Research Journal of Health Sciences最新文献

{"title":"Medication interruptions and associated factors among nurses working in pediatric unit at a selected referral hospital in Rwanda","authors":"A. Nkurunziza, G. Chironda, G. Katende, L. Rajeswaran, E. Munyaneza, Madeleine Mukeshim","doi":"10.4314/rejhs.v9i4.1","DOIUrl":"https://doi.org/10.4314/rejhs.v9i4.1","url":null,"abstract":"Introduction: Interruptions have been proven to cause medication administration errors in pediatric settings. Therefore, this study assessed the medication interruptions and associated factors among nurses in a pediatric unit at a selected referral hospital in Rwanda. \u0000Methods: A descriptive observational study was conducted among 59 nurses using a developed observational checklist. Data were entered into SPSS, version 26. Descriptive and inferential statistics were used to analyze the data. The IRB of the University of Rwanda approved the study. \u0000Results: Among the 414 medication administrations observed, 149 (36%) had interruptions. The main source of interruption was technical problem (14.5%) with interruption from direct care (12%) as the main reason. The factors associated with interruption occurrence were shift of the day, time of medication round, duration and phase of medication administration and nurse perception (p = 0.001), age (p=0.046), educational level (p = 0.044) and professional experience (p = 0.031). \u0000Conclusion: The existence of medication interruptions is evident with associated factors predominantly being demographics and technical. Therefore, the authors recommended that an in-service training program for nurses regarding medication administration errors. The hospital leadership should address the technical problems including availing the required materials for medication administration. \u0000  \u0000French title: Interruptions médicamenteuses et facteurs associés chez les infirmières travaillant dans l'unité pédiatrique d'un hôpital de référence sélectionné au Rwanda \u0000Introduction : Il a été prouvé que les interruptions provoquent des erreurs d'administration de médicaments en milieu pédiatrique. Par conséquent, cette étude a évalué les interruptions de médication et les facteurs associés chez les infirmières d'une unité de pédiatrie d'un hôpital de référence sélectionné au Rwanda. \u0000Méthode de l'étude : Une étude observationnelle descriptive a été menée auprès de 59 infirmières à l'aide d'une liste de contrôle d'observation élaborée. Les données ont été saisies dans SPSS, 26. Des statistiques descriptives et inférentielles ont été utilisées pour analyser les données. L'IRB de l'Université du Rwanda a approuvé l'étude. \u0000Résultats de l'étude : Parmi les 414 administrations de médicaments observées, 149 (36 %) ont subi des interruptions. La principale source d'interruption était un problème technique (14,5 %) avec l'interruption des soins directs (12 %) comme principale raison. Les facteurs associés à l'occurrence d'interruption étaient décalage de la journée, heure de la tournée de médicaments, durée et phase d'administration des médicaments et perception de l'infirmière (p = 0,001), âge (p=0,046), niveau d'éducation (p = 0,044) et expérience professionnelle (p = 0,031). \u0000Conclusion : L'existence d'interruptions de médication est évidente avec des facteurs associés principalement démographiques et techniques. Par conséquent, les aute","PeriodicalId":29646,"journal":{"name":"Research Journal of Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46986385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High level of perceived stress among essential workers during the COVID 19 lockdown in a Nigerian state","authors":"J. Falade, A. M. Oshatimi, A. Oyebanji, A. Babatola, J. Fadare, O. Olatunya, O. O. Falade","doi":"10.4314/rejhs.v9i4.3","DOIUrl":"https://doi.org/10.4314/rejhs.v9i4.3","url":null,"abstract":"Background: COVID-19 pandemic caused unexpected socio-economic changes globally. This study determined the prevalence and factors associated with perceived stress among essential workers during the COVID-19 lockdown in Ekiti State, Nigeria.Method: A cross-sectional descriptive study that involved 588 essential workers in Ekiti State, Nigeria during the COVID-19 lockdown. The Perceived Stress Scale was used in the study Chi-square test of statistical significance and multivariate analysis using binary logistic regression were used in the analysis and the level of statistical significance was determined by a p-value of <0.05.Results: The prevalence of high perceived stress levels among all the respondents, health workers, and non-health workers were 64.1% (63.3-70.6), while health workers and non-health workers had a prevalence of 70.1% (65.5 -73.3) and 56.5% (23.5-38.7) respectively. The majority of the respondents related their sources of stress to inadequate transportation (63.3%), hearing of COVID related news (47.4%), and lack of finance (55.1%). Using Logistic Regression respondent respondents who were not satisfied with the support they received from the government during the pandemic had three fold high stress levels than respondents who were satisfied with the support received from the government [AOR= 3.228, (CI= 1.771- 5.886)]. Furthermore, the odd of the high stress level was one fold increased among male respondents than female respondents [AOR = 1.08 CI= (1.410-6.215). Conclusion: Stress management is recommended given the high-stress level among essential workers. \u0000  \u0000French title: Niveau de stress perçu chez les travailleurs essentiels pendant le casanier du COVID-19 dans l'état d'Ekiti, au Nigéria \u0000Contexte général de l'étude : La pandémie de COVID-19 a provoqué des changements socio-économiques inattendus dans le monde. Cette étude a déterminé la prévalence et les facteurs liés au stress perçu à un niveau parmi les travailleurs essentiels pendant la période de confinement du COVID-19 dans l'état d'Ekiti, au Nigéria.Méthode de l'étude : Une étude descriptive transversale qui a impliqué 588 travailleurs essentiels dans l'état d'Ekiti, au Nigéria, dans le cadre du confinement COVID-19. L'échelle de stress perçu a été utilisée dans le test du Chi carré de l'étude et une analyse multi variée a été utilisée. Le niveau statistiquement significatif a été déterminé par une valeur p < 0,05.Résultats de l'étude: Le total des répondants non-agents de santé et agents de santé présentait une prévalence de niveaux élevés de stress perçu de 64,1% (63,3-70,6), 56,5% (23,5-38,7) et 70,1% (65,5 - 73,3). La majorité des répondants ont lié leurs sources de stress à un transport inadéquat (63,3 %), à l'audition de nouvelles liées à COVID (47,4 %) et au manque de financement (55,1 %) En utilisant la régression logistique, les répondants qui étaient insatisfaits du soutien gouvernemental pendant la pandémie avaient des niveaux de stress trois fois plus é","PeriodicalId":29646,"journal":{"name":"Research Journal of Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47060163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of the demographic pattern and outcomes of acute chemical poisoning in patients in a tertiary hospital in South-western Nigeria","authors":"O. Adejumo, S. S. Owolade, O. Lawal, O. Junaid, O. Egbi, A. Enikuomehin, B.A Umufo","doi":"10.4314/rejhs.v9i4.4","DOIUrl":"https://doi.org/10.4314/rejhs.v9i4.4","url":null,"abstract":"Introduction: Acute chemical poisoning is a public health problem especially in developing countries where there is unrestricted access to chemical products, underreporting and absence of poisoning registers. Despite its importance, there is limited information on acute poisoning among adult population in Nigeria. The study was aimed at determining the demographic pattern and short term outcomes of acute chemical poisoning in patients in a tertiary health institution in South-western Nigeria over a 2 year period.Methodology: Records of cases of acute chemical poisoning over a 2-year period were retrieved and the following information extracted: socio-demographic data of patient, type of substance ingested, type of poisoning, reason for poisoning, intervention, and outcome of treatment. Results:There were 58 patients with a M:F ratio of 1:1.1. The mean age was 28.53±13.47 years. The most commonly ingested chemical was organophosphate seen in 31(53.4%). Poisoning was deliberate in 43 (74.1%); 36 patients (62.1%) had atropine; 16 patients (27.6%) had gastric lavage; one patient (1.7%) was dialyzed and 2 patients (3.4%) were admitted into ICU. Mortality rate was 8.6%. Conclusion: Deliberate acute chemical poisoning was common in young adults. Organophosphate is the most commonly ingested chemical. Government should enforce laws that that would restrict access to potentially harmful chemicals. \u0000French title: Schéma et résultats à court terme d'une intoxication chimique aiguë dans un hôpital tertiaire du sud-ouest du Nigéria \u0000Introduction : Les intoxications chimiques aiguës sont un problème de santé publique en particulier dans les pays en développement où il existe un accès illimité aux produits chimiques, une sous-déclaration et l'absence de registres des intoxications. Malgré son importance, il existe peu d'informations sur les intoxications aiguës parmi la population adulte au Nigéria.Objectif de l'étude: Déterminer le schéma démographique et les résultats à court terme des intoxications chimiques aiguës chez les patients d'un établissement de santé tertiaire du sud-ouest du Nigéria sur une période de 2 ans.Méthode de l'étude : Des dossiers de cas d'intoxication chimique aiguë sur une période de 2 ans ont été récupérés et les informations suivantes extraites : données sociodémographiques du patient, type de substance ingérée, type d'intoxication, raison de l'intoxication, intervention et résultat du traitement.Résultat de l'étude : Il y avait 58 patients avec un rapport M : F de 1:1,1. L'âge moyen était de 28,53 ± 13,47 ans. Le produit chimique le plus couramment ingéré était l'organophosphate vuswzsw3 dans 31 (53,4 %). L'empoisonnement était délibéré dans 43 (74,1 %); 36 patients (62,1%) avaient de l'atropine ; 16 patients (27,6 %) ont eu un lavage gastrique ; un patient (1,7%) a été dialysé et 2 patients (3,4%) ont été admis en réanimation. Le taux de mortalité était de 8,6%. Conclusion : Les intoxications chimiques aiguës délibérées étaient fré","PeriodicalId":29646,"journal":{"name":"Research Journal of Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42688701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collaborative governance: The antidote for effective implementation of malaria elimination programme in Nigeria","authors":"B. A. Taleat, K. W. Olawoyin","doi":"10.4314/rejhs.v9i4.7","DOIUrl":"https://doi.org/10.4314/rejhs.v9i4.7","url":null,"abstract":"Objective: The study examined the way inter-governmental collaboration can be improved to enhance malaria elimination programme in Southwestern Nigeria. Methodology: Primary data were collected through the administration of questionnaire and conduct of interviews. The study population comprised all categories of staff in the National Malaria Elimination Programme; staffs of Malaria Elimination Programme in three states and nine Local Governments in Southwestern Nigeria. A sample size of 388 respondents was selected for questionnaire administration from the study population. Interviews were conducted to complement information collected through questionnaire. Data collected were analysed using appropriate statistical methods. Results: The study revealed that increased allocation of funds; establishment of several anti-malaria programmes at all levels of government and integrated decision making were ways collaborative governance can be improved to enhance malaria elimination programme in the study area. Conclusion: The study concluded that collaborative governance is a sine qua non to the effective implementation of government programmes.","PeriodicalId":29646,"journal":{"name":"Research Journal of Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46783835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogen peroxide measurements: its wet deposition in Higashi-Hiroshima city, concentration in Kurose River and role towards hydroxyl radical formation","authors":"A. J. Anifowose, O. Olabode, I.S. Adedotun, H. Sakugawa","doi":"10.4314/rejhs.v9i4.8","DOIUrl":"https://doi.org/10.4314/rejhs.v9i4.8","url":null,"abstract":"No Abstract.","PeriodicalId":29646,"journal":{"name":"Research Journal of Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46607524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Male participation in family planning: An untapped potential for increasing utilization of family planning services in Ondo, Southwestern Nigeria","authors":"R. O. Akande, O. Israel, A. Adefemi, E.O.K Leramo","doi":"10.4314/rejhs.v9i4.2","DOIUrl":"https://doi.org/10.4314/rejhs.v9i4.2","url":null,"abstract":"Background: Men play crucial roles in the utilization of family planning services hence, ensuring their commitment to these services is essential for increasing family planning uptake. This study therefore, assessed the level of male participation in family planning services utilization and its associated factors in Ondo west LGA, Ondo State, Nigeria. Methods: The study utilized a community-based cross-sectional design. Multi-stage sampling technique was used to select 433 eligible respondents. Quantitative data were collected using semi-structured questionnaires and analyzed using IBM SPSS version 23; bivariate and multivariate analyses were done using Chi-square and binary logistic regression respectively at 5% level of significance.Results: 55% and 48.5% of the study participants, had poor knowledge and perception about family planning services respectively. At bivariate level, there were statistically significant associations between age (p = 0.046), number of children (p < 0.001), level of education (p = 0.023), and the utilization of FP services by the respondents. Conclusion: The knowledge of the respondents about FP services was poor and if unaddressed, could infringe upon the rights of their spouses to access such services. Increasing male participation may require targeting married men for educational interventions. \u0000  \u0000French title: Participation des hommes à la planification familiale : un potentiel  inexploité pour accroître l'utilisation des services de planification familiale à Ondo, dans le sud-ouest du Nigéria \u0000Contexte général de l'étude : Les hommes jouent un rôle important dans l'utilisation des services de planification familiale, par conséquent, obtenir leur engagement envers ces services est essentiel pour augmenter l'adoption de la planification familiale. Par conséquent, cette étude a évalué le niveau de participation des hommes dans l'utilisation des services de planification familiale et ses facteurs associés à Ondo West, Ondo State, Nigéria.Méthode de l'étude : Une étude transversale communautaire, les répondants étant des hommes mariés. Une technique d'échantillonnage à plusieurs degrés a été utilisée pour sélectionner 433 répondants admissibles. Les données ont été recueillies à l'aide de questionnaires semi-structurés. Les données ont été analysées à l'aide d'IBM SPSS version 23 ; des analyses bi variées et multi variées ont été effectuées en utilisant respectivement une régression logistique du chi carré et binaire à un niveau de signification de 5%.Résultat de l'étude : Environ 55 % et 48,5 % des participants à l'étude avaient respectivement une connaissance et une perception médiocres des services de planification familiale. Au niveau bi varié, il y avait des associations statistiquement significatives entre l'âge (p = 0,046), le nombre d'enfants (p < 0,001), le niveau d'éducation (p = 0,023) et l'utilisation des services de PF par les répondants.Conclusion : La connaissance des répondants sur les services de PF ","PeriodicalId":29646,"journal":{"name":"Research Journal of Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49245943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal biochemical parameters among term neonates with perinatal asphyxia and their non-asphyxiated controls in Osogbo","authors":"O. Kayode, O. Adebami, O. Oyedeji, S. Oninla, S. B. Oseni, A. Odeyemi","doi":"10.4314/REJHS.V9I3.12","DOIUrl":"https://doi.org/10.4314/REJHS.V9I3.12","url":null,"abstract":"Objective: This study aimed to determine the prevalence of abnormal biochemical parameters among neonates with perinatal asphyxia in comparison to their non-asphyxiated controls.Methodology: This is a prospective case - control study involving 54 asphyxiated term neonates and 54 non-asphyxiated term babies at LAUTECH teaching hospital, Osogbo. Serum levels of Sodium, Bicarbonate, Chloride, Calcium and Potassium were determined daily for 72 hours in both groups using standard methods. The results were compared.Results: The overall prevalence of abnormal biochemical parameters namely hyponatraemia, hypocalcaemia, metabolic acidosis, hypochloraemia and hypokalaemia among the asphyxiated versus non-asphyxiated babies in the first 72 hours of life were 30.9% vs 19.8% (p < 0.020); 28.4% vs 4.9% (p < 0.000); 30.9% vs 3.1% (p < 0.0001); 27.2% vs 25.9% (p < 0.200) and 24.7% vs 3.1% (p < 0.070) respectively.Conclusion: Babies with hypoxic ischaemic encephalopathy stage III significantly showed the worst biochemical parameters; early estimation of serum electrolytes in neonates with perinatal asphyxia may be appropriate for timely intervention. \u0000 ","PeriodicalId":29646,"journal":{"name":"Research Journal of Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48990140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of patients with acute heart failure in North Central Nigeria","authors":"J. Ogunmodede, P. Kolo, M. O. Bojuwoye, B. Dele-Ojo, A. J. Ogunmodede, A. Omotoso","doi":"10.4314/REJHS.V9I3.3","DOIUrl":"https://doi.org/10.4314/REJHS.V9I3.3","url":null,"abstract":"Objectives: Heart failure (HF) is an important cause of hospital admission in Nigeria. HF is increasingly prevalent because the population is aging and HF epidemiology is changing. We aimed at profiling the socio-demographic, clinical and echocardiographic (Echo)  characteristics of patients admitted for acute HF. This is one of the largest cohorts of HF patients profiled in Nigeria so far. \u0000Methods: Cross sectional design. Socio-demographic, clinical and Echo data were collected from 455 patients admitted for AHF at University of Ilorin Teaching Hospital, North central, Nigeria. \u0000Results: Mean age of patients was 58.9± 15.7years, (men were older than women, P= 0.006). 265(58.2%) were males, most patients were aged >60 years, 4.8% had pre-existing Type2 Diabetes mellitus. 53.2% of patients presented in New York Heart Association Stages III and IV. Median duration of admission was 11days (IQR, 6-17), intrahospital mortality- 11.6%. Hypertension was the commonest aetiological factor (62.4%), followed by dilated cardiomyopathy 17.6%, rheumatic heart disease (6.6%), Peripartum cardiomyopathy (5.3%), and others. \u0000Conclusion: AHF patients in our study are older than those in previous studies in Nigeria and sub-Saharan Africa. Hypertension is main driver of AHF, and patients largely present with clinically advanced disease necessitating stronger public health education about risk factors and early presentation. \u0000 ","PeriodicalId":29646,"journal":{"name":"Research Journal of Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43717868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of anxiety symptoms and associated factors among Nigerians newly posted for National Youth Service Corps programme in North-Western Nigeria","authors":"A. Amoko, A. Ayodapo, T. O. Dele, H. Abitare","doi":"10.4314/REJHS.V9I3.4","DOIUrl":"https://doi.org/10.4314/REJHS.V9I3.4","url":null,"abstract":"Objectives: This study was done to determine the prevalence of anxiety symptoms and assess the associated factors among new  members of national youth service corps (NYSC) programme in North-Western Nigeria.Method: A clinic-based descriptive cross-sectional study with convenient sampling method using selfadministered questionnaires was done among 157, 2018 Batch-C, corps members at Dakingari orientation camp in Kebbi State, over a period of three weeks. The prevalence of anxiety symptoms was determined using anxiety subset of Hospital Anxiety and Depression scale. Data were analyzed with SPSS-16 andChi-square was used to assess the degree of association between anxiety symptoms and certain factors. Pvalue of less than 0.05 was considered statistically significant.Results: The prevalence of anxiety symptoms was 50.0% among the respondents. There was a significant association between the presence of anxiety symptoms and age of the respondents (P-value= 0.006).Conclusion: The high prevalence of anxiety symptoms among the new NYSC members suggests the need to take preventive measures such as incorporation of subjects on what should be expected during service year into the undergraduate learning curriculum. Doctors attending to youth corps members, especially when on camp, should routinely screen them for anxiety symptoms. ","PeriodicalId":29646,"journal":{"name":"Research Journal of Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44751363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"in vivo antibacterial and therapeutic properties of P. ostreatus against Staphylococcus aureus","authors":"B. A. Oyekanmi, A. Onifade, I. Osho, O. Ajayi","doi":"10.4314/REJHS.V9I3.8","DOIUrl":"https://doi.org/10.4314/REJHS.V9I3.8","url":null,"abstract":"Objectives: The use of natural products is embraced by a larger percentage of the world population. Most species of fungi including mushrooms produce useful secondary metabolites that stimulate the immune system against infection and diseases. Investigations were conducted to assay the therapeutic potentials of P. ostreatus against pathogenic staph infection.Methods: The methanol extract of P. ostreatus was prepared using the cold extraction method. Thirty Wistar albino rats weighing 82.0 g to 99.2 g were distributed into 6 groups of 5 and inoculated orally with actively growing Staphylococcus aureus suspension. P. ostreatus methanol extract LD > 5000 mg/kg 50 was used to determine the graded doses for the study. Graded doses of the extract 625 mg, 1250 mg, and 2500 mg were administered orally to the experimental animals for seven days.Results: The negative control and 625 mg had skin ulceration while 1250 mg to 2500 mg produced apparently healthy skin. Bacterial count after 7 days post-treatment was significantly high in the negative control and 625 mg dose (32.00 x 104 ± 6.10b; 43.40 x 104 ± 6.20b Cfu/ml) P< 0.05. Haematological and serum biochemical values were not significantly P < 0.05 affected. Pleurotus ostreatus administration at 1250 to 2500 mg produced a statistically low colony count that was comparable with 13.33 mg Ciprofloxacin and placebo.Conclusion: Pleurotus ostreatus at 1250 to 2500 mg was able to produce clinical recovery from S. aureus infection while 625 mg could not. The extract had no deleterious effect on the blood parameters, liver enzymes, and kidney biomarkers. \u0000 ","PeriodicalId":29646,"journal":{"name":"Research Journal of Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46779599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}