Pulse最新文献

{"title":"High Signal Resolution Pulse Oximetry as a Prognostic Indicator of Radiotherapy Toxicity: A Pilot Study.","authors":"Karolina Jezierska,&nbsp;Agnieszka Macała,&nbsp;Ryszard Krzyminiewski,&nbsp;Piotr Woźniak,&nbsp;Magdalena Łukowiak,&nbsp;Anna Sękowska-Namiotko,&nbsp;Wojciech Podraza","doi":"10.1159/000519100","DOIUrl":"https://doi.org/10.1159/000519100","url":null,"abstract":"<p><strong>Introduction: </strong>Radiotherapy plays a prominent role in the multidisciplinary treatment of cancers. Despite new irradiation techniques, radiation-induced cardiotoxicity remains a leading cause of morbidity and mortality. Therefore, prognostic indicators of radiotherapy toxicity are essential. This study aimed to investigate the influence of applied radiotherapy on the pulse wave recording and thereby on cardiovascular health, as well as to assess whether high signal resolution (HSR) pulse oximetry could be used as a prognostic indicator of radiotherapy toxicity.</p><p><strong>Methods: </strong>A total of 19 patients treated with radiotherapy to the lung or left breast were analyzed. Pulse oximetry was performed on all eligible patients (before and after the administration of a radiation dose) using the PULS-HSR program, which increases the resolution of the pulse wave recording.</p><p><strong>Results: </strong>Among the analyzed variables, we found the total dose administered to the target, as well as the treatment duration, significantly positively correlated with the change in ventricle/aorta volume ratio. The ventricle/aorta volume ratio parameter is the ratio between the area under the HSR pulse wave generated by the contraction of the left ventricle until the aortic valve closes and the area of the HSR pulse wave responsible for expansion and contraction of the aorta.</p><p><strong>Conclusion: </strong>The pilot study indicates HSR pulse oximetry, especially the ventricle/aorta volume ratio parameter, as a potential prognostic indicator of toxicity from radiation for breast and lung cancers.</p>","PeriodicalId":29774,"journal":{"name":"Pulse","volume":"9 3-4","pages":"83-88"},"PeriodicalIF":2.2,"publicationDate":"2021-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8739934/pdf/pls-0009-0083.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39739616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sickle Cell Disease-Induced Pulmonary Hypertension: A Review of Pathophysiology, Management, and Current Literature.","authors":"Abu Baker Sheikh,&nbsp;Adeel Nasrullah,&nbsp;Erick Daniel Lopez,&nbsp;Mian Tanveer Ud Din,&nbsp;Shazib Sagheer,&nbsp;Ishan Shah,&nbsp;Nismat Javed,&nbsp;Rahul Shekhar","doi":"10.1159/000519101","DOIUrl":"https://doi.org/10.1159/000519101","url":null,"abstract":"<p><p>Sickle cell disease is an inherited hemoglobinopathy leading to the synthesis of hemoglobin S. Hemoglobin S results in the formation of abnormal sickle-shaped erythrocytes that lead to hematologic abnormalities such as hemolytic anemia and increased risks of thrombosis. Another particular problem encountered with the disease is pulmonary hypertension. The objective of this narrative review is to discuss the prevalence, pathophysiology mechanisms, diagnostic techniques, treatment options, and prognostic indicators in the setting of sickle cell disease with pulmonary hypertension. Additionally, the review also highlights other advancements that are being investigated. Considering the significant morbidity, mortality, and prevalence of pulmonary hypertension in patients with sickle cell disease, it is important to account for the aforementioned domains in the future guidelines to provide optimal and individualized care to the high-risk individuals as well as reduce the progression of disease, morbidity, and mortality rates.</p>","PeriodicalId":29774,"journal":{"name":"Pulse","volume":"9 3-4","pages":"57-63"},"PeriodicalIF":2.2,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740209/pdf/pls-0009-0057.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39724772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Similar Myocardial Perfusion and Vascular Stiffness in Children and Adolescents with High Lipoprotein (a) Levels, in Comparison with Healthy Controls.","authors":"Kyriaki Papadopoulou-Legbelou,&nbsp;Areti Triantafyllou,&nbsp;Olga Vampertzi,&nbsp;Nikolaos Koletsos,&nbsp;Stella Douma,&nbsp;Efimia Papadopoulou-Alataki","doi":"10.1159/000517871","DOIUrl":"https://doi.org/10.1159/000517871","url":null,"abstract":"<p><strong>Background and aims: </strong>This study investigated the possible correlation between elevated lipoprotein (a) (Lp(a)) levels and early vascular aging biomarkers in healthy children and adolescents.</p><p><strong>Methods: </strong>Twenty-seven healthy children/adolescents, mean age 9.9 ± 3.7 years, with high Lp(a) levels without other lipid abnormalities and 27 age- and sex-matched controls with normal Lp(a) levels, were included in the study. The investigation of possible early vascular aging was assessed by measuring vascular function indices: carotid intima-media thickness (c-IMT), pulse wave velocity (PWV), augmentation index (AIx), and subendocardial viability ratio (SEVR).</p><p><strong>Results: </strong>Although serum lipid values were within normal levels, mean values of total cholesterol and apolipoprotein B were higher in the group of children with high Lp(a) levels than controls (<i>p</i> = 0.006 and <i>p</i> < 0.001, respectively). Vascular function indices did not show significant differences, neither between the 2 groups nor in the subgroups of children with increased Lp(a) levels. These subgroups were defined by the presence or absence of family history of premature coronary artery disease. Lp(a) levels did not show a significant correlation with the other parameters studied, both regarding the whole sample (patients and controls), as well as in the subgroups of elevated Lp(a) levels. However, in the group of children with high Lp(a) levels, c-IMT and PWV were positively correlated with diastolic blood pressure (<i>r</i> = 0.427, <i>p</i> = 0.026 and <i>r</i> = 0.425, <i>p</i> = 0.030, respectively), while SEVR was negatively correlated with AIx (<i>r</i> = -0.455, <i>p</i> = 0.017).</p><p><strong>Conclusions: </strong>Healthy children and adolescents with high Lp(a) levels do not yet have impaired vascular indices, compared to controls. However, in order to prevent early atherosclerosis, it is crucial to early identify and follow up children with high Lp(a) levels and positive family history of premature coronary disease or other cardiovascular risk factors.</p>","PeriodicalId":29774,"journal":{"name":"Pulse","volume":"9 3-4","pages":"64-71"},"PeriodicalIF":2.2,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740010/pdf/pls-0009-0064.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39739614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large Artery Stiffness: A Companion to the 2015 AHA Science Statement on Arterial Stiffness.","authors":"Jimena Rey-García,&nbsp;Raymond R Townsend","doi":"10.1159/000518613","DOIUrl":"https://doi.org/10.1159/000518613","url":null,"abstract":"<p><p>Large artery stiffness (LAS) has proven to be an independent risk factor for cardiovascular disease and mortality. Nevertheless, the position of current hypertension guidelines regarding the usefulness of assessing LAS differs across different continents. In general, European Guidelines recognize pulse wave velocity (PWV) as a marker of target organ damage but do not recommend its systematic use in general population. Asian guidelines consider PWV as a recommended test at diagnosis of hypertension, in contrast to North American guidelines that do not state any position about its usefulness. However, PWV predicts cardiovascular events, and several studies have shown that it improves risk classification adjusting for established risk factors especially for intermediate-risk patients. Finally, some advances have been made related to treatments affecting LAS. Dietary interventions such as sodium restriction and exercise-based interventions have a modest effect in reducing LAS. Pharmacological interventions, such as statins, or more recent advances with mineralocorticoid blocker seem to have a beneficial effect. Last, controversial effects of renal denervation on LAS have been found. Our goal here is to update the reader on LAS on these areas since the 2015 American Heart Association Scientific Statement.</p>","PeriodicalId":29774,"journal":{"name":"Pulse","volume":"9 1-2","pages":"1-10"},"PeriodicalIF":2.2,"publicationDate":"2021-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527919/pdf/pls-0009-0001.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39580050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Converting and Standardizing Various Measures of Arterial Stiffness to Pulse Wave Velocity.","authors":"Taha Alhalimi,&nbsp;Jisok Lim,&nbsp;Drew Gourley,&nbsp;Hirofumi Tanaka","doi":"10.1159/000517872","DOIUrl":"https://doi.org/10.1159/000517872","url":null,"abstract":"<p><strong>Background: </strong>A variety of arterial stiffness measures have been used to assess the impacts of disease states and various interventions without clear consensus among them. One of the primary problems faced by investigators conducting systematic reviews and meta-analyses is the lack of standardized methodology with a same unit to evaluate and compare investigations using different arterial stiffness measures. Therefore, the purpose of this study was to derive and summarize standardized equations to convert commonly used image-based measures of arterial stiffness to local pulse wave velocity (PWV).</p><p><strong>Methods: </strong>We first conducted a literature search to obtain and summarize conversion equations in the published literature such that these equations can be found in one convenient location. Then, we generated regression equations using the data collected in a well-controlled laboratory-based study, in which all measures of arterial stiffness were obtained in 49 apparently healthy participants.</p><p><strong>Results: </strong>All literature-based conversion equations produced similar local PWV values and were moderately and significantly correlated with directly measured carotid-femoral PWV (cfPWV) with a Pearson's <i>r</i> ranging from 0.41 to 0.50. The local PWV using laboratory-based equations were modestly associated with cfPWV (<i>r</i> = 0.39-0.49) with an exception of incremental elastic modulus (<i>r</i> = 0.15, <i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>Commonly used measures of ultrasound-based arterial stiffness can be converted to local PWV and compared with a reference standard measure of arterial stiffness.</p>","PeriodicalId":29774,"journal":{"name":"Pulse","volume":"9 3-4","pages":"72-82"},"PeriodicalIF":2.2,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740287/pdf/pls-0009-0072.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39739615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cold Pressor Test Influences the Cardio-Ankle Vascular Index in Healthy Overweight Young Adults.","authors":"Supaporn Kulthinee,&nbsp;Nitirut Nernpermpisooth,&nbsp;Montatip Poomvanicha,&nbsp;Jidapa Satiphop,&nbsp;Thizanamadee Chuang-Ngu,&nbsp;Napaporn Kaleeluan,&nbsp;Kittisak Thawnashom,&nbsp;Anuchit Manin,&nbsp;Rosarin Kongchan,&nbsp;Kingkarn Yinmaroeng,&nbsp;Peerapong Kitipawong,&nbsp;Phatiwat Chotimol","doi":"10.1159/000517617","DOIUrl":"https://doi.org/10.1159/000517617","url":null,"abstract":"<p><strong>Objective: </strong>The cold pressor test (CPT) has been shown a potential sympathoexcitatory stimulus which increases aortic pulse wave velocity and the aortic augmentation index, suggesting that noninvasively, arterial stiffness parameters are altered by the CPT. The cardio-ankle vascular index (CAVI) is widely used for reflecting arterial stiffness, and the ankle-brachial index (ABI) for evaluating peripheral artery disease in obesity. We aimed to assess CAVI and ABI in overweight young adults in the context of sympathetic activation by using the CPT.</p><p><strong>Methods: </strong>160 participants were divided into 2 groups: 86 normal-weight (body mass index [BMI] 18.50-22.99 kg/m²) and 74 overweight (BMI ≥23 kg/m²). The CPT was performed by immersing a participant's left hand into cold water (3-5°C) for 3 min, and CAVI and ABI assessment.</p><p><strong>Results: </strong>At baseline, the CAVI in the overweight group was significantly less than that in the normal-weight group (5.79 ± 0.85 vs. 6.10 ± 0.85; <i>p</i> < 0.05). The mean arterial pressure (MAP) for overweight was significantly greater than that for normal-weight subjects (93.89 ± 7.31 vs. 91.10 ± 6.72; <i>p</i> < 0.05). During the CPT, the CAVI increased in both normal-weight and overweight subjects, the CAVI value was greater during the CPT in overweight subjects by 14.36% (6.62 ± 0.95 vs. 5.79 ± 0.85, <i>p</i> < 0.05) and in normal-weight subjects by 8.03% (6.59 ± 1.20 vs. 6.10 ± 0.85, <i>p</i> < 0.05) than those baseline values. The CPT evoked an increase in systolic blood pressure (SBP), diastolic BP (DBP), heart rate (HR,) and pulse pressure (PP) in both groups. After a 4-min CPT period, the CAVI returned values similar to the baseline values in both groups, and the SBP, DBP, MAP, and PP in overweight participants were significantly higher than those in normal-weight participants. However, there was no significant difference in the ABI at baseline, during CPT, and post-CPT in either group.</p><p><strong>Conclusions: </strong>Our results indicated that the CAVI was influenced by sympathetic activation response to the CPT in both normal-weight and overweight young adults. Specifically, during the CPT, the percentage change of the CAVI in overweight response was greater in normal-weight participants than baseline values in each group. The ABI was not found significantly associated with CPT. These findings suggesting that sympathoexcitatory stimulus by CPT influence CAVI results.</p>","PeriodicalId":29774,"journal":{"name":"Pulse","volume":"9 1-2","pages":"30-37"},"PeriodicalIF":2.2,"publicationDate":"2021-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000517617","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39580053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-Related Differences in Hypertrophic Cardiomyopathy: A Systematic Review and Meta-Analysis.","authors":"Angkawipa Trongtorsak,&nbsp;Natchaya Polpichai,&nbsp;Sittinun Thangjui,&nbsp;Jakrin Kewcharoen,&nbsp;Ratdanai Yodsuwan,&nbsp;Amrit Devkota,&nbsp;Harvey J Friedman,&nbsp;Alfonso Q Estrada","doi":"10.1159/000517618","DOIUrl":"https://doi.org/10.1159/000517618","url":null,"abstract":"<p><strong>Background: </strong>Gender-related differences in phenotypic expression and outcomes have been established in many cardiac conditions; however, the impact of gender in hypertrophic cardiomyopathy (HCM) remains unclear. We conducted a systematic review and meta-analysis to assess the differences in clinical outcomes between female and male HCM patients.</p><p><strong>Methods: </strong>We searched MEDLINE and EMBASE from inception to October 2020. Included were cohort studies that compared outcomes of interest including all-cause mortality, HCM-related mortality, and worsening heart failure (HF) or HF hospitalization between male and female. Data from each study were combined using the random effects model to calculate pooled odds ratio (OR) with 95% confidence interval (CI).</p><p><strong>Results: </strong>Eleven retrospective cohort studies with a total of 9,427 patients (3,719 females) were included. Female gender was significantly associated with an increased risk of all-cause mortality (pooled OR = 1.63, 95% CI: 1.26-2.10, <i>p</i> ≤ 0.001), HCM-related mortality (pooled OR = 1.47, 95% CI: 1.08-2.01, <i>p</i> = 0.015), and worsening HF or HF hospitalization (pooled OR = 2.05, 95% CI: 1.76-2.39, <i>p</i> ≤ 0.001).</p><p><strong>Conclusions: </strong>Female gender was associated with a worse prognosis in HCM. These findings suggest the need for improved care in women including early identification of disease and more possible aggressive management. Moreover, gender-based strategy may benefit in HCM patients.</p>","PeriodicalId":29774,"journal":{"name":"Pulse","volume":"9 1-2","pages":"38-46"},"PeriodicalIF":2.2,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527921/pdf/pls-0009-0038.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39579977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Cardio-Ankle Vascular Index and Ankle-Brachial Index in Patients with Peripheral Arterial Disease.","authors":"Taichiro Hayase","doi":"10.1159/000515357","DOIUrl":"https://doi.org/10.1159/000515357","url":null,"abstract":"<p><strong>Introduction: </strong>The cardio-ankle vascular index (CAVI) is a well-known index to evaluate arterial stiffness and predict cardiovascular risk.</p><p><strong>Methods: </strong>We investigated whether CAVI can predict severity and extent of peripheral arterial disease. This study was a single-center, retrospective, observational study approved by the Ethics Committee of Yokohama Shintoshi Neurosurgical Hospital. A total of 96 patients (males, 63) with an abnormal ankle-brachial blood pressure index (ABI) of <0.9 and who underwent extremity arteriography at our hospital from 2015 to 2018 were enrolled in this study. We defined that CAVI with a range of <8.0 was normal.</p><p><strong>Results: </strong>Coronary angiography and extremity arteriography were performed for patients who had intermittent claudication and abnormal ABI. We divided the affected limbs into 3 categories: above-the-knee artery stenosis, above-the-knee artery chronic total occlusion, and only below-the-knee artery stenosis/occlusion groups. CAVI pseudonormalization was seen in 28, 76, and 19%, respectively. The above-the-knee artery stenosis and the only below-the-knee artery stenosis/occlusion groups had a high odds ratio of abnormalization of CAVI (3.1, 95% confidence interval [CI]: 1.39-7.22; <i>p</i> = 0.05, 4.56, 95% CI: 1.64-14.7).</p><p><strong>Discussion/conclusion: </strong>In the presence of the above-the-knee artery chronic total occlusion, CAVI pseudonormalization was likely to be seen. The presence of CTO in the above-the-knee artery is one cause of pseudonormalized CAVI. In the range of ABI, in which stenotic lesions and obstructive lesions coexist, it may be possible to detect the existence of CTO by a combination of both ABI and CAVI.</p>","PeriodicalId":29774,"journal":{"name":"Pulse","volume":"9 1-2","pages":"11-16"},"PeriodicalIF":2.2,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000515357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39580051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of Stress-Derived E/e' Ratio in Asymptomatic Hypertensive Patients.","authors":"Ragab A Mahfouz,&nbsp;Mohammed Abdelhamed,&nbsp;Islam Galal,&nbsp;Moataz Elsanan","doi":"10.1159/000511217","DOIUrl":"https://doi.org/10.1159/000511217","url":null,"abstract":"<p><strong>Purpose: </strong>We sought to investigate the usefulness of stress echocardiography-derived E/e' in predicting subclinical atherosclerosis in asymptomatic hypertensive patients.</p><p><strong>Materials and methods: </strong>71 newly diagnosed untreated hypertensive patients (48 ± 13 years, 65% males) and 30 age- and sex-matched healthy controls were recruited. Resting and exercise echocardiography was performed to assess resting diastolic blood pressure and the diastolic stress parameters. Coronary flow reserve (CFR) was evaluated as well.</p><p><strong>Results: </strong>Based on CFR values, newly diagnosed, untreated hypertensives were stratified into hypertensives with microvascular dysfunction (MVD; 34 patients had CFR <2.0) and those without MVD (37 patients had CFR ≥2.0). Patients with MVD had a significantly higher C-reactive protein level (<i>p</i> < 0.05) and lower metabolic equivalent values (<i>p</i> < 0.05). With resting echocardiography, only the left atrial volume index (LAVI) was significantly increased in those with MVD compared with those without MVD and controls (<i>p</i> < 0.05). With exercise echo, the E/e' was significantly increased in MVD patients compared with those without MVD and controls (<i>p</i> < 0.001). Importantly, the percentage of subjects with exercise E/e' ≥15 was 76.5% (26 patients in the group with MVD), 4.1% (3 patients in the group without MVD), and 0% in controls. At univariate analysis, high-sensitivity C-reactive protein (<i>p</i> < 0.05), LAVI (<i>p</i> < 0.05), and exercise E/e' (<i>p</i> < 0.001) were independently associated with reduced CFR. On the other hand, at multivariate analysis, only exercise E/e' was the independent predictor of reduced CFR in newly diagnosed hypertensives.</p><p><strong>Conclusion: </strong>We have demonstrated significant associations between exercise-derived raised left ventricular pressure and coronary MVD in newly diagnosed untreated hypertensive patients. Herein, we supposed that exercise-derived E/e' could predict subclinical atherosclerosis and might be a risk parameter for newly diagnosed untreated hypertensive patients.</p>","PeriodicalId":29774,"journal":{"name":"Pulse","volume":"8 3-4","pages":"92-98"},"PeriodicalIF":2.2,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000511217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39220871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Serum Magnesium and the Risk of Venous Thromboembolism in Men: A Long-Term Prospective Cohort Study.","authors":"Setor K Kunutsor,&nbsp;Jari A Laukkanen","doi":"10.1159/000515409","DOIUrl":"https://doi.org/10.1159/000515409","url":null,"abstract":"<p><strong>Background and objective: </strong>Serum magnesium, an essential trace element involved in processes that regulate cardiovascular function, has been linked to the risk of atherosclerotic cardiovascular disease. However, the potential association between serum magnesium and venous thromboembolism (VTE) has not been previously investigated. We aimed to assess the prospective association of serum magnesium with the risk of VTE.</p><p><strong>Methods: </strong>Serum magnesium was measured using atomic absorption spectrometry in 2,361 men aged 42-61 years with no history of VTE at baseline in the Kuopio Ischemic Heart Disease prospective cohort. Cox regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for VTE.</p><p><strong>Results: </strong>A total of 159 incident VTE events were recorded during a median follow-up of 27.1 years. The risk of VTE per 1 SD increase in serum magnesium in the age-adjusted analysis was (HR 1.30; 95% CI 0.46-3.69). The association remained consistent in analyses adjusted for systolic blood pressure, body mass index, total cholesterol, triglycerides, smoking status, a history of type 2 diabetes, a history of coronary heart disease, medication for dyslipidemia, alcohol consumption, physical activity, socioeconomic status, serum active calcium, high-sensitivity C-reactive protein, and a history of cancer (HR 1.38; 95% CI 0.48-3.96). Comparing the extreme tertiles of serum magnesium, the corresponding adjusted HRs were 1.17 (95% CI 0.81-1.70) and 1.17 (95% CI 0.81-1.70), respectively.</p><p><strong>Conclusion: </strong>In a middle-aged Caucasian male population, serum-circulating magnesium was not associated with a future risk of VTE. Further studies in women, other age groups, and other populations are required to generalize these findings.</p>","PeriodicalId":29774,"journal":{"name":"Pulse","volume":"8 3-4","pages":"108-113"},"PeriodicalIF":2.2,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000515409","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39222232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}