{"title":"猫癣菌(Opisthorchis felineus)血索素的免疫调节作用及其通过激活炎症小体参与减轻过敏性炎症的作用。","authors":"Anasyasiay Pavlovna Melenteva","doi":"10.36691/rja16930","DOIUrl":null,"url":null,"abstract":"Hemozoin is a dark brown insoluble biocrystal, an excretory product of a number of hematophageal parasites (Schistosoma mansoni, Plasmodium falciparum and Opisthorchis felineus). This excretory product is a promising compound of parasitic origin for study, has pronounced immunomodulatory properties. This review presents an analysis of the accumulated literature data regarding the immunomodulatory effect of the trematode Opisthorchis felineus and its closely related species. The literature data on the immunomodulatory effect of hemozoin of various origins are analyzed. Current information on the immune mechanisms of inflammasome activation and the possible role of hemozoin in reducing allergic inflammation through this mechanism is presented.","PeriodicalId":270411,"journal":{"name":"Russian Journal of Allergy","volume":"32 6","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Immunomodulatory effect of hemozoin from Opisthorchis felineus and its participation in reducing allergic inflammation through activation of the inflammasome.\",\"authors\":\"Anasyasiay Pavlovna Melenteva\",\"doi\":\"10.36691/rja16930\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Hemozoin is a dark brown insoluble biocrystal, an excretory product of a number of hematophageal parasites (Schistosoma mansoni, Plasmodium falciparum and Opisthorchis felineus). This excretory product is a promising compound of parasitic origin for study, has pronounced immunomodulatory properties. This review presents an analysis of the accumulated literature data regarding the immunomodulatory effect of the trematode Opisthorchis felineus and its closely related species. The literature data on the immunomodulatory effect of hemozoin of various origins are analyzed. Current information on the immune mechanisms of inflammasome activation and the possible role of hemozoin in reducing allergic inflammation through this mechanism is presented.\",\"PeriodicalId\":270411,\"journal\":{\"name\":\"Russian Journal of Allergy\",\"volume\":\"32 6\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-05-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of Allergy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36691/rja16930\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Allergy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36691/rja16930","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Immunomodulatory effect of hemozoin from Opisthorchis felineus and its participation in reducing allergic inflammation through activation of the inflammasome.
Hemozoin is a dark brown insoluble biocrystal, an excretory product of a number of hematophageal parasites (Schistosoma mansoni, Plasmodium falciparum and Opisthorchis felineus). This excretory product is a promising compound of parasitic origin for study, has pronounced immunomodulatory properties. This review presents an analysis of the accumulated literature data regarding the immunomodulatory effect of the trematode Opisthorchis felineus and its closely related species. The literature data on the immunomodulatory effect of hemozoin of various origins are analyzed. Current information on the immune mechanisms of inflammasome activation and the possible role of hemozoin in reducing allergic inflammation through this mechanism is presented.