将硒纳入生物分子的酶促策略

IF 5.3 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Chase M. Kayrouz , Mohammad R. Seyedsayamdost
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引用次数: 0

摘要

微量元素硒(Se)对地球上大多数生物的生理机能至关重要。硒在生物体内最常见的形式是硒蛋白,其中的硒半胱氨酸通常是关键氧化还原过程的催化中心。硒还存在于其他几类生物分子中,包括核酸、糖和修饰氨基酸,但人们对硒在这些代谢物功能中的作用了解较少。尽管硒普遍存在,但目前只发现了少量硒特异性生物合成途径。其中约有一半是在过去三年中首次表征的,这表明硒代谢组可能比以前认识到的更加多样化。在此,我们回顾了我们对这一有趣的生化领域的最新理解进展,并讨论了未来发现工作的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enzymatic strategies for selenium incorporation into biological molecules

The trace element selenium (Se) is essential to the physiology of most organisms on the planet. The most well documented of Se's biological forms are selenoproteins, where selenocysteine often serves as the catalytic center for crucial redox processes. Se is also found in several other classes of biological molecules, including nucleic acids, sugars, and modified amino acids, although its role in the function of these metabolites is less understood. Despite its prevalence, only a small number of Se-specific biosynthetic pathways have been discovered. Around half of these were first characterized in the past three years, suggesting that the selenometabolome may be more diverse than previously appreciated. Here, we review the recent advances in our understanding of this intriguing biochemical space, and discuss prospects for future discovery efforts.

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来源期刊
CiteScore
8.30
自引率
3.40%
发文量
1601
期刊介绍: ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.
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