Adolescent with severe atopic dermatitis and comorbid joit disease: remission achievement by selective JAK1-inhibitor treatment

Atopic dermatitis is a heterogenous in terms of inflammatory pathways and severity prognosis skin disease. Some patients demonstrate severe recurrent course of the disease which do not respond on standard topical anti-inflammatory preparations. Comorbid diseases (not only atopic ones) could serve additional factors complicating atopic dermatitis control achievement. The adolescent patient (well-known for low adherence to topical treatment) could become a special difficulty in clinical management. A clinical case of successful systemic therapy (upadacitinib 15mg QD) of severe atopic dermatitis patient comorbid with immunologically-driven joint disease presented. Previous topical treatment of atopic dermatitis was inefficient. Effectiveness (indexes SCORAD and DLQI, digital itch scale) and safety (laboratory data and complains) were evaluated for more than 1 year (15 months) of therapy. Rapid and sustain positive changes in course control of atopic dermatitis with possible T2-associated and other inflammatory mediators were demonstrated.