Journal of Allergy and Therapy最新文献

{"title":"Allergic rhinosinusitis treated by a sublingual nano-immunotherapy","authors":"G. Gilbert","doi":"10.4172/2155-6121-C2-008","DOIUrl":"https://doi.org/10.4172/2155-6121-C2-008","url":null,"abstract":"F a very long time the so-called modern medicine has been exerting its therapeutic effects through inhibiting actions. It is, with a closer look, anti-everything! We offer a different model, called the Bio Immune(G)ene Medicine, based on the connectivity and regulation of the pathophysiological processes affecting cells in a given disease. It is thus a biomimetic method aiming at being as close as possible to the molecular processes involved in a pathological state at several levels, with a strong focus on epigenetic regulation by using numerous microRNAs. To this end, a strict approach at the biological level is necessary, in order to highlight as many factors involved in the disease as possible and then be able to introduce a regulatory treatment. To perform this, we have at our disposal a nanotherapy administered sublingually, in order to facilitate the transmission of the ultra-low molecular doses to the immunocompetent cells, which are present in large numbers in the oropharyngeal mucosa. This kind of therapeutic approach is very-well suited for allergic diseases such as rhinosinusitis. We will try to show in this presentation how the identification and validation of some pathophysiological processes can lead to a very effective therapy with no side-effect, relying only on regulation mechanisms at both the molecular and cellular levels, applied in this case to allergic rhinosinusitis.","PeriodicalId":290131,"journal":{"name":"Journal of Allergy and Therapy","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114528956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The comparison of the level of the IL-2, IL-6, IL-10, IFN-andgamma; and serum cortisol hormone in young athlete and non-athlete men","authors":"Mahdi Ghasemiartiyan","doi":"10.4172/2155-6121-C2-009","DOIUrl":"https://doi.org/10.4172/2155-6121-C2-009","url":null,"abstract":"","PeriodicalId":290131,"journal":{"name":"Journal of Allergy and Therapy","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120993661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Experience of Being Tested for Allergies: The Views of Children and Their Parents","authors":"Helen E. Smith, Clare E Brown, Annalee Robertson, Laura H. Stuttaford, R. Rashid, Christina J. Jones","doi":"10.4172/2155-6121.1000287","DOIUrl":"https://doi.org/10.4172/2155-6121.1000287","url":null,"abstract":"Background: Children with suspected allergies can be tested for IgE sensitivities with in vivo or in vitro testing, but parents’ and childrens’ experiences of these different allergy test modalities have not been studied. \u0000Objective: To investigate parents’ and childrens’ experiences and views of allergy testing (Skin Prick Testing (SPT) and allergen-specific IgE blood tests). \u0000Methods: Qualitative study of children and their parents attending a paediatric allergy clinic. Semi-structured interviews were conducted by telephone using an interview guide that explored their experience of allergy testing. Interviews were digitally recorded and transcribed verbatim. Thematic content analysis was performed. \u0000Results: 16 parents and 6 children were interviewed. The characteristics of skin prick tests particularly valued were the immediacy and visibility of results, which enabled testing and interpretation to be achieved within a single clinic appointment. In vitro testing offered simplicity and speed, with only a single puncture site and procedural speed. Some perceived it to be a superior test as it was a laboratory-based test. Parental accounts of in vitro testing often included reference to their own discomfort, as well as their young child’s discomfort as they were restrained for venepuncture. \u0000Conclusion and clinical relevance: Several areas for improvement in allergy testing service provision were highlighted, particularly a need for greater information in advance about what will happen in the allergy clinic to reduce anxiety and misunderstandings. Also, SPT with an already identified allergen can cause concern and distress as it appeared to contradict previous instructions given for allergen avoidance.","PeriodicalId":290131,"journal":{"name":"Journal of Allergy and Therapy","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124757787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Hormones Effects on the Control of Menopausal Asthma","authors":"S. Aissani, I. Ararem, H. Haouichat, M. Haffaf, A. Zitouni","doi":"10.4172/2155-6121.1000275","DOIUrl":"https://doi.org/10.4172/2155-6121.1000275","url":null,"abstract":"Introduction: Asthma can persist after menopause but can also occur in pre- or post-menopause. The aging of the bronchial tree and the fall of the hormones during the menopause can influence the control of asthma. \u0000Methods and methods: This is a prospective descriptive study from 2011 to 2017. It involved 106 postmenopausal asthmatic patients divided into two groups according to the onset of asthma before or after menopause. These women received prick tests for the most common allergens, spirometry and a dosage of progesterone and estradiol. \u0000Results: These asthmatics are 45 to 70 years old with an average age of 58.39 ± 7.32 years. They have an average body mass index (BMI) of 28.83 ± 5.68 kg/m2. The almost exclusively passive smoking exposure is found in more than half of the cases. \u0000When asthma occurs after menopause (24 patients), the average BMI is 29.12 ± 4.46 kg/m2. These women were postmenopausal earlier in 12.5% of cases and had positive skin tests in only 23.8% of cases. When asthma occurred before menopause (82 patients), the average BMI was 28.87 ± 5.06 kg/m2. These women have been menopausal at normal age but have decreased respiratory function. Overall uncontrolled asthma was found in 58.5% of patients with postmenopausal asthma and 43.9% in those with pre-menopausal asthma with a statistically significant difference (p=0.04). \u0000There was no significant difference in hormone levels studied between the two groups. But the severity and uncontrolled asthma are associated with significantly higher estradiol levels. \u0000Conclusion: The involvement of estrogen in the control and severity of asthma is not negligible in this study. The possible interaction of these hormones with other field factors such as smoking exposure and obesity is strongly suspected.","PeriodicalId":290131,"journal":{"name":"Journal of Allergy and Therapy","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127805940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunotherapy Using IFN-Gamma for Cefaclor Allergy: Case Reports","authors":"G. Noh, Bum Soo Kim, W. Kim, C. Han, Chang Won Ha, Ihl Bohng Choi","doi":"10.4172/2155-6121.1000274","DOIUrl":"https://doi.org/10.4172/2155-6121.1000274","url":null,"abstract":"Cefaclor is prescribed worldwide and is one of the most frequently prescribed oral antibiotics. Several allergic reactions to cefaclor were reported. Desensitization for cefaclor allergy has been attempted and not all desensitization of cefaclor has been successful. IFN-gamma has been used for the tolerance induction for food allergies of both IgE-mediated and non-IgE mediated type. IFN-gamma was reported to have tolerogenic effects for allergen-specific allergies. Recently, IFN-gamma was introduced for desensitization for aspirin in acute myocardial syndrome. In this case report, two cases of patients who had anaphylactic allergies to cefaclor and treated successfully by desensitization using IFN-gamma were reported.","PeriodicalId":290131,"journal":{"name":"Journal of Allergy and Therapy","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122038190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Young people's views on the design of adrenaline auto-injectors: A qualitative study","authors":"L. Leach, Helen E. Smith, Clare E Brown, M. Davies, Christina J. Jones","doi":"10.4172/2155-6121.1000271","DOIUrl":"https://doi.org/10.4172/2155-6121.1000271","url":null,"abstract":"Background: “Young people’s compliance with carriage of adrenaline auto-injectors (AAI) may be as low as 41%, yet we lack research exploring their preferences regarding these devices.” Objective: This qualitative study explored young people’s ideas about AAI design and features which may facilitate their carriage and use. Methods: Young people aged 13-18 years prescribed an AAI for severe allergic reaction were invited to participate in in-depth, semi-structured, face-to-face interviews about AAI design. Interviews were recorded, transcribed verbatim and analyzed using thematic content analysis. Results: From 23 interviews, seven major themes were identified: accessibility and carriage, comprehensibility of instructions, indication of correct administration, safety, speed of administration, visibility and identification and precise drug delivery. Young people made several suggestions for how AAIs may be adapted to improve carriage, including reduced size to enable pocket-carriage. Comprehensibility was thought to be enhanced by the use of pictographic instructions and audio-prompts to encourage prompt and accurate administration. Needle guards were seen as beneficial to reduce needle phobia, prevent accidental injury and provide reassurance that the device had been administered. Young people were conflicted between wanting a device which enabled discreet carriage, versus an AAI which was bold and clearly identifiable as a medical device in case of emergency. Conclusion: This study identified key AAI features important to young people, together with design issues deterring day-to-day carriage of AAIs and their emergency, time-pressured usage. We demonstrated considerable scope for AAI design modifications to improve young peoples’ perception of devices and facilitate their carriage and use.","PeriodicalId":290131,"journal":{"name":"Journal of Allergy and Therapy","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132907680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rush Immunotherapy Using IFN-Gamma for Aspirin in Acute Coronary Syndrome: Case Report","authors":"G. Noh, S. Kang, Kyu-Sun Lee, W. Kim, C. Han, Ihl Bohng Choi, Chang Won Ha, Hyeryeon Noh","doi":"10.4172/2155-6121.1000269","DOIUrl":"https://doi.org/10.4172/2155-6121.1000269","url":null,"abstract":"Aspirin plays a key role in the secondary prevention of atherothrombotic events and thrombotic complications after stent implantation and aspirin sensitivity is a limitation for the implantation of bare-metal and drug-eluting coronary stents. Several desensitization protocols have been described. In this report, desensitization by introducing IFN-gamma as an immunomodulatory adjuvant was successful for the patients who required early invasive management and the prompt administration of aspirin but failed the classical desensitization by showing allergic symptoms and signs during desensitization.","PeriodicalId":290131,"journal":{"name":"Journal of Allergy and Therapy","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134482414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exhaled Nitric Oxide and Symptom Severity in Children with Allergic Rhinitis","authors":"J. Kim, Ji Sun Park, S. Moon, D. Lim, S. Hwang, Y. Park","doi":"10.4172/2155-6121.1000268","DOIUrl":"https://doi.org/10.4172/2155-6121.1000268","url":null,"abstract":"Objective: There have been few reliable biomarkers to evaluate allergic rhinitis (AR) severity in children. This study aimed to investigate a biomarker for assessing AR severity in children. \u0000Methods: A total of 107 children with AR (80) and non-allergic rhinitis (NAR, 27) were included in this study. The fraction of exhaled nitric oxide (FeNO) was measured and AR severity and duration was graded in patients with AR. We assessed the association between FeNO and the Allergic Rhinitis and its Impact on Asthma (ARIA) classes. \u0000Results: FeNO levels in the AR and NAR groups were 34.7 ± 22.1 and 17.0 ± 13.1 ppb, respectively (p=0.001). FeNO levels were significantly different (p<0.05) in the four ARIA classes: 14.3 ± 3.7 ppb in the mild intermittent group, 22.7 ± 4.8 ppb in the mild persistent group, 32.1 ± 16.1 ppb in the moderate-to-severe intermittent group, and 48.2 ± 25.2 ppb in the moderate-to-severe persistent group. We collapsed the 4 ARIA classes into 2 groups based on severity or duration. FeNO levels of the mild symptom group and moderate-to-severe symptom group were 18.7 ± 6.0 and 41.1 ± 23.0 ppb, respectively, which were significantly different (p=0.001). FeNO levels of the intermittent duration group (n=36) and persistent duration group (n=44) were 26.6 ± 15.9 and 41.2 ± 24.4 ppb, respectively, which were significantly different (p=0.001). \u0000Conclusion: FeNO levels were higher in children with increased severity and duration of AR. FeNO could be an indicator for classifying severity and evaluating treatment efficacy in children with AR.","PeriodicalId":290131,"journal":{"name":"Journal of Allergy and Therapy","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127918110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suppressive Effect of a Thioamide-Related Compound SH-2251 on a Murine Allergic Rhinitis Model","authors":"Takashi Kitani, S. Maruyama, Kunihide Aoishi, Naoya Nishida, H. Ogawa, Yasunori Abe, Yuji Hayashi, M. Yamashita, N. Hato","doi":"10.4172/2155-6121.1000267","DOIUrl":"https://doi.org/10.4172/2155-6121.1000267","url":null,"abstract":"Background: SH-2251 inhibits IL-5 production and type2 airway inflammation in a murine bronchial asthma model. However, the therapeutic effect of SH-2251 on allergic rhinitis (AR) has not been tested. We investigated whether or not SH-2251 could improve the nasal symptoms and inflammation in the nasal mucosa of a murine model of AR. \u0000Methods: AR was induced via intraperitoneal injection of ovalbumin (OVA) followed by daily intranasal challenge with OVA. SH-2251 (10 mg/kg) or vehicle (DMSO+Tween80) was administered orally once a day in the same period as the nasal challenge. Nasal symptoms were evaluated by counting the number of sneezing and nasal rubbing events on days 14, 17, 21, 28 and 35. On day 35, the levels of Il4, Il5, Il13, Ifnγ and Il1rl1 mRNA in the nasal mucosa were examined. The histological findings were examined on day 36. \u0000Results: The numbers of sneezing and nasal rubbing events were significantly decreased by the administration of SH-2251. Both eosinophil infiltration and the hickness of the nasal mucosa were improved in the SH-2251- administered mice compared that in vehicle-treated control mice. The mRNA expression of Il5, Il13 and Il1rl1 in the nasal mucosa was significantly decreased in the SH-2251-treated group compared to the vehicle group. \u0000Conclusion: These results suggest that SH-2251 may be a new therapeutic candidate for AR. In addition, SH-2251 might improve the pathogenesis of type2 chronic inflammation by targeting the IL-33 signaling via the inhibition of Il1rl1 expression.","PeriodicalId":290131,"journal":{"name":"Journal of Allergy and Therapy","volume":"193 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132200978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diaphragm Muscle Contraction Decrease in a Mouse Model of Ovalbumin-Induced Allergic Airway Inflammation","authors":"Kazunobu Yamaguchi, C. Shindoh, M. Miura","doi":"10.4172/2155-6121.1000265","DOIUrl":"https://doi.org/10.4172/2155-6121.1000265","url":null,"abstract":"Objective: We investigated diaphragm contractile and inflammatory properties of mice with OVA sensitization and challenge. \u0000Methods: BALB/c mice were sensitized to OVA by intraperitoneal (i.p.) injection at 0 and 7 days, and challenged with aerosolized OVA on 21, 22, and 23 days (O/O group). Budesonide/Formoterol combination was inhaled on days 21, 22, and 23 before OVA challenge on those same days (O/OC group). Control mice were sensitized and challenged with an aerosolized saline (O-group). The diaphragm contractile and inflammatory properties were measured on day 24. NOS activity in the diaphragm muscle was evaluated by NADPH diaphorase staining. IL-4 and IL-13 levels of BALF, as well as lung tissue and diaphragm muscle homogenates were measured by ELISA. \u0000Results: Force-frequency (F/f) curves of O/O and O/OC shifted downward in comparison with O- (p<0.05). NADPH diaphorase staining results of O/O and O/OC showed a significantly higher density compared with O-. The IL-4 level of diaphragm muscle homogenates increased significantly in the O/O compared with the O- and O/OC. \u0000Conclusions: OVA sensitization and challenge decreased diaphragm muscle contraction, increased NOS activity, IL-4 levels of diaphragm in a mouse model. Budesonide/Formoterol combination could protect diaphragm muscle weakness and inflammation. According to the traditional concept of the contemporary Immunology, neither autoimmune diseases nor allergic diseases can be cured completely. Nevertheless, a fortunate coincidence led me to discovery of a novel concept that eliminations of the causes of these diseases are possible. In other words, combinations of pathogenic antibodies with responsible cells, namely, cytolytic T lymphocytes in cases of autoimmune diseases and mast cells in cases of allergic diseases, can be decomposed by replacing the pathogenic antibodies with non-specific antibodies. In more detail, intradermal injections with a non-specific antigen preparation induce production of non-specific antibodies in the body of the patient. Repetitions of the injections bring about an accumulation of them. Accumulated non-specific antibodies will occupy most of the receptors on the surface of responsible cells. When the accumulation reaches the sufficient level, virtually no pathogenic antibodies would remain on the receptors. That is, no causes of the diseases remain. Naturally, where there is no cause, there is no disease. Details are demonstrated elsewhere.","PeriodicalId":290131,"journal":{"name":"Journal of Allergy and Therapy","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117256078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}