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Mitteilungen der DGU. DGU通讯。
IF 0.5 4区 医学
Urologie Pub Date : 2025-05-01 DOI: 10.1007/s00120-025-02586-6
{"title":"Mitteilungen der DGU.","authors":"","doi":"10.1007/s00120-025-02586-6","DOIUrl":"https://doi.org/10.1007/s00120-025-02586-6","url":null,"abstract":"","PeriodicalId":29782,"journal":{"name":"Urologie","volume":"64 5","pages":"501-505"},"PeriodicalIF":0.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Termine. Termine。
IF 0.5 4区 医学
Urologie Pub Date : 2025-05-01 DOI: 10.1007/s00120-025-02588-4
{"title":"Termine.","authors":"","doi":"10.1007/s00120-025-02588-4","DOIUrl":"https://doi.org/10.1007/s00120-025-02588-4","url":null,"abstract":"","PeriodicalId":29782,"journal":{"name":"Urologie","volume":"64 5","pages":"528-530"},"PeriodicalIF":0.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AUO.
IF 0.5 4区 医学
Urologie Pub Date : 2025-05-01 DOI: 10.1007/s00120-025-02580-y
{"title":"AUO.","authors":"","doi":"10.1007/s00120-025-02580-y","DOIUrl":"https://doi.org/10.1007/s00120-025-02580-y","url":null,"abstract":"","PeriodicalId":29782,"journal":{"name":"Urologie","volume":"64 5","pages":"526-527"},"PeriodicalIF":0.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Human papillomavirus (HPV) vaccination for cancer prevention]. [人乳头瘤病毒（HPV）疫苗预防癌症]。
IF 0.5 4区 医学
Urologie Pub Date : 2025-04-30 DOI: 10.1007/s00120-025-02597-3
Julius Benedikt Schneede, Peter Schneede
{"title":"[Human papillomavirus (HPV) vaccination for cancer prevention].","authors":"Julius Benedikt Schneede, Peter Schneede","doi":"10.1007/s00120-025-02597-3","DOIUrl":"https://doi.org/10.1007/s00120-025-02597-3","url":null,"abstract":"<p><strong>Background: </strong>In 2005, the first approval study of a preventive quadrivalent human papillomavirus (HPV) vaccine in young women triggered vaccination strategies around the world.</p><p><strong>Objective: </strong>We aimed to investigate how successful these vaccination interventions have been in preventing cancer so far.</p><p><strong>Methods: </strong>To this end, we reviewed the relevant literature of the past two decades regarding vaccination rates and the subsequent decline in HPV-associated diseases worldwide.</p><p><strong>Results: </strong>For various reasons, many countries that offer HPV vaccinations are still missing their goals for primary cancer prevention. In Germany, for example, vaccination rates are completely inadequate, and urologists are not even recognized as vaccinators.</p><p><strong>Conclusion: </strong>Cancer prevention through HPV vaccination is zur Hausen's scientific legacy to the world. However, each country must continuously analyze and combat its specific reasons for failing in HPV vaccination. New HPV vaccines will continue the global success story in the future.</p>","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Boys' health from a urologic perspective]. [从泌尿学角度看男孩的健康]。
IF 0.5 4区 医学
Urologie Pub Date : 2025-04-29 DOI: 10.1007/s00120-025-02596-4
Jens Rosellen, Petra Anheuser
{"title":"[Boys' health from a urologic perspective].","authors":"Jens Rosellen, Petra Anheuser","doi":"10.1007/s00120-025-02596-4","DOIUrl":"https://doi.org/10.1007/s00120-025-02596-4","url":null,"abstract":"<p><p>Boys' health and health promotion are crucial for preventing diseases in later life. Urology can take preventive action in all areas of male development, sexuality, and reproduction. This includes imparting knowledge about normal puberty development and general health care measures but also encompasses sex education about contraceptives and sexually transmitted diseases. This may include a focused physical examination and a check of vaccination protection. In order to implement these measures and to facilitate reaching the target group, it is useful to create specific advice services such as a boys' consultation hour. The content and depth of the conversation should be based on the life situation and prior knowledge of the person seeking advice. In this way, urology can also be a competent contact for questions about men's health in later phases of life.</p>","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[First diagnosis of renal cell carcinoma via a testicular metastasis]. 【通过睾丸转移首次诊断肾细胞癌】。
IF 0.5 4区 医学
Urologie Pub Date : 2025-04-24 DOI: 10.1007/s00120-025-02584-8
Leonhard Buck, Hans Christoph von Knobloch, Jakob Kohler, Fatih Yalcin, Christiane Maria Stuhlmann-Laeisz, Severin Rodler, Jonas Jarczyk, Philipp Nuhn
{"title":"[First diagnosis of renal cell carcinoma via a testicular metastasis].","authors":"Leonhard Buck, Hans Christoph von Knobloch, Jakob Kohler, Fatih Yalcin, Christiane Maria Stuhlmann-Laeisz, Severin Rodler, Jonas Jarczyk, Philipp Nuhn","doi":"10.1007/s00120-025-02584-8","DOIUrl":"https://doi.org/10.1007/s00120-025-02584-8","url":null,"abstract":"<p><p>This case report describes a rare case of testicular metastasis from renal cell carcinoma, which led to first diagnosis of the primary. The patient presented with a progressive painless swelling of the left testicle. After initial suspicion of a testicular tumor, inguinal excision of the testis was performed, which confirmed the presence of a clear cell carcinoma. Further investigations revealed evidence of a primary carcinoma on the left-lower pole of the kidney, which was removed by partial nephrectomy. Histopathologically, clear cell renal cell carcinoma was confirmed. Treatment was supplemented by adjuvant immunotherapy with pembrolizumab. Postoperative follow-up has shown no evidence of recurrence to date.</p>","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Urodynamics in Germany: Indications and Application in Urological Hospital and Practice Settings]. [尿动力学在德国：指征和应用在泌尿外科医院和实践设置]。
IF 0.5 4区 医学
Urologie Pub Date : 2025-04-14 DOI: 10.1007/s00120-025-02579-5
Viktoria Menzel, Livia Kontschak, Marcus Sondermann, Markus Grabbert, Angelika Borkowetz, Sherif Mehralivand, Nicole Eisenmenger, Johannes Huber, Christian Thomas, Daniela Schultz-Lampel, Martin Baunacke
{"title":"[Urodynamics in Germany: Indications and Application in Urological Hospital and Practice Settings].","authors":"Viktoria Menzel, Livia Kontschak, Marcus Sondermann, Markus Grabbert, Angelika Borkowetz, Sherif Mehralivand, Nicole Eisenmenger, Johannes Huber, Christian Thomas, Daniela Schultz-Lampel, Martin Baunacke","doi":"10.1007/s00120-025-02579-5","DOIUrl":"https://doi.org/10.1007/s00120-025-02579-5","url":null,"abstract":"<p><strong>Background: </strong>Urodynamic studies (UDS) are an established diagnostic tool in urology. However, international studies, including those from Germany, indicate a decline in their use. This trend may be attributed to guideline adjustments and changes in indications.</p><p><strong>Objective: </strong>The study aims to analyse the current practice and distribution of indications for UDS in urological clinics and practices in Germany.</p><p><strong>Materials and methods: </strong>Between March 2023 and October 2023, 259 urological clinics and a representative sample of 280 outpatient urologists nationwide were surveyed about their UDS procedures. Data on methods, personnel and indications were collected.</p><p><strong>Results: </strong>In all, 80% of clinics and 44% of practices participated. 58% of clinics performed fewer than 100 UDS annually. Only 15% of practices performed UDS themselves. Common procedures such as uroflowmetry (99%) and cystometry (98%) are widely implemented, whereas video urodynamics (53%) are less frequent. The most common indications in clinics are neurogenic bladder dysfunction (24%), overactive bladder (21%) and female stress incontinence (19%). Practices showed similar trends, with neurogenic bladder dysfunction (30%) and overactive bladder (26%) as primary indications. University hospitals and specialized centres performed UDS more often for complex conditions, while non-university clinics frequently addressed stress incontinence.</p><p><strong>Conclusion: </strong>Despite declining numbers, UDS remain central to urological diagnostics. Indication patterns vary by clinic type. These results provide insights into the application of UDS in Germany and underline its important role in urological diagnostics.</p>","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Occlusive azoospermia in unilateral cystic alteration of the seminal vesicle and contralateral seminal vesicle agenesis-case report]. [单侧精囊改变和对侧精囊发育不全的闭塞性无精子症- 1例报告]。
IF 0.5 4区 医学
Urologie Pub Date : 2025-04-14 DOI: 10.1007/s00120-025-02578-6
Clarissa Wittler, D Engeler, J Rührup
{"title":"[Occlusive azoospermia in unilateral cystic alteration of the seminal vesicle and contralateral seminal vesicle agenesis-case report].","authors":"Clarissa Wittler, D Engeler, J Rührup","doi":"10.1007/s00120-025-02578-6","DOIUrl":"https://doi.org/10.1007/s00120-025-02578-6","url":null,"abstract":"<p><p>A 29-year-old man with primary infertility for 2 years presented for further evaluation. Repeated spermiograms showed azoospermia and an acidic pH. Sonographically, both testes showed normal size and parenchyma, but the vas deferens was bilaterally not palpable. Magnetic resonance imaging showed a cystically dilated left vas deferens and a dilated left seminal vesicle. The right vas deferens could not be visualized. Testicular sperm extraction (TESE) was successful and showed only slight impairment of the spermatogenesis with a Johnson score of 9.</p>","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Specialized ambulatory palliative care for urological tumors]. 泌尿系统肿瘤的专科门诊姑息治疗。
IF 0.5 4区 医学
Urologie Pub Date : 2025-04-04 DOI: 10.1007/s00120-025-02573-x
Stephan Degener, Nici Markus Dreger, Friedrich-Carl von Rundstedt, Marie-Therese Schmitz, Ulrich Grabenhorst, Oliver Schmalz, Klaus Weckbecker, Johannes Just
{"title":"[Specialized ambulatory palliative care for urological tumors].","authors":"Stephan Degener, Nici Markus Dreger, Friedrich-Carl von Rundstedt, Marie-Therese Schmitz, Ulrich Grabenhorst, Oliver Schmalz, Klaus Weckbecker, Johannes Just","doi":"10.1007/s00120-025-02573-x","DOIUrl":"https://doi.org/10.1007/s00120-025-02573-x","url":null,"abstract":"<p><strong>Background: </strong>Urologic tumors comprise about 20% of cancer diagnoses in Germany. To date, there are no studies with large datasets on the palliative situation of patients with urological tumors in the home environment, although dignified end-of-life care in the home environment is the wish of most cancer patients.</p><p><strong>Methods: </strong>Data from 5125 patients who received specialized outpatient palliative care (SAPV) with an underlying urological cancer between 2017 and 2021 were included in the analysis.</p><p><strong>Result: </strong>The analysis showed that 91.5% of patients died at home and the symptom burden remained stable or decreased slightly during treatment. The median survival time of patients receiving SAPV was 24 days. Factors such as age, performance status, loss of appetite, weakness, and pain at the start of treatment influenced the survival time of the patients. Relatives were largely very satisfied with the care provided.</p><p><strong>Conclusion: </strong>The study provides important insights into the palliative care of patients with urological tumors and underlines the importance of SAPV for dignified end-of-life care.</p>","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Bispecific antibodies in prostate cancer therapy]. 双特异性抗体在前列腺癌治疗中的应用
IF 0.5 4区 医学
Urologie Pub Date : 2025-04-02 DOI: 10.1007/s00120-025-02574-w
Susanne Jung, Jonas Heitmann, Martin Pflügler, Gundram Jung, Steffen Rausch, Helmut Salih
{"title":"[Bispecific antibodies in prostate cancer therapy].","authors":"Susanne Jung, Jonas Heitmann, Martin Pflügler, Gundram Jung, Steffen Rausch, Helmut Salih","doi":"10.1007/s00120-025-02574-w","DOIUrl":"https://doi.org/10.1007/s00120-025-02574-w","url":null,"abstract":"<p><p>Prostate cancer (PC) is the second most common cancer in men. As soon as androgen deprivation therapy fails, treatment options are limited. Despite intense efforts, hardly any of the T cell-based immunotherapeutic strategies that have revolutionized oncological treatment in other cancer entities are yet established for the treatment of PC. This includes immune checkpoint inhibition, which generally reinforces T cell-immunity but failed to achieve broad activity in PC, as well as chimeric antigen receptor T (CART) cells and bispecific antibodies (bsAbs), which specifically mobilize T cells against tumor cells. Compared to CART cells, bsAbs have the advantage of being readily available \"off-the-shelf\" reagents. Currently several bispecific constructs are in development for PC. While development of some was discontinued due to substantial side effects or development of anti-drug antibodies, others have yielded promising results. These include in particular bsAbs directed against six-transmembrane epithelial antigen of the prostate 1 (STEAP1) and prostate-specific membrane antigen (PSMA), which are currently being evaluated in both patients with metastasized disease and biochemical relapse. The concepts underlying the different constructs, the current status of clinical development, and future perspectives are discussed.</p>","PeriodicalId":29782,"journal":{"name":"Urologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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