International Journal of Pharma Medicine and Biological Sciences最新文献_第6页

The Effect of Salbutamol towards Heart Rate in Neutrophilic and Eosinophilic Asthma Patient 沙丁胺醇对嗜中性粒细胞和嗜酸性粒细胞哮喘患者心率的影响

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2018-10-01 DOI: 10.18178/IJPMBS.7.4.88-91

Hanif Purbaya, Moch. Rizki Efendi, Afief Mulyawijaya, A. Z. Arjana

引用次数: 0

Extraction of Saffron Crocin as a Natural Pharmaceutical Source with Crystallization Method 结晶法提取藏红花藏红花素的研究

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2018-10-01 DOI: 10.18178/ijpmbs.7.4.84-87

Sahebeh Sedaghati, F. Abbaszadeh

{"title":"Extraction of Saffron Crocin as a Natural Pharmaceutical Source with Crystallization Method","authors":"Sahebeh Sedaghati, F. Abbaszadeh","doi":"10.18178/ijpmbs.7.4.84-87","DOIUrl":"https://doi.org/10.18178/ijpmbs.7.4.84-87","url":null,"abstract":" Abstract—separation of crocin as anti-cancer and antioxidant ingredient would be useful commercially and clinically. In this research with crystallization method, saffron Crocin was extracted. Ethanol 80% and acetone was chosen as the best extraction solvent. Crystallization and purification process was performed in two steps in zero and -5c° degree. In first step, saffron Crocin was extracted with ethanol and after keeping in -5c° for 23 days obtained Crystals were separated. Obtained Crocin crystals from the first step had low purity and the pure crystals were yielded during the second crystallization. Extraction and purity of Crocin. Crystals were studied by UV-visible spectrophotometry and Fourier transform spectrometry and High Performance Liquid Chromatogram analysis compared to Crocin Sigma-Aldrich. Results shows that the extraction intensity and purity of the obtained Crocins were significantly higher (28.32 times). Measurement of color showed the color strength was more than sigma-Aldrich about 7.5 time. The results of this research showed that purchased Crocin according to the chromatograms is not pure and some unknown impurity were seen. Besides, Chromatogram spectra's shows that obtained Crocin crystals were in higher purity than purchased one. This information illustrated that this crocin because of high purity can be used as a reliable and valid standard.","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"196 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116362201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Tissue Distribution of Copper in Mice Following Exposure to Arsenic in Drinking Water 饮水中砷暴露后小鼠体内铜的组织分布

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2018-07-01 DOI: 10.18178/IJPMBS.7.3.63-66

Younghee Kim, Jiguk Kim, Kisok Kim

引用次数: 0

Safety and Efficacy Evaluation on Combination of Lansium domesticum Fruit Extract and Hibiscus rosa-sinensis Flower Extract as Lightening Agent for Cosmetic 家兰果提取物与芙蓉花提取物联合作化妆品亮白剂的安全性与有效性评价

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2018-07-01 DOI: 10.18178/ijpmbs.7.3.67-70

Kilala Tilaar, Maily Fransiska Devi Junardy Kilala Tilaar, E. Subroto, M. Maily, F. D. Junardy, D. Puspitosari

{"title":"Safety and Efficacy Evaluation on Combination of Lansium domesticum Fruit Extract and Hibiscus rosa-sinensis Flower Extract as Lightening Agent for Cosmetic","authors":"Kilala Tilaar, Maily Fransiska Devi Junardy Kilala Tilaar, E. Subroto, M. Maily, F. D. Junardy, D. Puspitosari","doi":"10.18178/ijpmbs.7.3.67-70","DOIUrl":"https://doi.org/10.18178/ijpmbs.7.3.67-70","url":null,"abstract":"This study was designed to investigate the potency of a combination of Lansium (Lansium domesticum) fruit extract and Hibiscus (Hibiscus rosa-sinensis) flower extract (LHE) as cosmetic active ingredient. The in vitro tyrosinase inhibition method was used to evaluate the potency of LHE in inhibit melanin production thus potential to delivered lightening benefits for skin. The result was confirmed by 4week in vivo lightening study on human skin. Prior to this in vivo efficacy study, safety evaluation was conducted using Single Closed Patch Test (SCPT) for skin and Hen's Egg Test – Chorioallantoic Membrane (HET-CAM) to evaluate the irritation at ocular level. LHE showed tyrosinase inhibition of 49.37%, which indicates that LHE has potency to be used as lightening active ingredients in cosmetics products. After 4 weeks of application in human skin, the efficacy test showed that LHE contained lotion base significantly increased skin moisture content and reduced its melanin index. Furthermore, safety evaluation of the lotion by SCPT and HET-CAM showed that it is safe for human skin and eyes. LHE is proven to be safe and effective as active ingredient in cosmetic.","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"174 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124283948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Human Gut Microbiome Analysis and Multi-omics Approach 人类肠道微生物组分析和多组学方法

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2018-07-01 DOI: 10.18178/ijpmbs.7.3.52-57

T. Sirangelo

{"title":"Human Gut Microbiome Analysis and Multi-omics Approach","authors":"T. Sirangelo","doi":"10.18178/ijpmbs.7.3.52-57","DOIUrl":"https://doi.org/10.18178/ijpmbs.7.3.52-57","url":null,"abstract":"Given the importance of human gut microbioma in human health, its role has been recently reviewed and even now is the subject of many investigations. It is known that traditional culture methods are limited for analyzing it and that high-throughput sequencing, omics technologies instead allow to deepen the behaviour of microbial ecology. With the application of omics technologies, as metagenomics, metascriptomics, metaproteomics and metabolomics, many progress has been made in this field. Their integration, referred to as multi-omics approach, provides more evidence for biological mechanisms. This review highlights that omics approaches can be powerful tools in analyzing the human gut microbiome. The current scenario and examples of recently published landmark work are discussed and some limitations are outlined. Their combination is analyzed and relevant studies allowing us to link the expression of disease-associated microbial functions to distinct taxa are treated. Furthermore, recent system level approaches for integrating different omics layers are discussed and some researches aimed to develop a framework for the reconstruction of a large microbial community are examined. However, even today, we are aware that the multi-layer datasets integration is a challenging issue and that a careful planning of a multiomics application is thus required.","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"200 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116153596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Efficacy of Peg-IFNα Anti-viral Treatment Were Evaluated by Variation of Peripheral Th17 Cells in Chronic Hepatitis C Patients 通过观察慢性丙型肝炎患者外周血Th17细胞的变化，评价Peg-IFNα抗病毒治疗的疗效

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2018-07-01 DOI: 10.18178/IJPMBS.7.3.58-62

Alex Xu

{"title":"The Efficacy of Peg-IFNα Anti-viral Treatment Were Evaluated by Variation of Peripheral Th17 Cells in Chronic Hepatitis C Patients","authors":"Alex Xu","doi":"10.18178/IJPMBS.7.3.58-62","DOIUrl":"https://doi.org/10.18178/IJPMBS.7.3.58-62","url":null,"abstract":"IL-17-producing T helper (Th17) cells have been shown to play an important role in many liver diseases. The aim of this study is to investigate changes in the frequency of Th17 cells in peripheral blood of chronic hepatitis C (CHC) patients. The Th17 frequencies of 36 chronic hepatitis C patients were compared with those of 20 normal controls. All samples were quantitatively analyzed by flow cytometer. Serum IL-17 levels were evaluated using the ELISA assay. There was a higher frequency of circulating Th17 cells and IL-17 levels in CHC patients than controls (3.46±1.53% and 2.05±0.88% for Th17 cells, 86.21±29.28 pg/ml and 58.05±14.17 pg/ml for IL-17 levels) (P < 0.01). There were no significant differences in Th17 frequency and IL-17 levels between the groups of CHC patients with HCV RNA genotype 1b and 2a. The percentage of circulating Th17 cells increased significantly, correlating positively with ALT and negatively with HCVRNA. After 4 weeks of pegIFNα-2a treatment, the patients who acquired rapid virological response (RVR) had a higher pretreatment Th17 frequency compared with that of patients without RVR. During the 24 weeks of treatment with peg-IFNα-2a, Th17 cell frequency increased during the initial 4 weeks, then subsequently declined. In conclusion, Th17 cells and IL-17 were significantly increased in CHC patients and they were a positive correlation with ALT but a negative correlation with HCV RNA. Results suggest that an increase in Th17 cells is associated with inflammatory liver damage and persistent infection of HCV. The characteristics of Th17 variation during peg-IFNα-2a treatment imply that Th17 cells may serve as potent immunological markers for evaluating the efficacy of peg-IFNα anti-viral treatment. ","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117228975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Suitability and Efficacy of Perioperative Antibiotics in Relation with the Surgical Wound after Appendectomy 阑尾切除术后围手术期抗生素应用的适宜性及疗效

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2016-10-01 DOI: 10.18178/ijpmbs.5.4.222-226

E. Amelia, Bambang Arianto, A. Purnamayanti

{"title":"The Suitability and Efficacy of Perioperative Antibiotics in Relation with the Surgical Wound after Appendectomy","authors":"E. Amelia, Bambang Arianto, A. Purnamayanti","doi":"10.18178/ijpmbs.5.4.222-226","DOIUrl":"https://doi.org/10.18178/ijpmbs.5.4.222-226","url":null,"abstract":"There is no research currently exist about the use \u0000of ceftriaxone as perioverative antibiotics for appendicitis \u0000patient in Haji General Hospital Surabaya, so its \u0000relationship with the surgical wound after appendectomy is \u0000remain unknown. This research is conducted to determine \u0000the suitability and efficacy of ceftriaxone, also to identify \u0000other factors that influence the surgical wound. This was a \u0000prospective cohort study of 25 patients (a \u0000ge ≥ 15 years old) \u0000between June \u0000– \u0000August 2015. The specimens culture \u0000demonstrated that 12 bacteria were E. coli, 1 ESBL- \u0000producing E. coli and 12 negative. Antibiotics susceptibility \u0000testing showed that 41,67% E. coli was susceptible to \u0000ceftriaxone. There was no significant relationship between \u0000suitability of postoperative antibiotics and surgical wound \u0000after appendectomy in non-perforated cases (p=0,505), \u0000while perforated case defined a significant relationship \u0000(p=0,011). The factors which significantly related with \u0000surgical wound were gender (p=0,014) and duration of \u0000surgery (p=0,017). Ceftriaxone was still effective as \u0000perioperative antibiotics. Postoperative antibiotics were \u0000only required for perforated appendicitis, whereas \u0000prophylactic antibiotic was known to be adequate in the \u0000case of non-perforated.","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"293 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130984049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antiimmunotoxic of Black Cumin Seed Oil (Nigella sativa Oil) in DMBA (Dimethylbenzantracene)-Induced Mice 黑孜然籽油(Nigella sativa Oil)对二甲苯诱导小鼠的抗免疫毒性研究

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2015-07-01 DOI: 10.18178/IJPMBS.4.3.171-174

T. Hidayati, I. Habib, A. Akrom

{"title":"Antiimmunotoxic of Black Cumin Seed Oil (Nigella sativa Oil) in DMBA (Dimethylbenzantracene)-Induced Mice","authors":"T. Hidayati, I. Habib, A. Akrom","doi":"10.18178/IJPMBS.4.3.171-174","DOIUrl":"https://doi.org/10.18178/IJPMBS.4.3.171-174","url":null,"abstract":"A single and repeated doses of DMBA are toxic to immune system. Black cumin seed oil (BCSO) is immunoprotector agent. A study was performed to identify antiimmunitoxicity effects of BCSO on DMBA-induced SD mice. This study was conducted with an experimental design with BCSO administration group and a normal control group. DMBA induction was administered by two methods: a single dose of 15mg/mouse per oral (DMBA15group), and repeated doses of 10 × 20mg/kgb twice/week for 5 weeks (DMBA20/group). Normal control was a non-DMBAinduced group while diseased groups were DMBA-induced groups, DMBA15 and DMBA20. Treatment groups were DMBA 15 and DMBA 20 which were given 0.25ml/kgBCSO 14 days before and during DMBA induction (DMBA15BCSO and DMBA20BCSO groups. Observation was carried out on peripheral blood, spleen histological description and spleen weight, CD4 and CD4CD25 lymphocyte counts. Results showed that the single and repeated doses of DMBA in SD mice are immunosuppressive and hematotoxic. The administration of 0.25ml/kgbwBCSO can decrease the immunosuppressive and hematotoxic effects of DMBA. The number of leukocyte and CD4Th in the treatment groups was higher than the diseased group (p < 0.05). Conclusion: BCSO is the antihematotoxic immunoprotector for diseased groups.","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129812733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Tumor Volume Determination Technique Using Pixel Filling and Discrete Integral Function 基于像素填充和离散积分函数的肿瘤体积测定技术

International Journal of Pharma Medicine and Biological Sciences Pub Date : 2015-07-01 DOI: 10.18178/ijpmbs.4.3.188-191

A. Aboaba, S. Hameed, O. Khalifa, A. H. Hashim, N. R. M. Zain

引用次数: 0

Brief Counseling and Mobile Phone Short Message Service (SMS) Increase Patient Compliance 简短的咨询和手机短信服务(SMS)增加患者的依从性

International Journal of Pharma Medicine and Biological Sciences Pub Date : 1900-01-01 DOI: 10.18178/ijpmbs.4.3.175-179

A. Akrom, A. Nurwijayanti

{"title":"Brief Counseling and Mobile Phone Short Message Service (SMS) Increase Patient Compliance","authors":"A. Akrom, A. Nurwijayanti","doi":"10.18178/ijpmbs.4.3.175-179","DOIUrl":"https://doi.org/10.18178/ijpmbs.4.3.175-179","url":null,"abstract":"Abstract—Chronic Obstructive Pulmonary Disease (COPD) \u0000is a chronic inflammatory lung disease that is irreversible \u0000and progressive. One of the factors that plays a role in the \u0000success of COPD disease control is compliance in taking the \u0000drug. This research aimed to know the effect of SMS and \u0000brief counseling on compliance level in COPD outpatient at \u0000Pulmonary special Hospital in Bantul Yogyakarta. The \u0000research was conducted between the December 2014 and \u0000January 2015. This research used experimental study with \u0000pre and post controlled group design. There were 33 \u0000patients for each group. The intervention group received \u0000SMS and brief counseling, while the control group received \u0000standard care. The level of compliance data was collected \u0000based on interviews using Morisky Medication Adherence \u0000Scale (MMAS) questionnaire. The results showed that from \u000066 patients, 49 patients (72.2%) had a high level of compliance, 12 patients (18.2%) a moderate compliance and \u00005 patients (7.6%) a low compliance. MMAS analysis results \u0000showed that there was significant difference p = 0.000 ( 0.05). SMS and brief counseling in patients with COPD effectively enhanced the patient's compliance.","PeriodicalId":281523,"journal":{"name":"International Journal of Pharma Medicine and Biological Sciences","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116973521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7