Heart Rhythm O2Pub Date : 2025-09-01DOI: 10.1016/j.hroo.2025.06.009
Muhammad R. Afzal MD, FHRS , Emile G. Daoud MD, FHRS , Mahmoud Gomaa MD , Toshimasa Okabe MD, FHRS , Salvatore J. Savona MD, FHRS , Natee Sirinvaravong MD , Matthew Tong MD , Mahmoud Houmsse MD, FHRS , Ralph S. Augostini MD, FHRS , Steven J. Kalbfleisch MD, FHRS , Eric Miller MD , Evan Thomas MD, PHD , Terence M. Williams MD, PhD , Michael Weldon MS, DABR , John D. Hummel MD, FHRS , Jeremy Brownstein MD
{"title":"Target delineation workflow and outcomes of stereotactic cardiac radioablation","authors":"Muhammad R. Afzal MD, FHRS , Emile G. Daoud MD, FHRS , Mahmoud Gomaa MD , Toshimasa Okabe MD, FHRS , Salvatore J. Savona MD, FHRS , Natee Sirinvaravong MD , Matthew Tong MD , Mahmoud Houmsse MD, FHRS , Ralph S. Augostini MD, FHRS , Steven J. Kalbfleisch MD, FHRS , Eric Miller MD , Evan Thomas MD, PHD , Terence M. Williams MD, PhD , Michael Weldon MS, DABR , John D. Hummel MD, FHRS , Jeremy Brownstein MD","doi":"10.1016/j.hroo.2025.06.009","DOIUrl":"10.1016/j.hroo.2025.06.009","url":null,"abstract":"<div><h3>Background</h3><div>Stereotactic body radiation therapy (SBRT) is an emerging modality for the treatment of ventricular tachycardia (VT). The workflow for delineation of the SBRT target is evolving.</div></div><div><h3>Objective</h3><div>This project describes the procedural workflow and outcomes of SBRT for VT.</div></div><div><h3>Methods</h3><div>The primary indication for SBRT was recurrent VT despite maximal contemporary treatment. Target delineation for SBRT involved combining imaging and electrophysiological data. VT burden, defined as the number of sustained VT episodes per month, was compared as the primary outcome. Secondary outcomes assessed included reduction of antitachycardia pacing and defibrillator shock episodes and reduction in the number of antiarrhythmic drugs per patient during follow-up.</div></div><div><h3>Results</h3><div>Workup for VT target delineation and radiation delivery was conducted in 25 patients receiving 27 SBRT procedures. VT management prior to SBRT consideration included ≥2 catheter ablations in 22 (88%) and surgical sympathectomy in 7 patients (28%). Of the 27 performed cases, SBRT target delineation incorporated electrocardiogram of clinical VT in 16 (59%), at least 2 noninvasive imaging modalities to assess scar in 24 (89%), and invasive electroanatomic mapping in 25 (93%). Among 16 patients with a complete 6-month follow-up, the reduction of VT burden per month was 81% (<em>P</em> < .05). Reduction in antitachycardia pacing and defibrillator shocks per month was 86% and 98%, respectively (<em>P</em> < .05). The number of patients on ≥2 antiarrhythmic drugs decreased from 69% to 0% (<em>P</em> < .01). One patient developed diaphragmatic paralysis after SBRT.</div></div><div><h3>Conclusion</h3><div>In patients with recurrent VT despite maximal contemporary antiarrhythmic therapies, SBRT offers a safe alternative once the target is adequately delineated by combining imaging and electrophysiological data.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 9","pages":"Pages 1401-1411"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Rhythm O2Pub Date : 2025-09-01DOI: 10.1016/j.hroo.2025.07.088
David Savage-Lobeck, Poonam Tawde
{"title":"ID: 4344886 DEEP LEARNING ANALYSIS OF ELECTROCARDIOGRAMS FOR AUTOMATED DETECTION OF CARDIAC ARRHYTHMIAS IN PEDIATRIC PATIENTS","authors":"David Savage-Lobeck, Poonam Tawde","doi":"10.1016/j.hroo.2025.07.088","DOIUrl":"10.1016/j.hroo.2025.07.088","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 9","pages":"Page S36"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Rhythm O2Pub Date : 2025-09-01DOI: 10.1016/j.hroo.2025.07.093
Joseph Sokol, Roman Sandler, Aakriti Gupta, Judith Buckland, Anna Gilgur, Marko Petrov, Jacob Segev, Avi Motova, Lorina Dascal, Yaron Valach, Ariel Shmerling, Jason Yao, Travis Dahlen
{"title":"ID: 4342839 AUTO-CONTOUR LA - A SEMANTIC SEGMENTATION APPROACH TO LEFT ATRIAL NAVIGATION IN INTRACARDIAC ECHOCARDIOGRAPHY","authors":"Joseph Sokol, Roman Sandler, Aakriti Gupta, Judith Buckland, Anna Gilgur, Marko Petrov, Jacob Segev, Avi Motova, Lorina Dascal, Yaron Valach, Ariel Shmerling, Jason Yao, Travis Dahlen","doi":"10.1016/j.hroo.2025.07.093","DOIUrl":"10.1016/j.hroo.2025.07.093","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 9","pages":"Page S39"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ID: 4349993 QUALITATIVE EVALUATION FRAMEWORK FOR COMPARING THE EFFECTIVENESS OF LARGE LANGUAGE MODELS THAT POWER HEALTH CARE CONVERSATIONS USING GENERATIVE ARTIFICIAL INTELLIGENCE IN ATRIAL FIBRILLATION","authors":"Sainyam Galhotra, Hemang Jiwnani, Audrey Nicholson, Prashanthan Sanders, Ajay Tripuraneni","doi":"10.1016/j.hroo.2025.07.059","DOIUrl":"10.1016/j.hroo.2025.07.059","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 9","pages":"Pages S19-S20"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Rhythm O2Pub Date : 2025-09-01DOI: 10.1016/j.hroo.2025.07.033
Oguz Akbilgic, Ibrahim Karabayir, Luke Patterson, Christopher Schaich, Austin Seals, Turgay Celik, David Herrington
{"title":"ID: 4340767 SEX DISCORDANCE ACCORDING TO NOVEL ECG SEX INDEX IS ASSOCIATED WITH ATRIAL FIBRILLATION AND ATRIAL FLUTTER","authors":"Oguz Akbilgic, Ibrahim Karabayir, Luke Patterson, Christopher Schaich, Austin Seals, Turgay Celik, David Herrington","doi":"10.1016/j.hroo.2025.07.033","DOIUrl":"10.1016/j.hroo.2025.07.033","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 9","pages":"Page S5"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144987993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Rhythm O2Pub Date : 2025-09-01DOI: 10.1016/j.hroo.2025.08.020
Fatima Azzahrae Benaich, Ahmed Rossasy, Mohammed Elalfy, Mohamed Elmosalamy, Moahmed El Saaed
{"title":"SOLVING TWO PROBLEMS WITH A SIMPLE SOLUTION: A CASE OF LEFT BUNDLE BRANCH AREA PACING","authors":"Fatima Azzahrae Benaich, Ahmed Rossasy, Mohammed Elalfy, Mohamed Elmosalamy, Moahmed El Saaed","doi":"10.1016/j.hroo.2025.08.020","DOIUrl":"10.1016/j.hroo.2025.08.020","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 9","pages":"Pages 1480-1481"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Rhythm O2Pub Date : 2025-09-01DOI: 10.1016/j.hroo.2025.08.021
Ahmed Ramadan, Alberto Musella, Lorenzo Gigli, Fabrizio Guarracini, Matteo Baroni, Alberto Preda, Marisa Varrenti, Roberto Menè, Antonio Frontera, Patrizio Mazzone
Heart Rhythm O2Pub Date : 2025-09-01DOI: 10.1016/j.hroo.2025.06.008
Calder D. Sheagren PhD , Terenz Escartin MSc , Jaykumar H. Patel BSc , Jennifer Barry BSc , Kelvin Chow PhD , Xiaoming Bi PhD , Maria Terricabras MD, MSc , Graham A. Wright PhD
{"title":"Arrhythmia substrate identification using wideband motion-corrected late gadolinium enhancement magnetic resonance imaging in a swine model of myocardial infarction with taped implantable cardioverter-defibrillators","authors":"Calder D. Sheagren PhD , Terenz Escartin MSc , Jaykumar H. Patel BSc , Jennifer Barry BSc , Kelvin Chow PhD , Xiaoming Bi PhD , Maria Terricabras MD, MSc , Graham A. Wright PhD","doi":"10.1016/j.hroo.2025.06.008","DOIUrl":"10.1016/j.hroo.2025.06.008","url":null,"abstract":"<div><h3>Background</h3><div>Sudden cardiac death is a leading worldwide cause of cardiac mortality and is largely related to ventricular tachycardia (VT) in patients with known myocardial scarring. In these patients, implantable cardioverter-defibrillator (ICD) therapy reduces arrhythmia-related mortality. However, curative procedures such as catheter ablation are used to homogenize regions of scar and remove structural re-entry circuits that cause VT.</div></div><div><h3>Objective</h3><div>In this paper, we conduct a preliminary experiment comparing 2-dimensional (2D) late gadolinium enhancement (LGE) and 3-dimensional (3D) LGE without an ICD with wideband motion-corrected (WB-MOCO) LGE with an ICD in a cohort of infarcted Yorkshire swine.</div></div><div><h3>Methods</h3><div>Animals were imaged after infarct with conventional 2D and 3D LGE without an ICD present and 2D WB-MOCO LGE with an ICD present. Images were analyzed to determine heterogeneous tissue corridor (HTC) count and location, which were compared with circuit exit locations determined using a 12-lead electrocardiogram.</div></div><div><h3>Results</h3><div>We found a statistically significant increase in HTC count with WB-MOCO LGE, but no significant differences in the number of true-positive or false-positive HTCs per subject.</div></div><div><h3>Conclusion</h3><div>WB-MOCO LGE has reduced specificity to physiologically relevant HTCs than conventional 2D or 3D LGE.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 9","pages":"Pages 1419-1427"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}