Immunotherapy Using IFN-Gamma for Cefaclor Allergy: Case Reports

Cefaclor is prescribed worldwide and is one of the most frequently prescribed oral antibiotics. Several allergic reactions to cefaclor were reported. Desensitization for cefaclor allergy has been attempted and not all desensitization of cefaclor has been successful. IFN-gamma has been used for the tolerance induction for food allergies of both IgE-mediated and non-IgE mediated type. IFN-gamma was reported to have tolerogenic effects for allergen-specific allergies. Recently, IFN-gamma was introduced for desensitization for aspirin in acute myocardial syndrome. In this case report, two cases of patients who had anaphylactic allergies to cefaclor and treated successfully by desensitization using IFN-gamma were reported.