UrologiePub Date : 2024-10-01DOI: 10.1007/s00120-024-02452-x
{"title":"BvDU Kurz notiert.","authors":"","doi":"10.1007/s00120-024-02452-x","DOIUrl":"https://doi.org/10.1007/s00120-024-02452-x","url":null,"abstract":"","PeriodicalId":29782,"journal":{"name":"Urologie","volume":"63 10","pages":"1065-1066"},"PeriodicalIF":0.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UrologiePub Date : 2024-10-01Epub Date: 2024-06-06DOI: 10.1007/s00120-024-02375-7
Sabine Bohnet-Joschko, Lara Schmidt
{"title":"[Digital care of chronic wounds].","authors":"Sabine Bohnet-Joschko, Lara Schmidt","doi":"10.1007/s00120-024-02375-7","DOIUrl":"10.1007/s00120-024-02375-7","url":null,"abstract":"","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":"1037-1039"},"PeriodicalIF":0.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UrologiePub Date : 2024-10-01Epub Date: 2024-08-14DOI: 10.1007/s00120-024-02418-z
Simon Filmar, A J Gross, C Tonus, S Hook, C M Rosenbaum, B Becker, C Netsch, P Gattenloehner
{"title":"[Rare case of leiomyosarcoma of the urinary bladder in a young man].","authors":"Simon Filmar, A J Gross, C Tonus, S Hook, C M Rosenbaum, B Becker, C Netsch, P Gattenloehner","doi":"10.1007/s00120-024-02418-z","DOIUrl":"10.1007/s00120-024-02418-z","url":null,"abstract":"<p><p>Leiomyosarcomas are rare, highly aggressive tumors of the urinary bladder. With approximately 200 cases reported in the literature, there is limited data on the prognosis and treatment of these neoplasms. Curative treatment approaches are primarily characterized by radical surgery, especially radical cystectomy. However, this procedure is associated with significant impairments in the quality of life for patients. This circumstance forms the basis for considering a curative treatment approach with partial cystectomy for a 19-year-old man with leiomyosarcoma of the urinary bladder.</p>","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":"1028-1032"},"PeriodicalIF":0.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UrologiePub Date : 2024-10-01Epub Date: 2024-09-27DOI: 10.1007/s00120-024-02444-x
Fabian P Stangl
{"title":"[Bacterial vaccines for the management of recurrent urinary tract infections: a systematic review and meta-analysis].","authors":"Fabian P Stangl","doi":"10.1007/s00120-024-02444-x","DOIUrl":"10.1007/s00120-024-02444-x","url":null,"abstract":"","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":"1047-1049"},"PeriodicalIF":0.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142355426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UrologiePub Date : 2024-10-01DOI: 10.1007/s00120-024-02445-w
{"title":"Er ist nicht weit, der Tellerrand….","authors":"","doi":"10.1007/s00120-024-02445-w","DOIUrl":"https://doi.org/10.1007/s00120-024-02445-w","url":null,"abstract":"","PeriodicalId":29782,"journal":{"name":"Urologie","volume":"63 10","pages":"1060"},"PeriodicalIF":0.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UrologiePub Date : 2024-10-01DOI: 10.1007/s00120-024-02448-7
{"title":"Mitteilungen der DGU.","authors":"","doi":"10.1007/s00120-024-02448-7","DOIUrl":"https://doi.org/10.1007/s00120-024-02448-7","url":null,"abstract":"","PeriodicalId":29782,"journal":{"name":"Urologie","volume":"63 10","pages":"1061-1064"},"PeriodicalIF":0.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UrologiePub Date : 2024-10-01Epub Date: 2024-09-05DOI: 10.1007/s00120-024-02440-1
Jozefina Casuscelli, Gunhild von Amsberg, Margitta Retz
{"title":"[Paradigm shift in systemic therapy for metastatic urothelial carcinoma-antibody-drug conjugates (ADCs) and fibroblast growth factor receptor (FGFR) inhibitors].","authors":"Jozefina Casuscelli, Gunhild von Amsberg, Margitta Retz","doi":"10.1007/s00120-024-02440-1","DOIUrl":"10.1007/s00120-024-02440-1","url":null,"abstract":"<p><strong>Background: </strong>Patients with locally advanced or metastatic urothelial carcinoma face a poor prognosis. Standard first-line treatment involves platinum-based combinations followed by avelumab maintenance therapy. Follow-up therapies include enfortumab vedotin, vinflunine, and taxanes.</p><p><strong>Objective: </strong>To analyze new drug combinations in first-line and follow-up treatment for metastatic urothelial carcinoma concerning their clinical relevance, toxicities, and novel treatment sequences.</p><p><strong>Materials and methods: </strong>Analysis of new study data from EV-302/KN-A39 (enfortumab vedotin and pembrolizumab) and CheckMate-901 (nivolumab and gemcitabine-cisplatin) for untreated metastatic patients as well as TROPHY-U-01 (sacituzumab govitecan) and THOR (erdafitinib) for later lines.</p><p><strong>Results: </strong>The new standard in first-line treatment for metastatic urothelial carcinoma is the combination of enfortumab vedotin and pembrolizumab. For cisplatin-eligible patients with contraindications to enfortumab vedotin, the combination of nivolumab and gemcitabine-cisplatin offers an alternative. Erdafitinib presents a new biomarker-based option in the follow-up treatment of metastatic urothelial carcinoma.</p><p><strong>Conclusion: </strong>These novel combinations are revolutionizing the treatment standard for metastatic urothelial carcinoma and necessitate a new approach to managing side effects.</p>","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":"1002-1010"},"PeriodicalIF":0.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UrologiePub Date : 2024-10-01Epub Date: 2024-08-14DOI: 10.1007/s00120-024-02420-5
Jan Hausmann, Camilla M Grunewald
{"title":"[Can muscle invasive bladder cancer be treated without cystectomy in the future? : New data on trimodal therapy and bladder preservation after systemic therapy alone].","authors":"Jan Hausmann, Camilla M Grunewald","doi":"10.1007/s00120-024-02420-5","DOIUrl":"10.1007/s00120-024-02420-5","url":null,"abstract":"<p><p>Muscle invasive bladder cancer is generally an aggressive disease. Radical cystectomy (RC) is traditionally the treatment of choice. Due to possible advantages in morbidity, peri-interventional mortality, and quality of life, bladder-preserving treatment strategies are of interest. Here, trimodal therapy (TMT) consisting of maximum transurethral resection and subsequent radiochemotherapy with subsequent cystoscopic follow-up plays an important role. Current cohort analyses indicate equivalent oncological results of TMT to RC in selected patients. However, the use of systemic therapy alone with combined chemo-/immunotherapy or cytotoxic combination therapy also shows promising efficacy both in early surrogate parameters and in oncological endpoints. Overall, studies to date suggest that bladder preservation is possible without compromising oncologic outcomes. Future developments aim to refine patient selection by combining different risk factors and biomarkers to further improve outcomes.</p>","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":"985-993"},"PeriodicalIF":0.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}