Heart Rhythm O2最新文献

{"title":"ID: 4347953 CLINICAL PERFORMANCE OF AN ATRIAL FIBRILLATION BURDEN TRACKING ALGORITHM: COMPARISONS AGAINST REFERENCE PUBLIC AND CLINICAL E-TEXTILE DATA","authors":"Arezoo Karimizadeh, Amin Mahnam, Soosan Beheshti, Alireza Hosseinzadeh, Meysam Pirbaglou, Bastien Moineau, Milad Alizadeh-Meghrazi, Yaariv Khaykin","doi":"10.1016/j.hroo.2025.07.028","DOIUrl":"10.1016/j.hroo.2025.07.028","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 9","pages":"Page S3"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID: 4342169 DEEP LEARNING-BASED IDENTIFICATION OF LATENT PAROXYSMAL AF FROM REAL-WORLD SMARTPHONE ACQUIRED PPG IN SINUS RHYTHM","authors":"Myrte Barthels, Thomas De Cooman, Pieter Vandervoort, Henri Gruwez, David Duncker","doi":"10.1016/j.hroo.2025.07.100","DOIUrl":"10.1016/j.hroo.2025.07.100","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 9","pages":"Pages S43-S44"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulsed field ablation vs high-power short duration/very high-power short duration pulmonary vein isolation—Systematic review and meta-analysis with Kaplan-Meier reconstructed individual patient data","authors":"Raymond Pranata MD ,&nbsp;William Kamarullah MD ,&nbsp;Giky Karwiky MD ,&nbsp;Chaerul Achmad MD, PhD ,&nbsp;Mohammad Iqbal MD, PhD, FHRS ,&nbsp;Jae-Sun Uhm MD, PhD","doi":"10.1016/j.hroo.2025.06.011","DOIUrl":"10.1016/j.hroo.2025.06.011","url":null,"abstract":"<div><h3>Background</h3><div>High-power/very high-power short-duration (HPSD/VHPSD) pulmonary vein isolation has greater efficacy than does conventional pulmonary vein isolation, while pulsed field ablation (PFA) is associated with a significantly shorter procedural duration with comparable efficacy.</div></div><div><h3>Objective</h3><div>This meta-analysis compared the efficacy, procedural duration, and safety of PFA vs HPSD/VHPSD ablation.</div></div><div><h3>Methods</h3><div>Atrial tachyarrhythmia (ATa) recurrence was defined as any episode of atrial fibrillation, flutter, or tachycardia lasting &gt;30 seconds, detected by Holter monitoring or electrocardiography, after a 3-month blanking period. The intervention group received PFA and the control group received HPSD/VHPSD ablation.</div></div><div><h3>Results</h3><div>Eight studies (mostly retrospective observational) comprising 1411 patients were analyzed. ATa recurrence occurred less frequently in the PFA group than in the HPSD/VHPSD ablation group (15% in PFA vs 25% in HPSD/VHPSD ablation; odds ratio 0.57; 95% confidence interval [CI] 0.40–0.81; <em>P</em> = .002; I² = 31.4%, <em>P</em> = .374). Meta-regression analysis indicated that the benefit of PFA was not significantly influenced by paroxysmal atrial fibrillation, sex, age, hypertension, or left ventricular ejection fraction. Reconstructed Kaplan-Meier curves showed greater freedom from ATa recurrence in the PFA group, and subsequent reconstructed individual patient data Cox regression analysis showed a lower hazard ratio (hazard ratio 0.68; 95% CI 0.48–0.97; <em>P</em> = .033). Pulmonary vein reconnection rates were comparable (32% in PFA vs 35% in HPSD/VHPSD ablation; odds ratio 0.84; 95% CI 0.53–1.34; <em>P</em> = .473). PFA significantly reduced total procedural duration (mean difference –29.67 minutes; 95% CI –38.31 to –21.03 minutes; <em>P</em> &lt; .001). Complications rates were similar between the 2 groups.</div></div><div><h3>Conclusion</h3><div>PFA was potentially associated with a comparable or reduced ATa recurrence rate and a shorter procedural duration compared with HPSD/VHPSD ablation while maintaining similar complication rates. Further randomized controlled trials are warranted to validate these findings.</div></div><div><h3>PROSPERO registration number</h3><div>CRD420251034443.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 9","pages":"Pages 1268-1277"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presenting the abstracts from CardioRhythm Congress 2025","authors":"Jeanne E. Poole MD, FHRS","doi":"10.1016/j.hroo.2025.08.004","DOIUrl":"10.1016/j.hroo.2025.08.004","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 9","pages":"Page 1476"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catheter ablation of macro-reentrant atrial tachycardia in adults with Ebstein anomaly: A narrative review","authors":"Norman C. Wang MD, MS, FHRS ,&nbsp;Natasha K. Wolfe MD ,&nbsp;Sara M. Trucco MD ,&nbsp;William E. Katz MD ,&nbsp;Gavin W. Hickey MD ,&nbsp;Manling Zhang MD, MS ,&nbsp;Chad M. Kosanovich MD ,&nbsp;Ezeldeen Abuelkasem MBBCh, MSc ,&nbsp;Andrew H. Voigt MD, FHRS","doi":"10.1016/j.hroo.2025.05.029","DOIUrl":"10.1016/j.hroo.2025.05.029","url":null,"abstract":"<div><div>Improving survival rates of patients with Ebstein anomaly have increased the relevance of catheter ablation of macro-reentrant atrial tachycardia (MRAT). Our objectives were, first, to present a case report and, second, to provide a comprehensive review. A search of articles providing detailed information on adults with Ebstein anomaly who underwent catheter ablation of MRAT was performed. PubMed was queried using “Ebstein” and “ablation” as Medical Subject Headings terms, followed by a review of references and citations. Of the 56 patients included in the final review, which included the case report patient, 40 patients (71%) had only typical atrial flutter and 2 patients (4%) had left atrial involvement. The American Heart Association and American College of Cardiology Adult Congenital Heart Disease Anatomic and Physiological classification was not reported in any of the retrieved articles. Pre-procedural imaging localizing the coronary sinus ostium on the ventricular side of a tricuspid valve prosthesis may indicate the need to perform catheter ablation on the ventricular side to achieve bi-directional block across the cavotricuspid isthmus. Long-term recurrence of atrial tachyarrhythmias occurred in 6 of 23 patients (26.1%) where it was reported. In conclusion, catheter ablation is a viable option for adults with Ebstein anomaly and MRAT.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 9","pages":"Pages 1448-1460"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of electrode–tissue proximity on formation of pulsed field ablation lesions: Using multi-electrode impedance measurements","authors":"Marijn H.A. Groen PhD ,&nbsp;Jeffrey M. Fish DVM ,&nbsp;Peter Loh MD, PhD ,&nbsp;René van Es PhD","doi":"10.1016/j.hroo.2025.05.026","DOIUrl":"10.1016/j.hroo.2025.05.026","url":null,"abstract":"<div><h3>Background</h3><div>For pulsed field ablation (PFA), the effect of electrode–tissue contact or proximity remains unclear.</div></div><div><h3>Objective</h3><div>In this porcine study, the effect of electrode–tissue proximity was studied after 3 weeks of follow-up, using a custom device in which the electrode–tissue distance could be varied for every electrode.</div></div><div><h3>Methods</h3><div>An impedance-based method was used to determine electrode–tissue proximity or contact. During a bench experiment, the relation between contact value per electrode and electrode–tissue distance was studied. In addition, in 10 pigs epicardial ablation using a custom 6-polar linear ablation device was performed using bipolar, biphasic deliveries on randomized locations on the heart. After 3 weeks, macroscopic analysis was used to compare lesion width for left vs right ventricle. Based on histology, the lesion area and depth were related to electrode–tissue contact.</div></div><div><h3>Results</h3><div>Analysis of 96 bench measurements showed a decrease in tissue-proximity index with increasing distance. Lesions on the right ventricle were wider compared to the lesions on the left ventricle, 9.0 ± 1.9 mm vs 6.5 ± 1.0 mm (<em>P</em> &lt; .001), respectively. A total of 162 lesions showed that a higher tissue-proximity index was associated with deeper and larger lesions; lesion depth was 1.3 ± 0.5 mm vs 1.5 ± 0.5 mm (<em>P</em> = .016) and lesion area 6.4 ± 2.7 mm² vs 8.3 ± 2.9 mm² (<em>P</em> &lt; .001) for low vs high indices respectively.</div></div><div><h3>Conclusion</h3><div>This study shows that higher electrode–tissue proximity may result in deeper PFA lesions, and is, therefore, an important parameter in improving PFA lesions. Therefore, confirmation of tissue contact using impedance-based measurements may improve PFA ablation efficacy in a clinical setting.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 9","pages":"Pages 1412-1418"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic biomarkers and biological pathways associated with atrial fibrillation in heart failure patients with reduced ejection fraction","authors":"Teun B. Petersen MSc ,&nbsp;Mylène Barry-Loncq de Jong MD ,&nbsp;Jie Fen Chin MD ,&nbsp;Navin Suthahar MD, PhD ,&nbsp;Peter J. van der Spek PhD ,&nbsp;Peter D. Katsikis MD, PhD ,&nbsp;K. Martijn Akkerhuis MD, PhD ,&nbsp;Victor A. Umans MD, PhD ,&nbsp;Rudolf A. de Boer MD, PhD ,&nbsp;Bas M. van Dalen MD, PhD ,&nbsp;Jasper J. Brugts MD, PhD ,&nbsp;Folkert W. Asselbergs MD, PhD ,&nbsp;Eric Boersma PhD ,&nbsp;Dimitris Rizopoulos PhD ,&nbsp;Sing-Chien Yap MD, PhD ,&nbsp;Isabella Kardys MD, PhD","doi":"10.1016/j.hroo.2025.06.007","DOIUrl":"10.1016/j.hroo.2025.06.007","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation (AF) and heart failure (HF) are intertwined conditions with high mortality and impact on quality of life. The biological mechanisms at play in patients with HF with vs without AF may differ.</div></div><div><h3>Objectives</h3><div>This study aimed to describe differences in circulating proteins with putative pathophysiological effects between HF with reduced ejection fraction (HFrEF) patients with and without AF.</div></div><div><h3>Methods</h3><div>We examined 377 patients with ambulant HFrEF and measured 4210 circulating proteins in baseline blood samples using an aptamer-based multiplex proteomic approach. Associations between AF (AF history or on baseline electrocardiogram) and the proteins were assessed using regression models adjusted for age, sex, kidney function, and duration of HF at baseline. Associations of AF-related proteins with biological processes were evaluated using enrichment analyses.</div></div><div><h3>Results</h3><div>The median age [25th–75th percentile] was 64 years [55–72], 73% [274 of 377] were male, 28% [104 of 375] had New York Heart Association class III/IV, and 37% [139 of 377] had AF (either AF history [36%, 137 of 377] or AF on baseline electrocardiogram [8%, 30 of 374]). We found 71 proteins significantly associated with AF (false discovery rate &lt; .05), including well-studied (eg, troponin T, insulin-like growth factor-binding protein 7, microfibril-associated glycoprotein 4, bone morphogenetic protein 10, angiopoietin 2) and lesser-studied proteins (eg, olfactomedin−like protein 3, keratocan, basigin) in the AF domain. Our pathway analysis revealed modules of proteins related to various underlying mechanisms, such as nervous system development, elastic fiber assembly, protein glycosylation, and ether lipid metabolism.</div></div><div><h3>Conclusions</h3><div>Patients with HFrEF with AF have distinct circulating proteomic profiles, and these differences are related to various biological mechanisms. This study provides an overview of the systemic biological pathways associated with AF in patients with HFrEF, confirms (pre-)clinical findings regarding AF-related proteins, and could inform future research in novel treatment targets and HFrEF-AF management after careful validation.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 9","pages":"Pages 1296-1305"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID: 4349955 UTILIZING A LARGE LANGUAGE MODEL TO ASSIGN BILLING CODES AND IMPROVE CLINICAL DOCUMENTATION","authors":"Victor A. Abrich,&nbsp;Richard Abrich","doi":"10.1016/j.hroo.2025.07.026","DOIUrl":"10.1016/j.hroo.2025.07.026","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 9","pages":"Pages S1-S2"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID: 4346888 DIAGNOSTIC YIELD AND HEALTHCARE UTILIZATION OF WEARABLE NOTIFICATIONS FOR ATRIAL FIBRILLATION","authors":"Krishna Pundi,&nbsp;Ben Viggiano,&nbsp;Natasha Din,&nbsp;Richard Yoo,&nbsp;Jun Fan,&nbsp;Mintu P. Turakhia,&nbsp;Nigam Shah","doi":"10.1016/j.hroo.2025.07.099","DOIUrl":"10.1016/j.hroo.2025.07.099","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 9","pages":"Page S43"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LEFT BUNDLE AREA PACING OUTCOMES AMONG PATIENTS WITH VERY WIDE QRS – INSIGHTS FROM AN AFRICAN REGISTRY","authors":"Willy Mucyo,&nbsp;Mzee Ngunga,&nbsp;Marcus Ngantcha,&nbsp;Miriam Msunza,&nbsp;Jeilan Mohamed,&nbsp;Brian Vezi","doi":"10.1016/j.hroo.2025.08.011","DOIUrl":"10.1016/j.hroo.2025.08.011","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"6 9","pages":"Page 1477"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}