Heart Rhythm O2Pub Date : 2026-09-01Epub Date: 2026-09-18DOI: 10.1016/j.hroo.2026.08.003
Yingshuo Liu, Alex El Darzi, Yunsung Chung, Christian M. Massad, Yishi Jia, Carlo El Khoury, Mohammad Montaser Atasi, Michel Abou Khalil, Yara Menassa, Abboud Hassan, Cong Zhao, Kexin Liu, Mary M. Maleckar, Amitabh C. Pandey, Han Feng, Nassir F. Marrouche
{"title":"ID: 4569904 THE WEARABLE AI-PPG AF BURDEN: A PASSIVE AND DYNAMIC BURDEN TOOL WITH AN ECG-DISTILLED DEEP FOUNDATION MODEL IN HEARTBEAT","authors":"Yingshuo Liu, Alex El Darzi, Yunsung Chung, Christian M. Massad, Yishi Jia, Carlo El Khoury, Mohammad Montaser Atasi, Michel Abou Khalil, Yara Menassa, Abboud Hassan, Cong Zhao, Kexin Liu, Mary M. Maleckar, Amitabh C. Pandey, Han Feng, Nassir F. Marrouche","doi":"10.1016/j.hroo.2026.08.003","DOIUrl":"10.1016/j.hroo.2026.08.003","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"7 9","pages":"Pages S1-S2"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149000798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart Rhythm O2Pub Date : 2026-09-01Epub Date: 2026-06-18DOI: 10.1016/j.hroo.2026.06.007
Elisa Hennings MD, PhD, Stefanie Aeschbacher PhD, Pia Neuschwander PhD, Michael Coslovsky PhD, Ioanna Istampoulouoglou MD, Anne Leuppi-Taegtmeyer MD, Rebecca E. Paladini PhD, Lukas Strobel, Tobias Reichlin MD, Nicolas Rodondi MD, Jürg H. Beer MD, Giulio Conte MD, Angelo Auricchio MD, Giorgio Moschovitis MD, Marcello Di Valentino MD, Luise Adam MD, Maria Luisa De Perna MD, Leo H. Bonati MD, Felix Mahfoud MD, Philipp Krisai MD, Michael Kühne MD
{"title":"Drug-drug interactions of NOACs with comedication: Prevalence and implications for adverse events in patients with atrial fibrillation","authors":"Elisa Hennings MD, PhD, Stefanie Aeschbacher PhD, Pia Neuschwander PhD, Michael Coslovsky PhD, Ioanna Istampoulouoglou MD, Anne Leuppi-Taegtmeyer MD, Rebecca E. Paladini PhD, Lukas Strobel, Tobias Reichlin MD, Nicolas Rodondi MD, Jürg H. Beer MD, Giulio Conte MD, Angelo Auricchio MD, Giorgio Moschovitis MD, Marcello Di Valentino MD, Luise Adam MD, Maria Luisa De Perna MD, Leo H. Bonati MD, Felix Mahfoud MD, Philipp Krisai MD, Michael Kühne MD","doi":"10.1016/j.hroo.2026.06.007","DOIUrl":"10.1016/j.hroo.2026.06.007","url":null,"abstract":"<div><h3>Background</h3><div>The clinical relevance of drug-drug interactions associated with non‒vitamin K-antagonist oral anticoagulants (NOACs) in patients with atrial fibrillation (AF) remains poorly understood.</div></div><div><h3>Objective</h3><div>We evaluated the prevalence of pharmacokinetic and pharmacodynamic drug-drug interactions and their association with adverse clinical outcomes in patients with AF receiving NOACs.</div></div><div><h3>Methods</h3><div>We analyzed patients from the prospective, multicenter Swiss-AF cohort study. We used frailty survival models to investigate the association of the different potential interactions with the respective clinical adverse outcomes (major bleeding, clinically relevant non-major bleeding, any bleeding, ischemic stroke or systemic embolism).</div></div><div><h3>Results</h3><div>Our analysis comprised 1732 patients with AF (mean age 73 ± 8 years, 501 [29%] women) with a median follow-up period of 6 years. For 683 of these patients (39%), we recorded ≥1 potential drug-drug interaction. In the multivariable adjusted model, the hazard ratio of drug-drug interaction was 1.21 (95% confidence interval [CI] 0.84–1.75, <em>P</em> = .31) for major bleeding, 1.22 (95% CI 0.92–1.62, <em>P</em> = .17) for clinically relevant nonmajor bleeding, 1.22 (95% CI 0.97–1.54, <em>P</em> = .09) for any bleeding, and 1.00 (95% CI 0.22–4.53, <em>P</em> = .99) for ischemic stroke or systemic embolism.</div></div><div><h3>Conclusion</h3><div>In a large real-world cohort of patients with AF, the prevalence of potential interactions of long-term comedication with NOACs was high. We found no strong evidence of an association between these interactions and an increased risk of bleeding or the composite outcome ischemic stroke or systemic embolism.</div></div><div><h3>Registration</h3><div>Clinical Trial Registration: <span><span>https://clinicaltrials.gov/ct2/show/NCT02105844</span><svg><path></path></svg></span></div></div><div><h3>ClinicalTrials.gov Identifier</h3><div>NCT02105844</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"7 9","pages":"Pages 1680-1690"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148981077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Atrial electrogram amplitude–guided Bachmann bundle pacing implantation: A single-center experience","authors":"Daisuke Yoshimoto MD, Yuichiro Sakamoto MD, Yuko Uemura MD, Ryo Yamaguchi MD, Hirokazu Naganawa MD, Takahiko Suzuki MD","doi":"10.1016/j.hroo.2026.06.003","DOIUrl":"10.1016/j.hroo.2026.06.003","url":null,"abstract":"<div><h3>Background</h3><div>Bachmann bundle pacing (BBp) seems to be associated with reduced incidence and persistence of atrial fibrillation. The Bachmann bundle area is located at the junction between the superior vena cava and the right atrium. Pacemaker leads were implanted just inferior to a site demonstrating an abrupt increase in electrogram amplitude as the lead delivery system was advanced inferoseptally from the superior vena cava toward the right atrium as long as adequate sensing and capture thresholds were demonstrated. Subsequent to the implant, paced P waves were evaluated for evidence of Bachmann bundle capture.</div></div><div><h3>Objective</h3><div>This study aimed to evaluate the feasibility, safety, and short-term outcomes of an atrial electrogram amplitude–guided implantation strategy for BBp.</div></div><div><h3>Methods</h3><div>We retrospectively included 50 patients who underwent dual-chamber pacemaker or implantable cardioverter-defibrillator implantation with attempted BBp between September 2023 and December 2024. The atrial pacing lead was fixed just below the site demonstrating an abrupt change in atrial electrogram amplitude, typically exceeding 1 mV.</div></div><div><h3>Results</h3><div>Atrial septal lead implantation was achieved in all patients, with successful BBp (meeting electrocardiogram criteria) in 44 (88%). The median mapping time was 134.5 seconds. Immediately after fixing the lead, the mean capture threshold was 1.86 ± 1.00 V at 0.4 ms, improving to 0.834 ± 0.315 V by the end of the procedure. During the 6-month follow-up, pacing parameters remained stable, with no lead dislodgement, pericardial effusion, or device-related infection.</div></div><div><h3>Conclusion</h3><div>BBp using the lumenless pacing lead and delivery catheter, guided by an atrial electrogram amplitude–based strategy, is safe, feasible, and reproducible.</div></div>","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"7 9","pages":"Pages 1714-1724"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148981199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ID: 4571044 CLINICAL VALIDATION OF WIRELESS SINGLE LEAD FOREARM PATCH AND FINGER CAP ELECTROCARDIOGRAM SENSORS AND QUALITY-AWARE DATA ANALYTICS FOR PERSONALIZED CARDIAC HEALTH MONITORING IN HOME HEALTHCARE","authors":"Jomole Varghese Vadakkan, Sabarimalai Manikandan Mottaiyan, Linga Reddy Cenkeramaddi","doi":"10.1016/j.hroo.2026.08.064","DOIUrl":"10.1016/j.hroo.2026.08.064","url":null,"abstract":"","PeriodicalId":29772,"journal":{"name":"Heart Rhythm O2","volume":"7 9","pages":"Page S37"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149000750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}