Allergic rhinosinusitis treated by a sublingual nano-immunotherapy

F a very long time the so-called modern medicine has been exerting its therapeutic effects through inhibiting actions. It is, with a closer look, anti-everything! We offer a different model, called the Bio Immune(G)ene Medicine, based on the connectivity and regulation of the pathophysiological processes affecting cells in a given disease. It is thus a biomimetic method aiming at being as close as possible to the molecular processes involved in a pathological state at several levels, with a strong focus on epigenetic regulation by using numerous microRNAs. To this end, a strict approach at the biological level is necessary, in order to highlight as many factors involved in the disease as possible and then be able to introduce a regulatory treatment. To perform this, we have at our disposal a nanotherapy administered sublingually, in order to facilitate the transmission of the ultra-low molecular doses to the immunocompetent cells, which are present in large numbers in the oropharyngeal mucosa. This kind of therapeutic approach is very-well suited for allergic diseases such as rhinosinusitis. We will try to show in this presentation how the identification and validation of some pathophysiological processes can lead to a very effective therapy with no side-effect, relying only on regulation mechanisms at both the molecular and cellular levels, applied in this case to allergic rhinosinusitis.