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Recent advances in antibody glycoengineering for the gain of functions 为获得功能而进行抗体糖工程设计的最新进展
IF 7.8 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2024-01-03 DOI: 10.1016/j.cbpa.2023.102420
Zhi Liu , Xiangman Zou , Feng Tang , Wei Huang
{"title":"Recent advances in antibody glycoengineering for the gain of functions","authors":"Zhi Liu ,&nbsp;Xiangman Zou ,&nbsp;Feng Tang ,&nbsp;Wei Huang","doi":"10.1016/j.cbpa.2023.102420","DOIUrl":"10.1016/j.cbpa.2023.102420","url":null,"abstract":"<div><p>Glycans play important roles in antibody functions, and antibody glycoengineering has long been an important research field. Here, we summarize the significant strategies of antibody glycoengineering, including expressed antibody glycoengineering in mammalian cell expression systems, chemo-enzymatic antibody glycoengineering, and yeast expression system-based antibody engineering, as well as the applications of glycoengineering in antibody-drug conjugates. These advances in antibody glycoengineering will provide a comprehensive understanding and inspire us to develop more advanced techniques to achieve glycoengineered antibodies.</p></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1367593123001588/pdfft?md5=f80fbde880018e5f2525695ebf650429&pid=1-s2.0-S1367593123001588-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139084240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent chemical synthesis and immunological evaluation of glycans related to bacterial lipopolysaccharides 与细菌脂多糖有关的聚糖的最新化学合成和免疫学评估
IF 7.8 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2024-01-03 DOI: 10.1016/j.cbpa.2023.102424
Chunjun Qin , Guangzong Tian , Jing Hu , Xiaopeng Zou , Jian Yin
{"title":"Recent chemical synthesis and immunological evaluation of glycans related to bacterial lipopolysaccharides","authors":"Chunjun Qin ,&nbsp;Guangzong Tian ,&nbsp;Jing Hu ,&nbsp;Xiaopeng Zou ,&nbsp;Jian Yin","doi":"10.1016/j.cbpa.2023.102424","DOIUrl":"10.1016/j.cbpa.2023.102424","url":null,"abstract":"<div><p>O-Antigens and core oligosaccharides from bacterial lipopolysaccharides (LPS) are often structurally unique and immunologically active, have become attractive targets in the development of antibacterial vaccines. Structurally well-defined and pure oligosaccharides can be used in identifying protective epitopes of the carbohydrate antigens, which is important for the design of an effective vaccine. Here, the recent progress on chemical synthesis and immunological evaluation of glycans related to O-antigens and core oligosaccharides from bacterial LPS are summarized.</p></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S136759312300162X/pdfft?md5=8456ecc52887b73119ec119804ebdbb4&pid=1-s2.0-S136759312300162X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139084477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in enzymatic and chemoenzymatic synthesis of N- and O-glycans 酶法和化学酶法合成 N-和 O-聚糖的最新进展
IF 7.8 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2023-12-22 DOI: 10.1016/j.cbpa.2023.102417
Zhi-Fei Hu , Kan Zhong , Hongzhi Cao
{"title":"Recent advances in enzymatic and chemoenzymatic synthesis of N- and O-glycans","authors":"Zhi-Fei Hu ,&nbsp;Kan Zhong ,&nbsp;Hongzhi Cao","doi":"10.1016/j.cbpa.2023.102417","DOIUrl":"10.1016/j.cbpa.2023.102417","url":null,"abstract":"<div><p>Glycosylation is one of the most common post-translational modifications of proteins, which plays essential roles in regulating the biological functions of proteins. Efficient and versatile methods for the synthesis of homogeneous and well-defined N- and O-glycans remain an urgent need for biological studies and biomedical applications. Despite their structural complexity, tremendous progress has been made in the synthesis of N- and O-glycans in recent years. This review discusses some recent advances in the enzymatic and chemoenzymatic synthesis of N- and O-glycans.</p></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1367593123001552/pdfft?md5=8d54c894613bc44a3e9f6f4548f02e9f&pid=1-s2.0-S1367593123001552-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139031808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and application of bacterial exopolysaccharides 细菌外多糖的合成与应用
IF 7.8 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2023-12-21 DOI: 10.1016/j.cbpa.2023.102418
Gijs Ruijgrok, Dung-Yeh Wu, Herman S. Overkleeft, Jeroen D.C. Codée
{"title":"Synthesis and application of bacterial exopolysaccharides","authors":"Gijs Ruijgrok,&nbsp;Dung-Yeh Wu,&nbsp;Herman S. Overkleeft,&nbsp;Jeroen D.C. Codée","doi":"10.1016/j.cbpa.2023.102418","DOIUrl":"https://doi.org/10.1016/j.cbpa.2023.102418","url":null,"abstract":"<div><p>Exopolysaccharides are produced and excreted by bacteria in the generation of biofilms to provide a protective environment. These polysaccharides are generally generated as heterogeneous polymers of varying length, featuring diverse substitution patterns. To obtain well-defined fragments of these polysaccharides, organic synthesis often is the method of choice, as it allows for full control over chain length and the installation of a pre-determined substitution pattern. This review presents several recent syntheses of exopolysaccharide fragments of <em>Pseudomonas aeruginosa</em> and <em>Staphylococcus aureus</em> and illustrates how these have been used to study biosynthesis enzymes and generate synthetic glycoconjugate vaccines.</p></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1367593123001564/pdfft?md5=15331be6f20b5e18febb754761bdd91a&pid=1-s2.0-S1367593123001564-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138838860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome 界限模糊：跨越化学暴露组和代谢组之间的界限
IF 7.8 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2023-12-11 DOI: 10.1016/j.cbpa.2023.102407
Cristina Balcells , Yitao Xu , Rubén Gil-Solsona , Léa Maitre , Pablo Gago-Ferrero , Hector C. Keun
{"title":"Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome","authors":"Cristina Balcells ,&nbsp;Yitao Xu ,&nbsp;Rubén Gil-Solsona ,&nbsp;Léa Maitre ,&nbsp;Pablo Gago-Ferrero ,&nbsp;Hector C. Keun","doi":"10.1016/j.cbpa.2023.102407","DOIUrl":"10.1016/j.cbpa.2023.102407","url":null,"abstract":"<div><p>The aetiology of every human disease lies in a combination of genetic and environmental factors, each contributing in varying proportions. While genomics investigates the former, a comparable holistic paradigm was proposed for environmental exposures in 2005, marking the onset of exposome research. Since then, the exposome definition has broadened to include a wide array of physical, chemical, and psychosocial factors that interact with the human body and potentially alter the epigenome, the transcriptome, the proteome, and the metabolome. The chemical exposome, deeply intertwined with the metabolome, includes all small molecules originating from diet as well as pharmaceuticals, personal care and consumer products, or pollutants in air and water. The set of techniques to interrogate these exposures, primarily mass spectrometry and nuclear magnetic resonance spectroscopy, are also extensively used in metabolomics. Recent advances in untargeted metabolomics using high resolution mass spectrometry have paved the way for the development of methods able to provide in depth characterisation of both the internal chemical exposome and the endogenous metabolome simultaneously. Herein we review the available tools, databases, and workflows currently available for such work, and discuss how these can bridge the gap between the study of the metabolome and the exposome.</p></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S136759312300145X/pdfft?md5=e36893631f90880959495d50207b6d36&pid=1-s2.0-S136759312300145X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138569864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Glycobiology (2023) 编辑概述:糖生物学(2023)
IF 7.8 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2023-11-11 DOI: 10.1016/j.cbpa.2023.102406
Matthew S. Macauley
{"title":"Editorial overview: Glycobiology (2023)","authors":"Matthew S. Macauley","doi":"10.1016/j.cbpa.2023.102406","DOIUrl":"https://doi.org/10.1016/j.cbpa.2023.102406","url":null,"abstract":"","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92121890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small-molecule tools for YEATS domain proteins YEATS结构域蛋白质的小分子工具。
IF 7.8 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2023-11-03 DOI: 10.1016/j.cbpa.2023.102404
Michael A. Erb
{"title":"Small-molecule tools for YEATS domain proteins","authors":"Michael A. Erb","doi":"10.1016/j.cbpa.2023.102404","DOIUrl":"10.1016/j.cbpa.2023.102404","url":null,"abstract":"<div><p>Chromatin reader domains are protein folds that bind to post-translational modifications of histones and other chromatin-associated proteins. Compared to other families of reader domains, the discovery that YEATS domains bind to acylated lysines is relatively recent. Four human proteins harbor a YEATS domain, and each is present in protein complexes that regulate chromatin and transcription (ENL, AF9, YEATS2, and YEATS4). Without chemical tools to enable temporally resolved perturbations, it is often unclear how reader domains contribute to protein function. Here, we will discuss recent progress in developing small-molecule tools for YEATS domains and highlight their usefulness for making biological discoveries.</p></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71476150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm O-连接糖肽和糖蛋白化学合成的最新进展：探索生物学领域的先进合成工具。
IF 7.8 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2023-10-26 DOI: 10.1016/j.cbpa.2023.102405
Jie Zhao , Farong Ye , Ping Huang , Ping Wang
{"title":"Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm","authors":"Jie Zhao ,&nbsp;Farong Ye ,&nbsp;Ping Huang ,&nbsp;Ping Wang","doi":"10.1016/j.cbpa.2023.102405","DOIUrl":"10.1016/j.cbpa.2023.102405","url":null,"abstract":"<div><p><span><span>Glycoproteins play crucial roles in various </span>biological processes. To investigate the relationship between </span>glycan structure and function, researchers have employed various chemical methods to precisely synthesize homogeneous O-glycoproteins. This review summarizes the recent progress of their synthetic strategies, highlighting the significant advancements in this area.</p></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66783244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo 量化细胞内和体内糖苷水解酶酶活性的策略。
IF 7.8 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2023-10-17 DOI: 10.1016/j.cbpa.2023.102403
Matthew C. Deen , Pierre-André Gilormini , David J. Vocadlo
{"title":"Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo","authors":"Matthew C. Deen ,&nbsp;Pierre-André Gilormini ,&nbsp;David J. Vocadlo","doi":"10.1016/j.cbpa.2023.102403","DOIUrl":"10.1016/j.cbpa.2023.102403","url":null,"abstract":"<div><p><span>Within their native milieu of the cell, the activities of enzymes<span> are controlled by a range of factors including protein interactions and post-translational modifications. The involvement of these factors in fundamental cell biology and the etiology of diseases is stimulating interest in monitoring enzyme activities within tissues. The creation of synthetic substrates, and their use with different imaging modalities, to detect and quantify enzyme activities has great potential to propel these areas of research. Here we describe the latest developments relating to the creation of substrates for imaging and quantifying the activities of </span></span>glycoside<span> hydrolases, focusing on mammalian systems. The limitations of current tools and the difficulties within the field are summarised, as are prospects for overcoming these challenges.</span></p></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49672262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer 代谢干预提高晚期癌症的免疫疗法和靶向治疗效果。
IF 7.8 2区 生物学
Current Opinion in Chemical Biology Pub Date : 2023-10-06 DOI: 10.1016/j.cbpa.2023.102401
Helena Oliveres , Marta Cascante , Joan Maurel
{"title":"Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer","authors":"Helena Oliveres ,&nbsp;Marta Cascante ,&nbsp;Joan Maurel","doi":"10.1016/j.cbpa.2023.102401","DOIUrl":"10.1016/j.cbpa.2023.102401","url":null,"abstract":"<div><p>Current standard-of-care for metastatic colorectal cancer patients includes chemotherapy and anti-angiogenic or anti-epidermal growth factor receptor for microsatellite stable tumors and pembrolizumab for microsatellite instable tumors. However, despite the available therapies, the prognosis remains poor. In recent years, new drugs combined with immune checkpoint inhibitors have been tested in microsatellite stable metastatic colorectal cancer patients, but the benefit was modest. Here, we review the metabolic interactions between the immune microenvironment and cancer cells. More specifically, we highlight potential correlatives of tumor immune and metabolic features with transcriptomic classifications such as the Consensus Molecular Subtype. Finally, we discuss the unmet need of immune-metabolic signatures and the value of a new signature (IMMETCOLS) for guiding new strategies in metastatic colorectal cancer. We conclude that the field is ready to propose customized strategies for modifying metabolism and improving immunotherapy and targeted therapy efficacy.</p></div>","PeriodicalId":291,"journal":{"name":"Current Opinion in Chemical Biology","volume":null,"pages":null},"PeriodicalIF":7.8,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1367593123001394/pdfft?md5=c15ede0b7c2cad886a2219e14a2bdaa3&pid=1-s2.0-S1367593123001394-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41100647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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