Spatiotemporal tissue temperature during cryoablation using different balloons

IF 2.9 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart Rhythm O2 Pub Date : 2025-09-01 DOI:10.1016/j.hroo.2025.06.005

Akio Chikata MD, PhD , Takeshi Kato MD, PhD , Hiroaki Ide MEng , Tatsuya Fukutani MEng , Shuhei Fujita MD, PhD , Kazuo Usuda MD, PhD , Michiro Maruyama MD, PhD , Kan-ichi Otowa MD, PhD , Takashi Kusayama MD, PhD , Kenshi Hayashi MD, PhD , Masayuki Takamura MD, PhD

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Abstract

Background

Differences in tissue temperature trends and distribution between two commercially available balloons during cryoablation remain unclear.

Objective

We sought to evaluate spatiotemporal tissue temperatures during cryoablation using different cryoballoons.

Methods

An in vitro pulmonary vein model was constructed from porcine myocardial tissue to simulate pulmonary vein anatomy and venous flow. A multitemperature sensor sheet was placed behind the muscles. After confirming pulmonary vein occlusion, cryoablation was performed using the Arctic Front Advance Pro (AFA-Pro) and POLARx FIT (28 and 31 mm) to evaluate the time course of spatial tissue temperatures.

Results

POLARx FIT 28 mm showed the lowest force for pulmonary vein (5.5 ± 1.0 N for AFA-Pro, 4.0 ± 0.8 N for POLARx FIT 28 mm, and 4.1 ± 0.7 N for POLARx FIT 31 mm, respectively (P < .05; POLARx FIT 28 mm vs AFA-Pro), and the lowest tissue temperature after 180 seconds of cryoablation (−44.7 ± 2.3°C for AFA-Pro, −50.1 ± 5.7°C for POLARx FIT 28 mm, and, −44.7 ± 2.4°C for POLARx FIT 31 mm, respectively (P < .05; POLARx FIT, 28 mm vs AFA-Pro and POLARx FIT, 31 mm). Multipoint sensor analysis revealed that only POLARx FIT 28 mm achieved a tissue temperature < −50°C, while the POLARx FIT 31 mm created a significantly larger area with a tissue temperature of −30°C or lower.

Conclusion

Among commercially available balloons, the POLARx FIT of 28 mm achieved the greatest tissue temperature drop, whereas the POLARx FIT of 31 mm created the broadest cooled tissue area.

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不同球囊冷冻消融时的时空组织温度

背景：在冷冻消融过程中，两种商用气球之间的组织温度趋势和分布差异尚不清楚。目的探讨不同低温球囊在低温消融过程中的时空组织温度变化。方法以猪心肌组织为材料，建立体外肺静脉模型，模拟肺静脉解剖和静脉流动。在肌肉后面放置了一个多温度传感器片。在确认肺静脉闭塞后，使用Arctic Front Advance Pro （AFA-Pro）和POLARx FIT（28和31 mm）进行冷冻消融，以评估空间组织温度的时间过程。ResultsPOLARx适合28毫米显示肺静脉力最低(5.5±1.0 N AFA-Pro, 4.0±0.8 N POLARx适合28毫米,和4.1±0.7 N POLARx适合31毫米,分别(P & lt; . 05; POLARx适合28毫米vs AFA-Pro),和最低的组织温度的冷冻消融术后180秒(−44.7±2.3°C, AFA-Pro−50.1±5.7°C POLARx适合28毫米,,−44.7±2.4°C POLARx适合31毫米,分别(P & lt; . 05; POLARx健康,28毫米vs AFA-Pro POLARx适合,31毫米)。多点传感器分析显示，只有POLARx FIT 28mm达到了- 50°C的组织温度，而POLARx FIT 31 mm在- 30°C或更低的组织温度下创造了更大的区域。结论在市售气球中，28mm的POLARx FIT的组织温度下降幅度最大，而31mm的POLARx FIT的组织冷却面积最大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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