Russian Journal of Allergy最新文献

{"title":"Modern possibilities of allergy diagnostics in real clinical practice","authors":"G. A. Novik, O. B. Tamrazova, M. V. Zhdanova, A. V. Tamrazova, Olga I. Filimonova","doi":"10.36691/rja16937","DOIUrl":"https://doi.org/10.36691/rja16937","url":null,"abstract":"More than 20% of people worldwide suffer from allergic diseases. The high prevalence and wide range of provoking factors complicate the diagnostic search, which leads, on the one hand, to inadequately extensive dietary and regimen restrictions that reduce the quality of life of patients, and on the other hand, to the failure to identify life-threatening allergens. The article discusses modern laboratory methods for diagnosing allergic diseases, including the latest multicomponent methods. Clinical examples are also presented demonstrating the effectiveness of diagnosis and selection of patient management tactics using the ALEX 2 test system","PeriodicalId":270411,"journal":{"name":"Russian Journal of Allergy","volume":"15 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141272011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent with severe atopic dermatitis and comorbid joit disease: remission achievement by selective JAK1-inhibitor treatment","authors":"A. Kamaev, O. V. Trusova","doi":"10.36691/rja16946","DOIUrl":"https://doi.org/10.36691/rja16946","url":null,"abstract":"Atopic dermatitis is a heterogenous in terms of inflammatory pathways and severity prognosis skin disease. Some patients demonstrate severe recurrent course of the disease which do not respond on standard topical anti-inflammatory preparations. Comorbid diseases (not only atopic ones) could serve additional factors complicating atopic dermatitis control achievement. The adolescent patient (well-known for low adherence to topical treatment) could become a special difficulty in clinical management. A clinical case of successful systemic therapy (upadacitinib 15mg QD) of severe atopic dermatitis patient comorbid with immunologically-driven joint disease presented. Previous topical treatment of atopic dermatitis was inefficient. Effectiveness (indexes SCORAD and DLQI, digital itch scale) and safety (laboratory data and complains) were evaluated for more than 1 year (15 months) of therapy. Rapid and sustain positive changes in course control of atopic dermatitis with possible T2-associated and other inflammatory mediators were demonstrated.","PeriodicalId":270411,"journal":{"name":"Russian Journal of Allergy","volume":"62 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141102006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activated zinc pyrithione in topical treatment of atopic dermatitis. Clinical cases.","authors":"Alla O. Litovkina, Evgeniy V. Smolnikov, Olga G. Elisyutina, Elena S. Fedenko","doi":"10.36691/rja16947","DOIUrl":"https://doi.org/10.36691/rja16947","url":null,"abstract":"Atopic dermatitis (AD) is a systemic multifactorial genetically determined inflammatory skin condition characterized by an impairment of the epidermal barrier and Type 2 inflammation. AD is highly prevalent, especially among children. Many authors consider AD as the initial stage of the atopic march, which typically manifests in the first year of life. Topical agents such as topical glucocorticosteroids (TCS) and topical calcineurin inhibitors (TCIs) are the first-line treatments for AD. In recent years, there has been an increasing use of modern systemic anti-inflammatory agents, such as monoclonal antibodies and Janus kinase inhibitors. \u0000Modern TCS and their combinations, have a proven high safety profile. However, available data on adverse events associated with their use often lead patients and their parents to develop a negative, phobic attitude towards treatment with these drugs. Zinc pyrithione, an activated form of zinc, is a safe and highly effective medication with anti-inflammatory, antifungal, and antibacterial properties. \u0000This article presents two clinical cases of moderate to severe ad in children, demonstrating the effectiveness of using activated zinc pyrithione in comprehensive therapy for this condition.","PeriodicalId":270411,"journal":{"name":"Russian Journal of Allergy","volume":"44 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141103809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FEATURES OF SENSITIZATION IN PATIENTS WITH ALOPECIA AREATA, ASSOCIATED WITH ATOPIC DISEASES","authors":"G. Tereshchenko","doi":"10.36691/rja16904","DOIUrl":"https://doi.org/10.36691/rja16904","url":null,"abstract":"BACKGROUND: Association of alopecia areata (AA) and atopic diseases (AD) has been confirmed in clinical, epidemiologic, genetic and immunologic studies. The study of sensitization and AD structure in AA-patients makes it possible to develop atopy screening and suggest additional treatment options for AA. \u0000AIMS: To determine the sensitization spectrum and AD structure in patients with AA considering the age and clinical form of alopecia. \u0000MATERIALS AND METHODS: A comparative uncontrolled study was conducted. The data of 162 patients 5 - 51 years with AA, atopic dermatitis, asthma, allergic rhinitis/rhinoconjuctivitis for the period from April 2022 to May 2023 were used. The nature of sensitization and the structure of AD were analyzed. Clinical forms of AA were assessed by the hair-loss area. \u0000RESULTS: The patients were divided according to AA-status: the first group included 54 AA-patients with AD, the second (comparison group) - 108 atopic patients without AA. Subgroups were formed according to age: in group 1 - 31 (57%) were children (5 - 17 y.o.), 23 (43%) - adults 18 years and older; in group 2 – 58 (54%) and 50 (46%) children and adults, respectively. \u0000Among AA-patients seasonal pollen sensitization prevailed (22/54 people); polyvalent sensitization was observed in 13/54 people, 6 of whom had severe forms of AA, 6 - ophiasis. Comparison of the sensitization spectrum between the groups revealed no differences. In group of adult AA-patients isolated respiratory allergies were significantly less frequent (OR 0.21; CI [0.07- 0.60], p=0.004), but combined AD were more frequently observed (OR 4.71; CI [1.43-15.58], p=0.012). Most patients with severe AA were children (8/12) with polyvalent sensitization and respiratory and combined AD. \u0000CONCLUSIONS: The comorbidity of AA and atopy is manifested by an increased incidence of severe alopecia in childhood and a tendency to progression of allergic inflammation, realized in the form of combined AD. The spectrum of sensitization in patients with and without AA does not differ and characterized by the predominance of the most common allergens (plant pollen). These results indicate the need for timely atopy detection and desensitization therapy in AA-patients, especially with early onset and active disease.","PeriodicalId":270411,"journal":{"name":"Russian Journal of Allergy","volume":"72 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141113902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPERIENCE OF LANADELUMAB USAGE FOR LONG-TERM PROPHYLAXIS OF ATTACKS IN HEREDITARY ANGIOEDEMA IN PATIENTS OF THE MOSCOW REGION","authors":"E. V. Proskurina, Natalya V. Morozova, Konstantin A. Kokushkin","doi":"10.36691/rja16913","DOIUrl":"https://doi.org/10.36691/rja16913","url":null,"abstract":"BACKGROUND: Hereditary angioedema (HAE) is a rare disease with high frequency for orphan diseases. The autosomal dominant type of inheritance leads to a significant number of affected patients in families. Angioedema attacks significantly impair the quality of life. HAE causes life-threatening conditions which depend on edema’s localization.AIM: To evaluate the efficacy and safety of lanadelumab for long-term prophylaxis in HAE in routine practice.MATERIALS AND METHODS: 16 patients with HAE were enrolled in the observational single-center study. The data were researched: sex, patients age, age of symptoms onset, efficacy of previous methods of therapy, type of HAE, genetics of the disease, contraindications for other prophylaxis methods.The efficacy of therapy was evaluated according to the duration of the course, the frequency of administration, the number of attacks of edema during the period of observation, and the improvement of the quality of life according to the AAS28 scale. Safety of use was evaluated by the presence of adverse events during the investigation. RESULTS: The long-term prophylaxis with lanadelumab was effectively and safety for all of 16 patients. Single attacks during of therapy were provoked by the influence of significant triggers. Life-threatening attacks were not registered. The frequency of lanadelumab injections was reduced after 12 months of usage for 50% of patients. The improvement of the quality of life (from 6 to 38 according to AAS28 scale) was confirmed for all patients. Adverse events weren’t registered during the period of treatment.CONCLUSION: The long-term prophylaxis of edema in HAE with lanadelumab usage was approved as efficiently and safety.","PeriodicalId":270411,"journal":{"name":"Russian Journal of Allergy","volume":"50 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141113355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of Bruton's tyrosine kinase in pathogenesis of chronic spontaneous urticaria and the prospects for the use of new treatment.","authors":"E. Fedenko, O. Elisyutina, N. Ilina","doi":"10.36691/rja16941","DOIUrl":"https://doi.org/10.36691/rja16941","url":null,"abstract":"Chronic spontaneous urticaria is a fairly common disease with an unpredictable course, burdensome symptoms and a significant negative impact on patients` quality of life. Despite the established stepwise approach to treatment with antihistamines in standard and increased dosages, anti-IgE therapy, there remains a portion of patients with unsatisfactory control of urticaria symptoms, with the need to develop drugs that target new therapeutic targets. Mast cells, basophils and B cells are key cells involved in the pathogenesis of urticaria; activation, differentiation, proliferation, cytokine secretion and degranulation in all three types of cells is regulated via Bruton's tyrosine kinase signalling pathway through FcεRI and BCR receptors respectively. Inhibition of Bruton's tyrosine kinase is being developed as a new therapeutic strategy for chronic spontaneous urticaria. Here we present overview of the current understanding of chronic spontaneous urticarial`s pathogenesis, the role of Bruton's tyrosine kinase, the history of medical use of Bruton's tyrosine kinase inhibitors, as well as clinical data on the use of new Bruton's tyrosine kinase inhibitors in patients with chronic spontaneous urticaria who have not achieved adequate disease control with antihistamines.","PeriodicalId":270411,"journal":{"name":"Russian Journal of Allergy","volume":"16 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141122378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causes and clinical symptoms of anaphylactic reactions in children: experience of the first «Pediatric Moscow Anaphylaxis Registry» in the Russian Federation","authors":"Alexander Pampura, N. Esakova, Sergey Zimin, Ekaterina Кovtun, Yanina Kara, Elena Busova, Zareta Bzhekshieva, Marina Leonteva, Egor Konovalov, Stanislav Lushnikov, Irina Vitkovskaya, Valery Gorev","doi":"10.36691/rja16907","DOIUrl":"https://doi.org/10.36691/rja16907","url":null,"abstract":"BACKGROUND: In Russian, there was a problem of the lack of registry of anaphylaxis, as the most important tool for monitoring this group of patients. Since 2022, the first \"Pediatric Moscow Anaphylaxis Registry\" has started working at the Morozov Children's Hospital. \u0000AIMS: Analysis of data from the Pediatric Moscow Anaphylaxis Registry to determine frequency, causes andclinical characteristics of anaphylaxis among children of the Moscow region. \u0000MATERIALS AND METHODS: Statistical analysis of the questionnaire data of 69 children aged 0-18, who were prospectively included in the Register during emergency hospitalization due to anaphylaxis, was carried out. \u0000RESULTS: The incidence of anaphylaxis among children hospitalized with acute allergic reactions from May 2022 to September 2023 was 5.8%. Higher percentage of anaphylaxis (38%) were observed among adolescents aged 13-18, three patients developed anaphylaxis in the first year of life (minimum age 1 month). Boys (70%) prevailed among patients under the age of 13, and girls (56%) prevailed among adolescents aged 13-18 (p=0.042). 75% anaphylaxis developed at home. \u0000Food anaphylaxis was dominant (75%-91%). Tree nuts were the most common trigger of food anaphylaxis – 35%, and confectionery products - 17%. 56% of children experienced symptoms from 4 or more organ systems, the most common symptoms were: skin/mucous (94%), respiratory (78%) and laryngeal symptoms (64%). Emergency care, diagnosed anaphylaxis in 22%, administration of epinephrine was 54%. The frequency of epinephrine use among children under 3 years was lower compared to adolescents aged 13-18 (25% vs 76%, p=0.003). \u0000CONCLUSIONS:Data from the \"Pediatric Moscow Register of Anaphylaxis\" showed a high incidence of anaphylaxis among patients with acute allergic reactions. More than 1/3 of anaphylaxis occurs in adolescents aged 13-18 years, anaphylaxis occurs in the first month of life. Most often, anaphylaxis occurs at home, which requires training patients to eliminate the trigger. The dominant cause of anaphylaxis in children in the Russian, regardless of age, are food allergens, tree nuts induce food anaphylaxis in more than 1/3 of cases. The emergency care diagnoses anaphylaxis in 22% of cases, epinephrine is administered in 54%, minimal use of epinephrine was among children under 3 years of age.","PeriodicalId":270411,"journal":{"name":"Russian Journal of Allergy","volume":"127 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of the formation of early immunological tolerance during immunotherapy with allergens in patients with allergic rhinitis.","authors":"Daria A. Volkova, Gulnara R Bikchantaeva, A. V. Luntsov, O. A. Bareycheva, Nailya N Umarova, O. Skorokhodkina","doi":"10.36691/rja16932","DOIUrl":"https://doi.org/10.36691/rja16932","url":null,"abstract":"Background: The effectiveness of AIT has been proven in studies. Studying the level and expanded spectrum of Th1, Th2, Treg and Breg cytokines against the background of AIT, as well as asIgG4, is promising, which will clarify the mechanisms of the effectiveness of AIT in patients with AR. \u0000Aim: To evaluate the clinical effectiveness of AIT in patients with AR and to identify the most significant biomarkers of the formation of early immunological tolerance. \u0000Materials and methods We examined 30 patients with AR aged 19 to 60 years who received AIT. The clinical effectiveness was assessed using the CSMS. All patients had their serum levels of IL-4, IL-13, IFN-γ, IL-12, IL-10, TGF-β, and asIgG4 recorded at baseline and 6 months after the start of AIT. \u0000Results: AIT has been demonstrated to be highly clinically effective in achieving control of AR. At baseline, the total CSMS score was 3.75 [3.33; 4.5], at the end of 6 months - 1.83[1.17;2.67] (p=0.000002). When analyzing the dynamics of the cytokine profile and asIgG4, an increasing in the level of TGF-b (p = 0.000002), IL-12 (p = 0.000002) and asIgG4 (p = 0.000003) was revealed, as well as a decreasing in the level of IL- 4 (p=0.000024) 6 months after the start of AIT. We did not register an increase in IFN-γ and the expected increase in IL-10 and decrease of IL-13. The correlation and PCA showed that the clinical effect of AIT was associated with an increase in TGF-β and IL-12, a moderate increase in asIgG4 with a decrease of IL-4. \u0000Conclusions: The results demonstrate the high clinical effectiveness of AIT within 6 months from the moment of its initiation. Significant marker of the effectiveness of AIT at the stage of early tolerance formation is TGF-β, which increasement was in correlation with an increased IL-12 with a decrease of IL-4. The increase in asIgG4 is less pronounced. The conducted correlation and PCA showed the relationship of the discussed biomarkers with the CSMS, which may indicate in favor of their choice as potential biomarkers for assessing the effectiveness of AIT.","PeriodicalId":270411,"journal":{"name":"Russian Journal of Allergy","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140979046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of selenium in the functioning of components of the immune system: content analysis of modern literature","authors":"Mariia A. Shikina, Nadeghda E. Chapova, Daria D. Kuznetsova, Yury V. Zhernov, Mariia M. Kozhevnikova, Polina V. Pronina, Kirill V. Moiseev, Timurbulat R. Samigullin","doi":"10.36691/rja16923","DOIUrl":"https://doi.org/10.36691/rja16923","url":null,"abstract":"Selenium is an essential trace element. Adequate selenium intake is necessary for the optimal functioning of cellular and humoral processes in the body. A lack of selenium in the diet leads to the aggravation of the course of infectious diseases and also potentiates the occurrence of tumor diseases. This review study reveals data on the metabolic pathways of selenium, its role in the functioning of the immune system, and its antitumor and antioxidant protection. The role of selenium in the implementation of antiviral defenses in the body is discussed in detail. In conditions of selenium deficiency, many viral infections, including COVID-19, are associated with the development of an unfavorable prognosis. In particular, the problem of the occurrence of myocarditis during COVID-19 infection is considered, and data on the pathogenesis of this condition and a possible connection with selenium deficiency are summarized.","PeriodicalId":270411,"journal":{"name":"Russian Journal of Allergy","volume":"107 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomodulatory effect of hemozoin from Opisthorchis felineus and its participation in reducing allergic inflammation through activation of the inflammasome.","authors":"Anasyasiay Pavlovna Melenteva","doi":"10.36691/rja16930","DOIUrl":"https://doi.org/10.36691/rja16930","url":null,"abstract":"Hemozoin is a dark brown insoluble biocrystal, an excretory product of a number of hematophageal parasites (Schistosoma mansoni, Plasmodium falciparum and Opisthorchis felineus). This excretory product is a promising compound of parasitic origin for study, has pronounced immunomodulatory properties. This review presents an analysis of the accumulated literature data regarding the immunomodulatory effect of the trematode Opisthorchis felineus and its closely related species. The literature data on the immunomodulatory effect of hemozoin of various origins are analyzed. Current information on the immune mechanisms of inflammasome activation and the possible role of hemozoin in reducing allergic inflammation through this mechanism is presented.","PeriodicalId":270411,"journal":{"name":"Russian Journal of Allergy","volume":"32 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140981395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}