Heart Rhythm O2Pub Date : 2025-06-01DOI: 10.1016/j.hroo.2025.03.024
Sanket S. Dhruva MD, MHS , Kurt Marunick MBA , Hans J. Moore MD, FHRS , Gregory Rohrbach DNP , Thomas L. Rotering MPH , Merritt H. Raitt MD, FHRS
{"title":"Veterans health administration national cardiac device surveillance program: Structured, centralized remote monitoring for cardiovascular implantable electronic devices to improve quality of care","authors":"Sanket S. Dhruva MD, MHS , Kurt Marunick MBA , Hans J. Moore MD, FHRS , Gregory Rohrbach DNP , Thomas L. Rotering MPH , Merritt H. Raitt MD, FHRS","doi":"10.1016/j.hroo.2025.03.024","DOIUrl":"10.1016/j.hroo.2025.03.024","url":null,"abstract":"<div><div>Remote monitoring (RM) is central to care of patients with cardiovascular implantable electronic devices (CIEDs). However, because RM care presents a large and increasing clinician workload, solutions are needed to increase care efficiency. The Veterans Health Administration National Cardiac Device Surveillance Program (VHANCDSP) is a response to this need by centralizing RM processes, reviewing all RM transmissions, identifying patients affected by recalls, and providing guidance on clinical response for 122 VHA CIED clinics across the United States and Puerto Rico. The VHANCDSP promotes participation and adherence in RM, ensuring evidence-based care. The centralized infrastructure also positions the VHANCDSP to evaluate and implement quality improvement interventions, ultimately enhancing clinical care for patients with CIEDs. This article describes and reflects on this infrastructure and provides specific recommendations about how high-quality RM care can be provided in care other health care systems.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 6","pages":"Pages 893-902"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Rhythm O2Pub Date : 2025-06-01DOI: 10.1016/j.hroo.2025.03.012
Don W. Wallick PhD , Dragan Juzbasich MS , Celeen Khrestian BS , Daniel Laurita BS , Seungyup Lee PhD, FHRS
{"title":"Phasic effects of cardiac-synchronized vagus nerve stimulation on spatiotemporal behavior of the sinoatrial node in swine","authors":"Don W. Wallick PhD , Dragan Juzbasich MS , Celeen Khrestian BS , Daniel Laurita BS , Seungyup Lee PhD, FHRS","doi":"10.1016/j.hroo.2025.03.012","DOIUrl":"10.1016/j.hroo.2025.03.012","url":null,"abstract":"<div><h3>Background</h3><div>Recent clinical trials of cervical vagus nerve stimulation (VNS) in heart failure patients failed to demonstrate the expected benefits seen in experimental studies, potentially due to subtherapeutic VNS levels. The timing and burst firing of VNS affects cardiac cycle length (CL) prolongation and the shift of the sinoatrial node (SAN) from a superior to inferior position in mammals, including humans.</div></div><div><h3>Objective</h3><div>The study sought to determine if parasympathetic nerves of swine respond in a similar manner to other studies in mammals.</div></div><div><h3>Methods</h3><div>Seven pigs were anesthetized using isoflurane for surgical instrumentation before the study. Once completed, the anesthesia was switched to α-chloralose. Cardiac-synchronized VNS was performed in bursts for 10 to 20 cardiac cycles. The synchronization of the bursts varied by 100-ms increments following sensed atrial depolarization. Epicardial mapping was performed to characterize the spatiotemporal behavior of the SAN during VNS in 6 of 7 animals.</div></div><div><h3>Results</h3><div>The average cardiac CL before VNS was 517 ± 73 ms. Altering the synchronized delay of the VNS resulted in CL prolongations (range 16 ± 6% to 27 ± 18%) in pigs, similar to those observed in other mammals. Interestingly, the SAN shifted inferiorly in only 2 of 6 mapped animals during VNS regardless of the extent of CL prolongation. These shift sites, the superior SAN and inferior SAN, alternated between the 2 locations as the CL changed.</div></div><div><h3>Conclusion</h3><div>The temporal behavior of the SAN during cardiac-synchronized VNS in swine is similar to that observed in other mammals, but its spatial behavior is different. Because burst firing of VNS is physiological, future work in swine on its effect on mitigating heart failure should be studied.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 6","pages":"Pages 864-873"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Rhythm O2Pub Date : 2025-06-01DOI: 10.1016/j.hroo.2025.02.016
Alphonsus Liew MBBS , Nadeev Wijesuriya MBBS , Sandra Howell MBBS , Felicity de Vere MBBS , Joshua Wilcox MBBS , Tiffany Patterson PhD , Steven Niederer PhD , Christopher Aldo Rinaldi MD, FHRS
{"title":"Cardiac implantable electronic devices in the setting of tricuspid valve intervention: Risks, options, extraction and future perspectives: A state-of-the-art review","authors":"Alphonsus Liew MBBS , Nadeev Wijesuriya MBBS , Sandra Howell MBBS , Felicity de Vere MBBS , Joshua Wilcox MBBS , Tiffany Patterson PhD , Steven Niederer PhD , Christopher Aldo Rinaldi MD, FHRS","doi":"10.1016/j.hroo.2025.02.016","DOIUrl":"10.1016/j.hroo.2025.02.016","url":null,"abstract":"<div><div>Tricuspid regurgitation is associated with increased risk of heart failure and mortality. To address this, tricuspid valve (TV) interventions in the form of transcatheter and surgical TV procedures have rapidly emerged. TV interventions are associated with a significant risk of conduction system disease necessitating permanent pacemaker (PPM) implantation. Limited data and current guidelines suggest that transvalvular PPM should be avoided to preserve the function of replaced or repaired TVs. With the rapid increase of transcatheter tricuspid valve-in-valve replacements in the last decade, the incidence of pre-existing PPM lead entrapment poses a clinical challenge in which lead extraction is indicated, particularly in the context of device infection. In this review article, we discuss the risks of conduction system disease associated with different TV interventions, the options for pacing, defibrillator therapy and cardiac resynchronization therapy that spare the TV, and the management of pre-existing transvalvular pacing leads before TV intervention. Furthermore, we discuss the future perspectives in this field, including a completely leadless cardiac resynchronization therapy-defibrillator system, and propose an algorithm for cardiac implantable electronic devices (CIED) implantation during or after TV intervention.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 6","pages":"Pages 880-892"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Rhythm O2Pub Date : 2025-06-01DOI: 10.1016/j.hroo.2025.03.008
Bradley J. Reinoehl BS, Destino Roman BS, Joel Reinoehl MD
{"title":"Reply: Complete heart block during permanent His bundle pacing: Is it a novel complication?","authors":"Bradley J. Reinoehl BS, Destino Roman BS, Joel Reinoehl MD","doi":"10.1016/j.hroo.2025.03.008","DOIUrl":"10.1016/j.hroo.2025.03.008","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 6","pages":"Page 908"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Rhythm O2Pub Date : 2025-06-01DOI: 10.1016/j.hroo.2025.03.021
Samuel F. Sears PhD , Samantha McCrary MS , Tiffany Andrade PA-C , Lauren Rousseau MPAS, PA-C, CCDS , Ann Kirkness RN , Allana Fantin CNE, MSc, BScN , Julie B. Shea MSN, NP
{"title":"ICD support groups: Are they still relevant now?","authors":"Samuel F. Sears PhD , Samantha McCrary MS , Tiffany Andrade PA-C , Lauren Rousseau MPAS, PA-C, CCDS , Ann Kirkness RN , Allana Fantin CNE, MSc, BScN , Julie B. Shea MSN, NP","doi":"10.1016/j.hroo.2025.03.021","DOIUrl":"10.1016/j.hroo.2025.03.021","url":null,"abstract":"<div><div>While implantable cardioverter-defibrillators (ICDs) save lives in patients at risk for potentially life-threatening arrhythmias, ICD shocks may prompt fear and anxiety and cause potential psychological trauma in patients. Since the beginning of the ICD’s broad use, healthcare professionals recognized the unique demands and experiences associated with this therapy. Some clinics responded by initiating patient-focused meetings broadly referred to as “ICD support groups” to address the mental health challenges in these patients. Decades of research have now underscored the importance of ICD patients’ psychological and behavioral processes and their associations with adverse health outcomes. ICD patients frequently report disease-specific mental health symptoms, including ICD shock anxiety, poor device acceptance, body image concerns, and decreased physical activity, that require unique clinical expertise from professionals to effectively manage. The original impetus for ICD support groups persists, but relatively few ICD support groups remain active. Online offerings may have taken on some of these functions. We suggest that ICD support groups remain a strategic intervention to address patient psychological and lifestyle concerns. This paper reviews the value of ICD support groups in the United States, Australia, and Canada and analyzes the current state and potential value of ICD support groups.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 6","pages":"Pages 874-879"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between ultra-short-term heart rate variability of time fluctuation and atrial fibrillation: Evidence from MIMIC-IV","authors":"Xiaodi Tang MD , Yue Wu MD , Xiaofei Zhang MD , Kexin Zhang MS , Ying Xie MD , Yangong Chao MD , Rong He MD, PhD , Ping Zhang MD, PhD","doi":"10.1016/j.hroo.2025.03.006","DOIUrl":"10.1016/j.hroo.2025.03.006","url":null,"abstract":"<div><h3>Background</h3><div>Ultra-short-term heart rate variability (usHRV) has been found to be associated with atrial fibrillation (AF); however, research in this area is currently limited.</div></div><div><h3>Objective</h3><div>This study aimed to investigate the association between usHRV metrics and AF.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included 48,416 participants from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. UsHRV time domain and frequency domain metrics were also collected. We examined the connection between usHRV and AF in electrocardiogram samples collected from 08:00 to 18:00, 18:00 to 08:00, and all day to understand the impact of time on the findings. To address the research objectives, we used Cox regression analysis, stratified curve fitting, threshold effect analysis, subgroup analysis, and the assessment of interaction effects.</div></div><div><h3>Results</h3><div>During an average follow-up of 1.88 years, 3611 (7.5%) participants developed AF. UsHRV time domain metrics were unstable in a day, and the HR was more significant in those ≥55 years of age, with a statistically significant interaction. In contrast, the usHRV frequency metrics are more clinically significant and stable. The hazard ratios for the 08:00 to 18:00 samples were 0.79 (95% confidence interval [CI] 0.74–0.84) for log(ratio of low frequency and high frequency), 0.74 (95% CI 0.67–0.80) for log(low-frequency normalized units), and 2.26 (95% CI 1.80–2.84) for log(high-frequency normalized units), respectively.</div></div><div><h3>Conclusion</h3><div>The frequency domain metrics of usHRV exhibit strong stability, surpassing those derived from time domain metrics, and offer improved convenience compared with HRV. This makes them particularly notable for their clinical significance.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 6","pages":"Pages 818-826"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Rhythm O2Pub Date : 2025-06-01DOI: 10.1016/j.hroo.2025.03.007
Saad Ullah Malik MD, Pugazhendhi Vijayaraman MD
{"title":"Complete heart block during permanent His bundle pacing: Is it a novel complication?","authors":"Saad Ullah Malik MD, Pugazhendhi Vijayaraman MD","doi":"10.1016/j.hroo.2025.03.007","DOIUrl":"10.1016/j.hroo.2025.03.007","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 6","pages":"Page 908"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144320985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Rhythm O2Pub Date : 2025-06-01DOI: 10.1016/j.hroo.2025.03.004
Elizabeth D. Paratz MBBS, PhD , Emily Nehme PhD , Ashanti Dantanarayana BSc , Kelila Freedman MSc , Daniel Coakley MD , Louise Fahy MB BCh, BAO , Stephanie Rowe BBiomed, MD , Bruce Wilkie MA, MBBS , Adam Trytell MBBS , David Anderson MBBS, PhD , Andreas Pflaumer MD , Dion Stub MBBS, PhD , Andre La Gerche MBBS, PhD , Ziad Nehme PhD
{"title":"Cardiac arrest in the Australian Alps: A 20-year analysis","authors":"Elizabeth D. Paratz MBBS, PhD , Emily Nehme PhD , Ashanti Dantanarayana BSc , Kelila Freedman MSc , Daniel Coakley MD , Louise Fahy MB BCh, BAO , Stephanie Rowe BBiomed, MD , Bruce Wilkie MA, MBBS , Adam Trytell MBBS , David Anderson MBBS, PhD , Andreas Pflaumer MD , Dion Stub MBBS, PhD , Andre La Gerche MBBS, PhD , Ziad Nehme PhD","doi":"10.1016/j.hroo.2025.03.004","DOIUrl":"10.1016/j.hroo.2025.03.004","url":null,"abstract":"<div><h3>Background</h3><div>Alpine tourism annually attracts over 100 million visitors globally. Age and cardiovascular comorbidities in alpine tourists are increasing, and rates of out-of-hospital cardiac arrest (OHCA) have been hypothesized to be higher due to exertion and physiological stress.</div></div><div><h3>Methods</h3><div>Cases of alpine OHCA from 2002 to 2021 were identified from the statewide Victorian Ambulance Cardiac Arrest Registry. Alpine and nonalpine OHCA characteristics were compared. Causes of alpine OHCA were obtained from hospital discharge diagnoses and the National Coronial Information System.</div></div><div><h3>Results</h3><div>Approximately 15.3 million alpine visits were recorded over the time period, during which 13 alpine OHCAs occurred (0.04% of 32,179 OHCAs, 0.8 OHCAs per million alpine visits). Compared with nonalpine OHCAs in a public setting, alpine OHCA patients were younger (median age 52 years vs 63 years, <em>P =</em> .0373), with higher rates of bystander defibrillation (54.5% vs 13.5%, <em>P <</em> .0001). Survival to hospital discharge did not significantly differ between alpine (38.5%) and nonalpine OHCA patients. Ischemic heart disease was the commonest identified cause of alpine OHCA in both survivors and nonsurvivors.</div></div><div><h3>Conclusion</h3><div>Alpine OHCA is very rare in Australia, accounting for 1 in 5000 OHCAs and fewer than 1 in a million ski field visitors. Despite remoteness and access challenges, alpine OHCA survival is high, driven by prognostically favorable arrest-related factors and coordinated local systems of care prioritizing early bystander intervention.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 6","pages":"Pages 835-842"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of cardiac energetics in left bundle branch area pacing using noninvasive pressure–volume loops","authors":"Naoya Inoue MD , Shuji Morikawa MD , Yuji Ito MD , Yohei Takayama MD , Takehiro Hiramatsu MD , Ryo Ohinata MD , Daiki Okamoto MD , Toyoaki Murohara MD, PhD","doi":"10.1016/j.hroo.2025.03.015","DOIUrl":"10.1016/j.hroo.2025.03.015","url":null,"abstract":"<div><h3>Background</h3><div>Conduction system pacing, particularly left bundle branch area pacing (LBBAP), is emerging as the preferred strategy for bradyarrhythmias and cardiac resynchronization therapy because of its clinical benefits. However, the differences in the impact of LBBAP vs right ventricular pacing (RVP) on cardiac energetics remain unclear.</div></div><div><h3>Objective</h3><div>The purpose of this study was to compare the effects of LBBAP and RVP on cardiac energetics using a novel noninvasive pressure–volume (PV) loop algorithm derived from cardiac magnetic resonance (CMR).</div></div><div><h3>Methods</h3><div>We included patients who underwent permanent pacemaker implantation with LBBAP or RVP between January 2021 and October 2024, followed by CMR imaging. Noninvasive PV loops were calculated using volumes derived from CMR and a time-varying elastance model. The parameters obtained from the PV loop analysis were compared between the LBBAP and RVP groups. Sensitivity analyses were performed by varying the left ventricular end-diastolic pressure (3–40 mm Hg) and excluding anodal pacing cases.</div></div><div><h3>Results</h3><div>Of the 235 patients, 15 were analyzed (LBBAP group, n = 7; RVP group, n = 8). The end-systolic PV relationship was significantly higher in the LBBAP group (2.25 mm Hg/mL [1.85–2.55]) compared to the RVP group (1.39 mm Hg/mL [1.33–1.69]; <em>P</em> <.0001). The potential energy and PV area were significantly lower in the LBBAP group (<em>P</em> = .0006 and <em>P</em> = .006, respectively), whereas the ventricular efficiency was significantly higher (63.1% vs 57.4%; <em>P</em> = .006).</div></div><div><h3>Conclusion</h3><div>LBBAP reduces myocardial energy consumption and improves ventricular efficiency compared with RVP, suggesting its advantages in pacing-associated cardiac energetics.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 6","pages":"Pages 789-798"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}