Journal of the American Nutrition Association最新文献

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Role of a Whole Plant Foods Diet in Breast Cancer Prevention and Survival. 全植物性饮食在乳腺癌预防和生存中的作用。
IF 6.8 4区 医学
Journal of the American Nutrition Association Pub Date : 2025-01-09 DOI: 10.1080/27697061.2024.2442631
Mariana Del Carmen Fernández-Fígares Jiménez
{"title":"Role of a Whole Plant Foods Diet in Breast Cancer Prevention and Survival.","authors":"Mariana Del Carmen Fernández-Fígares Jiménez","doi":"10.1080/27697061.2024.2442631","DOIUrl":"https://doi.org/10.1080/27697061.2024.2442631","url":null,"abstract":"<p><p>Breast cancer (BC) is one of the leading causes of death and morbidity among women worldwide. Epidemiologic evidence shows that the risk of BC and other chronic diseases decreases as the proportion of whole plant foods increases, while the proportion of animal foods (fish, meat, poultry, eggs, seafood, and dairy products) and non-whole plant foods (e.g., refined grains, added sugars, French fries) in the diet decreases. Whole plant foods include fruits, vegetables, roots, tubers, whole grains, legumes, nuts, and seeds from which no edible part has been removed and to which no non-whole food been added. A whole plant foods diet lowers insulin resistance, inflammation, excess body fat, cholesterol, and insulin-like growth factor 1 and sex hormone bioavailability; it also increases estrogen excretion, induces favorable changes in the gut microbiota, and may also favorably affect mammary microbiota composition and decrease the risk of early menarche, all contributing to reduced BC incidence, recurrence, and mortality. This review explores the connection between a whole plant foods diet and BC risk and mortality as well as the potential mechanisms involved. Additionally, this diet is compared with other dietary approaches recommended for BC. A whole plant foods diet seems the optimal dietary pattern for BC and overall disease prevention as it exclusively consists of whole plant foods which, based on existing evidence, lead to the best health outcomes.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-17"},"PeriodicalIF":6.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Could New Palm-Free Structured Lipids Mitigate Postprandial Hyperlipidemia and Inflammation Induced by High-Fat Meals in Swiss Mice? 新的无棕榈结构脂能减轻瑞士小鼠高脂餐诱导的餐后高脂血症和炎症吗?
IF 6.8 4区 医学
Journal of the American Nutrition Association Pub Date : 2025-01-09 DOI: 10.1080/27697061.2024.2449524
Alice da Silva Malveira, Vanessa Alves, Gabriela de Matuoka E Chiocchetti, Alessandra Gambero, Amanda Rejane Alves de Ávila, Guilherme de Figueiredo Furtado, Juliana Alves Macedo, Valdecir Luccas, Gabriela Alves Macedo
{"title":"Could New Palm-Free Structured Lipids Mitigate Postprandial Hyperlipidemia and Inflammation Induced by High-Fat Meals in Swiss Mice?","authors":"Alice da Silva Malveira, Vanessa Alves, Gabriela de Matuoka E Chiocchetti, Alessandra Gambero, Amanda Rejane Alves de Ávila, Guilherme de Figueiredo Furtado, Juliana Alves Macedo, Valdecir Luccas, Gabriela Alves Macedo","doi":"10.1080/27697061.2024.2449524","DOIUrl":"https://doi.org/10.1080/27697061.2024.2449524","url":null,"abstract":"<p><p>A high-fat meal can cause postprandial hyperlipemia, initiating an acute inflammatory response. New structured lipids (SLs) free from trans and palm fatty acids are emerging as food structurants.</p><p><p><b>Objective:</b> We evaluated the postprandial response and inflammatory profiles in Swiss mice after oral administration of SLs in high-fat meals.</p><p><p><b>Methods:</b> SLs with different contents of long-chain saturated fatty acids were synthesized through an interesterification process involving soybean, peanut oils and crambe hard fat.</p><p><p><b>Results:</b> SLs containing 23.79% (SL1), 32.01% (SL2), and 43.87% (SL3) of total saturated fatty acids reduced the absorption of serum triglycerides and appeared to mitigate postprandial inflammation by interleukin-6. A faster gastric emptying rate after consuming SL3 was corroborated by the fecal presence of behenic acid.</p><p><p><b>Conclusions:</b> Our results suggest that SLs, free from palm and trans fats, may have the potential to mitigate inflammation, reduce the postprandial response, and lower absorption upon acute consumption.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-9"},"PeriodicalIF":6.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-Obesogenic and Antioxidant Potential of Lychee Seed Flour in Zebrafish Fed a High-Fat Diet. 荔枝籽粉对高脂肪饲料斑马鱼的抗肥胖和抗氧化作用。
IF 6.8 4区 医学
Journal of the American Nutrition Association Pub Date : 2025-01-09 DOI: 10.1080/27697061.2024.2446285
João Paulo Lima de Oliveira, William Franco Carneiro, Kiara Cândido Duarte da Silva, Moises Silvestre de Azevedo Martins, Gilson Gustavo Lucinda Machado, Leonardo Abrahão Nogueira, Mary Suzan Varaschin, Eduardo Valério de Barros Vilas Boas, Luis David Solis Murgas, Elisângela Elena Nunes Carvalho
{"title":"Anti-Obesogenic and Antioxidant Potential of Lychee Seed Flour in Zebrafish Fed a High-Fat Diet.","authors":"João Paulo Lima de Oliveira, William Franco Carneiro, Kiara Cândido Duarte da Silva, Moises Silvestre de Azevedo Martins, Gilson Gustavo Lucinda Machado, Leonardo Abrahão Nogueira, Mary Suzan Varaschin, Eduardo Valério de Barros Vilas Boas, Luis David Solis Murgas, Elisângela Elena Nunes Carvalho","doi":"10.1080/27697061.2024.2446285","DOIUrl":"https://doi.org/10.1080/27697061.2024.2446285","url":null,"abstract":"<p><strong>Objective: </strong>Obesity has become one of the major public health issues and is associated with various comorbidities, including type 2 diabetes mellitus, dyslipidemia, and hypertension. Lychee seeds are considered promising ingredients for developing functional foods owing to their nutraceutical properties and phytochemical composition. This study aimed to induce obesity in zebrafish (<i>Danio rerio</i>) through a hyperlipidic diet supplemented with different concentrations of lychee seed flour and to evaluate its effects on adipose tissue, biochemical parameters, oxidative stress, and caudal fin regeneration.</p><p><strong>Methods: </strong>A total of 200 adult zebrafish were u anded and divided into five experimental groups: control, hyperlipidic diet (HFD), and HFD supplemented with 2%, 4%, and 6% lychee seed flour. After 12 wk of feeding, biochemical parameters (glycemia, triglycerides, total cholesterol, high-density lipoprotein-HDL, aspartate aminotransferase-AST, alanine aminotransferase-ALT, and cortisol) and oxidative stress biomarkers, such as Catalase (CAT), Superoxide Dismutase (SOD), Glutathione-S-Transferase (GST), Glutathione (GSH), and Reactive Oxygen Species (ROS), were evaluated.</p><p><strong>Results: </strong>The results showed that the HFD4% group exhibited a significant reduction in the diameter of visceral adipocytes compared with the control, HFD, and HFD2% groups. There was a higher prevalence of severe steatosis in the control and HFD groups and mild steatosis in the HFD6% group. The HFD4% and HFD6% groups had the lowest glycemic levels, whereas the HFD6% group had the highest HDL levels. Supplementation with lychee seed flour also positively modulated oxidative stress biomarkers, with increased CAT and GST activity in the HFD6% group and reduced ROS in the HFD4% and HFD6% groups compared with the HFD group.</p><p><strong>Conclusion: </strong>It was concluded that adding 4 to 6% lychee seed flour may have beneficial effects on biochemical parameters and oxidative stress markers in HFD-fed zebrafish. The results indicate that lychee seed flour shows promise for use in foods and supplements targeting obesity prevention and management.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-14"},"PeriodicalIF":6.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malnutrition Severity Predicts Clinical Outcomes in Alcoholic Hepatitis: Evidence from National Data. 营养不良的严重程度可预测酒精性肝炎的临床结果:来自全国数据的证据。
IF 6.8 4区 医学
Journal of the American Nutrition Association Pub Date : 2025-01-01 Epub Date: 2024-07-29 DOI: 10.1080/27697061.2024.2383403
Ali Jaan, Iyiad Alabdul Razzak, Ammad Javaid Chaudhary, Umer Farooq, Abdul Moiz Khan, Laraib Fatima Sheikh, Ashish Dhawan, Byron Cryer
{"title":"Malnutrition Severity Predicts Clinical Outcomes in Alcoholic Hepatitis: Evidence from National Data.","authors":"Ali Jaan, Iyiad Alabdul Razzak, Ammad Javaid Chaudhary, Umer Farooq, Abdul Moiz Khan, Laraib Fatima Sheikh, Ashish Dhawan, Byron Cryer","doi":"10.1080/27697061.2024.2383403","DOIUrl":"10.1080/27697061.2024.2383403","url":null,"abstract":"<p><strong>Objective: </strong>Alcoholic hepatitis (AH) represents a severe manifestation of alcoholic liver disease (ALD) associated with a wide severity spectrum. ALD is linked to nutritional deficiencies, with the gravity of malnutrition escalating as alcohol abuse and ALD progress. This study aims to delve into the impact of malnutrition on the clinical trajectory of AH.</p><p><strong>Methods: </strong>We identified adult patients admitted with AH using the National Readmission Database (NRD) 2016-2020. We further classified AH patients based on the severity of malnutrition. We compared the outcomes of AH hospitalizations using a multivariate regression model.</p><p><strong>Results: </strong>We included 82,367 AH patients, of whom 15,693 (19.00%) had malnutrition. 4,243 (5.15%) patients exhibited mild to moderate malnutrition, 5,862 (7.07%) patients had severe malnutrition, and 5,588 (6.78%) patients had unspecified severity of malnutrition. We found that adjusted in-hospital mortality due to AH was higher in patients with malnutrition, corresponding to the severity of malnutrition (adjusted odds ratio [aOR] 1.62 and 3.14 in mild-moderate malnutrition and severe malnutrition, respectively; <i>p</i> < .01). Additionally, patients with malnutrition had progressively elevated odds of septic shock, vasopressor requirement, mechanical ventilation, and intensive care unit (ICU) admission with escalating intensity of malnutrition. Liver-related complications, such as spontaneous bacterial peritonitis, coagulopathy, hepatorenal syndrome, and hepatic encephalopathy, were also found to have an increased likelihood in the presence of malnutrition. Furthermore, resource utilization showed a progressive increase with increasing severity of malnutrition.</p><p><strong>Conclusion: </strong>Our findings indicate that malnutrition is a common comorbidity in AH patients, with varying degrees of severity, which correlates with higher mortality rates, emphasizing the critical role of nutritional status in the prognosis of AH. These findings underscore the importance of addressing and managing malnutrition in patients with AH, not only for its potential contribution to mortality but also because of its association with a spectrum of complications and increased healthcare resource utilization.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"22-28"},"PeriodicalIF":6.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Adherence to EAT-Lancet Diet and Risk of Hypertension: An 18-Year National Cohort Study in China. 坚持 EAT-Lancet 饮食与高血压风险之间的关系:中国一项为期 18 年的全国队列研究。
IF 6.8 4区 医学
Journal of the American Nutrition Association Pub Date : 2025-01-01 Epub Date: 2024-09-05 DOI: 10.1080/27697061.2024.2399826
Lifu Lei, Haixia Qin, Yushi Chen, Yu Sun, Wenwei Yin, Shiwen Tong
{"title":"Association Between Adherence to EAT-Lancet Diet and Risk of Hypertension: An 18-Year National Cohort Study in China.","authors":"Lifu Lei, Haixia Qin, Yushi Chen, Yu Sun, Wenwei Yin, Shiwen Tong","doi":"10.1080/27697061.2024.2399826","DOIUrl":"10.1080/27697061.2024.2399826","url":null,"abstract":"<p><strong>Objective: </strong>The EAT-Lancet Commission has proposed an EAT-Lancet diet (ELD), also known as a planetary health diet (PHD), which is environmentally sustainable and promotes human health. However, the association between this diet and the risk of hypertension remains unclear. This study aimed to determine whether adherence to ELD was associated with a lower risk of hypertension.</p><p><strong>Methods: </strong>11,402 adults without hypertension at baseline from the China Health and Nutrition Survey were included. The PHD score was used to evaluate ELD adherence, with higher scores reflecting better compliance. Cox proportional hazards regression analysis was utilized to estimate the hazard ratio (HR) with a 95% confidence interval (CI). Additionally, a subgroup analysis was performed to identify the possible effect modifiers, and a mediation analysis was conducted to explore the mediation effects of anthropometric measurements on the association between ELD and hypertension.</p><p><strong>Results: </strong>A total of 3993 participants (35%) developed hypertension during 93,058 person-years of follow-up. In the covariate-adjusted model, hypertension risk was reduced in the highest quartile participants compared to the lowest quartile of the PHD score (adjusted HR: 0.79, 95%CI: 0.71-0.87; <i>P</i>-trend < 0.001), which remained significant after sensitivity analysis. Notably, the association was also observed in isolated systolic hypertension, isolated diastolic hypertension, and systolic-diastolic hypertension. Subgroup analysis revealed that the inverse association between the PHD score and hypertension risk was more pronounced in nonsmokers and high-sodium intake consumers than in smokers and low-sodium consumers (<i>P</i>-interaction < 0.05). Additionally, mediation analysis revealed that 23.3% of the association between the PHD score and hypertension risk was mediated by the waist-to-height ratio.</p><p><strong>Conclusion: </strong>Our findings suggest that a higher adherence to ELD is associated with a lower risk of hypertension. These results emphasize that ELD may serve as a potential strategy to prevent hypertension.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"40-49"},"PeriodicalIF":6.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Bidirectional Association between Internet Use, Sleep Quality and Eating Behavior: A Cross-Sectional Study in Northwestern Thrace Region in Türkiye. 互联网使用、睡眠质量和饮食行为之间的双向关联:图尔基耶西北色雷斯地区的一项横断面研究。
IF 6.8 4区 医学
Journal of the American Nutrition Association Pub Date : 2025-01-01 Epub Date: 2024-09-05 DOI: 10.1080/27697061.2024.2399845
Murat Gürbüz, Hatice Merve Bayram
{"title":"The Bidirectional Association between Internet Use, Sleep Quality and Eating Behavior: A Cross-Sectional Study in Northwestern Thrace Region in Türkiye.","authors":"Murat Gürbüz, Hatice Merve Bayram","doi":"10.1080/27697061.2024.2399845","DOIUrl":"10.1080/27697061.2024.2399845","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the complex associations between Internet addiction, sleep disturbances, and disordered eating behaviors.</p><p><strong>Methods: </strong>This cross-sectional study included 646 students from 17 high schools in Edirne, Türkiye between December 2023 and May 2024. A face-to-face questionnaire was administered to assess demographic characteristics, Internet addiction (YIAT), sleep quality (PSQI), and eating behavior (TFEQ-R21).</p><p><strong>Results: </strong>In total, 644 students completed the study. The prevalence of Internet addiction among adolescents was 16.3%, with a similar prevalence among male and female adolescents. The prevalence of poor sleep quality among adolescents was 6.4%, and this trend was more pronounced in male adolescents, with an incidence of 13.0%. A weak positive correlation was observed between Internet addiction and disordered eating behavior. Additionally, a moderate positive correlation was observed between poor sleep quality and disordered eating behavior. Gender, maternal education level, Internet addiction, and poor sleep quality were significant predictors of eating disorders in adolescents.</p><p><strong>Conclusion: </strong>The findings of our study are of significant value in providing insights into the development of programs designed to prevent undesired eating behaviors.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"50-58"},"PeriodicalIF":6.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the Impact of Ashwagandha and Meditation on Stress Induced Obesogenic Eating Behaviours. 研究 Ashwagandha 和冥想对压力诱发的肥胖饮食行为的影响。
IF 6.8 4区 医学
Journal of the American Nutrition Association Pub Date : 2025-01-01 Epub Date: 2024-09-10 DOI: 10.1080/27697061.2024.2401054
Daniel Quinones, Michelle Barrow, Karin Seidler
{"title":"Investigating the Impact of Ashwagandha and Meditation on Stress Induced Obesogenic Eating Behaviours.","authors":"Daniel Quinones, Michelle Barrow, Karin Seidler","doi":"10.1080/27697061.2024.2401054","DOIUrl":"10.1080/27697061.2024.2401054","url":null,"abstract":"<p><p>Obesity has been identified as a rapidly rising pandemic within the developed world, potentially increasing the risks of type 2 diabetes and cardiovascular disease. Various studies have identified a positive association between stress, elevated cortisol levels and obesity. Mechanisms of the stress response lead to hyperpalatable food preference and increased appetite through the activation of the HPA axis, elevated cortisol and the resulting interactions with the dopaminergic system, neuropeptide Y, ghrelin, leptin and insulin. The methodology of this review involved a Systematic Search of the Literature with a Critical Appraisal of papers considering ashwagandha, mediation and mindfulness in relation to mechanisms of the stress response. It incorporated 12 searches yielding 330 hits. A total of 51 studies met the inclusion criteria and were critically appraised with ARRIVE, SIGN50 and Strobe checklists. Data from the 51 studies was extracted, coded into key themes and summarized in a narrative analysis. Thematic analysis identified 4 key themes related to ashwagandha and 2 key themes related to meditation. Results provide an overview of evidence assessing the efficacy of ashwagandha and meditation in relation to weight loss interventions by supporting the stress response and the pathways highlighted. Results of Clinical studies indicate that ashwagandha supports weight loss through reduced stress, cortisol and food cravings. Pre-clinical studies also suggest that ashwagandha possesses the capacity to regulate food intake by improving leptin and insulin sensitivity and reducing addictive behaviors through dopamine regulation. Clinical studies on meditation indicate it may enhance a weight loss protocol by reducing the stress response, cortisol release and blood glucose and improving eating behaviors.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"68-88"},"PeriodicalIF":6.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Relationship Between Central Obesity and Osteoarthritis in US Adults: The Mediating Role of Biological Aging Acceleration. 美国成年人中心性肥胖与骨关节炎之间的关系:生物老化加速的中介作用
IF 6.8 4区 医学
Journal of the American Nutrition Association Pub Date : 2025-01-01 Epub Date: 2024-09-04 DOI: 10.1080/27697061.2024.2389398
Qiang He, Jie Mei, Chengxin Xie, Zhen Wang, Xin Sun, Mengmeng Xu
{"title":"The Relationship Between Central Obesity and Osteoarthritis in US Adults: The Mediating Role of Biological Aging Acceleration.","authors":"Qiang He, Jie Mei, Chengxin Xie, Zhen Wang, Xin Sun, Mengmeng Xu","doi":"10.1080/27697061.2024.2389398","DOIUrl":"10.1080/27697061.2024.2389398","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the association between central obesity and the risk of osteoarthritis, and the mediating role of biological age and biological aging advance in this relationship.</p><p><strong>Methods: </strong>The study is based on data from the National Health and Nutrition Examination Survey (NHANES) for the years 2005-2018. Thirteen commonly used clinical traits were used to calculate the Klemera-Doubal method age (KDM-Age) and phenotypic age (Pheno-Age) as two measures of biological aging. Additionally, KDM-Age advance and Pheno-Age advance were calculated as two measures of biological aging advance. Weighted multivariable logistic regression was used to analyze the association between central obesity and the risk of osteoarthritis (OA). Mediation analysis was then applied to elucidate the role of biological aging and biological aging advance in this relationship.</p><p><strong>Results: </strong>A total of 31,162 subjects aged ≥20 years were included in this study, of which 3,964 subjects reported having OA (14%). Compared to the Non-OA group, the OA group showed significantly higher proportions of central obesity, KDM-Age, KDM-Age advance, PhenoAge, and PhenoAge advance. Compared to the Non-central obesity group, the central obesity group had higher KDM-Age, KDM-Age advance, PhenoAge, PhenoAge advance, and a higher risk of OA (<i>p</i> < 0.05). Additionally, higher KDM-Age, KDM-Age advance, PhenoAge, and PhenoAge advance were positively correlated with the risk of OA (<i>p</i> < 0.05). Mediation analysis revealed that part of the association between central obesity and the risk of OA was mediated by KDM-Age, KDM-Age advance, PhenoAge, and PhenoAge advance (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Central obesity increases the risk of OA, with part of this association being mediated by biological aging and biological aging advance.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"29-39"},"PeriodicalIF":6.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secondary Analysis of Sweetness Liking from Pilot Study Replacing Sugar Sweetened Soda with Flavored, Unsweetened Sparkling Water. 用无甜味气泡水替代加糖苏打水的试点研究中对甜味喜好的二次分析
IF 6.8 4区 医学
Journal of the American Nutrition Association Pub Date : 2025-01-01 Epub Date: 2024-07-22 DOI: 10.1080/27697061.2024.2369819
Vinícius Valicente, Nana Gletsu-Miller, Cordelia A Running
{"title":"Secondary Analysis of Sweetness Liking from Pilot Study Replacing Sugar Sweetened Soda with Flavored, Unsweetened Sparkling Water.","authors":"Vinícius Valicente, Nana Gletsu-Miller, Cordelia A Running","doi":"10.1080/27697061.2024.2369819","DOIUrl":"10.1080/27697061.2024.2369819","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate changes in sensory ratings (liking, sweetness intensity, \"just about right\" (JAR) level of sweetness) of 0-10.7% w/w sugar in soda after 1 and 2 wk of replacing sugar-sweetened soda consumption with unsweetened, flavored, sparkling water.</p><p><strong>Methods: </strong>Consumers of sugar-sweetened sodas (17 men and women, average age 28 years) replaced their sodas with unsweetened, flavored sparkling waters for 2 wk. Changes in sensory ratings were evaluated for sodas ranging from 0-10.7% w/w added sugar. In a secondary analysis, cluster analysis identified \"Sweet Likers\" (liking increased with sugar concentration) and \"Sweet Moderates\" (liking peaked in the middle of the concentration range) in the baseline ratings, and models for changes in sensory ratings were reevaluated by sweet-liking group.</p><p><strong>Results: </strong>The primary analyses showed no significant effects of the intervention on sweetness intensity or liking ratings. However, the secondary analysis showed that Sweet Likers reduced liking ratings for all sodas, but particularly for the highest concentration (<i>p</i> = 0.0021) after the intervention. Sweet Moderates, however, increased liking ratings after the intervention, driven by an increase in liking for the lower concentrations of sugar (<i>p</i> = 0.0058). Additionally, Sweet Moderates increased their overall ratings for sweetness intensity in sodas (<i>p</i> = 0.00074).</p><p><strong>Conclusion: </strong>These results suggest that the intervention may have been more successful in shifting sensory perception and acceptance of less-sweet sodas for Sweet Moderates than for Sweet Likers. These results should be verified in a larger sample that intentionally recruits by sweet liker status, to see if initial liking for sweetness may be a critical factor in interventions aiming to improve liking of less sweet beverages.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-13"},"PeriodicalIF":6.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is There a Relationship Between the Dietary Inflammatory Index and Clinical Attachment Loss in Patients with Periodontitis? 牙周炎患者的饮食炎症指数与临床附着丧失之间有关系吗?
IF 6.8 4区 医学
Journal of the American Nutrition Association Pub Date : 2025-01-01 Epub Date: 2024-07-25 DOI: 10.1080/27697061.2024.2382961
Seda Sultan Sağır, Eda Başmısırlı, Baturay Sapancı, Ömer Alperen Kırmızıgül, Neriman İnanç
{"title":"Is There a Relationship Between the Dietary Inflammatory Index and Clinical Attachment Loss in Patients with Periodontitis?","authors":"Seda Sultan Sağır, Eda Başmısırlı, Baturay Sapancı, Ömer Alperen Kırmızıgül, Neriman İnanç","doi":"10.1080/27697061.2024.2382961","DOIUrl":"10.1080/27697061.2024.2382961","url":null,"abstract":"<p><strong>Objective: </strong>The pathogenesis of periodontal diseases is partially driven by oxidative stress. However, studies on the relationship between periodontitis and the inflammatory load of diet are still insufficient. Therefore, this study aimed to examine the relationship between the diet's inflammatory load and periodontitis and clinical attachment loss (CAL).</p><p><strong>Methods: </strong>This cross-sectional study included 119 participants diagnosed with periodontitis according to the 1999 classification. The dietary inflammatory index (DII) was calculated using three-day food consumption records and divided into quartiles (Q1, Q2, and Q3). Body mass index (BMI) was calculated as weight and height (kg/m<sup>2</sup>). Clinical attachment loss (CAL) score was determined, and the patients were grouped with those CAL scores as 7 < CAL and ≥7 CAL.</p><p><strong>Results: </strong>Of the 119 patients with periodontitis, aged 46.24 ± 12.84 years, 45.3% were found to have an anti-inflammatory diet profile (<i>n</i> = 54). When the daily energy and nutrient intake of individuals were examined, it was found that the intake of omega-3 fatty acids (<i>p</i> = 0.004), black tea (<i>p</i> = 0.021), and green pepper (<i>p</i> = 0.029) was higher in those with CAL < 7 compared to those with CAL ≥ 7. There was no relationship between the patients' DII and CAL values. Daily energy, protein, fiber, vitamin A, vitamin E, folic acid, Fe, Zn, and Mg intake in patients with an anti-inflammatory diet in Q1 were higher than in Q2 and Q3 (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>This study found no relationship between DII levels and CAL scores. However, it was observed that periodontitis patients following an anti-inflammatory diet had higher intakes of omega-3 fatty acids, vitamins A, E, and C, as well as zinc and magnesium which are nutrients known to be effective against inflammation. These patients also had CAL scores below 7. Therefore, reducing the inflammatory load of the diet may prevent the development of periodontitis, and further research in this regard would be beneficial.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"14-21"},"PeriodicalIF":6.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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