Urologie最新文献

{"title":"[Immune checkpoint inhibition plus Bacillus Calmette-Guerin (BCG) therapy in BCG-naive high-risk non-muscle-invasive bladder cancer: a critical review in the context of current evidence].","authors":"Georgios Gakis, Frank Vom Dorp","doi":"10.1007/s00120-026-02922-4","DOIUrl":"https://doi.org/10.1007/s00120-026-02922-4","url":null,"abstract":"<p><strong>Background: </strong>Intravesical Bacillus Calmette-Guerin (BCG) therapy following transurethral resection (TURBT) remains an important standard treatment for high-risk non-muscle-invasive bladder cancer (NMIBC). Recent phase III trials have evaluated the addition of immune checkpoint inhibitors (IO) to further reduce recurrence rates.</p><p><strong>Methods: </strong>This review synthesizes data from the CREST (sasanlimab), POTOMAC (durvalumab), and ALBAN (atezolizumab) trials, focusing on surgical quality, BCG maintenance duration, and primary endpoint definitions.</p><p><strong>Results: </strong>CREST and POTOMAC demonstrated significant improvements in event-free or disease-free survival (both hazard ratio [HR] 0.68) when a 2-year BCG maintenance schedule was followed. In contrast, the ALBAN trial (HR 0.98) failed its primary endpoint. Key reasons for this discrepancy include the shortened BCG maintenance (1 year) and the inclusion of low-grade recurrences in the primary endpoint, which by international consensus do not constitute BCG failure. Data also show that IO cannot compensate for the omission of BCG maintenance. Severe systemic toxicity (grade 3-5) increased substantially with the combination therapy (up to 29%).</p><p><strong>Conclusion: </strong>Combination therapy strictly necessitates the full BCG maintenance schedule. Given the significant systemic toxicity and the current lack of a demonstrated overall survival benefit, careful patient selection is mandatory.</p>","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Outcomes of surgical strategies for pelvic organ prolapse with or without stress urinary incontinence].","authors":"Jennifer Kranz, Tanja Hüsch","doi":"10.1007/s00120-026-02917-1","DOIUrl":"https://doi.org/10.1007/s00120-026-02917-1","url":null,"abstract":"","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Perioperative treatment of muscle-invasive bladder cancer : Current treatment concepts].","authors":"Günter Niegisch, Camilla Grunewald","doi":"10.1007/s00120-026-02900-w","DOIUrl":"10.1007/s00120-026-02900-w","url":null,"abstract":"<p><p>Perioperative systemic treatment is a central component of the multimodal treatment of muscle-invasive bladder cancer (MIBC) and significantly improves the prognosis of patients. Current guidelines recommend an interdisciplinary tumor board for treatment planning, with cisplatin-based chemotherapy, checkpoint inhibitors used alone, sequentially or in combination as well as antibody-drug conjugates combined with checkpoint inhibitors being employed. Recent data demonstrate that the combination of gemcitabine, cisplatin, and durvalumab extends event-free and overall survival. Relative contraindications should be individually weighed up to enable as many patients as possible to receive adequate treatment. In particular, combination therapies involving antibody-drug conjugates are expected to gain importance in perioperative systemic treatment in the future.</p>","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":"999-1007"},"PeriodicalIF":0.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148631371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auswahlverfahren der wissenschaftlichen Beiträge zum DGU-Kongress 2026.","authors":"Jakob Neff","doi":"10.1007/s00120-026-02902-8","DOIUrl":"10.1007/s00120-026-02902-8","url":null,"abstract":"","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":"23-24"},"PeriodicalIF":0.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Endoscopic Enucleation of the Prostate Versus Transurethral Resection of the Prostate (TURP) for Benign Prostatic Hyperplasia : A systematic review and meta-analysis of randomized controlled studies].","authors":"Karl G Sommer","doi":"10.1007/s00120-026-02896-3","DOIUrl":"10.1007/s00120-026-02896-3","url":null,"abstract":"","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":"984-989"},"PeriodicalIF":0.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148798711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Urology care in Germany: statutory health insurance remuneration system in practices and hospitals].","authors":"Theodor Klotz","doi":"10.1007/s00120-026-02905-5","DOIUrl":"10.1007/s00120-026-02905-5","url":null,"abstract":"","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":"990-993"},"PeriodicalIF":0.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Generational shift in clinical urological care: status quo in German urology].","authors":"Sophie Knipper, Maria-Noemi Welte, Raisa Abrams-Pompe, Laura Bellut, Eva Maria Greiser, Annika Herlemann-Tilke, Karina Müller, Sandra Schönburg, Carolin Siech, Sarah Weinberger, Laura Wiemer, Margarete Teresa Walach","doi":"10.1007/s00120-026-02879-4","DOIUrl":"10.1007/s00120-026-02879-4","url":null,"abstract":"<p><strong>Background/objectives: </strong>Urological care in Germany is facing challenges due to high workload, an increasing desire for more flexible working time models, and the need to secure the next generation of professionals. Against this backdrop, workload, working time models, and job satisfaction among urologists in Germany were examined.</p><p><strong>Materials and methods: </strong>A nationwide online survey (mailing lists of Deutsche Gesellschaft für Urologie [DGU], Bundesverband der deutschen Urologie [BvDU], German Society of Residents in Urology [GeSRU]) conducted from October-December 2024 collected data on demographics, qualifications, work environment, workload, job satisfaction, and family situation among practicing urologists.</p><p><strong>Results: </strong>Of the 999 participants (66% male, 34% female, 0.1% diverse), 61% held a doctoral degree, 8% were habilitated (4% with a professorship), and 19% were involved in research. Most (73%) were surgically active; 67% focused on general urology and 36% on conservative-oncological care. While 74% worked full-time (≥ 40 h/week), 54% reported ≥ 50 h/week including overtime and on-call duties. The majority worked in outpatient settings (53%), 43% in inpatient care, and 2% in research, industry, or public service. Half lived with at least one child under 18. Parental leave had been taken by 31%, with 56% of them for more than 6 months. Overall, 80% reported a high or very high workload, 54% wished to reduce working hours, yet 56% were satisfied or very satisfied with their current job situation.</p><p><strong>Conclusion: </strong>The survey highlights a high workload combined with still considerable satisfaction with the profession among urologists in Germany. However, the majority desire a reduction in actual working hours, which indicates a need for structural adjustments to ensure the long-term attractiveness of the field of urology.</p>","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":"965-972"},"PeriodicalIF":0.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13503498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Patient transitioning is only successful if paediatric urology remains a part of urology].","authors":"Anne-Karoline Ebert","doi":"10.1007/s00120-026-02889-2","DOIUrl":"10.1007/s00120-026-02889-2","url":null,"abstract":"<p><p>Thanks to the excellent care of complex urogenital malformations during the neonatal period and childhood available today, an increasing number of patients require competent long-term care in adulthood. Ideally, urology takes responsibility for the transition of these individuals, who have a lifelong need for urological follow-up care. Only if adequate knowledge is available and maintained will these patients receive appropriate care throughout adult life. This care is demanding and must be reimbursed appropriately. Solid basic training in urology, as well as specialized additional training in paediatric and adolescent urology, can help to train competent experts.</p>","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":"926-933"},"PeriodicalIF":0.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148449724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Think internationally, act locally].","authors":"Katharina Schernig, Franziska Matthes, Andrea Stewig-Nitschke","doi":"10.1007/s00120-026-02907-3","DOIUrl":"10.1007/s00120-026-02907-3","url":null,"abstract":"","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":"994-998"},"PeriodicalIF":0.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148608161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Women in the history of urology-pioneers between professionalization, (in)visibility, and remembrance].","authors":"Julia Nebe, Friedrich Moll, Matthis Krischel","doi":"10.1007/s00120-026-02904-6","DOIUrl":"10.1007/s00120-026-02904-6","url":null,"abstract":"","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":"979-983"},"PeriodicalIF":0.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13503422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148631360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}