Chemistry and Physics of Lipids最新文献

{"title":"The influence of Leucidal – eco-preservative from radish – on model lipid membranes and selected pathogenic bacteria","authors":"Beata Wyżga ,&nbsp;Magdalena Skóra ,&nbsp;Katarzyna Hąc-Wydro","doi":"10.1016/j.chemphyslip.2023.105338","DOIUrl":"10.1016/j.chemphyslip.2023.105338","url":null,"abstract":"<div><p>In this work the effect of Leucidal - a natural preservative from radish dedicated to be used in cosmetics - on bacteria cells and model bacteria membranes was investigated. To get insight into the mechanism of action of this formulation the lipid Langmuir monolayers imitating <em>Escherichia coli</em> (<em>E. coli</em>) and <em>Staphylococcus aureus</em> (<em>S. aureus</em>) membranes were prepared. Then, the influence of Leucidal on model systems was investigated by means of the surface pressure/area measurements, penetration studies and Brewster Angle Microscopy (BAM) visualization. Similar experiments were done also for one component monolayers formed from the model membrane lipids. The in vitro tests were done on five different bacteria species (<em>E. coli, Enterococcus faecalis, S. aureus, Salmonella enterica, Pseudomonas aeruginosa</em>). Leucidal was found to decrease packing of the monolayers, however, it was excluded from the films at higher concentrations. Model membrane experiments evidenced also a stronger affinity of the components of this eco-preservative to <em>E. coli</em> vs <em>S. aureus</em> membrane. Among one component films, those formed from phosphatidylglycerols and cardiolipins were more sensitive to the presence of Leucidal. However, in vitro tests evidenced that Leucidal exerts stronger inhibitory effect against <em>S. aureus</em> bacteria as compared to <em>E. coli</em> strain. These findings were discussed from the point of view of the role of Leucidal components and the lipid membrane properties in the membrane - based mechanism of action of this preservative. The results allow one to suggest that the membrane may not be the main site of action of Leucidal on bacteria. Moreover, since high concentration of the tested preparation exerted antibacterial activity in relation to all tested bacteria, a low selectivity of Leucidal can be postulated, which may be problematic from the point of view of its effect on the skin microbiome.</p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"256 ","pages":"Article 105338"},"PeriodicalIF":3.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0009308423000609/pdfft?md5=baed64a17ac71d98e0ded7f957fbc620&pid=1-s2.0-S0009308423000609-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10272437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ionic liquids on biomembranes: A review on recent biophysical studies","authors":"Saheli Mitra ,&nbsp;Veerendra K. Sharma ,&nbsp;Sajal K. Ghosh","doi":"10.1016/j.chemphyslip.2023.105336","DOIUrl":"10.1016/j.chemphyslip.2023.105336","url":null,"abstract":"<div><p>Ionic liquids<span><span><span> (ILs) have been emerged as a versatile class of compounds that can be easily tuned to achieve desirable properties for various applications. The ability of ILs to interact with biomembranes has attracted significant interest, as they have been shown to modulate membrane properties in ways that may have implications for various </span>biological processes. This review provides an overview of recent studies that have investigated the interaction between ILs and biomembranes. We discuss the effects of ILs on the physical and chemical properties of biomembranes, including changes in membrane </span>fluidity<span>, permeability, and stability. We also explore the mechanisms underlying the interaction of ILs with biomembranes, such as electrostatic interactions<span>, hydrogen bonding<span>, and van der Waals forces. Additionally, we discuss the future prospects of this field.</span></span></span></span></p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"256 ","pages":"Article 105336"},"PeriodicalIF":3.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10100354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-plane and out-of-plane gigahertz sound velocities of saturated and unsaturated phospholipid bilayers from cryogenic to room temperatures","authors":"E.A. Dobrynina,&nbsp;V.A. Zykova,&nbsp;N.V. Surovtsev","doi":"10.1016/j.chemphyslip.2023.105335","DOIUrl":"10.1016/j.chemphyslip.2023.105335","url":null,"abstract":"<div><p><span><span>Here, we examined the gigahertz sound velocities of hydrated multibilayers of saturated (1,2-dimyristoyl-sn-glycero-3-phosphocholine, DMPC) and unsaturated (1,2-dioleoyl-sn-glycero-3-phosphocholine, DOPC) </span>phospholipids<span> by Brillouin spectroscopy. Out-of-plane and in-plane (lateral) phonons were studied independently of each other. Similar strong temperature dependences of the sound velocities were found for phonons of both types. The sound velocities in the low-temperature limit were two-fold higher than that at physiological temperatures; a significant part of the changes in sound velocity occurs in the solid-like gel phase. The factors that may be involved in the peculiar behavior of sound velocity include changes in the chain conformational state, relaxation susceptibility, changes in the </span></span>elastic modulus at infinite frequencies, and lateral packing of molecules.</p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"256 ","pages":"Article 105335"},"PeriodicalIF":3.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10072391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Raman imaging and chemometric methods in human normal bronchial and cancer lung cells: Raman biomarkers of lipid reprogramming","authors":"Monika Kopec,&nbsp;Karolina Beton-Mysur,&nbsp;Halina Abramczyk","doi":"10.1016/j.chemphyslip.2023.105339","DOIUrl":"https://doi.org/10.1016/j.chemphyslip.2023.105339","url":null,"abstract":"<div><p>This paper presents an approach to study biochemical changes in human normal bronchial cells (BEpiC) and human cancer lung cells (A549) by Raman spectroscopy and Raman imaging combined with chemometric methods. Based on Raman spectra and Raman imaging combined with chemometric methods we have proved that peaks at 845 cm⁻¹, 2845 cm⁻¹, 2936 cm⁻¹, 1444 cm⁻¹, 750 cm⁻¹, 1126 cm⁻¹, 1584 cm⁻¹, can be treated as Raman biomarkers probing phosphorylation, lipid reprogramming, oxidative phosphorylation and changes in cholesterol and cytochrome in normal and cancer cells. Raman analysis of the bands at 845 cm⁻¹, 2845 cm⁻¹, 1444 cm⁻¹, and 1126 cm⁻¹ in human cancer lung cells and human normal bronchial cells demonstrate enhanced phosphorylation and triglycerides <em>de novo</em> synthesis, reduced levels of cholesterol and cytochrome <em>c</em> in cancer cells. The sensitivity is equal to 100% (nucleus), 87.5% (mitochondria), 100% (endoplasmic reticulum), 87.5% (lipid droplets), 87.5% (cytoplasm), 87.5% (cell membrane) for A549 cell line and 83.3% (nucleus), 100% (mitochondria), 83.3% (endoplasmic reticulum), 100% (lipid droplets), 100% (cytoplasm), 83.3% (cell membrane) for BEpiC. The values of specificity for cross-validation equal 93.4% (nucleus), 85.5% (mitochondria), 89.5% (endoplasmic reticulum), 90.8% (lipid droplets), 61.8% (cytoplasm), 94.7% (cell membrane) for A549 cell line and 88.5% (nucleus), 85.9% (mitochondria), 85.9% (endoplasmic reticulum), 97.4% (lipid droplets), 75.6% (cytoplasm), 92.3% (cell membrane) for BEpiC. We have confirmed that Raman spectroscopy methods combined with PLS-DA are useful tools to monitor changes in human cancer lung cells and human normal bronchial cells.</p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"257 ","pages":"Article 105339"},"PeriodicalIF":3.4,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41080907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of amphiphilic carbosilane dendrons on lipid model membranes","authors":"Dominika Wrobel ,&nbsp;Antonin Edr ,&nbsp;Eliska Zemanova ,&nbsp;Tomáš Strašák ,&nbsp;Alena Semeradtova ,&nbsp;Jan Maly","doi":"10.1016/j.chemphyslip.2023.105314","DOIUrl":"10.1016/j.chemphyslip.2023.105314","url":null,"abstract":"<div><p><span>Amphiphilic dendrons represent a relatively novel class of molecules which may show many unique properties suitable for applications in a field of molecular biology and </span>nanomedicine<span><span>. They were frequently studied as platforms suitable for drug delivery systems as were, e.g. polymersomes or hybrid lipid-polymer nanoparticles. Recently, natural extracellular </span>lipid vesicles<span> (EVs), called exosomes (EXs), were shown to be a promising candidate in drug delivery applications. Formation of hybrid exosome-dendron nanovesicles could bring benefits in their simple conjugation with selective targeting moieties. Unfortunately, the complex architecture of biological membranes, EXs included, makes obstacles in elucidating the important parameters and mechanisms of interaction with the artificial amphiphilic structures.</span></span></p><p><span>The aim of the presented work was to study the interaction of two types of amphiphilic carbosilane dendritic structures (denoted as DDN-1 and DDN-2) suitable for further modification with streptavidin<span> (DDN-1) or using click-chemistry approach (DDN-2), with selected neutral and negatively charged lipid<span> model membranes<span>, partially mimicking the basic properties of natural EXs biomembranes. To meet the goal, a number of biophysical methods<span> were used for determination of the degree and mechanisms of the interaction. The results showed that the strength of interactions of amphiphilic dendrons with liposomes was related with surface charge of liposomes. Several steps of interactions were disclosed. The initialization step was mainly coupled with amphiphilic dendrons - liposomes surface interaction resulting in destabilization of large self-assembled amphiphilic dendrons structures. Such destabilization was more significant with liposomes of higher negative charge. With increasing concentration of amphiphilic dendrons in a solution the interactions were taking place also in the hydrophobic part of bilayer. Further increase of nanoparticle concentration resulted in a gradual dendritic cluster formation in a </span></span></span></span></span>lipid bilayer structure.</p><p>Due to high affinity of amphiphilic dendrons to model lipid bilayers the conclusion can be drawn that they represent promising platforms also for decoration of exosomes or other kinds of natural lipid vehicles. Such organized hybrid dendron-lipid biomembranes may be advantageous for their subsequent post-functionalization with small molecules, large biomacromolecules or polymers suitable for targeted drug-delivery or theranostic applications.</p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"255 ","pages":"Article 105314"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10205000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solubilization of biomimetic lipid mixtures by some commonly used non-ionic detergents","authors":"Amanda C. Caritá ,&nbsp;Rafaela R.M. Cavalcanti,&nbsp;Mariana S.S. Oliveira,&nbsp;Karin A. Riske","doi":"10.1016/j.chemphyslip.2023.105327","DOIUrl":"10.1016/j.chemphyslip.2023.105327","url":null,"abstract":"<div><p><span><span>Detergents are amphiphilic molecules often used to solubilize biological membranes<span> and separate their components. Here we investigate the solubilization of </span></span>lipid vesicles by the commonly used non-ionic detergents polyoxyethylene (20) oleyl ether (Brij 98), n-octyl-β-</span><span>D</span><span><span>-glucoside (OG), and n-dodecyl β-D maltoside<span><span> (DDM) and compare the results with the standard detergent Triton X-100 (TX-100). The vesicles were composed of palmitoyl oleoyl phosphatidylcholine<span> (POPC) or of a biomimetic<span> ternary mixture of POPC, egg </span></span></span>sphingomyelin<span> (SM) and cholesterol (2:1:2 molar ratio). To follow the solubilization profile of large unilamellar vesicles (LUVs), 90° light scattering measurements were done along the titration of LUVs with the detergents. Then, giant unilamellar vesicles (GUVs) were observed with </span></span></span>optical microscopy<span> during exposure to the detergents, to allow direct visualization of the solubilization process. Isothermal titration calorimetry<span> (ITC) was used to assess the binding constant<span> of the detergents in POPC bilayers<span>. The results show that the incorporation of TX-100, Brij 98 and, to a lesser extent, OG in the pure POPC liposomes leads to an increase in the vesicle area, which indicates their ability to redistribute between the two leaflets of the membrane in a short scale of time. On the other hand, DDM incorporates mainly in the external leaflet causing an increase in vesicle curvature/tension leading ultimately to vesicle burst. Only TX-100 and OG were able to completely solubilize the POPC vesicles, whereas the biomimetic ternary mixture was partially insoluble in all detergents tested. TX-100 and OG were able to incorporate in the bilayer of the ternary mixture and induce macroscopic phase separation of liquid-ordered (</span></span></span></span></span><em>Lo</em>) and liquid-disordered (<em>Ld</em><span>) domains, with selective solubilization of the latter. Combination of ITC data with turbidity results showed that TX-100 and OG can be incorporated up to almost 0.3 detergent/lipid, significantly more than Brij 98 and DDM. This fact seems to be directly related to their higher capacity to solubilize POPC membranes and their ability to induce macroscopic phase separation in the biomimetic lipid mixture.</span></p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"255 ","pages":"Article 105327"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9986853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transethosome: An ultra-deformable ethanolic vesicle for enhanced transdermal drug delivery","authors":"Alan Raj ,&nbsp;Kamal Dua ,&nbsp;Rajesh Sreedharan Nair ,&nbsp;C. Sarath Chandran ,&nbsp;Angel Treasa Alex","doi":"10.1016/j.chemphyslip.2023.105315","DOIUrl":"10.1016/j.chemphyslip.2023.105315","url":null,"abstract":"<div><p><span>Drug delivery through the skin improves solubility, bioavailability, and unwanted systemic side effects of the drug. The selection of a suitable carrier is a challenging process. The conventional lipid vesicles<span> have some limitations. They deliver the drug in the stratum corneum and have poor colloidal stability. Here comes the need for ultra-deformable lipid vesicles to provide the drug beyond the stratum corneum. Transethosomes are novel ultra-deformable vesicles that can deliver drugs into deeper tissues. The composition of transethosomes includes </span></span>phospholipid, ethanol and surfactants. Each ingredient has a pivotal role in the properties of the carrier. This review covers the design, preparation method, characterisation, and characteristics of the novel vesicle. Also, we cover the impact of surfactants on vesicular properties and the skin permeation behaviour of novel vesicles.</p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"255 ","pages":"Article 105315"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10204998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membrane lipid composition of Carnobacterium maltaromaticum CNCM I-3298, a highly cryoresistant lactic bacterium","authors":"HP. Ta ,&nbsp;C. Clarisse ,&nbsp;E. Maes ,&nbsp;N. Yamakawa ,&nbsp;Y. Guérardel ,&nbsp;F. Krzewinski ,&nbsp;W. Zarzycka ,&nbsp;D. Touboul ,&nbsp;A. Girardeau ,&nbsp;F. Fonseca ,&nbsp;A. Kermarrec ,&nbsp;M. Viau ,&nbsp;A. Riaublanc ,&nbsp;MH. Ropers","doi":"10.1016/j.chemphyslip.2023.105326","DOIUrl":"10.1016/j.chemphyslip.2023.105326","url":null,"abstract":"<div><p><span>The growing consumption of fermented products has led to an increasing demand for lactic acid bacteria (LAB), especially for LAB tolerant to freezing/thawing conditions. </span><span><em>Carnobacterium</em><em> maltaromaticum</em></span><span><span> is a psychrotrophic and freeze-thawing resistant lactic acid bacterium. The membrane is the primary site of damage during the cryo-preservation process and requires modulation to improve cryoresistance. However, knowledge about the membrane structure of this LAB genus is limited. We presented here the first study of the membrane </span>lipid<span> composition of </span></span><em>C. maltaromaticum</em><span><span> CNCM I-3298 including the polar heads and the fatty acid compositions of each lipid family (neutral lipids, glycolipids, phospholipids). The strain CNCM I-3298 is principally composed of glycolipids (32%) and </span>phospholipids<span> (55%). About 95% of glycolipids are dihexaosyldiglycerides while less than 5% are monohexaosyldiglycerides. The disaccharide chain of dihexaosyldiglycerides is composed of α-Gal(1−2)-α-Glc chain, evidenced for the first time in a LAB strain other than </span></span><span><em>Lactobacillus</em></span><span> strains. Phosphatidylglycerol is the main phospholipid (94%). All polar lipids are exceptionally rich in C18:1 (from 70% to 80%). Regarding the fatty acid composition, </span><em>C. maltaromaticum</em> CNCM I-3298 is an atypical bacterium within the genus <em>Carnobacterium</em> due to its high C18:1 proportion but resemble the other <em>Carnobacterium</em><span> strains as they mostly do not contain cyclic fatty acids.</span></p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"255 ","pages":"Article 105326"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10205021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in regulating lipid metabolism to prevent coronary heart disease","authors":"Jingchun Du ,&nbsp;Wei Wu ,&nbsp;Boran Zhu ,&nbsp;Weiwei Tao ,&nbsp;Lina Liu ,&nbsp;Xiaolan Cheng ,&nbsp;Min Zhao ,&nbsp;Jibiao Wu ,&nbsp;Yunlun Li ,&nbsp;Ke Pei","doi":"10.1016/j.chemphyslip.2023.105325","DOIUrl":"10.1016/j.chemphyslip.2023.105325","url":null,"abstract":"<div><p><span><span>The pathogenesis of coronary heart disease is a highly complex process, with lipid metabolism disorders being closely linked to its development. Therefore, this paper analyzes the various factors that influence lipid metabolism, including obesity, genes, </span>intestinal microflora<span>, and ferroptosis, through a comprehensive review of basic and clinical studies. Additionally, this paper delves deeply into the pathways and patterns of coronary heart disease. Based on these findings, it proposes various intervention pathways and therapeutic methods, such as the regulation of </span></span>lipoprotein<span> enzymes, lipid metabolites, and lipoprotein regulatory factors, as well as the modulation of intestinal microflora and the inhibition of ferroptosis. Ultimately, this paper aims to offer new ideas for the prevention and treatment of coronary heart disease.</span></p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"255 ","pages":"Article 105325"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10502958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of conformational states of POPC and DPPCd62 in POPC/DPPCd62/cholesterol mixtures using Raman spectroscopy","authors":"Yu.V. Zaytseva,&nbsp;I.V. Zaytseva,&nbsp;N.V. Surovtsev","doi":"10.1016/j.chemphyslip.2023.105337","DOIUrl":"https://doi.org/10.1016/j.chemphyslip.2023.105337","url":null,"abstract":"<div><p><span>Conformational states of phospholipid<span> chains in ternary mixtures of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), deuterated 1,2-dipalmitoyl-d62-sn-glycero-3-phosphocholine (DPPC</span></span>_d62<span>), and cholesterol (Chol) were studied by Raman spectroscopy<span>. Parameters of Raman peaks sensitive to conformational order have been used to determine chain order for mixtures over a wide range of compositions. A ternary diagram of fractions of phospholipid chains in conformationally ordered and disordered states has been constructed. It was found that the addition of POPC and cholesterol increases the fraction of DPPC chains in disordered conformations. The so-called liquid-ordered phase includes DPPC molecules in both ordered and disordered states in comparable proportions. It was found that POPC chains are partially ordered in mixtures with DPPC and cholesterol, in contrast to the case of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC). This maybe the underlying reason why ternary mixtures with POPC have different miscibility behavior compared to DOPC.</span></span></p></div>","PeriodicalId":275,"journal":{"name":"Chemistry and Physics of Lipids","volume":"256 ","pages":"Article 105337"},"PeriodicalIF":3.4,"publicationDate":"2023-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3273686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}