Heart Rhythm O2最新文献

{"title":"ID: 4533788 SYNTHETIC SCAR MAPPING WITHOUT MRI: MACHINE LEARNING GENERATION OF LGE-EQUIVALENT MAPS FROM ELECTROANATOMIC VOLTAGE SUBTRACTION FEATURES IN PATIENTS WITH VENTRICULAR TACHYCARDIA","authors":"Moez Alnazeer, Jerry Fan, Vinh Nguyen, Peter Y. Cheung, Gregory Olsovsky, Javier E. Banchs","doi":"10.1016/j.hroo.2026.08.014","DOIUrl":"10.1016/j.hroo.2026.08.014","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"7 9","pages":"Page S8"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID: 4570698 LONG-TERM NATURAL HISTORY OF TRANSVENOUS LEAD PARAMETERS FROM REAL-WORLD, POPULATION-WIDE REMOTE MONITORING DATA","authors":"Simrat Arora, Steven Summers, Tina Baykaner, Thomas F. Deering, Eugene Y. Fu, Anne M. Kroman, Andrea M. Russo, Prashanthan Sanders, James Freeman, Benjamin A. Steinberg","doi":"10.1016/j.hroo.2026.08.033","DOIUrl":"10.1016/j.hroo.2026.08.033","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"7 9","pages":"Pages S19-S20"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148995088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID: 4570875 COMPATIBILITY OF MICROAXIAL LEFT VENTRICULAR ASSIST CATHETERS WITH AN ELECTROANATOMIC MAPPING SYSTEM AND DUAL-ENERGY IRRIGATED CATHETER FOR VENTRICULAR MAPPING AND ABLATION IN A PORCINE CHRONIC INFARCT MODEL","authors":"Sei Iwai, Jennifer Maffre, Allan K. Symonette, Michelle Graham, Alfred Krollos, Phillip Lam, Jerry Martinez Contreras, Benjamin Manacop, Peter Llewellyn, Sathya D. Unudurthi, Jason T. Jacobson","doi":"10.1016/j.hroo.2026.08.009","DOIUrl":"10.1016/j.hroo.2026.08.009","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"7 9","pages":"Pages S5-S6"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148995385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID: 4568255 FIRST REPORTED CASE SERIES OF AF ABLATION USING THE STAR APOLLO MAPPING SYSTEM INTEGRATED WITH THE CARTO 3 SYSTEM","authors":"Matthew S. McKillop","doi":"10.1016/j.hroo.2026.08.038","DOIUrl":"10.1016/j.hroo.2026.08.038","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"7 9","pages":"Page S22"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148997655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular wall thickness on systolic-phase pulmonary vein CT as a marker for cardiac amyloidosis","authors":"Ziad Zalaquett MD, MSc,&nbsp;Mazen Hanna MD,&nbsp;Trejeeve Martyn MD,&nbsp;Rohit Moudgil MD, PhD,&nbsp;Mohamed Kanj MD,&nbsp;Milind Desai MD,&nbsp;Brian Griffin MD,&nbsp;Wael Jaber MD,&nbsp;Patrick Collier MD, PhD","doi":"10.1016/j.hroo.2026.06.001","DOIUrl":"10.1016/j.hroo.2026.06.001","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac amyloidosis (CA) is under-recognized and frequently associated with atrial fibrillation (AF). Pulmonary vein computed tomography (CT) is routinely obtained by electrophysiologists for AF ablation planning, but its potential for identifying incidental features of CA, such as increased left ventricular (LV) wall thickness, remains unexplored.</div></div><div><h3>Objective</h3><div>This study aimed to evaluate whether LV wall thickness measured on systolic-phase pulmonary vein CT can identify patients with CA.</div></div><div><h3>Methods</h3><div>We retrospectively identified 160 patients who underwent systolic-phase pulmonary vein CT for AF ablation planning, including 80 patients with confirmed CA, and 80 age- and sex-matched controls. LV anteroseptal and inferoseptal wall thickness were measured using multiplanar reconstruction.</div></div><div><h3>Results</h3><div>The mean age was 73 years, and 10% were female. Patients with CA had a significantly higher LV wall thickness than controls (mean septal thickness 22.3 ± 3.5 mm vs 14.9 ± 2.5 mm; <em>P</em> &lt; .001). Multivariable logistic regression identified combined LV septal thickness as an independent predictor of CA (odds ratio, 1.78; 95% confidence interval, 1.43–2.21; <em>P</em> &lt; .001). Receiver operating characteristic analysis demonstrated excellent discriminatory performance (area under the curve, 0.964; 95% confidence interval, 0.939–0.988; <em>P</em> &lt; .001), with a combined thickness of 36 mm being the optimal cutoff. Notably, 56% of patients with CA underwent pulmonary vein CT before definitive diagnosis, indicating potential for early recognition.</div></div><div><h3>Conclusion</h3><div>Systolic-phase LV wall thickness measured on pulmonary vein CT is significantly increased in patients with CA and may serve as an early imaging prompt for further diagnostic evaluation. Routine assessment of LV thickness on AF ablation CTs could provide an opportunity for earlier detection and intervention for unrecognized CA.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"7 9","pages":"Pages 1650-1655"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148981073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence and biomarker-driven prediction of post–coronary artery bypass grafting atrial fibrillation: Integrating clinical, genomic, and metabolic insights","authors":"Muhammad Usman Ghani MD,&nbsp;Abhishek Prasad MD,&nbsp;Jai Sivanandan Nagarajan MBBS,&nbsp;Darsh Tusharbhai Patel MD,&nbsp;Rupak Desai MBBS,&nbsp;Subramanian Gnanaguruparan MBBS,&nbsp;Subhasis Chatterjee MD","doi":"10.1016/j.hroo.2026.06.006","DOIUrl":"10.1016/j.hroo.2026.06.006","url":null,"abstract":"<div><h3>Background</h3><div>Postoperative atrial fibrillation (POAF) remains one of the most frequent and consequential complications after coronary artery bypass grafting, occurring in 15%–30% of patients and contributing to increased morbidity, prolonged hospitalization, and higher long-term mortality. Despite decades of investigation, traditional risk models have shown limited predictive accuracy owing to the multifactorial nature of POAF.</div></div><div><h3>Objective</h3><div>This review synthesizes the emerging evidence from recent studies applying artificial intelligence (AI) and machine learning (ML) approaches for POAF prediction, with focus on clinical, biochemical, genomic, and molecular dimensions.</div></div><div><h3>Methods</h3><div>We conducted a structured narrative review of PubMed/MEDLINE, Embase, and Google Scholar for studies evaluating AI and ML-based prediction of POAF following isolated coronary artery bypass grafting published from January 2020 through 2025. Search terms included POAF, coronary artery bypass grafting, ML, AI, pharmacogenomics, and biomarkers. A total of 9 studies met inclusion criteria and were synthesized narratively given the heterogeneity in study designs and outcomes.</div></div><div><h3>Results</h3><div>Across studies, modern algorithms demonstrate areas under the curve receiver operating characteristic between 0.80 and 0.93, with performance exceeding that reported for traditional clinical risk scores. However, external validation, model calibration, and biases remain to be fully addressed before clinical translation is considered.</div></div><div><h3>Conclusion</h3><div>The convergence of interpretable AI, metabolic and genetic biomarkers, and clinical data offers a promising path toward individualized risk stratification and targeted postoperative management.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"7 9","pages":"Pages 1800-1808"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148981078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic changes in cardiac autonomic function persist in the postacute phase after SARS-CoV-2 infection in a hamster model of COVID-19","authors":"Ting Liu PhD,&nbsp;Deepthi Ashok PhD,&nbsp;Andrew Pekosz PhD,&nbsp;Jason Villano DVM, MS, MSc,&nbsp;Brian O’Rourke PhD","doi":"10.1016/j.hroo.2026.05.022","DOIUrl":"10.1016/j.hroo.2026.05.022","url":null,"abstract":"<div><h3>Background</h3><div>Autonomic nervous system (ANS) dysfunction is a central feature of long coronavirus disease syndrome, yet little is known about how it develops during and after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.</div></div><div><h3>Objective</h3><div>This study aimed to characterize the time course of dynamic changes in linear and nonlinear heart rate variability measurements as indices of ANS function for up to 2 months after infection.</div></div><div><h3>Methods</h3><div>Hamsters implanted with radiotelemetry devices were inoculated with SARS-CoV-2. Electrocardiograms and subpleural pressures were recorded before infection, and for 56 days postinfection (DPI). Heart rate variability and respiratory sinus arrhythmia were analyzed and compared with the preinfection baseline or mock-infected controls. Ruxolitinib or mitochondrially targeted 2,2,6,6-tetramethylpiperidine-1-oxyl was administered from 4 days before infection to 10 DPI to assess the effects of Jak/Stat inhibition or antioxidant treatment, respectively.</div></div><div><h3>Results</h3><div>ANS activity follows 3 phases after infection: (1) a pronounced increase in parasympathetic activity relative to sympathetic activity during the acute phase of infection (1–4 DPI), (2) a decrease in overall ANS activity in the subacute phase (7–14 DPI), and (3) re-emergence of elevated sympathetic and parasympathetic inputs that continue to increase during the postacute phase (28–56 DPI). The conclusions are corroborated by changes in respiratory sinus arrhythmia analysis and acute pharmacologic inhibition of cholinergic and β-adrenergic signaling. Postacute ANS remodeling was suppressed by early inhibition of innate immune signaling or mitochondrial oxidative stress.</div></div><div><h3>Conclusion</h3><div>Cardiac dysautonomia after SARS-CoV-2 infection is phase dependent. Inhibiting early immune activation or mitochondrial oxidative stress during the acute phase offers a strategy to suppress postacute ANS remodeling that could contribute to long coronavirus disease syndrome.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"7 9","pages":"Pages 1746-1761"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148981080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical assessment of a novel ablation catheter specific to robotic magnetic navigation","authors":"Qingzhi Luo MD, PhD,&nbsp;Xiang Li MD, PhD,&nbsp;Yangyang Bao MD, PhD,&nbsp;Changjian Lin MD,&nbsp;Yun Xie MD,&nbsp;Yue Wei MD,&nbsp;Tianyou Ling MD, PhD, FHRS,&nbsp;Ning Zhang MD, PhD, FHRS,&nbsp;Kang Chen MD, PhD,&nbsp;Wenqi Pan MD, PhD, FHRS,&nbsp;Liqun Wu MD, PhD, FHRS,&nbsp;Qi Jin MD, PhD, FHRS","doi":"10.1016/j.hroo.2026.05.014","DOIUrl":"10.1016/j.hroo.2026.05.014","url":null,"abstract":"<div><h3>Background</h3><div>A novel catheter (Magbot) is needed to enable seamless integration with robotic magnetic navigation systems and third-party mapping platforms.</div></div><div><h3>Objective</h3><div>The goals of this study were to assess the contact force (CF) and lesion characteristics of the Magbot catheter under robotic magnetic navigation guidance and to compare these parameters with those of the RMT catheter solely for the CARTO system.</div></div><div><h3>Methods</h3><div>A total of 1200 CF measurements were collected for both the Magbot and RMT catheters when spanning different vector orientations, and catheter extensions were obtained in a simulation study. Subsequently, radiofrequency energy was delivered to an ex vivo porcine heart to create ablation lesions using 3 power settings: 30 W for 30 seconds, 40 W for 20 seconds, and 50 W for 15 seconds.</div></div><div><h3>Results</h3><div>CF values were highly dependent on both vector orientation and catheter extension. The Magbot catheter consistently yielded more favorable CF values across all anatomical configurations than did the RMT catheter. While no statistically significant difference in lesion size was observed between the 2 catheters across all tested energy settings, a consistent trend favoring the Magbot catheter was noted. Moreover, high-power ablation (50 W/15 seconds) generated lesions characterized by a significant increase in superficial width but a concomitant reduction in depth and overall volume. Notably, compared with the Magbot catheter, the RMT catheter was associated with a significantly higher incidence of steam pops, with risk escalating sharply at higher power levels.</div></div><div><h3>Conclusion</h3><div>The findings indicate that the Magbot catheter not only matched the RMT catheter in core lesion formation efficacy but also offered distinct advantages in terms of CF stability and safety profile.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"7 9","pages":"Pages 1735-1745"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148981085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early arrhythmia recurrence during the blanking period after pulsed-field ablation for atrial fibrillation","authors":"Fabian Jordan MD,&nbsp;Corinne Isenegger MD,&nbsp;Bedran Peker BSc,&nbsp;Jonas Brügger MD,&nbsp;Sven Knecht DSc,&nbsp;Philipp Krisai MD,&nbsp;Nicolas Schaerli MD,&nbsp;Gian Völlmin MS,&nbsp;Reto Stump MD,&nbsp;David Spreen MS,&nbsp;Felix Mahfoud MD,&nbsp;Christian Sticherling MD,&nbsp;Michael Kühne MD,&nbsp;Patrick Badertscher MD","doi":"10.1016/j.hroo.2026.05.012","DOIUrl":"10.1016/j.hroo.2026.05.012","url":null,"abstract":"<div><h3>Background</h3><div>Pulmonary vein isolation is a cornerstone in the treatment of atrial fibrillation, with procedural success traditionally assessed after a 3-month “blanking period” to account for early postablation arrhythmias. However, emerging evidence challenges this paradigm, particularly with nonthermal energy modalities such as pulsed-field ablation (PFA), which induce minimal inflammatory response.</div></div><div><h3>Objective</h3><div>The purpose of this study was to assess the prognostic relevance of early recurrence (ER) of atrial arrhythmia during the blanking period after PFA-based pulmonary vein isolation, with a focus on the timing of ER and its association with late recurrence (LR).</div></div><div><h3>Methods</h3><div>In this single-center study, 241 patients with atrial fibrillation underwent first-time PFA and were followed for ≥12 months. <em>ER</em> was defined as any atrial arrhythmia lasting &gt;30 seconds within the first 3 months of ablation. The primary outcome was freedom from LR beyond the blanking period.</div></div><div><h3>Results</h3><div>ER occurred in 48 (20%) of patients, with 23 (48%) occurring within the first month and 25 (52%) during the second or third month of ablation. LR was significantly more frequent in patients with ER (<em>P</em> &lt; .001), particularly when recurrence occurred after day 30. Multivariable Cox analysis identified ER during the second or third month (hazard ratio 6.1; 95% confidence interval 3.3–11.3) and ER during the first month (hazard ratio 3.6; 95% confidence interval 1.8–7.1) as the strongest independent predictors of LR. A subset of ERs resolved spontaneously.</div></div><div><h3>Conclusion</h3><div>The timing of ER after PFA strongly predicts LR, supporting reconsideration of the 90-day blanking period. It may be appropriate to shorten the blanking period for PFA, but late ER warrants clinical attention. Larger studies should validate timing-based blanking strategies.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"7 9","pages":"Pages 1621-1630"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148981125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID: 4570955 TOWARDS PREDICTING ATRIAL FIBRILLATION BURDEN: USING A NAÏVE RADIOMICS PIPELINE APPLIED TO PRE-PROCEDURE CARDIAC MAGNETIC RESONANCE IMAGES","authors":"Abboud Hassan,&nbsp;Christian M. Massad,&nbsp;Carlo El Khoury,&nbsp;Han Feng,&nbsp;Nassir F. Marrouche,&nbsp;Mary M. Maleckar","doi":"10.1016/j.hroo.2026.08.024","DOIUrl":"10.1016/j.hroo.2026.08.024","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"7 9","pages":"Pages S14-S15"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148994683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}