Journal of the American Nutrition Association最新文献

{"title":"A Standardized <i>Boswellia serrata</i> Extract Improves Knee Joint Function and Cartilage Morphology in Human Volunteers with Mild to Moderate Osteoarthritis in a Randomized Placebo-Controlled Study.","authors":"Brijesh Kumar, Abhijeet Balbhim Ghaytidak, Abhinav Kumar Pandey, Raghu Ram Somepalli, Praveen Sarda, Siba Prasad Raychaudhuri, Meher Prasanna Rokkam","doi":"10.1080/27697061.2024.2438894","DOIUrl":"https://doi.org/10.1080/27697061.2024.2438894","url":null,"abstract":"<p><strong>Background and objective: </strong><i>Boswellia serrata</i> Roxb. ex Colebr. (Family: Burseraceae; Genus: Boswellia) gum resin (Salai guggul) has profound therapeutic value in Ayurvedic and Unani medicines in alleviating several chronic inflammatory illnesses, including arthritis, asthma, skin and blood diseases, fever, etc. SN13108F (Aflapin^®) is a proprietary, standardized <i>Boswellia serrata</i> gum resin extract. This 180-day randomized, placebo-controlled clinical study aimed to evaluate cartilage morphology using magnetic resonance imaging (MRI), pain and joint function and long-term safety in the SN13108F-supplemented volunteers with knee osteoarthritis (KOA).</p><p><strong>Materials and methods: </strong>Eighty adult male and female subjects with the Kellgren-Lawrence grade II - III KOA were supplemented with SN13108F (100 mg/day) or a matched placebo for 180 consecutive days.</p><p><strong>Results: </strong>SN13108F reduced (<i>p</i> < 0.001; vs. baseline and placebo) Western Ontario and McMaster Universities Osteoarthritis Index, Visual Analogue Scale, Lequesne's Functional Index scores, improved six-minute walk test, and stair climb test. Post-trial MRI assessments of the tibiofemoral joints revealed that the cartilage volume, thickness, and joint space width were increased (<i>p</i> < 0.001; vs. placebo), and levels of high-sensitivity C-reactive protein, matrix metalloproteinase-3, Fibulin-3, type II collagen degradation peptide in serum, and cross-linked C-terminal telopeptide of type II collagen in urine were significantly reduced (<i>p</i> < 0.001; vs. baseline and placebo) in the SN13108F-supplemented subjects. Hematology, complete serum biochemistry, urine analysis, and the participants' vital signs did not alter between the groups.</p><p><strong>Conclusion: </strong>SN13108F supplementation is safe, and it mitigates joint pain and improves musculoskeletal function and cartilage morphology in KOA.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-12"},"PeriodicalIF":6.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are Nutrition Literacy and Sustainable Dietary Habits Associated with Cardiovascular Disease and Diabetes Developmental Risks?","authors":"Indrani Kalkan, Neda Saleki, İdil Alpat Yavaş, Merve Pehlivan, Nedime Gündüz","doi":"10.1080/27697061.2024.2435039","DOIUrl":"https://doi.org/10.1080/27697061.2024.2435039","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the association of nutritional literacy levels and sustainable nutritional behaviors with the risk of developing cardiovascular diseases and diabetes in the Turkish adult population.</p><p><strong>Methods: </strong>Sociodemographic information, disease history, nutritional habits, and physical activity levels of 3146 volunteer individuals (male = 1590, female = 1556) between the ages of 40-75 were collected using a questionnaire form and face-to-face interviews. The sustainable nutritional behaviors of the participants were evaluated using Turkish validated scales for Sustainable and Healthy Eating Behavior (SHE) and nutritional literacy levels with the Evaluation Instrument of Nutrition Literacy on Adults (EINLA). Cardiovascular disease risks of the participants were assessed with the Atherosclerotic Cardiovascular Disease (ASCVD) Risk Estimator program and the Heart Score (SCORE) scale and type-2 diabetes risk with the Finnish Diabetes Risk Score (FINDRISC). Each participant's 24-h food consumption record was obtained using the retrospective recall method.</p><p><strong>Results: </strong>It was determined that ASCVD and SCORE levels were significantly higher in males compared to females. It was observed that individuals with lower cardiovascular and diabetes risk scores had higher educational levels, and the risks increased significantly with age (<i>p</i> < 0.05). Anthropometric measurements such as body mass index, and waist hip circumference were significantly higher in those with higher cardiovascular and diabetes risk scores. Furthermore, in individuals with higher SCORE and FINDRISC levels, SHE and EINLA scores were significantly lower (<i>p</i> < 0.05). It was also observed that SCORE and diabetes risk scores increased with higher energy and macronutrient intakes.</p><p><strong>Conclusion: </strong>The risk of developing cardiovascular disease and diabetes was associated with sustainable nutritional behaviors and nutritional literacy. It may be suggested that increasing nutritional literacy and encouraging sustainable nutritional behaviors may be effective strategies in the management and reduction of the prevalence of certain chronic diseases. KEY TEACHING POINTSCardiovascular diseases and diabetes are two major chronic conditions that can be managed and treated through proper nutrition.Increased nutritional literacy levels and sustainable dietary habits may result in reduced risk of cardiovascular diseases and diabetes.Nutritionists should assess the patients' nutrition literacy levels and implement sustainable, health-focused nutrition education programs to enhance their understanding of nutrition.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-13"},"PeriodicalIF":6.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chia Oil (<i>Salvia hispanica</i> L.) Improves the Intestinal Health of <i>Wistar</i> Rats Fed a Hypercaloric Diet.","authors":"Violeta Nunes de Morais, Luiza de Paula Dias Moreira, Mariana Juste Contin Gomes, Mariana Grancieri, Haira Guedes Lucio, Renata Celi Lopes Toledo, Marcella Duarte Villas Mishima, Neuza Maria Brunoro Costa, Bárbara Pereira da Silva, Hércia Stampini Duarte Martino","doi":"10.1080/27697061.2024.2431271","DOIUrl":"https://doi.org/10.1080/27697061.2024.2431271","url":null,"abstract":"<p><strong>Background: </strong>A diet rich in fat and sugar is present in society everyday life, leading to the development of metabolic changes, especially in intestinal microbiota. Chia oil is a source of alpha-linolenic acid, which has antioxidant and anti-glycemic effects. Based on this, we hypothesized that chia oil may promote intestinal health.</p><p><strong>Objective: </strong>The study aims to investigate the effects of chia oil on gut microbiota and intestinal health in <i>Wistar</i> rats fed a high-fat and high-fructose diet (HFHF).</p><p><strong>Methods: </strong>The animals were separated into two groups and received the following diets: standard murine diet (AIN-93M) (<i>n</i> = 10) and HFHF (<i>n</i> = 20) to induce metabolic changes (phase I) during eight weeks. After that, the AIN-93M group remained unchanged, while the HFHF group was divided into two groups: HFHF (<i>n</i> = 10) and HFHF with chia oil (HFHF+CO) (<i>n</i> = 10) for ten weeks (phase II, chia oil treatment). We analyzed immunoglobulin A (IgA) levels, cecal pH, short-chain fatty acids (SCFAs), intestinal permeability, intestinal microbiome composition, histomorphometry, and murinometric parameters.</p><p><strong>Results: </strong>Chia oil consumption increased alpha-linolenic acid intake, IgA levels, propionic acid production, cecum weight, goblet cell number, thickness and depth of intestinal crypts, and the thickness of both circular and longitudinal muscle layers of the colon, and decreased cecal pH. No change was observed in the alpha and beta diversity between the HFHF and HFHF+CO groups. The HFHF+CO diet increased the relative abundance of genera <i>Lactobacillus</i> sp., <i>Faecalibacterium</i> sp., and <i>Erysipelatoclostridium</i> sp., compared to the AIN-93M group. No difference was observed in the intestinal permeability among the groups.</p><p><strong>Conclusion: </strong>Chia oil consumption is an alternative for improving the intestinal health of rats fed a HFHF diet.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-10"},"PeriodicalIF":6.8,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Test Anxiety on Nutritional Habits, Anthropometric Measurements, and Gastrointestinal Symptoms in Adolescents.","authors":"Merve Aytaç, Sinem Bayram","doi":"10.1080/27697061.2024.2431270","DOIUrl":"https://doi.org/10.1080/27697061.2024.2431270","url":null,"abstract":"<p><p><b>Objective:</b> Since exam periods are used as a benchmark to determine academic achievement, they may result in increased anxiety, changes in dietary behavior, weight fluctuations and increased gastrointestinal symptoms in students. For this reason, this research was conducted to evaluate the effect of test anxiety on nutritional status and gastrointestinal symptoms in adolescents.</p><p><p><b>Methods:</b> This study was conducted with 104 senior high school students who agreed to participate in the study in a private and public school in Ankara 7 months before the exam and 1 month before the exam to evaluate the effect of exam anxiety on nutritional status and gastrointestinal symptoms of students preparing for the university exam. Health status, nutritional status, anthropometric measurements, information about exam anxiety, International Physical Activity Questionnaire Short Form, Test Anxiety Inventory, Gastrointestinal Symptom Rating Scale, Food Frequency Questionnarie (FFQ) were asked to the students.</p><p><p><b>Results:</b> In both genders, the mean BMI-Z score increased during the second evaluation, indicating a significant difference in various dietary and lifestyle factors such as meal frequency, water intake, and nutrient intake. Most students were classified as minimally active. Additionally, the total score of affective, delusional, and test anxiety inventory increased closer to the exam date. Weak positive correlations were observed between gastrointestinal symptoms and affective, delusional, and test anxiety scores during the first evaluation, while a moderately strong positive correlation emerged during the second evaluation.</p><p><p><b>Conclusion:</b> The results of the current study support that students experience increased gastrointestinal symptoms during the exam period. Nutrition and stress reduction educations should be given in high schools both during and before the exam period in a multidisciplinary team consisted of dietitians and psychologists in order to provide healthy stress management.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-7"},"PeriodicalIF":6.8,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Diversity, Rather Than Quality, Parallels a Reduction in Metabolic Syndrome and a Favorable Gut Microbiome: The Dietary Diversity Score.","authors":"Mats L Wiese, Fabian Frost, Martin Bahls, Sabrina von Rheinbaben, Malte Rühlemann, Corinna Bang, Andre Franke, Matthias Nauck, Robin Bülow, Uwe Völker, Henry Völzke, Till Ittermann, Markus M Lerch, Ali A Aghdassi","doi":"10.1080/27697061.2024.2423775","DOIUrl":"10.1080/27697061.2024.2423775","url":null,"abstract":"<p><strong>Objective: </strong>Diet plays a crucial role in the development of metabolic syndrome (MetS). While dietary recommendations primarily focus on quality of food intake, the relevance and mechanisms of dietary diversity for the prevention of obesity and metabolic diseases are unclear. Here, we investigate the respective associations of dietary diversity and quality with MetS and gut microbiota composition.</p><p><strong>Methods: </strong>Pooled data from 2 independent population-based cohorts of the Study of Health in Pomerania (n = 6753) were used. Based on a validated food frequency questionnaire a novel dietary diversity score (DDS) and an established dietary quality score (DQS) were calculated. Both were correlated with anthropometric data and clinical components of MetS as well as with intestinal microbial composition (16S rRNA gene sequencing).</p><p><strong>Results: </strong>DDS was associated with a healthier metabolic phenotype and lower MetS risk in both cross-sectional (odds ratio [OR], 0.90; 95% CI, 0.82-0.93; <i>p</i> < 0.001) and longitudinal analyses of 5-year follow-up data (OR, 0.89; 95% CI, 0.79-0.99; <i>p</i> = 0.029). In contrast, there were hardly any favorable associations between DQS and MetS, neither cross-sectionally nor longitudinally. DDS explained 42.6% more beta diversity variation in gut microbiota than DQS and was linked to a more favorable microbial composition (e.g., less <i>Escherichia</i>/<i>Shigella</i> [<i>q</i> = 0.00576] and greater <i>Ruminococcaceae</i> [<i>q</i> = 0.01263] abundance).</p><p><strong>Conclusions: </strong>Dietary diversity, as determined by the novel DDS, reduces MetS risk, whereas dietary quality was less important in that regard. Greater dietary diversity was paralleled by greater microbiota diversity and a healthier gut microbiome. Future dietary recommendations should emphasize dietary diversity rather than absolute consumption of nutritional components.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-11"},"PeriodicalIF":6.8,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Efficacy of Mindfulness-Based Interventions in Treating Obesity, Obesity-Related Eating Disorders, and Diabetes Mellitus.","authors":"Antoine Aoun, Cedra Ghoussoub, Cynthia Farsoun, Angy Al Mallah, Faten Ayoub, Nancy Trezia, Sandra Abi Karam","doi":"10.1080/27697061.2024.2428290","DOIUrl":"10.1080/27697061.2024.2428290","url":null,"abstract":"<p><p>Mindfulness is the practice of focusing one's attention and energy on the present moment with an accepting attitude and an open mindset. Its adoption is increasingly utilized in addressing health concerns, particularly in the realm of nutrition. Mindful eating seeks to adjust disordered eating patterns by cultivating intentional awareness of the physical, mental, and emotional aspects of eating. Mindfulness techniques may involve meditation, breathing exercises, and simply being more attentive in daily activities. Integrating mindfulness into a nutrition strategy may improve digestion, foster a healthier relationship with food, and lead to making better choices aligned with overall well-being. This critical review aims to examine recent prevailing studies on the effects of mindfulness-based interventions (MBI) on weight regulation, eating disorders related to obesity, emotional eating, and diabetes management. For the methods section, the study utilized the Google Scholar and PubMed databases, employing the Medical Subject Headings (MeSH) descriptors. The search included articles published up to September 2024, resulting in a total of 122 articles gathered using various keyword combinations. Results show that out of the 122 studies, 28 articles were common, leaving a total of 94 articles. They included 33 randomized controlled trials (RCTs), 17 systematic reviews and meta-analyses, 11 observational studies, 14 reviews, and 19 others. The findings from these studies demonstrate the positive impact of MBI on conditions such as binge eating disorder, weight loss, emotional eating, and diabetes-related issues. In conclusion, the review supports the growing evidence suggesting that the incorporation of mindfulness can play a crucial role in managing obesity, eating disorders, and their associated consequences. However, further research is necessary to establish a definitive understanding of its effectiveness and how to integrate it into healthcare practices.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-14"},"PeriodicalIF":6.8,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Influence of a Bitter Melon Product on Indicators of Cardiometabolic Health in Adults with Prediabetes.","authors":"Liana L Guarneiri, Meredith L Wilcox, Chen-Meng Kuan, Kevin C Maki","doi":"10.1080/27697061.2024.2428301","DOIUrl":"https://doi.org/10.1080/27697061.2024.2428301","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to assess the impact of bitter melon extract supplementation on glycemia in individuals with prediabetes.</p><p><strong>Methods: </strong>This was a 12-week randomized, parallel, placebo-controlled study where 75 adults with prediabetes were randomly allocated into the low-dose bitter melon (300 mg/day) (<i>n</i> = 26), high-dose bitter melon (600 mg/day) (<i>n</i> = 24), or control (<i>n</i> = 25) groups.</p><p><strong>Results: </strong>At baseline and weeks 6 and 12, anthropometrics were measured, and fasting blood samples were obtained. The high-dose (1.05% ± 10.2%) and low-dose bitter melon (3.35% ± 13.2%) groups showed smaller increases in blood glucose levels at 12 wk, compared to the control group (11.0% ± 16.3%) (<i>p</i> < 0.05). A subgroup analysis of participants with age ≥ the median demonstrated a greater reduction in glycated hemoglobin at 12 wk in the high-dose bitter melon group (median change: -0.20%; IQRL: -0.20%, -0.05%) vs. the control group (median change: 0.00%; IQRL: -0.10%, 0.20%) (<i>p</i> = 0.017). Compliance with the interventions was >95%, and the study products were tolerated well.</p><p><strong>Conclusion: </strong>The bitter melon extract may help maintain a healthy level of glucose in adults with prediabetes.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-9"},"PeriodicalIF":6.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Effects of Durian and Banana Consumption on Thermic Effect of Food and Metabolic Responses in Healthy Adults.","authors":"Charlotte Yiin Ling, Michelle Ting Yun Yeo, Yan Kang, Shu Min Ng, Xinyan Bi, Christiani Jeyakumar Henry","doi":"10.1080/27697061.2024.2426563","DOIUrl":"https://doi.org/10.1080/27697061.2024.2426563","url":null,"abstract":"<p><strong>Objective: </strong>In traditional Chinese philosophy, durian is classified as a \"yang\" food with heaty properties, believed to raise body temperature and blood pressure (BP) after consumption. In contrast, bananas are considered as \"yin,\" possessing cooling effect. However, scientific evidence supporting these concepts is limited. This study aims to compare the metabolic effects in response to durian and banana ingestion.</p><p><strong>Methods: </strong>This randomized cross-over clinical study recruited 16 young, healthy Chinese participants (8 males and 8 females). All participants ingested isocaloric portion (367.5 kcal) of durian and banana with a wash-out period of at least 5 days. 3-h thermic effect of food (TEF) and substrate oxidation were assessed by indirect calorimetry. Postprandial vital signs and metabolic responses were measured over a period of 3 h.</p><p><strong>Results: </strong>Durian induced a higher and longer-lasting TEF than banana in most participants. Additionally, durian significantly lowered BP and increased triglyceride (TG) levels during 3 h after consumption, whereas bananas had no significant effects on these measures. Despite containing much fewer carbohydrates, durian prompted a comparable postprandial rise in blood glucose concentrations to that of banana.</p><p><strong>Conclusion: </strong>While durian offers nutritional benefits and a BP-lowering effect, moderation is recommended due to its high sugar and fat content, which can elevate blood glucose and lipid levels, and its \"heatiness\" may cause digestive discomforts and a sore throat according to anecdotal experiences.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-9"},"PeriodicalIF":6.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory Potency of Chlorogenic Acid from Apple Cider Vinegar Against Alzheimer's Disease: Molecular Docking and Dynamics Validation.","authors":"Smriti Tripathi, Sheikh Murtuja, Mohd Usman Siddique, Azim Ansari, Gourav Rakshit","doi":"10.1080/27697061.2024.2426558","DOIUrl":"https://doi.org/10.1080/27697061.2024.2426558","url":null,"abstract":"<p><strong>Objective: </strong>The primary cause of memory loss is Alzheimer's disease (AD). Recent studies have shown that natural compounds like apple cider vinegar (ACV) have anti-Alzheimer's capabilities. Essential components of ACV, such as gallic acid and chlorogenic acid, may be in charge of the drug's pharmacological effects.</p><p><strong>Methods: </strong>Using molecular docking and dynamics (MD), the current work looks at the aspect of ACV that protects against AD. To study the conformational relationships and interaction mechanisms between two biological molecules (such as interactions between proteins and drugs or between proteins), MD simulation is frequently used. MD can help understand molecular structural differences between proteins and small compounds. We used acetylcholinesterase (AChE, PDB ID: 1UT6) to MD chlorogenic and gallic acids, as well as the currently prescribed medication rivastigmine (Standard medication). Furthermore, we determine the binding affinity, which may be responsible for AChE inhibition. MD simulations were performed on docked complexes of chlorogenic acid, gallic acid, and rivastigmine with receptor 1UT6 for a 300 ns trajectory to ensure the stability of docked ligand-protein complexes.</p><p><strong>Results: </strong>The results showed that chlorogenic acid has the highest binding affinity and stability for AChE inhibition. In the docking and dynamics analysis, both techniques have predicted chlorogenic acid to be a potential constituent of ACV which shows a similar activity when compared to rivastigmine by virtue of binding affinity.</p><p><strong>Conclusion: </strong>These findings identify chlorogenic acid as the key component of ACV that protects against AD-related cognitive and behavioral impairments. This finding will be critical in the development of ACV-based drugs for Alzheimer's disease treatment.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-16"},"PeriodicalIF":6.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential of Herbal Compounds in Curing Dysmenorrhea Naturally: A Review.","authors":"Mukul Kumar, Deepika Kaushik, Naitika Gaba, Emel Oz, Jyoti Singh, Vikas Bansal, Ammu P Nair, Charalampos Proestos, Gülçin Emel Babagil, Margaret Brennan, Hilal Kiziltunc Ozmen, Vishal Kumar","doi":"10.1080/27697061.2024.2421525","DOIUrl":"https://doi.org/10.1080/27697061.2024.2421525","url":null,"abstract":"<p><p>Dysmenorrhea being an effect of uterine contractions in the endometrium is a consequential health concern that may hamper a woman quality of life and disrupt everyday activities. It is described as pain throughout the menstrual cycle which is one of the most prominent causes of pelvic pain in women. Traditional medicine and Ayurveda has for centuries stipulated and employed herbs to treat a variety of illnesses. These herbs contain various bioactive compounds that can be exploited to cure serious health complications of human body. The Purpose of this manuscript is to review every aspect of the menstrual cycle and its mechanism, as well as the application of various conventional treatments and herbal remedies. Numerous scientific studies have been carried out over the past several decades with the ultimate objective of preserving the traditional knowledge of medicinal herbs employed in food and medicine. Herbals like ginger, chamomile, fennel, saffron, onion, nimm primary compounds include Gingerols, terpenoids, flavonoids, coumarins, phyto-molecules, thiosulfanates that possess anti-inflammatory, anti-tumor activities, anti-hyperglycemia, and analgesic properties, which can lower the pain during dysmenorrhea. Literature was searched and data was collected related to herbs from different sources like Pubmed, Google scholar, Science direct. Despite many studies and research, there are many factors that need more information related to herbal medicines and it is necessary to acquire more knowledge about the pertinent hormonal balance induced by herbal remedies.</p>","PeriodicalId":29768,"journal":{"name":"Journal of the American Nutrition Association","volume":" ","pages":"1-12"},"PeriodicalIF":6.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}