Abnormal biochemical parameters among term neonates with perinatal asphyxia and their non-asphyxiated controls in Osogbo

O. Kayode, O. Adebami, O. Oyedeji, S. Oninla, S. B. Oseni, A. Odeyemi
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Abstract

Objective: This study aimed to determine the prevalence of abnormal biochemical parameters among neonates with perinatal asphyxia in comparison to their non-asphyxiated controls.Methodology: This is a prospective case - control study involving 54 asphyxiated term neonates and 54 non-asphyxiated term babies at LAUTECH teaching hospital, Osogbo. Serum levels of Sodium, Bicarbonate, Chloride, Calcium and Potassium were determined daily for 72 hours in both groups using standard methods. The results were compared.Results: The overall prevalence of abnormal biochemical parameters namely hyponatraemia, hypocalcaemia, metabolic acidosis, hypochloraemia and hypokalaemia among the asphyxiated versus non-asphyxiated babies in the first 72 hours of life were 30.9% vs 19.8% (p < 0.020); 28.4% vs 4.9% (p < 0.000); 30.9% vs 3.1% (p < 0.0001); 27.2% vs 25.9% (p < 0.200) and 24.7% vs 3.1% (p < 0.070) respectively.Conclusion: Babies with hypoxic ischaemic encephalopathy stage III significantly showed the worst biochemical parameters; early estimation of serum electrolytes in neonates with perinatal asphyxia may be appropriate for timely intervention.  
奥索博围产期窒息足月新生儿及其非窒息对照组生化指标异常
目的:本研究旨在确定围生期窒息新生儿与非窒息对照组的生化参数异常发生率。方法:这是一项前瞻性病例对照研究,涉及54名窒息足月新生儿和54名非窒息足月婴儿,奥索博LAUTECH教学医院。两组患者采用标准方法,连续72小时每天测定血清钠、碳酸氢盐、氯化物、钙和钾的水平。对结果进行比较。结果:窒息儿与非窒息儿在出生后72小时内低钠血症、低钙血症、代谢性酸中毒、低氯血症、低钾血症等生化指标异常总体患病率分别为30.9%和19.8% (p < 0.020);28.4% vs 4.9% (p < 0.000);30.9% vs 3.1% (p < 0.0001);27.2% vs 25.9% (p < 0.200), 24.7% vs 3.1% (p < 0.070)。结论:缺氧缺血性脑病ⅲ期患儿生化指标最差;早期估计围产期窒息新生儿的血清电解质可能适合及时干预。
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