary to enrich a variety of nanomaterials that can be electrodeposited. For instance, IrO_<i>x</i> is a popular material for the water oxidation reaction, but electrodeposition strategies for the controlled growth of IrO_<i>x</i> nanoparticles are lacking. Here, we demonstrate the anodic electrodeposition of IrO_<i>x</i> nanoparticles from aqueous nanodroplets. Field emission scanning electron microscopy (FESEM) and scanning transmission electron microscopy (STEM) images confirm the macro- and microstructure of the resulting nanoparticles. IrO_<i>x</i> nanoparticles of 43 ± 10 nm in diameter were achieved. X-ray photoelectron spectroscopy (XPS) showed the presence of Ir(III) and Ir(IV) hydrated oxyhydroxide species. The synthesis of IrO_<i>x</i> nanoparticles under anodic conditions using water nanodroplets expands the capabilities of our technique and provides a tunable platform for IrO_<i>x</i> nanoparticle electrodeposition.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.3c00061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140608889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On-the-Fly Monitoring of the Capture and Removal of Nanoplastics with Nanorobots","authors":"Dean I. Velikov, Anna Jancik-Prochazkova, Martin Pumera","doi":"10.1021/acsnanoscienceau.4c00002","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00002","url":null,"abstract":"Nanoplastics are considered an emerging organic persistent pollutant with possible severe long-term implications for the environment and human health; therefore, their remediation is of paramount importance. However, detecting and determining the concentration of nanoparticles in water is challenging and time-consuming due to their small size. In this work, we present a universal yet simple method for the detection and quantification of nanoplastics to monitor their removal from water using magnetic nanorobots. Nanoplastics were stained with a hydrophobic fluorescent dye to enable the use of photoluminescence techniques for their detection and quantification. Magnetic nanorobotic tools were employed to capture and subsequently remove the nanoplastics from contaminated waters. We demonstrated that nanorobots can capture and remove more than 90% of the nanoplastics from an aqueous solution within 120 min. This work shows that easy-to-use common fluorescent dyes combined with photoluminescence spectroscopy methods can be used as an alternative method for the detection and quantification of nanoplastics in water environments and swarming magnetic nanorobots for efficient capture and removal. These methods hold great potential for future research to improve the quantification and removal of nanoplastics in water, and it will ultimately reduce their harmful impact on the environment and human health.","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140593270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On-the-Fly Monitoring of the Capture and Removal of Nanoplastics with Nanorobots","authors":"Dean I. Velikov,&nbsp;Anna Jancik-Prochazkova and Martin Pumera*,&nbsp;","doi":"10.1021/acsnanoscienceau.4c0000210.1021/acsnanoscienceau.4c00002","DOIUrl":"https://doi.org/10.1021/acsnanoscienceau.4c00002https://doi.org/10.1021/acsnanoscienceau.4c00002","url":null,"abstract":"<p >Nanoplastics are considered an emerging organic persistent pollutant with possible severe long-term implications for the environment and human health; therefore, their remediation is of paramount importance. However, detecting and determining the concentration of nanoparticles in water is challenging and time-consuming due to their small size. In this work, we present a universal yet simple method for the detection and quantification of nanoplastics to monitor their removal from water using magnetic nanorobots. Nanoplastics were stained with a hydrophobic fluorescent dye to enable the use of photoluminescence techniques for their detection and quantification. Magnetic nanorobotic tools were employed to capture and subsequently remove the nanoplastics from contaminated waters. We demonstrated that nanorobots can capture and remove more than 90% of the nanoplastics from an aqueous solution within 120 min. This work shows that easy-to-use common fluorescent dyes combined with photoluminescence spectroscopy methods can be used as an alternative method for the detection and quantification of nanoplastics in water environments and swarming magnetic nanorobots for efficient capture and removal. These methods hold great potential for future research to improve the quantification and removal of nanoplastics in water, and it will ultimately reduce their harmful impact on the environment and human health.</p>","PeriodicalId":29799,"journal":{"name":"ACS Nanoscience Au","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnanoscienceau.4c00002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142010449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}